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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IFI27-IFI27 (FusionGDB2 ID:38311)

Fusion Gene Summary for IFI27-IFI27

check button Fusion gene summary
Fusion gene informationFusion gene name: IFI27-IFI27
Fusion gene ID: 38311
HgeneTgene
Gene symbol

IFI27

IFI27

Gene ID

3429

3429

Gene nameinterferon alpha inducible protein 27interferon alpha inducible protein 27
SynonymsFAM14D|ISG12|ISG12A|P27FAM14D|ISG12|ISG12A|P27
Cytomap

14q32.12

14q32.12

Type of geneprotein-codingprotein-coding
Descriptioninterferon alpha-inducible protein 27, mitochondrial2310061N23RikISG12(a)interferon alpha-induced 11.5 kDa proteininterferon-stimulated gene 12a proteininterferon alpha-inducible protein 27, mitochondrial2310061N23RikISG12(a)interferon alpha-induced 11.5 kDa proteininterferon-stimulated gene 12a protein
Modification date2020032920200329
UniProtAcc.

Q9H2X8

Ensembl transtripts involved in fusion geneENST00000298902, ENST00000444961, 
ENST00000448882, ENST00000555744, 
ENST00000557098, ENST00000557634, 
ENST00000298902, ENST00000557098, 
ENST00000555744, ENST00000557634, 
ENST00000444961, ENST00000448882, 
Fusion gene scores* DoF score7 X 5 X 4=1403 X 3 X 3=27
# samples 73
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IFI27 [Title/Abstract] AND IFI27 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIFI27(94582861)-IFI27(94581206), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIFI27

GO:0006915

apoptotic process

18330707

TgeneIFI27

GO:0006915

apoptotic process

18330707


check buttonFusion gene breakpoints across IFI27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IFI27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG230457IFI27chr14

94582861

+IFI27chr14

94581206

+


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Fusion Gene ORF analysis for IFI27-IFI27

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000298902ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000298902ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000444961ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000444961ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000448882ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000448882ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000555744ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000555744ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000557098ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000557098ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000557634ENST00000298902IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-5UTRENST00000557634ENST00000557098IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000298902ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000298902ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000444961ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000444961ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000448882ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000448882ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000555744ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000555744ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000557098ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000557098ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000557634ENST00000555744IFI27chr14

94582861

+IFI27chr14

94581206

+
5CDS-intronENST00000557634ENST00000557634IFI27chr14

94582861

+IFI27chr14

94581206

+
Frame-shiftENST00000298902ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
Frame-shiftENST00000298902ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+
Frame-shiftENST00000555744ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
Frame-shiftENST00000555744ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000444961ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000444961ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000448882ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000448882ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000557098ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000557098ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000557634ENST00000444961IFI27chr14

94582861

+IFI27chr14

94581206

+
In-frameENST00000557634ENST00000448882IFI27chr14

94582861

+IFI27chr14

94581206

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IFI27-IFI27


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IFI27-IFI27


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:94582861/chr14:94581206)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IFI27

Q9H2X8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in the apoptotic process and has a pro-apoptotic activity. {ECO:0000269|PubMed:27673746}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIFI27chr14:94582861chr14:94581206ENST0000029890205103_1120120.0RegionRequired for hepatitis C virus non-structural protein NS5A degradation
TgeneIFI27chr14:94582861chr14:94581206ENST0000055574405103_1120120.0RegionRequired for hepatitis C virus non-structural protein NS5A degradation
TgeneIFI27chr14:94582861chr14:94581206ENST000002989020534_570120.0TransmembraneHelical
TgeneIFI27chr14:94582861chr14:94581206ENST000002989020571_910120.0TransmembraneHelical
TgeneIFI27chr14:94582861chr14:94581206ENST000002989020599_1190120.0TransmembraneHelical
TgeneIFI27chr14:94582861chr14:94581206ENST000005557440534_570120.0TransmembraneHelical
TgeneIFI27chr14:94582861chr14:94581206ENST000005557440571_910120.0TransmembraneHelical
TgeneIFI27chr14:94582861chr14:94581206ENST000005557440599_1190120.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFI27chr14:94582861chr14:94581206ENST00000298902+15103_1120120.0RegionRequired for hepatitis C virus non-structural protein NS5A degradation
HgeneIFI27chr14:94582861chr14:94581206ENST00000555744+15103_1120120.0RegionRequired for hepatitis C virus non-structural protein NS5A degradation
HgeneIFI27chr14:94582861chr14:94581206ENST00000298902+1534_570120.0TransmembraneHelical
HgeneIFI27chr14:94582861chr14:94581206ENST00000298902+1571_910120.0TransmembraneHelical
HgeneIFI27chr14:94582861chr14:94581206ENST00000298902+1599_1190120.0TransmembraneHelical
HgeneIFI27chr14:94582861chr14:94581206ENST00000555744+1534_570120.0TransmembraneHelical
HgeneIFI27chr14:94582861chr14:94581206ENST00000555744+1571_910120.0TransmembraneHelical
HgeneIFI27chr14:94582861chr14:94581206ENST00000555744+1599_1190120.0TransmembraneHelical


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Fusion Gene Sequence for IFI27-IFI27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IFI27-IFI27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IFI27-IFI27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IFI27-IFI27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource