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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGF2BP1-BAIAP2 (FusionGDB2 ID:38500)

Fusion Gene Summary for IGF2BP1-BAIAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2BP1-BAIAP2
Fusion gene ID: 38500
HgeneTgene
Gene symbol

IGF2BP1

BAIAP2

Gene ID

10642

10458

Gene nameinsulin like growth factor 2 mRNA binding protein 1BAR/IMD domain containing adaptor protein 2
SynonymsCRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1BAP2|FLAF3|IRSP53|WAML
Cytomap

17q21.32

17q25.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor 2 mRNA-binding protein 1IGF-II mRNA-binding protein 1IGF2 mRNA-binding protein 1VICKZ family member 1ZBP-1coding region determinant-binding proteininsulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBPzipcode-bibrain-specific angiogenesis inhibitor 1-associated protein 2BAI1 associated protein 2IRS-58IRSp53/58WASP and MIM likefas ligand-associated factor 3insulin receptor substrate of 53 kDainsulin receptor substrate p53/p58insulin receptor substrate pro
Modification date2020031520200327
UniProtAcc

Q9NZI8

Q6UXY1

Ensembl transtripts involved in fusion geneENST00000515586, ENST00000290341, 
ENST00000431824, 		ENST00000321280, 
ENST00000321300, ENST00000392411, 
ENST00000428708, ENST00000435091, 
ENST00000575245, ENST00000575712, 
ENST00000416299, ENST00000573894, 
Fusion gene scores* DoF score3 X 3 X 2=1817 X 10 X 8=1360
# samples 318
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1360*10)=-2.91753783980803
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2BP1 [Title/Abstract] AND BAIAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGF2BP1(47109335)-BAIAP2(79073728), # samples:3
Anticipated loss of major functional domain due to fusion event.IGF2BP1-BAIAP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGF2BP1

GO:0017148

negative regulation of translation

9891060

HgeneIGF2BP1

GO:0070934

CRD-mediated mRNA stabilization

19029303


check buttonFusion gene breakpoints across IGF2BP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BAIAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-CI-6619-01BIGF2BP1chr17

47109335

-BAIAP2chr17

79073728

+
ChimerDB4READTCGA-CI-6619-01BIGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
ChimerDB4READTCGA-CI-6619IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+


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Fusion Gene ORF analysis for IGF2BP1-BAIAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000515586ENST00000321280IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000321300IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000392411IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000428708IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000435091IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000575245IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-3CDSENST00000515586ENST00000575712IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-intronENST00000515586ENST00000416299IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
3UTR-intronENST00000515586ENST00000573894IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
5CDS-intronENST00000290341ENST00000416299IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
5CDS-intronENST00000290341ENST00000573894IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
5CDS-intronENST00000431824ENST00000416299IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
5CDS-intronENST00000431824ENST00000573894IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000321280IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000321300IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000392411IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000428708IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000435091IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000575245IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000290341ENST00000575712IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000321280IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000321300IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000392411IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000428708IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000435091IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000575245IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+
Frame-shiftENST00000431824ENST00000575712IGF2BP1chr17

47109335

+BAIAP2chr17

79073728

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IGF2BP1-BAIAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGF2BP1chr1747109335+BAIAP2chr1779073727+3.44E-151
IGF2BP1chr1747109335+BAIAP2chr1779073727+3.44E-151
IGF2BP1chr1747109335+BAIAP2chr1779073727+3.44E-151
IGF2BP1chr1747109335+BAIAP2chr1779073727+3.44E-151

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IGF2BP1-BAIAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47109335/:79073728)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2BP1

Q9NZI8

BAIAP2

Q6UXY1

FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves a conserved 54-nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNP thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, prevents ACTB mRNA from being translated into protein. When the RNP complex reaches its destination near the plasma membrane, IGF2BP1 is phosphorylated. This releases the mRNA, allowing ribosomal 40S and 60S subunits to assemble and initiate ACTB protein synthesis. Monomeric ACTB then assembles into the subcortical actin cytoskeleton (By similarity). During neuronal development, key regulator of neurite outgrowth, growth cone guidance and neuronal cell migration, presumably through the spatiotemporal fine tuning of protein synthesis, such as that of ACTB (By similarity). May regulate mRNA transport to activated synapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA (By similarity). During interstinal wound repair, interacts with and stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may be crucial for colonic mucosal wound healing (By similarity). Binds to the 3'-UTR of IGF2 mRNA by a mechanism of cooperative and sequential dimerization and regulates IGF2 mRNA subcellular localization and translation. Binds to MYC mRNA, in the coding region instability determinant (CRD) of the open reading frame (ORF), hence prevents MYC cleavage by endonucleases and possibly microRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to the oncofetal H19 transcript and to the neuron-specific TAU mRNA and regulates their localizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds to the adenine-rich autoregulatory sequence (ARS) located in PABPC1 mRNA and represses its translation. PABPC1 mRNA-binding is stimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradation by disrupting microRNA-dependent interaction with AGO2. Promotes the directed movement of tumor-derived cells by fine-tuning intracellular signaling networks. Binds to MAPK4 3'-UTR and inhibits its translation. Interacts with PTEN transcript open reading frame (ORF) and prevents mRNA decay. This combined action on MAPK4 (down-regulation) and PTEN (up-regulation) antagonizes HSPB1 phosphorylation, consequently it prevents G-actin sequestration by phosphorylated HSPB1, allowing F-actin polymerization. Hence enhances the velocity of cell migration and stimulates directed cell migration by PTEN-modulated polarization. Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR and specifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts with HIV-1 GAG protein and blocks the formation of infectious HIV-1 particles. Reduces HIV-1 assembly by inhibiting viral RNA packaging, as well as assembly and processing of GAG protein on cellular membranes. During cellular stress, such as oxidative stress or heat shock, stabilizes target mRNAs that are recruited to stress granules, including CD44, IGF2, MAPK4, MYC, PTEN, RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250, ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892, ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263, ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769, ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952, ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:8132663, ECO:0000269|PubMed:9891060}.FUNCTION: Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IGF2BP1-BAIAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IGF2BP1-BAIAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGF2BP1-BAIAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGF2BP1-BAIAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource