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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IFI16-ENO1 (FusionGDB2 ID:38304) |
Fusion Gene Summary for IFI16-ENO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFI16-ENO1 | Fusion gene ID: 38304 | Hgene | Tgene | Gene symbol | IFI16 | ENO1 | Gene ID | 3428 | 2023 |
| Gene name | interferon gamma inducible protein 16 | enolase 1 | |
| Synonyms | IFNGIP1|PYHIN2 | ENO1L1|HEL-S-17|MPB1|NNE|PPH | |
| Cytomap | 1q23.1 | 1p36.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | gamma-interferon-inducible protein 16IFI16 beta isoforminterferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator | alpha-enolasec-myc promoter-binding protein-12-phospho-D-glycerate hydro-lyaseMYC promoter-binding protein 1alpha enolase like 1enolase 1, (alpha)enolase-alphaepididymis secretory protein Li 17non-neural enolasephosphopyruvate hydrataseplasminog | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | Q16666 | P06733 | |
| Ensembl transtripts involved in fusion gene | ENST00000295809, ENST00000340979, ENST00000368131, ENST00000368132, ENST00000359709, ENST00000430894, ENST00000448393, | ENST00000234590, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 26 X 31 X 13=10478 |
| # samples | 7 | 37 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/10478*10)=-4.82369428615275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IFI16 [Title/Abstract] AND ENO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IFI16(158979793)-ENO1(8938749), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IFI16 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12894224|24413532 |
| Hgene | IFI16 | GO:0002218 | activation of innate immune response | 21575908 |
| Hgene | IFI16 | GO:0030224 | monocyte differentiation | 9766636 |
| Hgene | IFI16 | GO:0032731 | positive regulation of interleukin-1 beta production | 21575908 |
| Hgene | IFI16 | GO:0042149 | cellular response to glucose starvation | 21573174 |
| Hgene | IFI16 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 14654789 |
| Hgene | IFI16 | GO:0043392 | negative regulation of DNA binding | 22291595 |
| Hgene | IFI16 | GO:0045071 | negative regulation of viral genome replication | 22291595 |
| Hgene | IFI16 | GO:0045824 | negative regulation of innate immune response | 22046441 |
| Hgene | IFI16 | GO:0045892 | negative regulation of transcription, DNA-templated | 9642285 |
| Hgene | IFI16 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11146555 |
| Hgene | IFI16 | GO:0051607 | defense response to virus | 21478870 |
| Hgene | IFI16 | GO:0071479 | cellular response to ionizing radiation | 14654789 |
| Hgene | IFI16 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 22046441 |
| Tgene | ENO1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 2005901 |
| Tgene | ENO1 | GO:0030308 | negative regulation of cell growth | 10082554 |
| Tgene | ENO1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10082554 |
| Tgene | ENO1 | GO:0061621 | canonical glycolysis | 29775581 |
| Tgene | ENO1 | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | 15459207 |
| Tgene | ENO1 | GO:2001171 | positive regulation of ATP biosynthetic process | 15459207 |
| Fusion gene breakpoints across IFI16 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ENO1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | DA702843 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
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Fusion Gene ORF analysis for IFI16-ENO1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000295809 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| 5UTR-3CDS | ENST00000340979 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| 5UTR-3CDS | ENST00000368131 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| 5UTR-3CDS | ENST00000368132 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| intron-3CDS | ENST00000359709 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| intron-3CDS | ENST00000430894 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| intron-3CDS | ENST00000448393 | ENST00000234590 | IFI16 | chr1 | 158979793 | + | ENO1 | chr1 | 8938749 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IFI16-ENO1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IFI16-ENO1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:158979793/:8938749) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFI16 | ENO1 |
| FUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}. | FUNCTION: Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:29775581, PubMed:1369209). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:2005901, PubMed:10802057, PubMed:12666133, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IFI16-ENO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for IFI16-ENO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IFI16-ENO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IFI16-ENO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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