Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IFT80-RARRES1 (FusionGDB2 ID:38446)

Fusion Gene Summary for IFT80-RARRES1

Fusion gene summary

Fusion gene information	Fusion gene name: IFT80-RARRES1
	Fusion gene ID: 38446
		Hgene	Tgene
	Gene symbol	IFT80	RARRES1
	Gene ID	57560	5918
	Gene name	intraflagellar transport 80	retinoic acid receptor responder 1
	Synonyms	ATD2\|FAP167\|SRTD2\|WDR56	LXNL\|PERG-1\|TIG1
	Cytomap	3q25.33	3q25.32
	Type of gene	protein-coding	protein-coding
	Description	intraflagellar transport protein 80 homologWD repeat domain 56WD repeat-containing protein 56intraflagellar transport 80 homolog	retinoic acid receptor responder protein 1RAR-responsive protein TIG1latexin-likephorbol ester-induced gene 1 proteinretinoic acid receptor responder (tazarotene induced) 1tazarotene-induced gene 1 protein
	Modification date	20200313	20200313
	UniProtAcc	Q9P2H3	.
	Ensembl transtripts involved in fusion gene	ENST00000326448, ENST00000483465, ENST00000496589, ENST00000477495,	ENST00000498640, ENST00000237696, ENST00000479756,
Fusion gene scores	* DoF score	4 X 5 X 3=60	3 X 3 X 3=27
	# samples	5	3
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: IFT80 [Title/Abstract] AND RARRES1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IFT80(160093600)-RARRES1(158422716), # samples:4
Anticipated loss of major functional domain due to fusion event.	IFT80-RARRES1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across IFT80 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RARRES1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-TQ-A7RK-01A	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
ChimerDB4	LGG	TCGA-TQ-A7RK-02A	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
ChimerDB4	LGG	TCGA-TQ-A7RK	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-

Top

Fusion Gene ORF analysis for IFT80-RARRES1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000326448	ENST00000498640	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
5CDS-5UTR	ENST00000483465	ENST00000498640	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
5CDS-5UTR	ENST00000496589	ENST00000498640	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
5UTR-3CDS	ENST00000477495	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
5UTR-3CDS	ENST00000477495	ENST00000479756	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
5UTR-5UTR	ENST00000477495	ENST00000498640	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
Frame-shift	ENST00000326448	ENST00000479756	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
Frame-shift	ENST00000483465	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
Frame-shift	ENST00000496589	ENST00000479756	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
In-frame	ENST00000326448	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
In-frame	ENST00000483465	ENST00000479756	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-
In-frame	ENST00000496589	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000326448	IFT80	chr3	160093600	-	ENST00000237696	RARRES1	chr3	158422716	-	2008	872	433	1221	262
ENST00000483465	IFT80	chr3	160093600	-	ENST00000479756	RARRES1	chr3	158422716	-	893	616	258	767	169
ENST00000496589	IFT80	chr3	160093600	-	ENST00000237696	RARRES1	chr3	158422716	-	1969	833	475	1182	235

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326448	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-	0.003639146	0.99636084
ENST00000483465	ENST00000479756	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-	0.9399223	0.060077745
ENST00000496589	ENST00000237696	IFT80	chr3	160093600	-	RARRES1	chr3	158422716	-	0.09037229	0.90962774

Top

Fusion Genomic Features for IFT80-RARRES1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IFT80-RARRES1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:160093600/chr3:158422716)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IFT80 Q9P2H3	.
FUNCTION: Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. {ECO:0000269\|PubMed:17468754}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

104_143

146

778.0

Repeat

Note=WD 2

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

12_50

146

778.0

Repeat

Note=WD 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

145_185

146

778.0

Repeat

Note=WD 3

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

186_225

146

778.0

Repeat

Note=WD 4

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

227_265

146

778.0

Repeat

Note=WD 5

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

267_306

146

778.0

Repeat

Note=WD 6

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000326448

504_542

146

778.0

Repeat

Note=WD 7

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

104_143

641.0

Repeat

Note=WD 2

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

12_50

641.0

Repeat

Note=WD 1

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

145_185

641.0

Repeat

Note=WD 3

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

186_225

641.0

Repeat

Note=WD 4

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

227_265

641.0

Repeat

Note=WD 5

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

267_306

641.0

Repeat

Note=WD 6

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000483465

504_542

641.0

Repeat

Note=WD 7

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

104_143

641.0

Repeat

Note=WD 2

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

12_50

641.0

Repeat

Note=WD 1

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

145_185

641.0

Repeat

Note=WD 3

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

186_225

641.0

Repeat

Note=WD 4

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

227_265

641.0

Repeat

Note=WD 5

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

267_306

641.0

Repeat

Note=WD 6

Hgene

IFT80

chr3:160093600

chr3:158422716

ENST00000496589

504_542

641.0

Repeat

Note=WD 7

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000237696

1_20

178

295.0

Topological domain

Lumenal

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000237696

43_294

178

295.0

Topological domain

Cytoplasmic

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000479756

1_20

178

229.0

Topological domain

Lumenal

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000479756

43_294

178

229.0

Topological domain

Cytoplasmic

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000237696

21_42

178

295.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Tgene

RARRES1

chr3:160093600

chr3:158422716

ENST00000479756

21_42

178

229.0

Transmembrane

Helical%3B Signal-anchor for type III membrane protein

Top

Fusion Gene Sequence for IFT80-RARRES1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>38446_38446_1_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000326448_RARRES1_chr3_158422716_ENST00000237696_length(transcript)=2008nt_BP=872nt
GCGCATGCGCGAACTCCTGGCGGGACCTACGCGGTAGAAGTTTCTACTAAGTGAAAAGGAAGAGCGAGGGATTCTTTTCTCTGTGGTCTA
CAGCAGCAGCACTATTATTAAAAATATTTGGAAAGACAACCTGGCAAGTTTTGAAAAAGATTTTTTTAAAAACGGTAGGGTTCCGCTCAC
AGTGGGAGGCGGGGCTCAGTGGTCCAGAAACGCCTCTTCAGAAGAGGGCGGGCTCGCCGAGAGGCGGGGTCTCGGGCCCACTCGGATGAC
GTGCCGCGTAGAAGTATCGCGGGAAGAGGAAGGGAGCGTAACTCTTAGAAGTCACTATGGTGACGGGGAGGTACCAGGTATTTGAGAGCA
ATCGCCACCGCTTTCCTGGAACTTGAGTAAATACAATCAAGTGGCATCTTAAATTTTTGCTGGAAGTGGAGTCATGAGACTAAAGATATC
TCTTTTAAAAGAACCAAAGCATCAAGAATTAGTAAGCTGTGTGGGCTGGACTACTGCTGAAGAGCTGTATTCATGTAGTGATGATCACCA
GATAGTGAAGTGGAACTTGTTAACCAGTGAAACAACTCAAATAGTAAAGCTTCCTGATGATATTTACCCTATTGATTTTCACTGGTTTCC
AAAAAGTTTGGGTGTAAAGAAACAAACCCAGGCAGAAAGCTTTGTCCTCACAAGTTCTGATGGTAAATTTCATCTGATTTCCAAGTTAGG
AAGAGTGGAAAAAAGTGTAGAAGCTCACTGTGGAGCAGTACTTGCAGGAAGATGGAATTATGAAGGAACAGCATTAGTTACAGTTGGAGA
AGATGGACAAATAAAAATTTGGTCAAAGACTGGGATGCTTAGATCAACTTTAGCTCAGCAAGATAATCATGGACATATTGATCCCTCTCT
GAGACTCATCTGGGATTTGGCTTTCCTTGGAAGCTCTTACGTGATGTGGGAAATGACAACACAGGTGTCACACTACTACTTGGCACAGCT
CACTAGTGTGAGGCAGTGGAAAACTAATGATGATACAATTGATTTTGATTATACTGTTCTACTTCATGAATTATCAACACAGGAAATAAT
TCCCTGTCGCATTCACTTGGTCTGGTACCCTGGCAAACCTCTTAAAGTGAAGTACCACTGTCAAGAGCTACAGACACCAGAAGAAGCCTC
CGGAACTGAAGAAGGATCAGCTGTAGTACCAACAGAGCTTAGTAATTTCTAAAAAGAAAAAATGATCTTTTTCCGACTTCTAAACAAGTG
ACTATACTAGCATAAATCATTCTTCTAGTAAAACAGCTAAGGTATAGACATTCTAATAATTTGGGAAAACCTATGATTACAAGTAAAAAC
TCAGAAATGCAAAGATGTTGGTTTTTTGTTTCTCAGTCTGCTTTAGCTTTTAACTCTGGAAGCGCATGCACACTGAACTCTGCTCAGTGC
TAAACAGTCACCAGCAGGTTCCTCAGGGTTTCAGCCCTAAAATGTAAAACCTGGATAATCAGTGTATGTTGCACCAGAATCAGCATTTTT
TTTTTAACTGCAAAAAATGATGGTCTCATCTCTGAATTTATATTTCTCATTCTTTTGAACATACTATAGCTAATATATTTTATGTTGCTA
AATTGCTTCTATCTAGCATGTTAAACAAAGATAATATACTTTCGATGAAAGTAAATTATAGGAAAAAAATTAACTGTTTTAAAAAGAACT
TGATTATGTTTTATGATTTCAGGCAAGTATTCATTTTTAACTTGCTACCTACTTTTAAATAAATGTTTACATTTCTAAATAATGAAATGT
GTTGAATGTTCTCGTGAAGATTTGTATACAAAGGAAAAATTTGTGCTAAACTGGAATTAAATGAAATGGTAATATTGCTTAACTTAAATT
TTACAAATAATAGAACGTCTGTCTCACCAGATAAAGCTGTCTGCAAACATGCATCAAAAGAAACACTGATGTAACTGAAAGTATATTAAA

>38446_38446_1_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000326448_RARRES1_chr3_158422716_ENST00000237696_length(amino acids)=262AA_BP=0
MRLKISLLKEPKHQELVSCVGWTTAEELYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQAESFVLTSSDGKFH
LISKLGRVEKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWSKTGMLRSTLAQQDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSH

--------------------------------------------------------------
>38446_38446_2_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000483465_RARRES1_chr3_158422716_ENST00000479756_length(transcript)=893nt_BP=616nt
TGCAGGTCTGTGAAAGAATAGGTAAATAAATTGAAAGTAAGGGCTGAGAAATTTTTGTAGCAATTTGACATTGTTATAATGTCCAATTTT
TCTAATATTTTATTTTTATTGTATCTTACGAAATATCCATATGCAATGGATTCGAAATAAAGAAAAATCTGGTCCTTCATCAGAACTAGG
AAAGCACTGATTTAAACATTTGGTCAGACATTTTAAATTGAATTAGTAAGCTGTGTGGGCTGGACTACTGCTGAAGAGCTGTATTCATGT
AGTGATGATCACCAGATAGTGAAGTGGAACTTGTTAACCAGTGAAACAACTCAAATAGTAAAGCTTCCTGATGATATTTACCCTATTGAT
TTTCACTGGTTTCCAAAAAGTTTGGGTGTAAAGAAACAAACCCAGGCAGAAAGCTTTGTCCTCACAAGTTCTGATGGTAAATTTCATCTG
ATTTCCAAGTTAGGAAGAGTGGAAAAAAGTGTAGAAGCTCACTGTGGAGCAGTACTTGCAGGAAGATGGAATTATGAAGGAACAGCATTA
GTTACAGTTGGAGAAGATGGACAAATAAAAATTTGGTCAAAGACTGGGATGCTTAGATCAACTTTAGCTCAGCAAGATAATCATGGACAT
ATTGATCCCTCTCTGAGACTCATCTGGGATTTGGCTTTCCTTGGAAGCTCTTACGTGATGTGGGAAATGACAACACAGGTGTCACACTAC
TACTTGGCACAGCTCACTAGTGTGAGGCAGTGGGTAAGAAAAACCTGAAAATTAACTTGTGCCACAAGAGTTACAATCAAAGTGGTCTCC

>38446_38446_2_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000483465_RARRES1_chr3_158422716_ENST00000479756_length(amino acids)=169AA_BP=119
MYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYE

--------------------------------------------------------------
>38446_38446_3_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000496589_RARRES1_chr3_158422716_ENST00000237696_length(transcript)=1969nt_BP=833nt
ACTCGGATGACGTGCCGCGTAGAAGTATCGCGGGAAGAGGAAGGGAGCGTAACTCTTAGAAGTCACTATGGTGACGGGGAGGTACCAGGT
ATTTGAGAGCAATCGCCACCGCTTTCCTGGAACTTGAGTAAATACAATCAAGTGGCATCTTAAATTTTTGCTGGAAGTGGAGTCATGAGA
CTAAAGATATCTCTTTTAAAAGAACCAAAGCATATCCTTTTAATGCTTATAAATCTTATTGGATTTTCTTAATTATAGTATTGTTAAAAG
TTTCTCTATTTTATATCCTAGTTGAAGAATAGATTTTTTTTTTCATTCCTTTAGTGGCTGTTTACCTAAATTGTTTTAAAGTATTTAAGA
TCATGTGTTAAAAATCTGGTCCTTCATCAGAACTAGGAAAGCACTGATTTAAACATTTGGTCAGACATTTTAAATTGAATTAGTAAGCTG
TGTGGGCTGGACTACTGCTGAAGAGCTGTATTCATGTAGTGATGATCACCAGATAGTGAAGTGGAACTTGTTAACCAGTGAAACAACTCA
AATAGTAAAGCTTCCTGATGATATTTACCCTATTGATTTTCACTGGTTTCCAAAAAGTTTGGGTGTAAAGAAACAAACCCAGGCAGAAAG
CTTTGTCCTCACAAGTTCTGATGGTAAATTTCATCTGATTTCCAAGTTAGGAAGAGTGGAAAAAAGTGTAGAAGCTCACTGTGGAGCAGT
ACTTGCAGGAAGATGGAATTATGAAGGAACAGCATTAGTTACAGTTGGAGAAGATGGACAAATAAAAATTTGGTCAAAGACTGGGATGCT
TAGATCAACTTTAGCTCAGCAAGATAATCATGGACATATTGATCCCTCTCTGAGACTCATCTGGGATTTGGCTTTCCTTGGAAGCTCTTA
CGTGATGTGGGAAATGACAACACAGGTGTCACACTACTACTTGGCACAGCTCACTAGTGTGAGGCAGTGGAAAACTAATGATGATACAAT
TGATTTTGATTATACTGTTCTACTTCATGAATTATCAACACAGGAAATAATTCCCTGTCGCATTCACTTGGTCTGGTACCCTGGCAAACC
TCTTAAAGTGAAGTACCACTGTCAAGAGCTACAGACACCAGAAGAAGCCTCCGGAACTGAAGAAGGATCAGCTGTAGTACCAACAGAGCT
TAGTAATTTCTAAAAAGAAAAAATGATCTTTTTCCGACTTCTAAACAAGTGACTATACTAGCATAAATCATTCTTCTAGTAAAACAGCTA
AGGTATAGACATTCTAATAATTTGGGAAAACCTATGATTACAAGTAAAAACTCAGAAATGCAAAGATGTTGGTTTTTTGTTTCTCAGTCT
GCTTTAGCTTTTAACTCTGGAAGCGCATGCACACTGAACTCTGCTCAGTGCTAAACAGTCACCAGCAGGTTCCTCAGGGTTTCAGCCCTA
AAATGTAAAACCTGGATAATCAGTGTATGTTGCACCAGAATCAGCATTTTTTTTTTAACTGCAAAAAATGATGGTCTCATCTCTGAATTT
ATATTTCTCATTCTTTTGAACATACTATAGCTAATATATTTTATGTTGCTAAATTGCTTCTATCTAGCATGTTAAACAAAGATAATATAC
TTTCGATGAAAGTAAATTATAGGAAAAAAATTAACTGTTTTAAAAAGAACTTGATTATGTTTTATGATTTCAGGCAAGTATTCATTTTTA
ACTTGCTACCTACTTTTAAATAAATGTTTACATTTCTAAATAATGAAATGTGTTGAATGTTCTCGTGAAGATTTGTATACAAAGGAAAAA
TTTGTGCTAAACTGGAATTAAATGAAATGGTAATATTGCTTAACTTAAATTTTACAAATAATAGAACGTCTGTCTCACCAGATAAAGCTG

>38446_38446_3_IFT80-RARRES1_IFT80_chr3_160093600_ENST00000496589_RARRES1_chr3_158422716_ENST00000237696_length(amino acids)=235AA_BP=1
MYSCSDDHQIVKWNLLTSETTQIVKLPDDIYPIDFHWFPKSLGVKKQTQAESFVLTSSDGKFHLISKLGRVEKSVEAHCGAVLAGRWNYE
GTALVTVGEDGQIKIWSKTGMLRSTLAQQDNHGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQLTSVRQWKTNDDTIDFDYTVLL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IFT80-RARRES1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IFT80-RARRES1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IFT80-RARRES1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source