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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGF2-CCT5 (FusionGDB2 ID:38523)

Fusion Gene Summary for IGF2-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: IGF2-CCT5
Fusion gene ID: 38523
HgeneTgene
Gene symbol

IGF2

CCT5

Gene ID

3481

22948

Gene nameinsulin like growth factor 2chaperonin containing TCP1 subunit 5
SynonymsC11orf43|GRDF|IGF-II|PP9974CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

11p15.5

5p15.2

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor IIT3M-11-derived growth factorinsulin-like growth factor 2 (somatomedin A)insulin-like growth factor type 2preptinT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020032220200313
UniProtAcc

P01344

P48643

Ensembl transtripts involved in fusion geneENST00000300632, ENST00000381389, 
ENST00000381392, ENST00000381395, 
ENST00000381406, ENST00000416167, 
ENST00000418738, ENST00000434045, 
ENST00000503026, ENST00000506600, 
ENST00000515390, ENST00000515676, 
ENST00000280326, 
Fusion gene scores* DoF score11 X 6 X 8=52858 X 14 X 17=13804
# samples 1261
** MAII scorelog2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGF2 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGF2(2150351)-CCT5(10250033), # samples:2
Anticipated loss of major functional domain due to fusion event.IGF2-CCT5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IGF2-CCT5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGF2

GO:0008284

positive regulation of cell proliferation

28873464

HgeneIGF2

GO:0042104

positive regulation of activated T cell proliferation

15694994

HgeneIGF2

GO:0043410

positive regulation of MAPK cascade

11500939

HgeneIGF2

GO:0045840

positive regulation of mitotic nuclear division

11500939

HgeneIGF2

GO:0046628

positive regulation of insulin receptor signaling pathway

11500939

HgeneIGF2

GO:0051897

positive regulation of protein kinase B signaling

11500939


check buttonFusion gene breakpoints across IGF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6314-01AIGF2chr11

2150351

-CCT5chr5

10250033

+
ChimerDB4UCSTCGA-N6-A4VG-01AIGF2chr11

2150351

-CCT5chr5

10250033

+


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Fusion Gene ORF analysis for IGF2-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000300632ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
5CDS-intronENST00000300632ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
5CDS-intronENST00000300632ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
5CDS-intronENST00000300632ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
Frame-shiftENST00000300632ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000381389ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000381392ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000381395ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000381406ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000416167ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000418738ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-3CDSENST00000434045ENST00000280326IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381389ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381389ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381389ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381389ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381392ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381392ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381392ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381392ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381395ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381395ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381395ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381395ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381406ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381406ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381406ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000381406ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000416167ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000416167ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000416167ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000416167ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000418738ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000418738ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000418738ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000418738ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000434045ENST00000503026IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000434045ENST00000506600IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000434045ENST00000515390IGF2chr11

2150351

-CCT5chr5

10250033

+
intron-intronENST00000434045ENST00000515676IGF2chr11

2150351

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IGF2-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGF2chr112150347-CCT5chr510250032+0.1132549940.88674504
IGF2chr112150347-CCT5chr510250032+0.1132549940.88674504

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IGF2-CCT5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:2150351/:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF2

P01344

CCT5

P48643

FUNCTION: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). {ECO:0000250|UniProtKB:P09535, ECO:0000269|PubMed:28873464, ECO:0000305|PubMed:24593700}.; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000269|PubMed:16912056}.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IGF2-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IGF2-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGF2-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGF2-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource