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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IFT81-GLIPR1L2 (FusionGDB2 ID:38450)

Fusion Gene Summary for IFT81-GLIPR1L2

check button Fusion gene summary
Fusion gene informationFusion gene name: IFT81-GLIPR1L2
Fusion gene ID: 38450
HgeneTgene
Gene symbol

IFT81

GLIPR1L2

Gene ID

28981

144321

Gene nameintraflagellar transport 81GLIPR1 like 2
SynonymsCDV-1|CDV-1R|CDV1|CDV1R|DV1|SRTD19-
Cytomap

12q24.11

12q21.2

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 81 homologcarnitine deficiency-associated gene expressed in ventricle 1carnitine deficiency-associated protein expressed in ventricle 1GLIPR1-like protein 2GLI pathogenesis related 1 like 2
Modification date2020031320200313
UniProtAcc

Q8WYA0

Q4G1C9

Ensembl transtripts involved in fusion geneENST00000242591, ENST00000552912, 
ENST00000361948, ENST00000549009, 
ENST00000320460, ENST00000378692, 
ENST00000441218, ENST00000547164, 
ENST00000378689, ENST00000435775, 
ENST00000550916, 
Fusion gene scores* DoF score6 X 6 X 5=1806 X 4 X 4=96
# samples 66
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFT81 [Title/Abstract] AND GLIPR1L2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIFT81(110618376)-GLIPR1L2(75804214), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IFT81 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GLIPR1L2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3BZ-06AIFT81chr12

110618376

-GLIPR1L2chr12

75804214

+
ChimerDB4SKCMTCGA-D3-A3BZ-06AIFT81chr12

110618376

+GLIPR1L2chr12

75804214

+


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Fusion Gene ORF analysis for IFT81-GLIPR1L2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000242591ENST00000320460IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000242591ENST00000378692IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000242591ENST00000441218IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000242591ENST00000547164IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000552912ENST00000320460IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000552912ENST00000378692IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000552912ENST00000441218IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-5UTRENST00000552912ENST00000547164IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-intronENST00000242591ENST00000378689IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-intronENST00000242591ENST00000435775IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-intronENST00000552912ENST00000378689IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
5CDS-intronENST00000552912ENST00000435775IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
In-frameENST00000242591ENST00000550916IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
In-frameENST00000552912ENST00000550916IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-3CDSENST00000361948ENST00000550916IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-3CDSENST00000549009ENST00000550916IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000361948ENST00000320460IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000361948ENST00000378692IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000361948ENST00000441218IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000361948ENST00000547164IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000549009ENST00000320460IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000549009ENST00000378692IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000549009ENST00000441218IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-5UTRENST00000549009ENST00000547164IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-intronENST00000361948ENST00000378689IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-intronENST00000361948ENST00000435775IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-intronENST00000549009ENST00000378689IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+
intron-intronENST00000549009ENST00000435775IFT81chr12

110618376

+GLIPR1L2chr12

75804214

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000552912IFT81chr12110618376+ENST00000550916GLIPR1L2chr1275804214+379614681302268712
ENST00000242591IFT81chr12110618376+ENST00000550916GLIPR1L2chr1275804214+417218445062644712

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000552912ENST00000550916IFT81chr12110618376+GLIPR1L2chr1275804214+0.0009481470.99905187
ENST00000242591ENST00000550916IFT81chr12110618376+GLIPR1L2chr1275804214+0.0008560690.99914396

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Fusion Genomic Features for IFT81-GLIPR1L2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IFT81chr12110618376+GLIPR1L2chr1275804213+0.0040750890.99592495
IFT81chr12110618376+GLIPR1L2chr1275804213+0.0040750890.99592495

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IFT81-GLIPR1L2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110618376/chr12:75804214)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IFT81

Q8WYA0

GLIPR1L2

Q4G1C9

FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region (PubMed:23990561). Required for ciliogenesis (PubMed:27666822, PubMed:23990561). Required for proper regulation of SHH signaling (PubMed:27666822). {ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:27666822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT81chr12:110618376chr12:75804214ENST00000242591+1219132_258446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000242591+1219306_389446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000552912+1219132_258446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000552912+1219306_389446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000242591+12192_121446677.0RegionNote=CH (calponin-homology)-like region
HgeneIFT81chr12:110618376chr12:75804214ENST00000552912+12192_121446677.0RegionNote=CH (calponin-homology)-like region
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000032046004292_34378254.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000037868902292_3430107.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000037869217292_3430238.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000043577505292_34378335.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000044121806292_34313280.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000054716403292_34378169.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000055091606292_34378345.0Compositional biasNote=Glu-rich
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000003786890258_1920107.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000003786921758_1920238.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000004412180658_19213280.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000032046004254_27478254.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000037868902254_2740107.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000037869217254_2740238.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000043577505254_27478335.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000044121806254_27413280.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000054716403254_27478169.0TransmembraneHelical
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST0000055091606254_27478345.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT81chr12:110618376chr12:75804214ENST00000242591+1219416_456446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000242591+1219490_622446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000361948+112132_2580432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000361948+112306_3890432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000361948+112416_4560432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000361948+112490_6220432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000552912+1219416_456446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000552912+1219490_622446677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110618376chr12:75804214ENST00000361948+1122_1210432.0RegionNote=CH (calponin-homology)-like region
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000003204600458_19278254.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000004357750558_19278335.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000005471640358_19278169.0DomainNote=SCP
TgeneGLIPR1L2chr12:110618376chr12:75804214ENST000005509160658_19278345.0DomainNote=SCP


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Fusion Gene Sequence for IFT81-GLIPR1L2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38450_38450_1_IFT81-GLIPR1L2_IFT81_chr12_110618376_ENST00000242591_GLIPR1L2_chr12_75804214_ENST00000550916_length(transcript)=4172nt_BP=1844nt
TGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGTTTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCG
GAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCGGTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGT
TAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGATCCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGG
GCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTGTCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAG
GAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGGTTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTT
TTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTC
TCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTC
TGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTC
TTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGC
TCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTC
TTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCA
AGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATT
TGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATC
TTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCC
AAGCTGCAGCAGATGCAAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATAAAATTTAATTTATATATGGTAACTGAAAAATTTC
CTAAAGAATTAGAAAATAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCAGAGCCAGCTATGGGCCATTCTGATCTTCTTGAAC
TTGAATCTAAAATAAATGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAAATGATGAGAAATGAGCCCATTGAAGGCAAACTCT
CACTGTATAGGCAACAGGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCC
TAGAGAGAGAAGCATCAGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCA
ATAAACTTCGAAGCAAGAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTG
AAGAACTTCTTAAGCAACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTAGCTTTATCACGGACTGCTAGAGCATGGGGAAAAA
AATGTTTGTTTACGCATAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAATTTTATGGTATTGGTGAAAATATGTGGGTCGGCC
CTGAAAATGAATTTACTGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAAATGTACAATTTTGAAAATGGCAGTTGCTCTGGAG
ACTGTTCTAATTATATTCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCTGTTACTCCATGTTCAAAAATTGGACATATTATAC
ATGCAGCAATTTTCATATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCTTATGAACCAGGAATATTTTGTACTCGATGTGGCA
GACGTGACAAATGCACAGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGC
CCCGGCCAGTTGTGTGTGATCCACTGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGATAG
TACAGTCTCAGTTTCCAAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAG
AGGAAGAGAAGAAAGAGAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAA
CACAAAAAGAAAAGATGGAGGAAGAGGAAAAATAAGAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATAC
AAAAAAAGACAGAAAAAAAAAAAAAGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCACCATTGGAATGTTTTTTATTCCC
TTCTCTCCTATACTTATTCAATCAATTTAAATTTGTAAAACAAAGAAACAAAAAACATGTAAGGTGGGCTCTTTGACACTAAGAACAGAT
AAAGACATGACAGGAAAAACACTGAAAAACATTTGACCAGTCTAATTAATCTTAAGATTTCACCATGTTATTCTAATAAAGTAGGGAATT
TTCATTTTCTAAACATGTTTCCATCTCTGTGTTTTAAATAGTAAGGTGCTTAAGATCATTCCAAGTTCATAACAACCATTGAATAAAATT
TGTATTTTTTTGTTTTTACTGTTACTGTCATAGTTTTTATTGGTGGTAGTGGTATTTTCATGTGATATTAAGGTATCTAATATTATTATT
TGTCTTTGTGGTTTTTGGAATAGTTTAAGTGGTACCTGTACATCCTGCTAGGATGCAAACTTATTATTTATAATTAATGTTCAATATTTC
ATTAAAGACTTGCTGTAATTTTCTGCCACCAAGGGCTAATAAATGCCATAATTTTAATTAGTTGTGGTAGAGGAATCTGGGTGCTTCCAA
ATTTATATGATAAAATAAATAAATTTTTTAAAAACTATTAACTTGTTATTCAATAGGTATAGTAAAAGTTAACAGATTAATAAGATAACT
GCTTACCACTAGTAATACTAATAAATGAACTAAATAAAAATACCTAGCATAGGAGATTTCTTTATCTATAAAATAAATGGATAGCACTAG
ATGACCACTAAGACCTCTTCCATCAATGAATATTCATGGATCAACTTTGTAAAGGAATCAATAGTAGTTGTGAAGTACACTAAGCAAACA
CCTGAGGGAAAAACTTGATTCCCATGAAAATATTCCTGAACTCAGCACCTTATATGGCAAAATAATAAATACCTTTTATTACTCAATTTT
AAAATAGGCAAAAAGCAATGTATAATATTTTTCCAATTGCCATTCCATACTCAGCTGTCTTATTGTTGCACACTTATTAGAACTCAATGT
GACTGAGATGTGAAAGGTTGATATAATTCTATTTATGACAGGGACTTAGGGAACTTATTCTAATTGAGAATCAGAGGCTTAATAAACCTG
AAGGTTTAAGTGAAAGAAATGACATTGAAAGAATCACTGCATATCTGATGTTTTCAAATAAAACAATCTCTGTTTTCTGGTTTTGATAGA
ATATTGTGTTCTAAAGCTATATTTCTCAATGTGTGGTTCCACTGAGGGAAAGAAAAAAAAAAAAACCTAGCATAGCCAAATACCTCAAAT
GGTATAAATGCTATGTGTATTTACTCTGTTGTTCTTTAGTTGTATCAATATTCTGTTAAAAACCTGTTCGAAGTAGGGCAAGATGAGAAT

>38450_38450_1_IFT81-GLIPR1L2_IFT81_chr12_110618376_ENST00000242591_GLIPR1L2_chr12_75804214_ENST00000550916_length(amino acids)=712AA_BP=446
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI
KFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLTWDV
ALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCA
VTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRIL

--------------------------------------------------------------
>38450_38450_2_IFT81-GLIPR1L2_IFT81_chr12_110618376_ENST00000552912_GLIPR1L2_chr12_75804214_ENST00000550916_length(transcript)=3796nt_BP=1468nt
GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT
TTCGTGAGGAGAATTTGAGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTT
TAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCC
AAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTC
AGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCA
GAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGT
GGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTC
TACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGA
GACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACA
GGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGC
AAAGCCTGAAAGTTTAATGAAGAGGCTAGAGGAGGAGATAAAATTTAATTTATATATGGTAACTGAAAAATTTCCTAAAGAATTAGAAAA
TAAGAAAAAGGAATTACATTTTTTACAAAAAGTAGTTTCAGAGCCAGCTATGGGCCATTCTGATCTTCTTGAACTTGAATCTAAAATAAA
TGAAATAAACACAGAAATTAACCAGTTGATTGAAAAGAAAATGATGAGAAATGAGCCCATTGAAGGCAAACTCTCACTGTATAGGCAACA
GGCATCTATCATTTCCCGTAAAAAAGAAGCCAAAGCTGAGGAACTTCAGGAGGCCAAGGAGAAGTTAGCCAGCCTAGAGAGAGAAGCATC
AGTAAAGAGAAATCAGACCCGTGAATTTGATGGTACTGAAGTTTTAAAGGGAGATGAGTTCAAACGATATGTCAATAAACTTCGAAGCAA
GAGTACAGTTTTCAAAAAGAAGCATCAGATAATAGCTGAACTTAAAGCTGAATTCGGTCTTTTGCAGAGGACTGAAGAACTTCTTAAGCA
ACGTCATGAAAATATTCAACAACAACTGACTTGGGATGTAGCTTTATCACGGACTGCTAGAGCATGGGGAAAAAAATGTTTGTTTACGCA
TAATATTTATTTACAAGATGTACAAATGGTCCATCCTAAATTTTATGGTATTGGTGAAAATATGTGGGTCGGCCCTGAAAATGAATTTAC
TGCAAGTATTGCTATCAGAAGTTGGCATGCAGAGAAGAAAATGTACAATTTTGAAAATGGCAGTTGCTCTGGAGACTGTTCTAATTATAT
TCAGCTTGTTTGGGACCACTCTTACAAAGTTGGTTGTGCTGTTACTCCATGTTCAAAAATTGGACATATTATACATGCAGCAATTTTCAT
ATGCAACTATGCGCCAGGAGGAACACTGACGAGAAGACCTTATGAACCAGGAATATTTTGTACTCGATGTGGCAGACGTGACAAATGCAC
AGATTTTCTATGCAGTAATGCAGATCGTGACCAAGCCACATATTACCGATTTTGGTATCCAAAATGGGAAATGCCCCGGCCAGTTGTGTG
TGATCCACTGTGCACATTCATTTTATTATTGAGAATATTATGTTTTATCCTGTGTGTCATAACTGTTTTGATAGTACAGTCTCAGTTTCC
AAATATCTTGTTGGAACAACAAATGATATTTACCCCTGAGGAATCTGAAGCAGGGAATGAAGAGGAGGAAAAAGAGGAAGAGAAGAAAGA
GAAAGAGGAAATGGAAATGGAAATAATGGAAATGGAGGAGGAAAAAGAAGAGAGAGAGGAGGAGGAGGAGGAAACACAAAAAGAAAAGAT
GGAGGAAGAGGAAAAATAAGAGTAGAAAGAGGAGGAAAAAGATGTATCACCAATATAAACCAAAAGTGTAATACAAAAAAAGACAGAAAA
AAAAAAAAAGTAAAACACTGAGTTTTAACAAGAAAGAAAATATGCAAACCACCATTGGAATGTTTTTTATTCCCTTCTCTCCTATACTTA
TTCAATCAATTTAAATTTGTAAAACAAAGAAACAAAAAACATGTAAGGTGGGCTCTTTGACACTAAGAACAGATAAAGACATGACAGGAA
AAACACTGAAAAACATTTGACCAGTCTAATTAATCTTAAGATTTCACCATGTTATTCTAATAAAGTAGGGAATTTTCATTTTCTAAACAT
GTTTCCATCTCTGTGTTTTAAATAGTAAGGTGCTTAAGATCATTCCAAGTTCATAACAACCATTGAATAAAATTTGTATTTTTTTGTTTT
TACTGTTACTGTCATAGTTTTTATTGGTGGTAGTGGTATTTTCATGTGATATTAAGGTATCTAATATTATTATTTGTCTTTGTGGTTTTT
GGAATAGTTTAAGTGGTACCTGTACATCCTGCTAGGATGCAAACTTATTATTTATAATTAATGTTCAATATTTCATTAAAGACTTGCTGT
AATTTTCTGCCACCAAGGGCTAATAAATGCCATAATTTTAATTAGTTGTGGTAGAGGAATCTGGGTGCTTCCAAATTTATATGATAAAAT
AAATAAATTTTTTAAAAACTATTAACTTGTTATTCAATAGGTATAGTAAAAGTTAACAGATTAATAAGATAACTGCTTACCACTAGTAAT
ACTAATAAATGAACTAAATAAAAATACCTAGCATAGGAGATTTCTTTATCTATAAAATAAATGGATAGCACTAGATGACCACTAAGACCT
CTTCCATCAATGAATATTCATGGATCAACTTTGTAAAGGAATCAATAGTAGTTGTGAAGTACACTAAGCAAACACCTGAGGGAAAAACTT
GATTCCCATGAAAATATTCCTGAACTCAGCACCTTATATGGCAAAATAATAAATACCTTTTATTACTCAATTTTAAAATAGGCAAAAAGC
AATGTATAATATTTTTCCAATTGCCATTCCATACTCAGCTGTCTTATTGTTGCACACTTATTAGAACTCAATGTGACTGAGATGTGAAAG
GTTGATATAATTCTATTTATGACAGGGACTTAGGGAACTTATTCTAATTGAGAATCAGAGGCTTAATAAACCTGAAGGTTTAAGTGAAAG
AAATGACATTGAAAGAATCACTGCATATCTGATGTTTTCAAATAAAACAATCTCTGTTTTCTGGTTTTGATAGAATATTGTGTTCTAAAG
CTATATTTCTCAATGTGTGGTTCCACTGAGGGAAAGAAAAAAAAAAAAACCTAGCATAGCCAAATACCTCAAATGGTATAAATGCTATGT
GTATTTACTCTGTTGTTCTTTAGTTGTATCAATATTCTGTTAAAAACCTGTTCGAAGTAGGGCAAGATGAGAATTATATTAAAAAGCCCT

>38450_38450_2_IFT81-GLIPR1L2_IFT81_chr12_110618376_ENST00000552912_GLIPR1L2_chr12_75804214_ENST00000550916_length(amino acids)=712AA_BP=446
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPESLMKRLEEEI
KFNLYMVTEKFPKELENKKKELHFLQKVVSEPAMGHSDLLELESKINEINTEINQLIEKKMMRNEPIEGKLSLYRQQASIISRKKEAKAE
ELQEAKEKLASLEREASVKRNQTREFDGTEVLKGDEFKRYVNKLRSKSTVFKKKHQIIAELKAEFGLLQRTEELLKQRHENIQQQLTWDV
ALSRTARAWGKKCLFTHNIYLQDVQMVHPKFYGIGENMWVGPENEFTASIAIRSWHAEKKMYNFENGSCSGDCSNYIQLVWDHSYKVGCA
VTPCSKIGHIIHAAIFICNYAPGGTLTRRPYEPGIFCTRCGRRDKCTDFLCSNADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRIL

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Fusion Gene PPI Analysis for IFT81-GLIPR1L2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IFT81-GLIPR1L2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IFT81-GLIPR1L2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource