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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IDS-PHACTR1 (FusionGDB2 ID:38278)

Fusion Gene Summary for IDS-PHACTR1

check button Fusion gene summary
Fusion gene informationFusion gene name: IDS-PHACTR1
Fusion gene ID: 38278
HgeneTgene
Gene symbol

IDS

PHACTR1

Gene ID

3423

221692

Gene nameiduronate 2-sulfatasephosphatase and actin regulator 1
SynonymsID2S|MPS2|SIDSEIEE70|RPEL|RPEL1|dJ257A7.2
Cytomap

Xq28

6p24.1

Type of geneprotein-codingprotein-coding
Descriptioniduronate 2-sulfatasealpha-L-iduronate sulfate sulfataseiduronate 2-sulfatase 14 kDa chainiduronate 2-sulfatase 42 kDa chainidursulfasephosphatase and actin regulator 1RPEL repeat containing 1
Modification date2020031320200313
UniProtAcc

P22304

.
Ensembl transtripts involved in fusion geneENST00000340855, ENST00000370441, 
ENST00000370443, ENST00000422081, 
ENST00000541269, ENST00000490775, 
ENST00000427113, ENST00000428056, 
ENST00000537071, 		ENST00000482982, 
ENST00000379345, ENST00000457702, 
ENST00000332995, ENST00000379329, 
ENST00000379335, ENST00000379348, 
ENST00000379350, 
Fusion gene scores* DoF score7 X 7 X 2=9810 X 10 X 8=800
# samples 712
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/800*10)=-2.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IDS [Title/Abstract] AND PHACTR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIDS(148577877)-PHACTR1(13160436), # samples:3
Anticipated loss of major functional domain due to fusion event.IDS-PHACTR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIDS

GO:0006027

glycosaminoglycan catabolic process

28593992


check buttonFusion gene breakpoints across IDS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHACTR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TQ-A8XE-02AIDSchrX

148577877

-PHACTR1chr6

13160436

+
ChimerDB4LGGTCGA-TQ-A8XEIDSchrX

148577877

-PHACTR1chr6

13160436

+


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Fusion Gene ORF analysis for IDS-PHACTR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000340855ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-3UTRENST00000370441ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-3UTRENST00000370443ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-3UTRENST00000422081ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-3UTRENST00000541269ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000340855ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000340855ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000370441ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000370441ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000370443ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000370443ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000422081ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000422081ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000541269ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-5UTRENST00000541269ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000340855ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000340855ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000340855ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000340855ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370441ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370441ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370441ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370441ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370443ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370443ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370443ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000370443ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000422081ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000422081ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000422081ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000422081ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000541269ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000541269ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000541269ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5CDS-intronENST00000541269ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-3CDSENST00000490775ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-3UTRENST00000490775ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-5UTRENST00000490775ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-5UTRENST00000490775ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-intronENST00000490775ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-intronENST00000490775ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-intronENST00000490775ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
5UTR-intronENST00000490775ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
Frame-shiftENST00000340855ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
Frame-shiftENST00000370441ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
Frame-shiftENST00000370443ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
In-frameENST00000422081ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
In-frameENST00000541269ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3CDSENST00000427113ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3CDSENST00000428056ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3CDSENST00000537071ENST00000379350IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3UTRENST00000427113ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3UTRENST00000428056ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-3UTRENST00000537071ENST00000482982IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000427113ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000427113ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000428056ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000428056ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000537071ENST00000379345IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-5UTRENST00000537071ENST00000457702IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000427113ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000427113ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000427113ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000427113ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000428056ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000428056ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000428056ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000428056ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000537071ENST00000332995IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000537071ENST00000379329IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000537071ENST00000379335IDSchrX

148577877

-PHACTR1chr6

13160436

+
intron-intronENST00000537071ENST00000379348IDSchrX

148577877

-PHACTR1chr6

13160436

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541269IDSchrX148577877-ENST00000379350PHACTR1chr613160436+5898165815762697373
ENST00000422081IDSchrX148577877-ENST00000379350PHACTR1chr613160436+5898165815762697373

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541269ENST00000379350IDSchrX148577877-PHACTR1chr613160436+0.0025441490.9974559
ENST00000422081ENST00000379350IDSchrX148577877-PHACTR1chr613160436+0.0025441490.9974559

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Fusion Genomic Features for IDS-PHACTR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IDSchrX148577876-PHACTR1chr613160435+5.12E-050.99994874
IDSchrX148577876-PHACTR1chr613160435+5.12E-050.99994874
IDSchrX148577876-PHACTR1chr613160435+5.12E-050.99994874
IDSchrX148577876-PHACTR1chr613160435+5.12E-050.99994874

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IDS-PHACTR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:148577877/chr6:13160436)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IDS

P22304

.
FUNCTION: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. {ECO:0000269|PubMed:10838181, ECO:0000269|PubMed:11731225, ECO:0000269|PubMed:28593992}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHACTR1chrX:148577877chr6:13160436ENST00000379350310138_163138485.0RepeatNote=RPEL 1
TgenePHACTR1chrX:148577877chr6:13160436ENST00000379350310422_447138485.0RepeatNote=RPEL 2
TgenePHACTR1chrX:148577877chr6:13160436ENST00000379350310460_484138485.0RepeatNote=RPEL 3
TgenePHACTR1chrX:148577877chr6:13160436ENST00000379350310498_523138485.0RepeatNote=RPEL 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHACTR1chrX:148577877chr6:13160436ENST00000379350310108_129138485.0MotifNuclear localization signal


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Fusion Gene Sequence for IDS-PHACTR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38278_38278_1_IDS-PHACTR1_IDS_chrX_148577877_ENST00000422081_PHACTR1_chr6_13160436_ENST00000379350_length(transcript)=5898nt_BP=1658nt
TTGGAGTTCAGCCACCTTAGCAAGTCCTGGGTTTGTTCTTCAGACTTTGCTGCTCGCCCATTGCCTGGATCGGGGGCTACTTTGTAAACC
ACCAGGAAGACTCCAGTGTTTCTGGTTAATTTTTAGATGTTTGTTAATTGCTCTTGGTCTCTCATTAATCCCCTGTGGGTCATCCAGGAA
ACATACTCACCACTGTCTGTTCTCTGAGTTTTCATTTCCAGGCATCCGCCCTGCCTGGATCTCCTCACCTGCCAGGAACTTCCTCTCCAC
AAGCCGGCCATCCCAGCAAAAGTTCTAACACCAAAGGTCTGGCAACTAGCCTGCCATCTTGTGCCTGGAGCCGCCTGCGTGCCACCTACT
CCCGAAGATGGGAACCTTGTTGCCAGTTGGGCAGATGCGGGGCAATCCTGTACCAAGACCCCATTTTACCACCTGCTTTCTCAGACCACT
CTGGAACCCACTGTCTCAGATTGTGTCTTCCAGGAAGCAGACCATGAGAGGGAGTTGGCAGGGCCAAAGATTTACTGGGGCTAACTAACA
CTCAGGAAAGGGATAGGAAGGAAACAGGGCTGGAGAGCAGGTTGAGCCCGACCTGACAGTCTCGAGCAGCCCAACAGGGAGGTGTGGAGC
AAGGGTTGCCCACTAGAGGGGCCTGCATTGGGTACGGGTGATGGGGTCCACATGGTACCTGGCATATAGCAGGCTGTGCAATCCATATTA
ACTGACTGGATAAATTAATGCTCAGAAAAGGTGCCCTGGAGAATGGGTGCGTGCTGAACACAATAGGGAAGGGCCCAGCATCTGCCTTGG
CATAGGCAGAACTGTGCTGTGCCCTGCAACAGGCCACCTGAGAGCTGCTTTGATCTTGTGTGTACATTAGACGACTGCCAGGGGCATGAA
GGGGATGTGCTTCCAGGGCATTTGCTGGCAGGGCGTCTTGTGATTTCTTGGTATTGGTGTGAGCATAGCCTGGCAGGAGAGGGCAGATCT
CCGTGCAAAGTATGTCAGAAAGCAGATGGAAGCCAGGCCCCCTCCTGAAAGAGGCTCCTTGAAGATAATTCTAACATCTTTGTCATCAGT
GTTGACATCTCTTGATTGTATCCTGTCATTCCATTTGAGATCTTCCTGGTTCTGGCTGGCATCCTCTGACATCACTCCAGCAGAAGAAAG
GGAAGGAACACGCTGCATTACTGCGTGGGATATCTTCTAACCATACCGATGATTCTCCGTATAGCTGGTCTTTTCCACCTTATCATCCTT
CCTCTGAGAAGTATGAAAACACTAAGACATGTCGAGGGCCAGATGGAGAACTCCATGCCAACCTGCTTTGCCCTGTGGATGTGCTGGATG
TTCCCGAGGGCACCTTGCCTGACAAACAGAGCACTGAGCAAGCCATACAGTTGTTGGAAAAGATGAAAACGTCAGCCAGTCCTTTCTTCC
TGGCCGTTGGGTATCATAAGCCACACATCCCCTTCAGATACCCCAAGGAATTTCAGAAGTTGTATCCCTTGGAGAACATCACCCTGGCCC
CCGATCCCGAGGTCCCTGATGGCCTACCCCCTGTGGCCTACAACCCCTGGATGGACATCAGGCAACGGGAAGACGTCCAAGCCTTAAACA
TCAGTGTGCCGTATGGTCCAATTCCTGTGGACTTTCAGCCCTGGAAAGGAAAATATCTATGAGGCAAAGCAGAGAAGAGCTGATAAAGCG
AGGAGTCCTGAAGGAAATCTATGATAAAGATGGGGAACTCTCTATATCCAATGAAGAGGACTCCCTAGAAAATGGGCAGTCCCTGAGCTC
CAGCCAGCTGTCTCTGCCTGCCCTGTCCGAAATGGAGCCAGTCCCAATGCCCAGGGATCCCTGCTCATATGAGGTGCTCCAACCGTCAGA
CATCATGGATGGGCCAGATCCTGGCGCCCCTGTGAAATTGCCTTGTCTGCCAGTGAAACTGTCGCCTCCGCTACCTCCAAAGAAAGTCAT
GATCTGTATGCCCGTGGGGGGGCCAGACCTCTCACTGGTGTCCTACACAGCCCAGAAGAGTGGCCAGCAGGGTGTGGCCCAGCACCACCA
CACTGTCCTGCCCTCCCAGATCCAGCACCAGCTGCAGTACGGCAGCCACGGCCAGCACCTCCCCTCCACCACCGGCTCCCTCCCCATGCA
