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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IFIT3-MORF4L1 (FusionGDB2 ID:38355) |
Fusion Gene Summary for IFIT3-MORF4L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IFIT3-MORF4L1 | Fusion gene ID: 38355 | Hgene | Tgene | Gene symbol | IFIT3 | MORF4L1 | Gene ID | 3437 | 10933 |
| Gene name | interferon induced protein with tetratricopeptide repeats 3 | mortality factor 4 like 1 | |
| Synonyms | CIG-49|GARG-49|IFI60|IFIT4|IRG2|ISG60|P60|RIG-G|cig41 | Eaf3|FWP006|HsT17725|MEAF3|MORFRG15|MRG15|S863-6 | |
| Cytomap | 10q23.31 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interferon-induced protein with tetratricopeptide repeats 3CIG49IFI-60KIFIT-3IFIT-4ISG-60interferon-induced 60 kDa proteininterferon-induced protein with tetratricopeptide repeats 4retinoic acid-induced gene G protein | mortality factor 4-like protein 1Esa1p-associated factor 3 homologMORF-related gene 15 proteinMORF-related gene on chromosome 15protein MSL3-1transcription factor-like protein MRG15 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O14879 | Q9UBU8 | |
| Ensembl transtripts involved in fusion gene | ENST00000371811, ENST00000371818, | ENST00000561171, ENST00000559345, ENST00000558502, ENST00000331268, ENST00000379535, ENST00000426013, ENST00000558746, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 8 X 3=216 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IFIT3 [Title/Abstract] AND MORF4L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IFIT3(91092384)-MORF4L1(79170555), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | IFIT3-MORF4L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IFIT3-MORF4L1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. IFIT3-MORF4L1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IFIT3 | GO:0008285 | negative regulation of cell proliferation | 17050680 |
| Hgene | IFIT3 | GO:0043066 | negative regulation of apoptotic process | 21190939 |
| Tgene | MORF4L1 | GO:0000724 | double-strand break repair via homologous recombination | 20332121 |
| Tgene | MORF4L1 | GO:0016575 | histone deacetylation | 14966270 |
| Tgene | MORF4L1 | GO:0043967 | histone H4 acetylation | 14966270 |
| Tgene | MORF4L1 | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene breakpoints across IFIT3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MORF4L1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-8678-01A | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
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Fusion Gene ORF analysis for IFIT3-MORF4L1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000371811 | ENST00000561171 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| 5CDS-5UTR | ENST00000371811 | ENST00000559345 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| 5CDS-intron | ENST00000371811 | ENST00000558502 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| Frame-shift | ENST00000371811 | ENST00000331268 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| Frame-shift | ENST00000371811 | ENST00000379535 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| Frame-shift | ENST00000371811 | ENST00000426013 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| Frame-shift | ENST00000371811 | ENST00000558746 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-3CDS | ENST00000371818 | ENST00000331268 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-3CDS | ENST00000371818 | ENST00000379535 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-3CDS | ENST00000371818 | ENST00000426013 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-3CDS | ENST00000371818 | ENST00000558746 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-3UTR | ENST00000371818 | ENST00000561171 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-5UTR | ENST00000371818 | ENST00000559345 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| intron-intron | ENST00000371818 | ENST00000558502 | IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170555 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IFIT3-MORF4L1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170554 | + | 0.20971967 | 0.79028034 |
| IFIT3 | chr10 | 91092384 | + | MORF4L1 | chr15 | 79170554 | + | 0.20971967 | 0.79028034 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IFIT3-MORF4L1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:91092384/:79170555) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IFIT3 | MORF4L1 |
| FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}. | FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IFIT3-MORF4L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for IFIT3-MORF4L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IFIT3-MORF4L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IFIT3-MORF4L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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