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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IDH3G-ANAPC7 (FusionGDB2 ID:38256)

Fusion Gene Summary for IDH3G-ANAPC7

Fusion gene summary

Fusion gene information	Fusion gene name: IDH3G-ANAPC7
	Fusion gene ID: 38256
		Hgene	Tgene
	Gene symbol	IDH3G	ANAPC7
	Gene ID	3421	51434
	Gene name	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	anaphase promoting complex subunit 7
	Synonyms	H-IDHG	APC7
	Cytomap	Xq28	12q24.11
	Type of gene	protein-coding	protein-coding
	Description	isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialIDH-gammaNAD (H)-specific isocitrate dehydrogenase gamma subunitNAD(+)-specific ICDH subunit gammaNAD+-specific ICDHisocitrate dehydrogenase (NAD(+)) 3 gammaisocitrate dehydrogenase 3 (NAD(+	anaphase-promoting complex subunit 7cyclosome subunit 7
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UJX3
	Ensembl transtripts involved in fusion gene	ENST00000217901, ENST00000370092, ENST00000370093, ENST00000427365, ENST00000497043,	ENST00000450008, ENST00000481473, ENST00000455511,
Fusion gene scores	* DoF score	2 X 2 X 1=4	11 X 8 X 4=352
	# samples	2	12
	** MAII score	log2(2/4*10)=2.32192809488736	log2(12/352*10)=-1.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IDH3G [Title/Abstract] AND ANAPC7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IDH3G(153051221)-ANAPC7(110819758), # samples:1
Anticipated loss of major functional domain due to fusion event.	IDH3G-ANAPC7 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. IDH3G-ANAPC7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IDH3G-ANAPC7 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ANAPC7	GO:0070979	protein K11-linked ubiquitination	18485873

Fusion gene breakpoints across IDH3G (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANAPC7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	CB048675	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+

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Fusion Gene ORF analysis for IDH3G-ANAPC7

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000217901	ENST00000450008	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
5CDS-intron	ENST00000217901	ENST00000481473	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
5CDS-intron	ENST00000370092	ENST00000450008	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
5CDS-intron	ENST00000370092	ENST00000481473	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
5CDS-intron	ENST00000370093	ENST00000450008	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
5CDS-intron	ENST00000370093	ENST00000481473	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
Frame-shift	ENST00000217901	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
In-frame	ENST00000370092	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
In-frame	ENST00000370093	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-3CDS	ENST00000427365	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-3CDS	ENST00000497043	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-intron	ENST00000427365	ENST00000450008	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-intron	ENST00000427365	ENST00000481473	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-intron	ENST00000497043	ENST00000450008	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+
intron-intron	ENST00000497043	ENST00000481473	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000370092

IDH3G

chrX

153051221

ENST00000455511

ANAPC7

chr12

110819758

3719

1712

186

1328

380

ENST00000370093

IDH3G

chrX

153051221

ENST00000455511

ANAPC7

chr12

110819758

3669

1662

1369

2424

351

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370092	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+	0.002411956	0.99758804
ENST00000370093	ENST00000455511	IDH3G	chrX	153051221	-	ANAPC7	chr12	110819758	+	0.002057992	0.99794203

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Fusion Genomic Features for IDH3G-ANAPC7

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IDH3G-ANAPC7

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153051221/chr12:110819758)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ANAPC7 Q9UJX3
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269\|PubMed:18485873}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

373_406

345

538.0

Repeat

Note=TPR 5

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

407_440

345

538.0

Repeat

Note=TPR 6

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

441_475

345

538.0

Repeat

Note=TPR 7

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

476_508

345

538.0

Repeat

Note=TPR 8

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

509_542

345

538.0

Repeat

Note=TPR 9

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

543_565

345

538.0

Repeat

Note=TPR 10

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

373_406

345

600.0

Repeat

Note=TPR 5

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

407_440

345

600.0

Repeat

Note=TPR 6

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

441_475

345

600.0

Repeat

Note=TPR 7

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

476_508

345

600.0

Repeat

Note=TPR 8

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

509_542

345

600.0

Repeat

Note=TPR 9

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

543_565

345

600.0

Repeat

Note=TPR 10

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

135_168

345

538.0

Repeat

Note=TPR 1

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

203_236

345

538.0

Repeat

Note=TPR 2

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

237_270

345

538.0

Repeat

Note=TPR 3

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000450008

271_304

345

538.0

Repeat

Note=TPR 4

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

135_168

345

600.0

Repeat

Note=TPR 1

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

203_236

345

600.0

Repeat

Note=TPR 2

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

237_270

345

600.0

Repeat

Note=TPR 3

Tgene

ANAPC7

chrX:153051221

chr12:110819758

ENST00000455511

271_304

345

600.0

Repeat

Note=TPR 4

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Fusion Gene Sequence for IDH3G-ANAPC7

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>38256_38256_1_IDH3G-ANAPC7_IDH3G_chrX_153051221_ENST00000370092_ANAPC7_chr12_110819758_ENST00000455511_length(transcript)=3719nt_BP=1712nt
GGTCGCGGTCCCCCCCTCAACATGGCGGCAGCGGTGCTCTAGGCGCCGGAAGGGGGCGTGAATCGGTGCGACCGCGCGCGTGCGCAGTAC
CGGGTCCGCGCCTGTCCCCGAAACTTCGCACCCCGTCGAACTCTCGCGAGAGCGGTATCTGCGTGTCGGGACGTGCGGAGGCTCTCACTT
TCCGTCATGGCGCTGAAGGTAGCGACCGTCGCCGGCAGCGCCGCGAAGGCGGTGCTCGGGCCAGCCCTTCTCTGCCGTCCCTGGGAGGTT
CTAGGCGCCCACGAGGTCCCCTCGAGGAACATCTTTTCAGAACAAACAATTCCTCCGTCCGCTAAGTATGGCGGGCGGCACACGGTGACC
ATGATCCCAGGGGATGGCATCGGGCCAGAGCTCATGCTGCATGTCAAGTCCGTCTTCAGGCACGCATGTGTACCAGTGGACTTTGAAGAG
GTGCACGTGAGTTCCAATGCTGATGAAGAGGACATTCGCAATGCCATCATGGCCATCCGCCGGAACCGCGTGGCCCTGAAGGGCAACATC
GAAACCAACCATAACCTGCCACCGTCGCACAAATCTCGAAACAACATCCTTCGCACCAGCCTGGACCTCTATGCCAACGTCATCCACTGT
AAGAGCCTTCCAGGCGTGGTGACCCGGCACAAGGACATAGACATCCTCATTGTCCGGGAGAACACAGAGGGCGAGTACAGCAGCCTGGAG
CATGAGAGTGTGGCGGGAGTGGTGGAGAGCCTGAAGATCATCACCAAGGCCAAGTCCCTGCGCATTGCCGAGTATGCCTTCAAGCTGGCG
CAGGAGAGCGGGCGCAAGAAAGTGACGGCCGTGCACAAGGCCAACATCATGAAACTGGGCGATGGGCTTTTCCTCCAGTGCTGCAGGGAG
GTGGCAGCCCGCTACCCTCAGATCACCTTCGAGAACATGATTGTGGATAACACCACCATGCAGCTGGTGTCCCGGCCCCAGCAGTTTGAT
GTCATGGTGATGCCCAATCTCTATGGCAACATCGTCAACAATGTCTGCGCGGGACTGGTCGGGGGCCCAGGCCTTGTGGCTGGGGCCAAC
TATGGCCATGTGTACGCGGTGTTTGAAACAGCTACGAGGAACACCGGCAAGAGTATCGCCAATAAGAACATCGCCAACCCCACGGCCACC
CTGCTGGCCAGCTGCATGATGCTGGACCACCTCAAGCTGCACTCCTATGCCACCTCCATCCGTAAGGCTGTCCTGGCATCCATGGACAAT
GAGAATGTGAGGTTCCCCTCGCACCCTACCCTGCTGCCCCGCCCAGTCTCCCCCTGCAGCCTCCTGTAGCCCGCCTCATGCACTGACCAC
AGCCCCCAGGGGAGGATGGTACTGGATCTGGCCCCATCTTCTGGCCCTTAGCTGGTGCCACTTCCCTCCTGTGGCAATCCCAGTCCTGCA
CGTCACAGGAGACAGCGGGGGGTGGCAGGGCCTGGTGTGTGCCGAGCCTGCCTGTGTCCTACAGATGCACACTCCGGACATCGGGGGCCA
GGGCACAACATCTGAAGCCATCCAGGACGTCATCCGCCACATCCGCGTCATCAACGGCCGGGCCGTGGAGGCCTAGGCTGGCCCTAGGAC
CTTCTTGGTTTGCTCCTTGGATTCCCCTTCCCACTCCAGCACCCCAGCCAGCCTGGTACGCAGATCCCAGAATAAAGCACCTTCTCCCTA
GACTGTCACAGCTTCTATAGCAAACGCTACTCCCGGGCCCTCTATTTAGGAGCCAAGGCCATTCAGCTGAACAGTAATAGTGTTCAAGCT
CTGCTACTTAAGGGAGCAGCACTTAGGAACATGGGCAGAGTCCAAGAAGCAATAATCCACTTTCGGGAGGCCATACGGCTCGCACCTTGT
CGCTTAGATTGTTATGAAGGTCTTATCGAATGTTACTTAGCCTCCAACAGTATTCGAGAAGCAATGGTAATGGCTAACAACGTTTACAAA
ACTCTGGGAGCAAATGCACAGACCCTTACCCTTTTAGCCACCGTTTGTCTTGAAGACCCAGTGACACAGGAGAAAGCCAAAACATTATTA
GATAAAGCCCTGACCCAAAGGCCAGATTACATTAAGGCTGTGGTGAAAAAAGCAGAACTACTTAGCAGAGAACAGAAATATGAAGATGGA
ATTGCTTTGCTGAGGAACGCACTGGCTAATCAGAGTGACTGTGTCCTGCATCGGATCCTAGGAGATTTCCTTGTAGCTGTCAATGAGTAT
CAGGAGGCAATGGACCAGTATAGTATAGCACTAAGTTTGGACCCCAATGACCAGAAGTCTCTAGAGGGGATGCAGAAGATGGAGAAGGAG
GAGAGTCCCACGGATGCCACTCAGGAGGAGGATGTGGACGACATGGAAGGGAGTGGGGAAGAAGGGGACCTGGAGGGCAGCGACAGTGAG
GCGGCCCAGTGGGCTGACCAGGAGCAGTGGTTCGGCATGCAGTGAGGGGGCGGCAGCTCCATGGCCGCAGTGGCCTGCCCTGCTCTGAGC
ACTTCCGTGGACTGAAGGAACCGTAGGAGCCTGCTCTCAGAAGGACAATGATTCAGCATGTGATTGCAGCAGGGGTCTCTGCCCCCTCGC
TCCCAATTCCTAGTCGTGACTTCATTTCTAAAACAGAGCCTGACCAACCTTCCATGTATCTCCATCCTCCCCTGCTCCAGCCAGGGAGGA
CTGAGGGAGTGCCCCGAGACCCACGCACATGTTGGGGCTTCTGGGCCAAGAGTACTTTTTATATAACTAATTTCTAAATCCAAAAGCTCA
AGGAATAGACAGTGTTCTGTGACATGGATTGGTTTGAAGGAGTTACCCACCATCCCAGCACGATAATGTCATCTCCCAAGTTGGATGGCA
GCACGATCTGGCCCTAGGGAGCTTCCTGTTCCCAGAAGTCATTGTCCTGGGCTATCCAGATGTCCCTAGTAAATCTTGCTTCCTTCTGCA
ATGTTAGTAATGCCTTAAGCTGACAGTTGCTATTTTGCAGAACAGTTTTCCTCTTTGCTTAGCTAGTAACTTGCCTCTGAGCCTGGGCTG
ATCTGAGAAACAGGTGTGACAAGAGCATGAACCAGAGGTGCACCTGGGGCAGTTCCCTAATAAAACTGGTTTGTACAGTCATGGTGTTGG
GGTGATCAGAATGGAAGCCCTTTTCAAAATAGACTCTTAGTATTTTTGTCTTATTCGCAATGCATTGATTCAGCCCCAGAATTATTTGCC
AGAAATAGACTTTCTTCCCCTGGTGTTGGGAGCCAGGAGGGTTGGAAAGCTCAGGAACCCTGAGCTGGTTCATCTGTTTGCATATTGGGT
AGGTTAATTTCCCTGGAGCCTGAGAGTCTTTGGCCAGATTTCAGCTGCGTCTGCCTGGCTCTTTTGCTGCAGCTGTGAGATTGGGGTCTG
GTTCCAGCAGTCTGTCACTGGTCAGCCTGAGTATCACACCCTGAGCTCTGGGGCTGGGAGTTTCTTCCCACACCCTCTCCCTTGTGCCTT
AAGTTGCGATGGCTCTGAGTATACAATTAATCGGAGGTGAGGGGTGGGTGTCACAGCTAATCCCAAATTCAAAAATTAGTCCAAGGTGCT
GCAAAATATAAATTTGATGTCAGTAGAAAGTCGTATCCTAAAATGTAAAAACTGTAAGTGTACAGTAGTTAATGAGCTCAGAACATCTGA

>38256_38256_1_IDH3G-ANAPC7_IDH3G_chrX_153051221_ENST00000370092_ANAPC7_chr12_110819758_ENST00000455511_length(amino acids)=380AA_BP=
MALKVATVAGSAAKAVLGPALLCRPWEVLGAHEVPSRNIFSEQTIPPSAKYGGRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVH
VSSNADEEDIRNAIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVRENTEGEYSSLEHE
SVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVM
VMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIRKAVLASMDNEN

--------------------------------------------------------------
>38256_38256_2_IDH3G-ANAPC7_IDH3G_chrX_153051221_ENST00000370093_ANAPC7_chr12_110819758_ENST00000455511_length(transcript)=3669nt_BP=1662nt
TCTCGCGAGAGCGGTATCTGCGTGTCGGGACGTGCGGAGGCTCTCACTTTCCGTCATGGCGCTGAAGGTAGCGACCGTCGCCGGCAGCGC
CGCGAAGGCGGTGCTCGGGCCAGCCCTTCTCTGCCGTCCCTGGGAGGTTCTAGGCGCCCACGAGGTCCCCTCGAGGAACATCTTTTCAGA
ACAAACAATTCCTCCGTCCGCTAAGTATGGCGGGCGGCACACGGTGACCATGATCCCAGGGGATGGCATCGGGCCAGAGCTCATGCTGCA
TGTCAAGTCCGTCTTCAGGCACGCATGTGTACCAGTGGACTTTGAAGAGGTGCACGTGAGTTCCAATGCTGATGAAGAGGACATTCGCAA
TGCCATCATGGCCATCCGCCGGAACCGCGTGGCCCTGAAGGGCAACATCGAAACCAACCATAACCTGCCACCGTCGCACAAATCTCGAAA
CAACATCCTTCGCACCAGCCTGGACCTCTATGCCAACGTCATCCACTGTAAGAGCCTTCCAGGCGTGGTGACCCGGCACAAGGACATAGA
CATCCTCATTGTCCGGGAGAACACAGAGGGCGAGTACAGCAGCCTGGAGCATGAGAGTGTGGCGGGAGTGGTGGAGAGCCTGAAGATCAT
CACCAAGGCCAAGTCCCTGCGCATTGCCGAGTATGCCTTCAAGCTGGCGCAGGAGAGCGGGCGCAAGAAAGTGACGGCCGTGCACAAGGC
CAACATCATGAAACTGGGCGATGGGCTTTTCCTCCAGTGCTGCAGGGAGGTGGCAGCCCGCTACCCTCAGATCACCTTCGAGAACATGAT
TGTGGATAACACCACCATGCAGCTGGTGTCCCGGCCCCAGCAGTTTGATGTCATGGTGATGCCCAATCTCTATGGCAACATCGTCAACAA
TGTCTGCGCGGGACTGGTCGGGGGCCCAGGCCTTGTGGCTGGGGCCAACTATGGCCATGTGTACGCGGTGTTTGAAACAGCTACGAGGAA
CACCGGCAAGAGTATCGCCAATAAGAACATCGCCAACCCCACGGCCACCCTGCTGGCCAGCTGCATGATGCTGGACCACCTCAAGTGAGT
GGCTCCCAGTGCCCCGCAAGCCCCTGGCCAGCCCTCCGGGCCCCAGGGACTGAAGGCTGGCTGTCCCATCCTCTAGGCTGCACTCCTATG
CCACCTCCATCCGTAAGGCTGTCCTGGCATCCATGGACAATGAGAATGTGAGGTTCCCCTCGCACCCTACCCTGCTGCCCCGCCCAGTCT
CCCCCTGCAGCCTCCTGTAGCCCGCCTCATGCACTGACCACAGCCCCCAGGGGAGGATGGTACTGGATCTGGCCCCATCTTCTGGCCCTT
AGCTGGTGCCACTTCCCTCCTGTGGCAATCCCAGTCCTGCACGTCACAGGAGACAGCGGGGGGTGGCAGGGCCTGGTGTGTGCCGAGCCT
GCCTGTGTCCTACAGATGCACACTCCGGACATCGGGGGCCAGGGCACAACATCTGAAGCCATCCAGGACGTCATCCGCCACATCCGCGTC
ATCAACGGCCGGGCCGTGGAGGCCTAGGCTGGCCCTAGGACCTTCTTGGTTTGCTCCTTGGATTCCCCTTCCCACTCCAGCACCCCAGCC
AGCCTGGTACGCAGATCCCAGAATAAAGCACCTTCTCCCTAGCTGTCACAGCTTCTATAGCAAACGCTACTCCCGGGCCCTCTATTTAGG
AGCCAAGGCCATTCAGCTGAACAGTAATAGTGTTCAAGCTCTGCTACTTAAGGGAGCAGCACTTAGGAACATGGGCAGAGTCCAAGAAGC
AATAATCCACTTTCGGGAGGCCATACGGCTCGCACCTTGTCGCTTAGATTGTTATGAAGGTCTTATCGAATGTTACTTAGCCTCCAACAG
TATTCGAGAAGCAATGGTAATGGCTAACAACGTTTACAAAACTCTGGGAGCAAATGCACAGACCCTTACCCTTTTAGCCACCGTTTGTCT
TGAAGACCCAGTGACACAGGAGAAAGCCAAAACATTATTAGATAAAGCCCTGACCCAAAGGCCAGATTACATTAAGGCTGTGGTGAAAAA
AGCAGAACTACTTAGCAGAGAACAGAAATATGAAGATGGAATTGCTTTGCTGAGGAACGCACTGGCTAATCAGAGTGACTGTGTCCTGCA
TCGGATCCTAGGAGATTTCCTTGTAGCTGTCAATGAGTATCAGGAGGCAATGGACCAGTATAGTATAGCACTAAGTTTGGACCCCAATGA
CCAGAAGTCTCTAGAGGGGATGCAGAAGATGGAGAAGGAGGAGAGTCCCACGGATGCCACTCAGGAGGAGGATGTGGACGACATGGAAGG
GAGTGGGGAAGAAGGGGACCTGGAGGGCAGCGACAGTGAGGCGGCCCAGTGGGCTGACCAGGAGCAGTGGTTCGGCATGCAGTGAGGGGG
CGGCAGCTCCATGGCCGCAGTGGCCTGCCCTGCTCTGAGCACTTCCGTGGACTGAAGGAACCGTAGGAGCCTGCTCTCAGAAGGACAATG
ATTCAGCATGTGATTGCAGCAGGGGTCTCTGCCCCCTCGCTCCCAATTCCTAGTCGTGACTTCATTTCTAAAACAGAGCCTGACCAACCT
TCCATGTATCTCCATCCTCCCCTGCTCCAGCCAGGGAGGACTGAGGGAGTGCCCCGAGACCCACGCACATGTTGGGGCTTCTGGGCCAAG
AGTACTTTTTATATAACTAATTTCTAAATCCAAAAGCTCAAGGAATAGACAGTGTTCTGTGACATGGATTGGTTTGAAGGAGTTACCCAC
CATCCCAGCACGATAATGTCATCTCCCAAGTTGGATGGCAGCACGATCTGGCCCTAGGGAGCTTCCTGTTCCCAGAAGTCATTGTCCTGG
GCTATCCAGATGTCCCTAGTAAATCTTGCTTCCTTCTGCAATGTTAGTAATGCCTTAAGCTGACAGTTGCTATTTTGCAGAACAGTTTTC
CTCTTTGCTTAGCTAGTAACTTGCCTCTGAGCCTGGGCTGATCTGAGAAACAGGTGTGACAAGAGCATGAACCAGAGGTGCACCTGGGGC
AGTTCCCTAATAAAACTGGTTTGTACAGTCATGGTGTTGGGGTGATCAGAATGGAAGCCCTTTTCAAAATAGACTCTTAGTATTTTTGTC
TTATTCGCAATGCATTGATTCAGCCCCAGAATTATTTGCCAGAAATAGACTTTCTTCCCCTGGTGTTGGGAGCCAGGAGGGTTGGAAAGC
TCAGGAACCCTGAGCTGGTTCATCTGTTTGCATATTGGGTAGGTTAATTTCCCTGGAGCCTGAGAGTCTTTGGCCAGATTTCAGCTGCGT
CTGCCTGGCTCTTTTGCTGCAGCTGTGAGATTGGGGTCTGGTTCCAGCAGTCTGTCACTGGTCAGCCTGAGTATCACACCCTGAGCTCTG
GGGCTGGGAGTTTCTTCCCACACCCTCTCCCTTGTGCCTTAAGTTGCGATGGCTCTGAGTATACAATTAATCGGAGGTGAGGGGTGGGTG
TCACAGCTAATCCCAAATTCAAAAATTAGTCCAAGGTGCTGCAAAATATAAATTTGATGTCAGTAGAAAGTCGTATCCTAAAATGTAAAA

>38256_38256_2_IDH3G-ANAPC7_IDH3G_chrX_153051221_ENST00000370093_ANAPC7_chr12_110819758_ENST00000455511_length(amino acids)=351AA_BP=89
MWQSQSCTSQETAGGGRAWCVPSLPVSYRCTLRTSGARAQHLKPSRTSSATSASSTAGPWRPRLALGPSWFAPWIPLPTPAPQPAWYADP
RIKHLLPSCHSFYSKRYSRALYLGAKAIQLNSNSVQALLLKGAALRNMGRVQEAIIHFREAIRLAPCRLDCYEGLIECYLASNSIREAMV
MANNVYKTLGANAQTLTLLATVCLEDPVTQEKAKTLLDKALTQRPDYIKAVVKKAELLSREQKYEDGIALLRNALANQSDCVLHRILGDF

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Fusion Gene PPI Analysis for IDH3G-ANAPC7

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IDH3G-ANAPC7

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IDH3G-ANAPC7

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source