CCCCTCGGGCTGCAGAATGATAGACGAGCTCAACAAAACGCTGGCCATGACCATGCAGAGGCTGGAAAGCTCTGAGCAGCGGGTCCCCTG
TTCCACTTCTTACCACAGCTCTGGGTTGCACTCGGGTGATGGGGTCACCAAAGCAGGACCTATGGGCCTTCCAGAAATAAGACAAGTGCC
AACTGTTGTGATTGAATGTGATGACAATAAAGAAAATGTGCCTCATGAGTCAGACTACGAAGACTCTTCTTGCCTGTATACAAGAGAAGA
GGAGGAAGAGGAGGAGGACGAAGACGACGACAGCTCATTATACACCAGCTCCCTGGCCATGAAGGTCTGCAGGAAGGACTCCTTAGCCAT
CAAACTCAGCAACAGGCCCTCCAAGCGAGAGCTGGAAGAAAAGAACATCCTTCCCAGGCAGACGGATGAGGAGCGGCTGGAGCTGAGGCA
ACAGATTGGCACCAAGCTCACCAGGCGGCTGAGCCAGAGGCCAACTGCAGAGGAACTGGAACAGAGGAACATTTTGAAACGTAAGTGACT
AAGCCCATGGCAATCCCTGATGTTTTGTGGCGGCTTTTGTTATTATTTAATGGTAGGCCACAAGGTTTCTACCTTGCGCCTCTGCGGAAA
GCATTGAAAACCTTTCTAACGGTTGAAGCTTCATGTGTGCATGTTAGAACACCAAAGACGACCTCCCCAAAGAGAAGGCAAATTTTATTC
CACTTTATTCTTTAGAAGCTCACGGGCGGCAGGCAGAACCTTCCTTTTAGTGAGTTGTAAAGTCAGAGAGAAGCTGAAAAATTAGAGTGA
GACCACTTATTATTTAATGATTTTTAAGAGCAGGGTCACCTTTAAACCAGAATTGGCTTGAAAATGGAGACTGTGATATGCACGGCTAAA
ATAAGGGAAATGTCCATTTGAACTGAGACTAGAAAGCATGACTTTGCATTGCAGCTGGCTGCTGTTGATAAAAATCCCTCATCCCTTTGA
ATGTTAAATTGAAAGACTAAGAAAGCATTTCCAAGTGAAGTGCTTCATGTCTGTCTCTCAGGATTCCCACAGCTGGTCCCGGGCATGCCT
GTCTGATGCTCTCATTCGAGGAAAACTGCCTTTCACCATTGCTGCAGACAGAAAAAAATAAATGAGCCCCTTGTTTGGTTTAGGACACAG
AGACATTTGAATATGTACAGAGGATCCACTTGGTGCTTTAAAAAAAAAAAGAGAAAACAGGATACAAAATACTAAAAGAGATCAAGCATT
TGATGGACAGCAGTATGCGTCAGTTTAGTGGTAGATATTAAATAACTTAAATATCAAACCATTCTATTCATTCATTGCTACCATTCTCGC
CAACACTGGCCTCAAGATAGTGAACAAATATTTCTGGCTTAATTCATGACCCTGTTCCCCCTACCCCACAACACACTTCTAATTTCTCTC
CAGAAGAGAAAGATATATACTATGCAGAGTTTTCTAGAAATGCTATGTTGTACAGACTGACTCCTTGCCTCCCCCGGCCCCCCCGCCCCG
CCCCGCCCCGTGCCCAGTAAATCACATGCAACCGCAGTGTGAGTTTGCCGGGAATTTCCACTGAAACCACACTAAGATATTCTTGACTTT
ACCTTTCTACCGTGCTCACTGTGGCCTTGTGACTTGGTCGGCATTTCGTAGTCTGCTGAAGGTGGGTGCTGGGTTCCGCTTTGGTGGGGA
GACCTGTTGCCTACAGCACCCACCCCCGCCCGACGCCCCCGCATGTCCGTTTATGTCAACTCTGCCTTTATCAATGTCTTGCCTCCCGTC
CCCACGCCAGCCGCCACTTCCTCAACTCTCAGTAGAAGTTATTTTCAGGATTAGCCTTCCTCAGTCGTGGGGGAACCCTACGCTTTGCCT
AGGTCTCTAGGAATGTGTGTTTACTTTTTTCTGCCCAAGGGGTACCCTTTAAAGTTTCCAAGCTTAATATTCTATATAATGAATTCAGAG
CTTTTTCAAAGCATTTCCAAGGTCAGGGAAGCATTTGGCTTGTAGGATGTCTTCCTTTCGGCCCCAATCTGGTACCTGAGCCATTATAAA
CTTCCCATTGTTGGAGAGAAAGATAAACAGCCAGGTGAACCTGTACAACTTACTCACAGCCCGCTGCTGTACTTGTGGCCTCTGACCTGA
GACCTAAACTCAAAGAAGCTAAAAGCCTCCGGGGGATTATTTAGGTTTCAGAAAATAGTGCTTATCACACCAGGAGTACGGTTTCTGGAG
AGATCTAAAATCCCCTAGCTCAGCTCTGGGCTCTCTCAAAGATATCAGATCCCCGCTGTGGCTTGTCCAGATCCCTGGGAGACTACAGGT
CCTTTGAGCTTGGGTTTTTACCGCCATCAACCAGGGAACTTAGATTCAGGGGACCAAAAAGGAGTTGTGAAAGATTGTTCCCATGGTTCT
CTTTTATTCTCTTCCCTAATCCCTCTTGTCCTGGCCACATAGTTGCAAATTAAAGAACTACTTGACCAATTCTAACAGGTTGGTCATTTC
ATAGTTTTGAAACTTTTCAGAAATCAACTTGTTTTCCCATAGGTTCTTATTTTTCCCTGTATTCTGGAACTATGTTCTCCTAAATATTTT
TTTAAATTTAATCTATTGCGATTGTTAAACAAAAAAAATGTCTAGTGGTATAAGAAAACATCCTCCAATAGTTTGTTTTAAAACTGATTT
TCTGAGCTTTCAGCCATTTGAGGAACTGCTCGGTGTTGGGTGGTGGGGAACAGGGCACAGAGATGCCATGGCTCAGCCCTGGAGCTTTGA
GAGCCTTGGGTTGGTTTCCAGCCCCACCCTGCCTGGTCCTGGGAGCAGCCCCTGTTCTGTCCAGCAGCCAGTGAGGCCCTGTGCACCTCT
GAGCACATAATGAACCCTCTGACGGTGGCAGCTGTAATGACGACATCGTAGGCCTTTCCTGGCCTGTCTTCCTAGTTGCCTAATGGGGTT
GTCTTGGTACCTTCTGCCTGAAAATTCATGAACCTGGGTTGGTCAATGGCTTTGAACTAAAGGTATCAATTCTGTAGGTGGTAGCTTGTG
GCCCCACCCCTCAGAGTGACCTAAGAAACGCACATAGGAGATGAAGGCTCCATGCTGTGTCAGCTGTGTCACAGGATGCCCGCCTTCACG
GCTCTGAAGGGACCTGTAGGATCAGAAGTCTGAGGCTAGTAATGAGGAGGAGAGCCGGCCCCACACAAAACATGACCACAGGAAAAAACC
TATCTGTGTAACCACTGAGCCAGGTAGGGTGTGACTGGCCACTTAACACCCCTGAGGCTTCAGATCCTCAGTTATAAACCAGGAGTGGTA
GACGAGGTGGTCACTAGGTCCCCTCATGGCCCTAGTATTCTGTGCTTCTGTAAATTTTCACCGTGTGCCCTCTAGCTGTCCCTGGTGACC
CAACATCCAGACCACCTTTTCTTCCATCCGTTTTCCCACCTGAGACATCGCAAAATGGGAGTTCCCTCCTTCTGGTTCTTGCTGTCTGCC
TCCCCATTTAACTCTGCTAGATTAATTCATACTAAGATATTAATGGCTGACTAGTTTAATAGGTTTTATCCCACTGAAATTTGCATTTGT
ACAAATGTCACTGTCTGGGGGCTCCCTACTTCCGGGTGTTGCTGTCTGCCCCCCAGTTTATCTCTACTAGATTAATTCATACTGAGCTAT

>38278_38278_1_IDS-PHACTR1_IDS_chrX_148577877_ENST00000422081_PHACTR1_chr6_13160436_ENST00000379350_length(amino acids)=373AA_BP=22
MDGHQATGRRPSLKHQCAVWSNSCGLSALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVP
MPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGS
HGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPH
ESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPT

--------------------------------------------------------------
>38278_38278_2_IDS-PHACTR1_IDS_chrX_148577877_ENST00000541269_PHACTR1_chr6_13160436_ENST00000379350_length(transcript)=5898nt_BP=1658nt
TTGGAGTTCAGCCACCTTAGCAAGTCCTGGGTTTGTTCTTCAGACTTTGCTGCTCGCCCATTGCCTGGATCGGGGGCTACTTTGTAAACC
ACCAGGAAGACTCCAGTGTTTCTGGTTAATTTTTAGATGTTTGTTAATTGCTCTTGGTCTCTCATTAATCCCCTGTGGGTCATCCAGGAA
ACATACTCACCACTGTCTGTTCTCTGAGTTTTCATTTCCAGGCATCCGCCCTGCCTGGATCTCCTCACCTGCCAGGAACTTCCTCTCCAC
AAGCCGGCCATCCCAGCAAAAGTTCTAACACCAAAGGTCTGGCAACTAGCCTGCCATCTTGTGCCTGGAGCCGCCTGCGTGCCACCTACT
CCCGAAGATGGGAACCTTGTTGCCAGTTGGGCAGATGCGGGGCAATCCTGTACCAAGACCCCATTTTACCACCTGCTTTCTCAGACCACT
CTGGAACCCACTGTCTCAGATTGTGTCTTCCAGGAAGCAGACCATGAGAGGGAGTTGGCAGGGCCAAAGATTTACTGGGGCTAACTAACA
CTCAGGAAAGGGATAGGAAGGAAACAGGGCTGGAGAGCAGGTTGAGCCCGACCTGACAGTCTCGAGCAGCCCAACAGGGAGGTGTGGAGC
AAGGGTTGCCCACTAGAGGGGCCTGCATTGGGTACGGGTGATGGGGTCCACATGGTACCTGGCATATAGCAGGCTGTGCAATCCATATTA
ACTGACTGGATAAATTAATGCTCAGAAAAGGTGCCCTGGAGAATGGGTGCGTGCTGAACACAATAGGGAAGGGCCCAGCATCTGCCTTGG
CATAGGCAGAACTGTGCTGTGCCCTGCAACAGGCCACCTGAGAGCTGCTTTGATCTTGTGTGTACATTAGACGACTGCCAGGGGCATGAA
GGGGATGTGCTTCCAGGGCATTTGCTGGCAGGGCGTCTTGTGATTTCTTGGTATTGGTGTGAGCATAGCCTGGCAGGAGAGGGCAGATCT
CCGTGCAAAGTATGTCAGAAAGCAGATGGAAGCCAGGCCCCCTCCTGAAAGAGGCTCCTTGAAGATAATTCTAACATCTTTGTCATCAGT
GTTGACATCTCTTGATTGTATCCTGTCATTCCATTTGAGATCTTCCTGGTTCTGGCTGGCATCCTCTGACATCACTCCAGCAGAAGAAAG
GGAAGGAACACGCTGCATTACTGCGTGGGATATCTTCTAACCATACCGATGATTCTCCGTATAGCTGGTCTTTTCCACCTTATCATCCTT
CCTCTGAGAAGTATGAAAACACTAAGACATGTCGAGGGCCAGATGGAGAACTCCATGCCAACCTGCTTTGCCCTGTGGATGTGCTGGATG
TTCCCGAGGGCACCTTGCCTGACAAACAGAGCACTGAGCAAGCCATACAGTTGTTGGAAAAGATGAAAACGTCAGCCAGTCCTTTCTTCC
TGGCCGTTGGGTATCATAAGCCACACATCCCCTTCAGATACCCCAAGGAATTTCAGAAGTTGTATCCCTTGGAGAACATCACCCTGGCCC
CCGATCCCGAGGTCCCTGATGGCCTACCCCCTGTGGCCTACAACCCCTGGATGGACATCAGGCAACGGGAAGACGTCCAAGCCTTAAACA
TCAGTGTGCCGTATGGTCCAATTCCTGTGGACTTTCAGCCCTGGAAAGGAAAATATCTATGAGGCAAAGCAGAGAAGAGCTGATAAAGCG
AGGAGTCCTGAAGGAAATCTATGATAAAGATGGGGAACTCTCTATATCCAATGAAGAGGACTCCCTAGAAAATGGGCAGTCCCTGAGCTC
CAGCCAGCTGTCTCTGCCTGCCCTGTCCGAAATGGAGCCAGTCCCAATGCCCAGGGATCCCTGCTCATATGAGGTGCTCCAACCGTCAGA
CATCATGGATGGGCCAGATCCTGGCGCCCCTGTGAAATTGCCTTGTCTGCCAGTGAAACTGTCGCCTCCGCTACCTCCAAAGAAAGTCAT
GATCTGTATGCCCGTGGGGGGGCCAGACCTCTCACTGGTGTCCTACACAGCCCAGAAGAGTGGCCAGCAGGGTGTGGCCCAGCACCACCA
CACTGTCCTGCCCTCCCAGATCCAGCACCAGCTGCAGTACGGCAGCCACGGCCAGCACCTCCCCTCCACCACCGGCTCCCTCCCCATGCA
CCCCTCGGGCTGCAGAATGATAGACGAGCTCAACAAAACGCTGGCCATGACCATGCAGAGGCTGGAAAGCTCTGAGCAGCGGGTCCCCTG
TTCCACTTCTTACCACAGCTCTGGGTTGCACTCGGGTGATGGGGTCACCAAAGCAGGACCTATGGGCCTTCCAGAAATAAGACAAGTGCC
AACTGTTGTGATTGAATGTGATGACAATAAAGAAAATGTGCCTCATGAGTCAGACTACGAAGACTCTTCTTGCCTGTATACAAGAGAAGA
GGAGGAAGAGGAGGAGGACGAAGACGACGACAGCTCATTATACACCAGCTCCCTGGCCATGAAGGTCTGCAGGAAGGACTCCTTAGCCAT
CAAACTCAGCAACAGGCCCTCCAAGCGAGAGCTGGAAGAAAAGAACATCCTTCCCAGGCAGACGGATGAGGAGCGGCTGGAGCTGAGGCA
ACAGATTGGCACCAAGCTCACCAGGCGGCTGAGCCAGAGGCCAACTGCAGAGGAACTGGAACAGAGGAACATTTTGAAACGTAAGTGACT
AAGCCCATGGCAATCCCTGATGTTTTGTGGCGGCTTTTGTTATTATTTAATGGTAGGCCACAAGGTTTCTACCTTGCGCCTCTGCGGAAA
GCATTGAAAACCTTTCTAACGGTTGAAGCTTCATGTGTGCATGTTAGAACACCAAAGACGACCTCCCCAAAGAGAAGGCAAATTTTATTC
CACTTTATTCTTTAGAAGCTCACGGGCGGCAGGCAGAACCTTCCTTTTAGTGAGTTGTAAAGTCAGAGAGAAGCTGAAAAATTAGAGTGA
GACCACTTATTATTTAATGATTTTTAAGAGCAGGGTCACCTTTAAACCAGAATTGGCTTGAAAATGGAGACTGTGATATGCACGGCTAAA
ATAAGGGAAATGTCCATTTGAACTGAGACTAGAAAGCATGACTTTGCATTGCAGCTGGCTGCTGTTGATAAAAATCCCTCATCCCTTTGA
ATGTTAAATTGAAAGACTAAGAAAGCATTTCCAAGTGAAGTGCTTCATGTCTGTCTCTCAGGATTCCCACAGCTGGTCCCGGGCATGCCT
GTCTGATGCTCTCATTCGAGGAAAACTGCCTTTCACCATTGCTGCAGACAGAAAAAAATAAATGAGCCCCTTGTTTGGTTTAGGACACAG
AGACATTTGAATATGTACAGAGGATCCACTTGGTGCTTTAAAAAAAAAAAGAGAAAACAGGATACAAAATACTAAAAGAGATCAAGCATT
TGATGGACAGCAGTATGCGTCAGTTTAGTGGTAGATATTAAATAACTTAAATATCAAACCATTCTATTCATTCATTGCTACCATTCTCGC
CAACACTGGCCTCAAGATAGTGAACAAATATTTCTGGCTTAATTCATGACCCTGTTCCCCCTACCCCACAACACACTTCTAATTTCTCTC
CAGAAGAGAAAGATATATACTATGCAGAGTTTTCTAGAAATGCTATGTTGTACAGACTGACTCCTTGCCTCCCCCGGCCCCCCCGCCCCG
CCCCGCCCCGTGCCCAGTAAATCACATGCAACCGCAGTGTGAGTTTGCCGGGAATTTCCACTGAAACCACACTAAGATATTCTTGACTTT
ACCTTTCTACCGTGCTCACTGTGGCCTTGTGACTTGGTCGGCATTTCGTAGTCTGCTGAAGGTGGGTGCTGGGTTCCGCTTTGGTGGGGA
GACCTGTTGCCTACAGCACCCACCCCCGCCCGACGCCCCCGCATGTCCGTTTATGTCAACTCTGCCTTTATCAATGTCTTGCCTCCCGTC
CCCACGCCAGCCGCCACTTCCTCAACTCTCAGTAGAAGTTATTTTCAGGATTAGCCTTCCTCAGTCGTGGGGGAACCCTACGCTTTGCCT
AGGTCTCTAGGAATGTGTGTTTACTTTTTTCTGCCCAAGGGGTACCCTTTAAAGTTTCCAAGCTTAATATTCTATATAATGAATTCAGAG
CTTTTTCAAAGCATTTCCAAGGTCAGGGAAGCATTTGGCTTGTAGGATGTCTTCCTTTCGGCCCCAATCTGGTACCTGAGCCATTATAAA
CTTCCCATTGTTGGAGAGAAAGATAAACAGCCAGGTGAACCTGTACAACTTACTCACAGCCCGCTGCTGTACTTGTGGCCTCTGACCTGA
GACCTAAACTCAAAGAAGCTAAAAGCCTCCGGGGGATTATTTAGGTTTCAGAAAATAGTGCTTATCACACCAGGAGTACGGTTTCTGGAG
AGATCTAAAATCCCCTAGCTCAGCTCTGGGCTCTCTCAAAGATATCAGATCCCCGCTGTGGCTTGTCCAGATCCCTGGGAGACTACAGGT
CCTTTGAGCTTGGGTTTTTACCGCCATCAACCAGGGAACTTAGATTCAGGGGACCAAAAAGGAGTTGTGAAAGATTGTTCCCATGGTTCT
CTTTTATTCTCTTCCCTAATCCCTCTTGTCCTGGCCACATAGTTGCAAATTAAAGAACTACTTGACCAATTCTAACAGGTTGGTCATTTC
ATAGTTTTGAAACTTTTCAGAAATCAACTTGTTTTCCCATAGGTTCTTATTTTTCCCTGTATTCTGGAACTATGTTCTCCTAAATATTTT
TTTAAATTTAATCTATTGCGATTGTTAAACAAAAAAAATGTCTAGTGGTATAAGAAAACATCCTCCAATAGTTTGTTTTAAAACTGATTT
TCTGAGCTTTCAGCCATTTGAGGAACTGCTCGGTGTTGGGTGGTGGGGAACAGGGCACAGAGATGCCATGGCTCAGCCCTGGAGCTTTGA
GAGCCTTGGGTTGGTTTCCAGCCCCACCCTGCCTGGTCCTGGGAGCAGCCCCTGTTCTGTCCAGCAGCCAGTGAGGCCCTGTGCACCTCT
GAGCACATAATGAACCCTCTGACGGTGGCAGCTGTAATGACGACATCGTAGGCCTTTCCTGGCCTGTCTTCCTAGTTGCCTAATGGGGTT
GTCTTGGTACCTTCTGCCTGAAAATTCATGAACCTGGGTTGGTCAATGGCTTTGAACTAAAGGTATCAATTCTGTAGGTGGTAGCTTGTG
GCCCCACCCCTCAGAGTGACCTAAGAAACGCACATAGGAGATGAAGGCTCCATGCTGTGTCAGCTGTGTCACAGGATGCCCGCCTTCACG
GCTCTGAAGGGACCTGTAGGATCAGAAGTCTGAGGCTAGTAATGAGGAGGAGAGCCGGCCCCACACAAAACATGACCACAGGAAAAAACC
TATCTGTGTAACCACTGAGCCAGGTAGGGTGTGACTGGCCACTTAACACCCCTGAGGCTTCAGATCCTCAGTTATAAACCAGGAGTGGTA
GACGAGGTGGTCACTAGGTCCCCTCATGGCCCTAGTATTCTGTGCTTCTGTAAATTTTCACCGTGTGCCCTCTAGCTGTCCCTGGTGACC
CAACATCCAGACCACCTTTTCTTCCATCCGTTTTCCCACCTGAGACATCGCAAAATGGGAGTTCCCTCCTTCTGGTTCTTGCTGTCTGCC
TCCCCATTTAACTCTGCTAGATTAATTCATACTAAGATATTAATGGCTGACTAGTTTAATAGGTTTTATCCCACTGAAATTTGCATTTGT
ACAAATGTCACTGTCTGGGGGCTCCCTACTTCCGGGTGTTGCTGTCTGCCCCCCAGTTTATCTCTACTAGATTAATTCATACTGAGCTAT

>38278_38278_2_IDS-PHACTR1_IDS_chrX_148577877_ENST00000541269_PHACTR1_chr6_13160436_ENST00000379350_length(amino acids)=373AA_BP=22
MDGHQATGRRPSLKHQCAVWSNSCGLSALERKISMRQSREELIKRGVLKEIYDKDGELSISNEEDSLENGQSLSSSQLSLPALSEMEPVP
MPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGPDLSLVSYTAQKSGQQGVAQHHHTVLPSQIQHQLQYGS
HGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSGDGVTKAGPMGLPEIRQVPTVVIECDDNKENVPH
ESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IDS-PHACTR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IDS-PHACTR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IDS-PHACTR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource