Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IFI6-PRDX2 (FusionGDB2 ID:38339)

Fusion Gene Summary for IFI6-PRDX2

Fusion gene summary

Fusion gene information	Fusion gene name: IFI6-PRDX2
	Fusion gene ID: 38339
		Hgene	Tgene
	Gene symbol	IFI6	PRDX2
	Gene ID	2537	7001
	Gene name	interferon alpha inducible protein 6	peroxiredoxin 2
	Synonyms	6-16\|FAM14C\|G1P3\|IFI-6-16\|IFI616	HEL-S-2a\|NKEF-B\|NKEFB\|PRP\|PRX2\|PRXII\|PTX1\|TDPX1\|TPX1\|TSA
	Cytomap	1p35.3	19p13.13
	Type of gene	protein-coding	protein-coding
	Description	interferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16	peroxiredoxin-2epididymis secretory sperm binding protein Li 2anatural killer cell-enhancing factor Bthiol-specific antioxidant 1thioredoxin peroxidase 1thioredoxin-dependent peroxide reductase 1torin
	Modification date	20200313	20200313
	UniProtAcc	P09912	.
	Ensembl transtripts involved in fusion gene	ENST00000339145, ENST00000361157, ENST00000362020,	ENST00000435703, ENST00000334482, ENST00000301522,
Fusion gene scores	* DoF score	10 X 8 X 7=560	7 X 4 X 6=168
	# samples	10	8
	** MAII score	log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IFI6 [Title/Abstract] AND PRDX2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IFI6(27994737)-PRDX2(12907980), # samples:1
Anticipated loss of major functional domain due to fusion event.	IFI6-PRDX2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PRDX2	GO:0019430	removal of superoxide radicals	20978343
Tgene	PRDX2	GO:0034599	cellular response to oxidative stress	20978343

Fusion gene breakpoints across IFI6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRDX2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-5577-01A	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-

Top

Fusion Gene ORF analysis for IFI6-PRDX2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000339145	ENST00000435703	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
5CDS-intron	ENST00000361157	ENST00000435703	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
5CDS-intron	ENST00000362020	ENST00000435703	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
Frame-shift	ENST00000339145	ENST00000334482	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
Frame-shift	ENST00000361157	ENST00000334482	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
Frame-shift	ENST00000362020	ENST00000334482	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
In-frame	ENST00000339145	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
In-frame	ENST00000361157	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-
In-frame	ENST00000362020	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361157	IFI6	chr1	27994737	-	ENST00000301522	PRDX2	chr19	12907980	-	773	426	35	511	158
ENST00000339145	IFI6	chr1	27994737	-	ENST00000301522	PRDX2	chr19	12907980	-	757	410	88	495	135
ENST00000362020	IFI6	chr1	27994737	-	ENST00000301522	PRDX2	chr19	12907980	-	765	418	15	503	162

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361157	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-	0.08859763	0.9114024
ENST00000339145	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-	0.033434443	0.96656555
ENST00000362020	ENST00000301522	IFI6	chr1	27994737	-	PRDX2	chr19	12907980	-	0.04906021	0.9509398

Top

Fusion Genomic Features for IFI6-PRDX2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IFI6-PRDX2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:27994737/chr19:12907980)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IFI6 P09912	.
FUNCTION: Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571). {ECO:0000269\|PubMed:15685448, ECO:0000269\|PubMed:17823654, ECO:0000269\|PubMed:25757571, ECO:0000269\|PubMed:26244642, ECO:0000269\|PubMed:27673746}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000339145

41_61

107

139.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000339145

4_24

107

139.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000339145

75_95

107

139.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000361157

41_61

131.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000361157

4_24

131.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000361157

75_95

131.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000362020

41_61

103

135.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000362020

4_24

103

135.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000362020

75_95

103

135.0

Transmembrane

Helical

Tgene

PRDX2

chr1:27994737

chr19:12907980

ENST00000435703

6_164

143.0

Domain

Thioredoxin

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000339145

99_119

107

139.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000361157

99_119

131.0

Transmembrane

Helical

Hgene

IFI6

chr1:27994737

chr19:12907980

ENST00000362020

99_119

103

135.0

Transmembrane

Helical

Tgene

PRDX2

chr1:27994737

chr19:12907980

ENST00000301522

6_164

170

199.0

Domain

Thioredoxin

Top

Fusion Gene Sequence for IFI6-PRDX2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>38339_38339_1_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000339145_PRDX2_chr19_12907980_ENST00000301522_length(transcript)=757nt_BP=410nt
GTGCCCATCTATCAGCAGGCTCCGGGCTGAAGATTGCTTCTCTTCTCTCCTCCAAGGTCTAGTGACGGAGCCCGCGCGCGGCGCCACCAT
GCGGCAGAAGGCGGTATCGCTTTTCTTGTGCTACCTGCTGCTCTTCACTTGCAGTGGGGTGGAGGCAGGTGAGAATGCGGGTAAGGATGC
AGGTAAGAAAAAGTGCTCGGAGAGCTCGGACAGCGGCTCCGGGTTCTGGAAGGCCCTGACCTTCATGGCCGTCGGAGGAGGACTCGCAGT
CGCCGGGCTGCCCGCGCTGGGCTTCACCGGCGCCGGCATCGCGGCCAACTCGGTGGCTGCCTCGCTGATGAGCTGGTCTGCGATCCTGAA
TGGGGGCGGCGTGCCCGCCGGGGGGCTAGTGGCCACGCTGCAGAGCCTCGTTTGTCCCGCTGGCTGGAAGCCTGGCAGTGACACGATTAA
GCCCAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAGGCTGGCTAACGGATAGTGAGCTTGTGCCCCTGCCTAGGTGCCTG
TGCTGGGTGTCCACCTGTGCCCCCACCTGGGTGCCCTATGCTGACCCAGGAAAGGCCAGACCTGCCCCTCCAAACTCCACAGTATGGGAC
CCTGGAGGGCTAGGCCAAGGCCTTCTCATGCCTCCACCTAGAAGCTGAATAGTGACGCCCTCCCCCAAGCCCACCCAGCCGCACACAGGC

>38339_38339_1_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000339145_PRDX2_chr19_12907980_ENST00000301522_length(amino acids)=135AA_BP=107
MRQKAVSLFLCYLLLFTCSGVEAGENAGKDAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALGFTGAGIAANSVAASLMSWSAIL

--------------------------------------------------------------
>38339_38339_2_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000361157_PRDX2_chr19_12907980_ENST00000301522_length(transcript)=773nt_BP=426nt
AAAAGCCAGCCTTCAGCCGGAGAACCGTTTACTCGCTGCTGTGCCCATCTATCAGCAGGCTCCGGGCTGAAGATTGCTTCTCTTCTCTCC
TCCAAGGTCTAGTGACGGAGCCCGCGCGCGGCGCCACCATGCGGCAGAAGGCGGTATCGCTTTTCTTGTGCTACCTGCTGCTCTTCACTT
GCAGTGGGGTGGAGGCAGGTAAGAAAAAGTGCTCGGAGAGCTCGGACAGCGGCTCCGGGTTCTGGAAGGCCCTGACCTTCATGGCCGTCG
GAGGAGGACTCGCAGTCGCCGGGCTGCCCGCGCTGGGCTTCACCGGCGCCGGCATCGCGGCCAACTCGGTGGCTGCCTCGCTGATGAGCT
GGTCTGCGATCCTGAATGGGGGCGGCGTGCCCGCCGGGGGGCTAGTGGCCACGCTGCAGAGCCTCGTTTGTCCCGCTGGCTGGAAGCCTG
GCAGTGACACGATTAAGCCCAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAGGCTGGCTAACGGATAGTGAGCTTGTGCC
CCTGCCTAGGTGCCTGTGCTGGGTGTCCACCTGTGCCCCCACCTGGGTGCCCTATGCTGACCCAGGAAAGGCCAGACCTGCCCCTCCAAA
CTCCACAGTATGGGACCCTGGAGGGCTAGGCCAAGGCCTTCTCATGCCTCCACCTAGAAGCTGAATAGTGACGCCCTCCCCCAAGCCCAC

>38339_38339_2_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000361157_PRDX2_chr19_12907980_ENST00000301522_length(amino acids)=158AA_BP=130
MLCPSISRLRAEDCFSSLLQGLVTEPARGATMRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPAL

--------------------------------------------------------------
>38339_38339_3_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000362020_PRDX2_chr19_12907980_ENST00000301522_length(transcript)=765nt_BP=418nt
AGAACCGTTTACTCGCTGCTGTGCCCATCTATCAGCAGGCTCCGGGCTGAAGATTGCTTCTCTTCTCTCCTCCAAGGTCTAGTGACGGAG
CCCGCGCGCGGCGCCACCATGCGGCAGAAGGCGGTATCGCTTTTCTTGTGCTACCTGCTGCTCTTCACTTGCAGTGGGGTGGAGGCAGGT
GAGAATGCGGGTAAGAAAAAGTGCTCGGAGAGCTCGGACAGCGGCTCCGGGTTCTGGAAGGCCCTGACCTTCATGGCCGTCGGAGGAGGA
CTCGCAGTCGCCGGGCTGCCCGCGCTGGGCTTCACCGGCGCCGGCATCGCGGCCAACTCGGTGGCTGCCTCGCTGATGAGCTGGTCTGCG
ATCCTGAATGGGGGCGGCGTGCCCGCCGGGGGGCTAGTGGCCACGCTGCAGAGCCTCGTTTGTCCCGCTGGCTGGAAGCCTGGCAGTGAC
ACGATTAAGCCCAACGTGGATGACAGCAAGGAATATTTCTCCAAACACAATTAGGCTGGCTAACGGATAGTGAGCTTGTGCCCCTGCCTA
GGTGCCTGTGCTGGGTGTCCACCTGTGCCCCCACCTGGGTGCCCTATGCTGACCCAGGAAAGGCCAGACCTGCCCCTCCAAACTCCACAG
TATGGGACCCTGGAGGGCTAGGCCAAGGCCTTCTCATGCCTCCACCTAGAAGCTGAATAGTGACGCCCTCCCCCAAGCCCACCCAGCCGC

>38339_38339_3_IFI6-PRDX2_IFI6_chr1_27994737_ENST00000362020_PRDX2_chr19_12907980_ENST00000301522_length(amino acids)=162AA_BP=134
MLCPSISRLRAEDCFSSLLQGLVTEPARGATMRQKAVSLFLCYLLLFTCSGVEAGENAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IFI6-PRDX2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IFI6-PRDX2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IFI6-PRDX2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source