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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IGF1R-PPP4R1 (FusionGDB2 ID:38488)

Fusion Gene Summary for IGF1R-PPP4R1

Fusion gene summary

Fusion gene information	Fusion gene name: IGF1R-PPP4R1
	Fusion gene ID: 38488
		Hgene	Tgene
	Gene symbol	IGF1R	PPP4R1
	Gene ID	3480	9989
	Gene name	insulin like growth factor 1 receptor	protein phosphatase 4 regulatory subunit 1
	Synonyms	CD221\|IGFIR\|IGFR\|JTK13	MEG1\|PP4(Rmeg)\|PP4R1
	Cytomap	15q26.3	18p11.22
	Type of gene	protein-coding	protein-coding
	Description	insulin-like growth factor 1 receptorIGF-I receptorsoluble IGF1R variant 1soluble IGF1R variant 2	serine/threonine-protein phosphatase 4 regulatory subunit 1serine/threonine phosphatase 4
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000268035, ENST00000558762, ENST00000560432,	ENST00000400555, ENST00000580583, ENST00000400556,
Fusion gene scores	* DoF score	24 X 15 X 6=2160	17 X 14 X 9=2142
	# samples	25	17
	** MAII score	log2(25/2160*10)=-3.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/2142*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IGF1R [Title/Abstract] AND PPP4R1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IGF1R(99467913)-PPP4R1(9595151), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IGF1R	GO:0043066	negative regulation of apoptotic process	12556535
Hgene	IGF1R	GO:0046328	regulation of JNK cascade	12556535
Hgene	IGF1R	GO:0046777	protein autophosphorylation	1846292\|7679099\|11162456
Hgene	IGF1R	GO:0048009	insulin-like growth factor receptor signaling pathway	7679099
Hgene	IGF1R	GO:0048015	phosphatidylinositol-mediated signaling	7692086
Hgene	IGF1R	GO:0051389	inactivation of MAPKK activity	12556535

Fusion gene breakpoints across IGF1R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP4R1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A1NF-01A	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-

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Fusion Gene ORF analysis for IGF1R-PPP4R1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000268035	ENST00000400555	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
5CDS-intron	ENST00000268035	ENST00000580583	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
5CDS-intron	ENST00000558762	ENST00000400555	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
5CDS-intron	ENST00000558762	ENST00000580583	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
In-frame	ENST00000268035	ENST00000400556	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
In-frame	ENST00000558762	ENST00000400556	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
intron-3CDS	ENST00000560432	ENST00000400556	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
intron-intron	ENST00000560432	ENST00000400555	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-
intron-intron	ENST00000560432	ENST00000580583	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000268035

IGF1R

chr15

99467913

ENST00000400556

PPP4R1

chr18

9595151

7192

3393

611

6193

1860

ENST00000558762

IGF1R

chr15

99467913

ENST00000400556

PPP4R1

chr18

9595151

7119

3320

538

6120

1860

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000268035	ENST00000400556	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-	0.001524892	0.99847513
ENST00000558762	ENST00000400556	IGF1R	chr15	99467913	+	PPP4R1	chr18	9595151	-	0.001409289	0.99859065

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Fusion Genomic Features for IGF1R-PPP4R1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IGF1R-PPP4R1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:99467913/chr18:9595151)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

491_609

927

1368.0

Domain

Fibronectin type-III 1

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

610_708

927

1368.0

Domain

Fibronectin type-III 2

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

735_828

927

1368.0

Domain

Fibronectin type-III 3

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

834_927

927

1368.0

Domain

Fibronectin type-III 4

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

127_164

934.0

Repeat

Note=HEAT 5

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

168_206

934.0

Repeat

Note=HEAT 6

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

1_25

934.0

Repeat

Note=HEAT 1

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

208_246

934.0

Repeat

Note=HEAT 7

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

248_285

934.0

Repeat

Note=HEAT 8

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

26_63

934.0

Repeat

Note=HEAT 2

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

287_324

934.0

Repeat

Note=HEAT 9

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

505_542

934.0

Repeat

Note=HEAT 10

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

568_606

934.0

Repeat

Note=HEAT 11

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

65_81

934.0

Repeat

Note=HEAT 3

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

698_734

934.0

Repeat

Note=HEAT 12

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

799_837

934.0

Repeat

Note=HEAT 13

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

82_119

934.0

Repeat

Note=HEAT 4

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400555

861_898

934.0

Repeat

Note=HEAT 14

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

127_164

951.0

Repeat

Note=HEAT 5

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

168_206

951.0

Repeat

Note=HEAT 6

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

208_246

951.0

Repeat

Note=HEAT 7

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

248_285

951.0

Repeat

Note=HEAT 8

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

26_63

951.0

Repeat

Note=HEAT 2

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

287_324

951.0

Repeat

Note=HEAT 9

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

505_542

951.0

Repeat

Note=HEAT 10

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

568_606

951.0

Repeat

Note=HEAT 11

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

65_81

951.0

Repeat

Note=HEAT 3

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

698_734

951.0

Repeat

Note=HEAT 12

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

799_837

951.0

Repeat

Note=HEAT 13

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

82_119

951.0

Repeat

Note=HEAT 4

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

861_898

951.0

Repeat

Note=HEAT 14

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

999_1274

927

1368.0

Domain

Protein kinase

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

977_980

927

1368.0

Motif

Note=IRS1- and SHC1-binding

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

1005_1013

927

1368.0

Nucleotide binding

ATP

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

741_935

927

1368.0

Topological domain

Extracellular

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

960_1367

927

1368.0

Topological domain

Cytoplasmic

Hgene

IGF1R

chr15:99467913

chr18:9595151

ENST00000268035

936_959

927

1368.0

Transmembrane

Helical

Tgene

PPP4R1

chr15:99467913

chr18:9595151

ENST00000400556

1_25

951.0

Repeat

Note=HEAT 1

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Fusion Gene Sequence for IGF1R-PPP4R1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>38488_38488_1_IGF1R-PPP4R1_IGF1R_chr15_99467913_ENST00000268035_PPP4R1_chr18_9595151_ENST00000400556_length(transcript)=7192nt_BP=3393nt
GGGAAGGAGCTCGCCGCGGCGGCGGCGGCGCTGAGGGAGGAGGCGGCGGCGAGCGGAGCCAGGAGGAGGAGGAGGAGGGGGAGCCGCTCA
TTCATTTTGACTCCGCGTTTCTGCCCCTCGCCGGCCTCGCCTGTGACCCGGACTTCGGGGCGATCTTGCGAACTGCGTCGCGCCCTCCCG
CGGCGGAAGCTCGGGCGTCCGGCCGCCTCCCGCGCGGCCAGGGCCGGGCTTGTTTTTCCTCGCCTAGGCAGATTTGGGCTTTGCCCCCTT
TCTTTGCAGTTTTCCCCCCTTCCTGCCTCTCCGGGTTTGAAAATGGAGGCCGACGACGCCGACAGCCCGCCCCGGCGCGCCTCGGGTTCC
CGACTCCGCCGAGCCCTGGGCCGCTGCTGCCGGCGCTGAGGGGCCGCCCCGCGCCGCCCGCCCCGTCCGCGCACCCGGAGGGCCCCGGCG
GCGCCGCCTTCGGAGTATTGTTTCCTTCGCCCTTGTTTTTGGAGGGGGAGCGAAGACTGAGTTTGAGACTTGTTTCCTTTCATTTCCTTT
TTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGAAAGGGGAATTTCATCCCAAATAAAAGGAATGAAGTCTGGCTCCGGAG
GAGGGTCCCCGACCTCGCTGTGGGGGCTCCTGTTTCTCTCCGCCGCGCTCTCGCTCTGGCCGACGAGTGGAGAAATCTGCGGGCCAGGCA
TCGACATCCGCAACGACTATCAGCAGCTGAAGCGCCTGGAGAACTGCACGGTGATCGAGGGCTACCTCCACATCCTGCTCATCTCCAAGG
CCGAGGACTACCGCAGCTACCGCTTCCCCAAGCTCACGGTCATTACCGAGTACTTGCTGCTGTTCCGAGTGGCTGGCCTCGAGAGCCTCG
GAGACCTCTTCCCCAACCTCACGGTCATCCGCGGCTGGAAACTCTTCTACAACTACGCCCTGGTCATCTTCGAGATGACCAATCTCAAGG
ATATTGGGCTTTACAACCTGAGGAACATTACTCGGGGGGCCATCAGGATTGAGAAAAATGCTGACCTCTGTTACCTCTCCACTGTGGACT
GGTCCCTGATCCTGGATGCGGTGTCCAATAACTACATTGTGGGGAATAAGCCCCCAAAGGAATGTGGGGACCTGTGTCCAGGGACCATGG
AGGAGAAGCCGATGTGTGAGAAGACCACCATCAACAATGAGTACAACTACCGCTGCTGGACCACAAACCGCTGCCAGAAAATGTGCCCAA
GCACGTGTGGGAAGCGGGCGTGCACCGAGAACAATGAGTGCTGCCACCCCGAGTGCCTGGGCAGCTGCAGCGCGCCTGACAACGACACGG
CCTGTGTAGCTTGCCGCCACTACTACTATGCCGGTGTCTGTGTGCCTGCCTGCCCGCCCAACACCTACAGGTTTGAGGGCTGGCGCTGTG
TGGACCGTGACTTCTGCGCCAACATCCTCAGCGCCGAGAGCAGCGACTCCGAGGGGTTTGTGATCCACGACGGCGAGTGCATGCAGGAGT
GCCCCTCGGGCTTCATCCGCAACGGCAGCCAGAGCATGTACTGCATCCCTTGTGAAGGTCCTTGCCCGAAGGTCTGTGAGGAAGAAAAGA
AAACAAAGACCATTGATTCTGTTACTTCTGCTCAGATGCTCCAAGGATGCACCATCTTCAAGGGCAATTTGCTCATTAACATCCGACGGG
GGAATAACATTGCTTCAGAGCTGGAGAACTTCATGGGGCTCATCGAGGTGGTGACGGGCTACGTGAAGATCCGCCATTCTCATGCCTTGG
TCTCCTTGTCCTTCCTAAAAAACCTTCGCCTCATCCTAGGAGAGGAGCAGCTAGAAGGGAATTACTCCTTCTACGTCCTCGACAACCAGA
ACTTGCAGCAACTGTGGGACTGGGACCACCGCAACCTGACCATCAAAGCAGGGAAAATGTACTTTGCTTTCAATCCCAAATTATGTGTTT
CCGAAATTTACCGCATGGAGGAAGTGACGGGGACTAAAGGGCGCCAAAGCAAAGGGGACATAAACACCAGGAACAACGGGGAGAGAGCCT
CCTGTGAAAGTGACGTCCTGCATTTCACCTCCACCACCACGTCGAAGAATCGCATCATCATAACCTGGCACCGGTACCGGCCCCCTGACT
ACAGGGATCTCATCAGCTTCACCGTTTACTACAAGGAAGCACCCTTTAAGAATGTCACAGAGTATGATGGGCAGGATGCCTGCGGCTCCA
ACAGCTGGAACATGGTGGACGTGGACCTCCCGCCCAACAAGGACGTGGAGCCCGGCATCTTACTACATGGGCTGAAGCCCTGGACTCAGT
ACGCCGTTTACGTCAAGGCTGTGACCCTCACCATGGTGGAGAACGACCATATCCGTGGGGCCAAGAGTGAGATCTTGTACATTCGCACCA
ATGCTTCAGTTCCTTCCATTCCCTTGGACGTTCTTTCAGCATCGAACTCCTCTTCTCAGTTAATCGTGAAGTGGAACCCTCCCTCTCTGC
CCAACGGCAACCTGAGTTACTACATTGTGCGCTGGCAGCGGCAGCCTCAGGACGGCTACCTTTACCGGCACAATTACTGCTCCAAAGACA
AAATCCCCATCAGGAAGTATGCCGACGGCACCATCGACATTGAGGAGGTCACAGAGAACCCCAAGACTGAGGTGTGTGGTGGGGAGAAAG
GGCCTTGCTGCGCCTGCCCCAAAACTGAAGCCGAGAAGCAGGCCGAGAAGGAGGAGGCTGAATACCGCAAAGTCTTTGAGAATTTCCTGC
ACAACTCCATCTTCGTGCCCAGACCTGAAAGGAAGCGGAGAGATGTCATGCAAGTGGCCAACACCACCATGTCCAGCCGAAGCAGGAACA
CCACGGCCGCAGACACCTACAACATCACCGACCCGGAAGAGCTGGAGACAGAGTACCCTTTCTTTGAGAGCAGAGTGGATAACAAGGAGA
GAACTGTCATTTCTAACCTTCGGCCTTTCACATTGTACCGCATCGATATCCACAGCTGCAACCACGAGGCTGAGAAGCTGGGCTGCAGCG
CCTCCAACTTCGTCTTTGCAAGGACTATGCCCGCAGAAGGAGCAGATGACATTCCTGGGCCAGTGACCTGGGAGCCAAGGCCTGAAAACT
CCATCTTTTTAAAGTGGCCGGAACCTGAGAATCCCAATGGATTGATTCTAATGTATGAAATAAAATACGGATCACAAGTTGAGGATCAGC
GAGAATGTGTGTCCAGACAGGAATACAGGAAGTATGGAGGGGCCAAGCTAAACCGGCTAAACCCGGGGAACTACACAGCCCGGATTCAGG
CCACATCTCTCTCTGGGAATGGGTCGTGGACAGATCCTGTGTTCTTCTATGTCCAGGCCAAAATTGGTGTGGATGACTACAGCTCAGAGT
CTGATGTGATTATTATACCTTCAGCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATTGGACAAGTATGCTGCAA
GTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGAAAGAGATTGTATTGCTG
TTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCCTCACATCGCACTGTTTT
GTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGCAGATCAGAATAATCAGG
TGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGACCAAAGTGTGCCCTGTCC
TCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGCTCCCATGGTTGGGAAGG
ATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAAGGTCTGTGCTGCCAATT
TTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTGTTCTGATAATGTATGGG
GAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAAATTATCAGCACTTTTTA
TTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTACTTTTGCTAATCCATCTA
GCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAGAGATCAAGAAGCCCCAG
AGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAACACGATGGAAGACCATG
CTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTCCTCAGAATCTCACCAGG
AAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCACTTCACAAGATTCAGCTC
TCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGAGCTTGAACAGAACTCTG
GGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCATGGCCACCAGAAAGGAAC
TGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTCCGCTGCACTACGTGCTT
CCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAATGAGCTACCAAATTGTA
AAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATATTCACAGCGATTCAGACT
TGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTTGTTAGATCAGTATTTAT
CTATGACTGACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGGTGTGGCCTTGACACTCG
GAAGACAGAATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACGAACTCTAGCATTCTCCA
TCCACGAGCTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTTAAAAGACCTCGATGAAG
TCAGGATAGGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCTTTATCAACTTCAGGAGT
TTTTGGTGACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGAGTTATATAGTCCCAGAG
ATGTTTATGACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTCCTACAAGTTGGTCAGCG
AGATGGTGAAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAACTTTGGCAGATGTCCCA
AGTGGTCTGGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCAGTTTGCTGTGCATCTCA
TGCCGCATCTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACAAACTCTACTAGAAAAAG
ACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCGTGACAGCGATGTCAAGT
ATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTACTAGAAGGCTTGAATCTCGG
TGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTCGGGGGAGGAGAGACCTTCC
TCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAAGTACAGTAAACACTATTAT
CTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTGTCTTCCTGACTGAATGAAA
CTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGTTTTATTTAACAATCGACAA
ATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACTCTTCTCTCCCAGGAAGGAC
TTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGAAAGGAGGGGTTTTTACATC
TCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACATTTACAGAATGGTTGCTGA
GTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTGGTGTTTTTAACTTGATCAT
GATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCTTTAATCATGCTGTTTAAAC
TGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTTTTGATTGTTTTCTAGATGT

>38488_38488_1_IGF1R-PPP4R1_IGF1R_chr15_99467913_ENST00000268035_PPP4R1_chr18_9595151_ENST00000400556_length(amino acids)=1860AA_BP=928
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYR
FEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAF
NPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVK
WNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEA
EKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVQAKIGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDD
ERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVE
TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQL
CSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRT
RDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGT
TSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVL
SAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQA
LLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGF
LKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWI
SYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLR

--------------------------------------------------------------
>38488_38488_2_IGF1R-PPP4R1_IGF1R_chr15_99467913_ENST00000558762_PPP4R1_chr18_9595151_ENST00000400556_length(transcript)=7119nt_BP=3320nt
GGAGGGGGAGCCGCTCATTCATTTTGACTCCGCGTTTCTGCCCCTCGCCGGCCTCGCCTGTGACCCGGACTTCGGGGCGATCTTGCGAAC
TGCGTCGCGCCCTCCCGCGGCGGAAGCTCGGGCGTCCGGCCGCCTCCCGCGCGGCCAGGGCCGGGCTTGTTTTTCCTCGCCTAGGCAGAT
TTGGGCTTTGCCCCCTTTCTTTGCAGTTTTCCCCCCTTCCTGCCTCTCCGGGTTTGAAAATGGAGGCCGACGACGCCGACAGCCCGCCCC
GGCGCGCCTCGGGTTCCCGACTCCGCCGAGCCCTGGGCCGCTGCTGCCGGCGCTGAGGGGCCGCCCCGCGCCGCCCGCCCCGTCCGCGCA
CCCGGAGGGCCCCGGCGGCGCCGCCTTCGGAGTATTGTTTCCTTCGCCCTTGTTTTTGGAGGGGGAGCGAAGACTGAGTTTGAGACTTGT
TTCCTTTCATTTCCTTTTTTTCTTTTCTTTTCTTTTTTTTTTTTTTTTTTTTTTTTGAGAAAGGGGAATTTCATCCCAAATAAAAGGAAT
GAAGTCTGGCTCCGGAGGAGGGTCCCCGACCTCGCTGTGGGGGCTCCTGTTTCTCTCCGCCGCGCTCTCGCTCTGGCCGACGAGTGGAGA
AATCTGCGGGCCAGGCATCGACATCCGCAACGACTATCAGCAGCTGAAGCGCCTGGAGAACTGCACGGTGATCGAGGGCTACCTCCACAT
CCTGCTCATCTCCAAGGCCGAGGACTACCGCAGCTACCGCTTCCCCAAGCTCACGGTCATTACCGAGTACTTGCTGCTGTTCCGAGTGGC
TGGCCTCGAGAGCCTCGGAGACCTCTTCCCCAACCTCACGGTCATCCGCGGCTGGAAACTCTTCTACAACTACGCCCTGGTCATCTTCGA
GATGACCAATCTCAAGGATATTGGGCTTTACAACCTGAGGAACATTACTCGGGGGGCCATCAGGATTGAGAAAAATGCTGACCTCTGTTA
CCTCTCCACTGTGGACTGGTCCCTGATCCTGGATGCGGTGTCCAATAACTACATTGTGGGGAATAAGCCCCCAAAGGAATGTGGGGACCT
GTGTCCAGGGACCATGGAGGAGAAGCCGATGTGTGAGAAGACCACCATCAACAATGAGTACAACTACCGCTGCTGGACCACAAACCGCTG
CCAGAAAATGTGCCCAAGCACGTGTGGGAAGCGGGCGTGCACCGAGAACAATGAGTGCTGCCACCCCGAGTGCCTGGGCAGCTGCAGCGC
GCCTGACAACGACACGGCCTGTGTAGCTTGCCGCCACTACTACTATGCCGGTGTCTGTGTGCCTGCCTGCCCGCCCAACACCTACAGGTT
TGAGGGCTGGCGCTGTGTGGACCGTGACTTCTGCGCCAACATCCTCAGCGCCGAGAGCAGCGACTCCGAGGGGTTTGTGATCCACGACGG
CGAGTGCATGCAGGAGTGCCCCTCGGGCTTCATCCGCAACGGCAGCCAGAGCATGTACTGCATCCCTTGTGAAGGTCCTTGCCCGAAGGT
CTGTGAGGAAGAAAAGAAAACAAAGACCATTGATTCTGTTACTTCTGCTCAGATGCTCCAAGGATGCACCATCTTCAAGGGCAATTTGCT
CATTAACATCCGACGGGGGAATAACATTGCTTCAGAGCTGGAGAACTTCATGGGGCTCATCGAGGTGGTGACGGGCTACGTGAAGATCCG
CCATTCTCATGCCTTGGTCTCCTTGTCCTTCCTAAAAAACCTTCGCCTCATCCTAGGAGAGGAGCAGCTAGAAGGGAATTACTCCTTCTA
CGTCCTCGACAACCAGAACTTGCAGCAACTGTGGGACTGGGACCACCGCAACCTGACCATCAAAGCAGGGAAAATGTACTTTGCTTTCAA
TCCCAAATTATGTGTTTCCGAAATTTACCGCATGGAGGAAGTGACGGGGACTAAAGGGCGCCAAAGCAAAGGGGACATAAACACCAGGAA
CAACGGGGAGAGAGCCTCCTGTGAAAGTGACGTCCTGCATTTCACCTCCACCACCACGTCGAAGAATCGCATCATCATAACCTGGCACCG
GTACCGGCCCCCTGACTACAGGGATCTCATCAGCTTCACCGTTTACTACAAGGAAGCACCCTTTAAGAATGTCACAGAGTATGATGGGCA
GGATGCCTGCGGCTCCAACAGCTGGAACATGGTGGACGTGGACCTCCCGCCCAACAAGGACGTGGAGCCCGGCATCTTACTACATGGGCT
GAAGCCCTGGACTCAGTACGCCGTTTACGTCAAGGCTGTGACCCTCACCATGGTGGAGAACGACCATATCCGTGGGGCCAAGAGTGAGAT
CTTGTACATTCGCACCAATGCTTCAGTTCCTTCCATTCCCTTGGACGTTCTTTCAGCATCGAACTCCTCTTCTCAGTTAATCGTGAAGTG
GAACCCTCCCTCTCTGCCCAACGGCAACCTGAGTTACTACATTGTGCGCTGGCAGCGGCAGCCTCAGGACGGCTACCTTTACCGGCACAA
TTACTGCTCCAAAGACAAAATCCCCATCAGGAAGTATGCCGACGGCACCATCGACATTGAGGAGGTCACAGAGAACCCCAAGACTGAGGT
GTGTGGTGGGGAGAAAGGGCCTTGCTGCGCCTGCCCCAAAACTGAAGCCGAGAAGCAGGCCGAGAAGGAGGAGGCTGAATACCGCAAAGT
CTTTGAGAATTTCCTGCACAACTCCATCTTCGTGCCCAGACCTGAAAGGAAGCGGAGAGATGTCATGCAAGTGGCCAACACCACCATGTC
CAGCCGAAGCAGGAACACCACGGCCGCAGACACCTACAACATCACCGACCCGGAAGAGCTGGAGACAGAGTACCCTTTCTTTGAGAGCAG
AGTGGATAACAAGGAGAGAACTGTCATTTCTAACCTTCGGCCTTTCACATTGTACCGCATCGATATCCACAGCTGCAACCACGAGGCTGA
GAAGCTGGGCTGCAGCGCCTCCAACTTCGTCTTTGCAAGGACTATGCCCGCAGAAGGAGCAGATGACATTCCTGGGCCAGTGACCTGGGA
GCCAAGGCCTGAAAACTCCATCTTTTTAAAGTGGCCGGAACCTGAGAATCCCAATGGATTGATTCTAATGTATGAAATAAAATACGGATC
ACAAGTTGAGGATCAGCGAGAATGTGTGTCCAGACAGGAATACAGGAAGTATGGAGGGGCCAAGCTAAACCGGCTAAACCCGGGGAACTA
CACAGCCCGGATTCAGGCCACATCTCTCTCTGGGAATGGGTCGTGGACAGATCCTGTGTTCTTCTATGTCCAGGCCAAAATTGGTGTGGA
TGACTACAGCTCAGAGTCTGATGTGATTATTATACCTTCAGCCCTGGACTTTGTCTCACAAGATGAAATGTTGACGCCCCTGGGGAGATT
GGACAAGTATGCTGCAAGTGAGAACATATTTAACAGACAAATGGTGGCCCGGAGTTTGCTCGATACCTTGAGGGAAGTCTGCGATGATGA
AAGAGATTGTATTGCTGTTTTGGAAAGAATTAGCAGATTGGCCGATGATTCAGAACCAACTGTGAGAGCGGAGCTGATGGAACAGGTGCC
TCACATCGCACTGTTTTGTCAAGAAAACCGGCCTTCAATACCATATGCTTTTTCAAAATTCTTACTACCTATTGTGGTTAGATACCTTGC
AGATCAGAATAATCAGGTGAGGAAAACAAGTCAGGCAGCTTTGCTGGCTCTGTTGGAGCAGGAGCTCATTGAACGATTTGATGTGGAGAC
CAAAGTGTGCCCTGTCCTCATAGAGCTGACAGCCCCAGATAGCAATGATGATGTGAAAACAGAAGCTGTGGCTATAATGTGCAAAATGGC
TCCCATGGTTGGGAAGGATATTACAGAGCGTCTTATCCTCCCTAGGTTTTGTGAGATGTGCTGCGATTGCAGAATGTTTCACGTTCGAAA
GGTCTGTGCTGCCAATTTTGGAGATATTTGCAGTGTAGTTGGCCAGCAAGCTACTGAAGAAATGTTGCTGCCCAGATTTTTCCAGCTTTG
TTCTGATAATGTATGGGGAGTCCGAAAGGCTTGTGCTGAATGCTTCATGGCGGTTTCATGTGCAACATGTCAAGAAATCCGACGGACCAA
ATTATCAGCACTTTTTATTAATTTGATCAGTGATCCTTCACGTTGGGTTCGCCAAGCAGCTTTTCAGTCTCTGGGACCTTTCATATCTAC
TTTTGCTAATCCATCTAGCTCAGGCCAGTATTTTAAAGAAGAAAGCAAAAGTTCAGAAGAGATGTCAGTAGAAAACAAAAATAGGACCAG
AGATCAAGAAGCCCCAGAGGATGTACAAGTCAGGCCAGAGGATACTCCTTCAGATCTCAGTGTTAGTAATTCCAGTGTCATACTGGAAAA
CACGATGGAAGACCATGCTGCTGAGGCATCCGGGAAGCCTCTAGGTGAAATTAGTGTTCCACTGGACAGCTCTTTACTTTGTACTTTGTC
CTCAGAATCTCACCAGGAAGCAGCTAGTAATGAGAATGATAAAAAACCTGGTAACTACAAATCTATGTTACGACCAGAGGTTGGCACCAC
TTCACAAGATTCAGCTCTCTTAGATCAGGAATTGTATAACTCCTTCCATTTCTGGAGGACTCCTCTTCCTGAAATAGATCTAGACATAGA
GCTTGAACAGAACTCTGGGGGAAAACCCAGCCCAGAGGGACCAGAGGAAGAATCTGAGGGCCCTGTGCCCAGTTCTCCAAACATCACCAT
GGCCACCAGAAAGGAACTGGAAGAAATGATAGAAAATCTAGAGCCCCACATTGATGATCCAGATGTTAAAGCACAAGTGGAAGTGCTGTC
CGCTGCACTACGTGCTTCCAGCCTGGATGCACATGAAGAGACCATCAGTATAGAAAAGAGAAGTGATTTGCAAGATGAACTGGATATAAA
TGAGCTACCAAATTGTAAAATAAATCAAGAAGATTCTGTGCCTTTAATCAGCGATGCTGTTGAGAATATGGACTCCACTCTTCACTATAT
TCACAGCGATTCAGACTTGAGCAACAATAGCAGTTTTAGCCCTGATGAGGAAAGGAGAACTAAAGTACAAGATGTTGTACCTCAGGCGTT
GTTAGATCAGTATTTATCTATGACTGACCCTTCTCGTGCACAGACGGTTGACACTGAAATTGCTAAGCACTGTGCATATAGCCTCCCTGG
TGTGGCCTTGACACTCGGAAGACAGAATTGGCACTGCCTGAGAGAGACGTATGAGACTCTGGCCTCAGACATGCAGTGGAAAGTTCGACG
AACTCTAGCATTCTCCATCCACGAGCTTGCAGTTATTCTTGGAGATCAATTGACAGCTGCAGATCTGGTTCCAATTTTTAATGGATTTTT
AAAAGACCTCGATGAAGTCAGGATAGGTGTTCTTAAACACTTGCATGATTTTCTGAAGCTTCTTCATATTGACAAAAGAAGAGAATATCT
TTATCAACTTCAGGAGTTTTTGGTGACAGATAATAGTAGAAATTGGCGGTTTCGAGCTGAACTGGCTGAACAGCTGATTTTACTTCTAGA
GTTATATAGTCCCAGAGATGTTTATGACTATTTACGTCCCATTGCTCTGAATCTGTGTGCAGACAAAGTTTCTTCTGTTCGTTGGATTTC
CTACAAGTTGGTCAGCGAGATGGTGAAGAAGCTGCACGCGGCAACACCACCAACGTTCGGAGTGGACCTCATCAATGAGCTTGTGGAGAA
CTTTGGCAGATGTCCCAAGTGGTCTGGTCGGCAAGCCTTTGTCTTTGTCTGCCAGACTGTCATTGAGGATGACTGCCTTCCCATGGACCA
GTTTGCTGTGCATCTCATGCCGCATCTGCTAACCTTAGCAAATGACAGGGTTCCTAACGTGCGAGTGCTGCTTGCAAAGACATTAAGACA
AACTCTACTAGAAAAAGACTATTTCTTGGCCTCTGCCAGCTGCCACCAGGAGGCTGTGGAGCAGACCATCATGGCTCTTCAGATGGACCG
TGACAGCGATGTCAAGTATTTTGCAAGCATCCACCCTGCCAGTACCAAAATCTCCGAAGATGCCATGAGCACAGCGTCCTCAACCTACTA
GAAGGCTTGAATCTCGGTGTCTTTCCTGCTTCCATGAGAGCCGAGGTTCAGTGGGCATTCGCCACGCATGTGACCTGGGATAGCTTTCGG
GGGAGGAGAGACCTTCCTCTCCTGCGGACTTCATTGCAGGTGCAAGTTGCCTACACCCAATACCAGGGATTTCAAGAGTCAAGAGAAAGT
ACAGTAAACACTATTATCTTATCTTGACTTTAAGGGGAAATAATTTCTCAGAGGATTATAATTGTCACCGAAGCCTTAAATCCTTCTGTC
TTCCTGACTGAATGAAACTTGAATTGGCAGAGCATTTTCCTTATGGAAGGGATGAGATTCCCAGAGACCTGCATTGCTTTCTCCTGGTTT
TATTTAACAATCGACAAATGAAATTCTTACAGCCTGAAGGCAGACGTGTGCCCAGATGTGAAAGAGACCTTCAGTATCAGCCCTAACTCT
TCTCTCCCAGGAAGGACTTGCTGGGCTCTGTGGCCAGCTGTCCAGCCCAGCCCTGTGTGTGAATCGTTTGTGACGTGTGCAAATGGGAAA
GGAGGGGTTTTTACATCTCCTAAAGGACCTGATGCCAACACAAGTAGGATTGACTTAAACTCTTAAGCGCAGCATATTGCTGTACACATT
TACAGAATGGTTGCTGAGTGTCTGTGTCTGATTTTTTCATGCTGGTCATGACCTGAAGGAAATTTATTAGACGTATAATGTATGTCTGGT
GTTTTTAACTTGATCATGATCAGCTCTGAGGTGCAACTTCTTCACATACTGTACATACCTGTGACCACTCTTGGGAGTGCTGCAGTCTTT
AATCATGCTGTTTAAACTGTTGTGGCACAAGTTCTCTTGTCCAAATAAAATTTATTAATAAGATCTATAGAGAGAGATATATACACTTTT
GATTGTTTTCTAGATGTCTACCAATAAATGCAATTTGTGACCTGTATTAATGATTTAAAGTGGGGAAACTAGATTAAAATATTTGTCTTT

>38488_38488_2_IGF1R-PPP4R1_IGF1R_chr15_99467913_ENST00000558762_PPP4R1_chr18_9595151_ENST00000400556_length(amino acids)=1860AA_BP=928
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRV
AGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYR
FEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAF
NPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVK
WNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEA
EKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVQAKIGVDDYSSESDVIIIPSALDFVSQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDD
ERDCIAVLERISRLADDSEPTVRAELMEQVPHIALFCQENRPSIPYAFSKFLLPIVVRYLADQNNQVRKTSQAALLALLEQELIERFDVE
TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQL
CSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRT
RDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEASGKPLGEISVPLDSSLLCTLSSESHQEAASNENDKKPGNYKSMLRPEVGT
TSQDSALLDQELYNSFHFWRTPLPEIDLDIELEQNSGGKPSPEGPEEESEGPVPSSPNITMATRKELEEMIENLEPHIDDPDVKAQVEVL
SAALRASSLDAHEETISIEKRSDLQDELDINELPNCKINQEDSVPLISDAVENMDSTLHYIHSDSDLSNNSSFSPDEERRTKVQDVVPQA
LLDQYLSMTDPSRAQTVDTEIAKHCAYSLPGVALTLGRQNWHCLRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGF
LKDLDEVRIGVLKHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNLCADKVSSVRWI
SYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IGF1R-PPP4R1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IGF1R-PPP4R1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IGF1R-PPP4R1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source