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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IGFBP3-ZDHHC8 (FusionGDB2 ID:38579) |
Fusion Gene Summary for IGFBP3-ZDHHC8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IGFBP3-ZDHHC8 | Fusion gene ID: 38579 | Hgene | Tgene | Gene symbol | IGFBP3 | ZDHHC8 | Gene ID | 3486 | 29801 |
| Gene name | insulin like growth factor binding protein 3 | zinc finger DHHC-type palmitoyltransferase 8 | |
| Synonyms | BP-53|IBP3 | DHHC8|ZDHHCL1|ZNF378 | |
| Cytomap | 7p12.3 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | insulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding protein | probable palmitoyltransferase ZDHHC8membrane-associated DHHC8 zinc finger proteinzinc finger DHHC-type containing 8zinc finger protein 378zinc finger, DHHC domain like containing 1 | |
| Modification date | 20200315 | 20200313 | |
| UniProtAcc | P17936 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000275521, ENST00000381083, ENST00000381086, ENST00000465642, | ENST00000468112, ENST00000320602, ENST00000334554, ENST00000405930, | |
| Fusion gene scores | * DoF score | 9 X 9 X 4=324 | 2 X 3 X 2=12 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/324*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IGFBP3 [Title/Abstract] AND ZDHHC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IGFBP3(45956812)-ZDHHC8(20128140), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IGFBP3-ZDHHC8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. IGFBP3-ZDHHC8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IGFBP3 | GO:0001933 | negative regulation of protein phosphorylation | 17591901 |
| Hgene | IGFBP3 | GO:0006468 | protein phosphorylation | 17434920 |
| Hgene | IGFBP3 | GO:0014912 | negative regulation of smooth muscle cell migration | 10766744 |
| Hgene | IGFBP3 | GO:0045663 | positive regulation of myoblast differentiation | 12599210 |
| Hgene | IGFBP3 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 10766744 |
| Tgene | ZDHHC8 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene breakpoints across IGFBP3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ZDHHC8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | Non-Cancer | TCGA-CG-5730-11A | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
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Fusion Gene ORF analysis for IGFBP3-ZDHHC8 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000275521 | ENST00000468112 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5CDS-3UTR | ENST00000381083 | ENST00000468112 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5CDS-3UTR | ENST00000381086 | ENST00000468112 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5UTR-3CDS | ENST00000465642 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5UTR-3CDS | ENST00000465642 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5UTR-3CDS | ENST00000465642 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| 5UTR-3UTR | ENST00000465642 | ENST00000468112 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| Frame-shift | ENST00000381086 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| Frame-shift | ENST00000381086 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| Frame-shift | ENST00000381086 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000275521 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000275521 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000275521 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000381083 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000381083 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| In-frame | ENST00000381083 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000275521 | IGFBP3 | chr7 | 45956812 | - | ENST00000334554 | ZDHHC8 | chr22 | 20128140 | + | 5009 | 764 | 26 | 2401 | 791 |
| ENST00000275521 | IGFBP3 | chr7 | 45956812 | - | ENST00000320602 | ZDHHC8 | chr22 | 20128140 | + | 3452 | 764 | 26 | 2401 | 791 |
| ENST00000275521 | IGFBP3 | chr7 | 45956812 | - | ENST00000405930 | ZDHHC8 | chr22 | 20128140 | + | 3216 | 764 | 26 | 2440 | 804 |
| ENST00000381083 | IGFBP3 | chr7 | 45956812 | - | ENST00000334554 | ZDHHC8 | chr22 | 20128140 | + | 5004 | 759 | 3 | 2396 | 797 |
| ENST00000381083 | IGFBP3 | chr7 | 45956812 | - | ENST00000320602 | ZDHHC8 | chr22 | 20128140 | + | 3447 | 759 | 3 | 2396 | 797 |
| ENST00000381083 | IGFBP3 | chr7 | 45956812 | - | ENST00000405930 | ZDHHC8 | chr22 | 20128140 | + | 3211 | 759 | 3 | 2435 | 810 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000275521 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.030245678 | 0.96975434 |
| ENST00000275521 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.0447334 | 0.95526665 |
| ENST00000275521 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.059988715 | 0.94001126 |
| ENST00000381083 | ENST00000334554 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.033035554 | 0.9669644 |
| ENST00000381083 | ENST00000320602 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.04921191 | 0.950788 |
| ENST00000381083 | ENST00000405930 | IGFBP3 | chr7 | 45956812 | - | ZDHHC8 | chr22 | 20128140 | + | 0.06720371 | 0.9327963 |
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Fusion Genomic Features for IGFBP3-ZDHHC8 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| IGFBP3 | chr7 | 45956811 | - | ZDHHC8 | chr22 | 20128139 | + | 0.78812903 | 0.21187101 |
| IGFBP3 | chr7 | 45956811 | - | ZDHHC8 | chr22 | 20128139 | + | 0.78812903 | 0.21187101 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IGFBP3-ZDHHC8 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:45956812/chr22:20128140) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IGFBP3 | . |
| FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000275521 | - | 2 | 5 | 138_161 | 210 | 496.6666666666667 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000275521 | - | 2 | 5 | 192_208 | 210 | 496.6666666666667 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000381083 | - | 2 | 5 | 138_161 | 216 | 102.0 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000381083 | - | 2 | 5 | 192_208 | 216 | 102.0 | Compositional bias | Note=Ser/Thr-rich |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000275521 | - | 2 | 5 | 36_117 | 210 | 496.6666666666667 | Domain | IGFBP N-terminal |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000381083 | - | 2 | 5 | 210_285 | 216 | 102.0 | Domain | Thyroglobulin type-1 |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000381083 | - | 2 | 5 | 36_117 | 216 | 102.0 | Domain | IGFBP N-terminal |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000275521 | - | 2 | 5 | 28_134 | 210 | 496.6666666666667 | Region | IGF-binding |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000381083 | - | 2 | 5 | 28_134 | 216 | 102.0 | Region | IGF-binding |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 170_190 | 128 | 674.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 212_765 | 128 | 674.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 149_169 | 128 | 674.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 191_211 | 128 | 674.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | IGFBP3 | chr7:45956812 | chr22:20128140 | ENST00000275521 | - | 2 | 5 | 210_285 | 210 | 496.6666666666667 | Domain | Thyroglobulin type-1 |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 104_154 | 128 | 674.0 | Domain | DHHC | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 104_154 | 220 | 766.0 | Domain | DHHC | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 104_154 | 220 | 779.0 | Domain | DHHC | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 1_13 | 128 | 674.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 35_52 | 128 | 674.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 74_148 | 128 | 674.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 170_190 | 220 | 766.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 1_13 | 220 | 766.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 212_765 | 220 | 766.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 35_52 | 220 | 766.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 74_148 | 220 | 766.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 170_190 | 220 | 779.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 1_13 | 220 | 779.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 212_765 | 220 | 779.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 35_52 | 220 | 779.0 | Topological domain | Lumenal | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 74_148 | 220 | 779.0 | Topological domain | Cytoplasmic | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 14_34 | 128 | 674.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000320602 | 2 | 9 | 53_73 | 128 | 674.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 149_169 | 220 | 766.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 14_34 | 220 | 766.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 191_211 | 220 | 766.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000334554 | 4 | 11 | 53_73 | 220 | 766.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 149_169 | 220 | 779.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 14_34 | 220 | 779.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 191_211 | 220 | 779.0 | Transmembrane | Helical | |
| Tgene | ZDHHC8 | chr7:45956812 | chr22:20128140 | ENST00000405930 | 4 | 11 | 53_73 | 220 | 779.0 | Transmembrane | Helical |
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Fusion Gene Sequence for IGFBP3-ZDHHC8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >38579_38579_1_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000320602_length(transcript)=3452nt_BP=764nt CCAGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCC TGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGC TGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGC GTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGA GCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGG CGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAA ATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCC ACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAG ATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCT GCTGTGGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGA AGCCGCCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCC GTAGCAAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGT TCAGCAGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACA AGTTTAGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGG ACGACAGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGC CATCCCCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATG TGGCCCTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCA GCCTGTCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACT CACCCTACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGC CCTCGCCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGC GCTCCCAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGG GCCCCCGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGA CGTCACTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCC CGGGGCCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACG CGGGCCCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGACCACCCTCAGCTGAAGA CTCCCCCAAGTAAGCTTAATGGGCAGTCCCCGGGCCTGGCCCGGCTGGGACCTGCCACCGGCCCCCCAGGGCCCTCTGCCAGCCCTACAC GGCACACGCTGGTTAAGAAGGTGTCCGGCGTGGGTGGGACCACCTACGAGATCTCGGTGTGAGGACTGACTGCCACACATCCGCCATGGT GCCACGGGGACCAGGACCCCACAGCGCACCCCCCCTCCCCACCAACTTCTCTGCCCCAGGGACCCGAGGCCACCCCAGCCTGGTGTGGAC CCATCGGCGGGAGAGAGTGCCACGCCTCCACAGCTTGCCCCAAGCGCTCTGCCTGCCCGTCCACTCATCTGCCCATGGGGAAGTCGGCTC ACTGGGACAAGGGCCACTGGGCTGGTCTGTGTCTGGGCCTGTCCCATGGCTGGGGCAGTGAGGGGGCCCAGTCAGCCTCTTTGGGGCACC CTCTCTCAGCCAGGCTTGGCCCACTGCCATCACCCAGCACCCCAGATCACCGCCAGGCCAGCCCCCAATGGTCCCCTTACGGACAGGTCC CAGAGATGGACAGAGGCACCCAGGGCCCCCACCGTCCTTCTGACACAGCCTGTGGGCTCCCGGACCGAGTGTCCCCCGCCAGGCTACTCC TAACTAACGCGTTGCCTTTCACGGACCCCGCTGGAAGCTTGTAGCTTGGCAAGGCTGATGCTTCTGCCCTGGCCTGCTCTGGGTGGTGGT GGATAGGTGGACAGACGGCCAGCCAGCCAGCTGTGGCCGGGGGCCCGGCTCCATGTGTCCCGTGTCTGTGTGCTGTGCTGCCGCGCCGTG TCTGATGTGTCAGTGCTCCGGCCGCCGCTGTCCCTTTCATCAAAGCCTTAACCTTTGCTTTATGCTCTTGTGGGAGGCGACGGGGGGGCA GGCGGGAGCAGGCACGGGGGTGATGCTGCCACAGGGGGCTGGTGACACCCAGAGCCCCCTCCCCAGCCCTCAGGCCCTCCCTGCCAAACT GGAGAACCCCACCCCAAGGCATGCCACGTCCGCAGCCCCGGCCTGGCTGCGGTGCTCGCGCCGTGGGAAAGCACACTGGGGAGGGGTCAG TGCTTCCCTTGGTGTCAGGGACCTGAGAGTAAGCACATGACAGCGTCTGCTTGCGTTGTGTCTGTTTTATGTTTTTATATCTACATCTAT >38579_38579_1_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000320602_length(amino acids)=791AA_BP=246 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI -------------------------------------------------------------- >38579_38579_2_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000334554_length(transcript)=5009nt_BP=764nt CCAGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCC TGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGC TGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGC GTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGA GCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGG CGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAA ATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCC ACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAG ATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCT GCTGTGGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGA AGCCGCCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCC GTAGCAAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGT TCAGCAGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACA AGTTTAGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGG ACGACAGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGC CATCCCCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATG TGGCCCTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCA GCCTGTCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACT CACCCTACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGC CCTCGCCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGC GCTCCCAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGG GCCCCCGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGA CGTCACTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCC CGGGGCCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACG CGGGCCCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGACCACCCTCAGCTGAAGA CTCCCCCAAGTAAGCTTAATGGGCAGTCCCCGGGCCTGGCCCGGCTGGGACCTGCCACCGGCCCCCCAGGGCCCTCTGCCAGCCCTACAC GGCACACGCTGGTTAAGAAGGTGTCCGGCGTGGGTGGGACCACCTACGAGATCTCGGTGTGAGGACTGACTGCCACACATCCGCCATGGT GCCACGGGGACCAGGACCCCACAGCGCACCCCCCCTCCCCACCAACTTCTCTGCCCCAGGGACCCGAGGCCACCCCAGCCTGGTGTGGAC CCATCGGCGGGAGAGAGTGCCACGCCTCCACAGCTTGCCCCAAGCGCTCTGCCTGCCCGTCCACTCATCTGCCCATGGGGAAGTCGGCTC ACTGGGACAAGGGCCACTGGGCTGGTCTGTGTCTGGGCCTGTCCCATGGCTGGGGCAGTGAGGGGGCCCAGTCAGCCTCTTTGGGGCACC CTCTCTCAGCCAGGCTTGGCCCACTGCCATCACCCAGCACCCCAGATCACCGCCAGGCCAGCCCCCAATGGTCCCCTTACGGACAGGTCC CAGAGATGGACAGAGGCACCCAGGGCCCCCACCGTCCTTCTGACACAGCCTGTGGGCTCCCGGACCGAGTGTCCCCCGCCAGGCTACTCC TAACTAACGCGTTGCCTTTCACGGACCCCGCTGGAAGCTTGTAGCTTGGCAAGGCTGATGCTTCTGCCCTGGCCTGCTCTGGGTGGTGGT GGATAGGTGGACAGACGGCCAGCCAGCCAGCTGTGGCCGGGGGCCCGGCTCCATGTGTCCCGTGTCTGTGTGCTGTGCTGCCGCGCCGTG TCTGATGTGTCAGTGCTCCGGCCGCCGCTGTCCCTTTCATCAAAGCCTTAACCTTTGCTTTATGCTCTTGTGGGAGGCGACGGGGGGGCA GGCGGGAGCAGGCACGGGGGTGATGCTGCCACAGGGGGCTGGTGACACCCAGAGCCCCCTCCCCAGCCCTCAGGCCCTCCCTGCCAAACT GGAGAACCCCACCCCAAGGCATGCCACGTCCGCAGCCCCGGCCTGGCTGCGGTGCTCGCGCCGTGGGAAAGCACACTGGGGAGGGGTCAG TGCTTCCCTTGGTGTCAGGGACCTGAGAGTAAGCACATGACAGCGTCTGCTTGCGTTGTGTCTGTTTTATGTTTTTATATCTACATCTAT ATATCTATAATTTTATTAAAAAAAAGAAAAAGAGTTATTTTGATTCTTTCCTTGGGCAAGGCCAGGGCTATTGCTGCAGGATCCCGAGTT AGGGGAGGGCAGGGGCCGGGCCCCAGAAGAGGGAGTGGCTGCTGTCTGGTGTGCAGGGGTCGGTGGGTTCCTCAGGGGCATTTCTGCCGA CTTGGGCTGAGTCAGAGGCTTGGGAAGAGGGGGCGGCCGATGGTCTGTGGCTGGGAAGTGTGAGGGTCTCTCGCCTTGGGTCTGTGTCAG TTCTGGCAGTGACAGGGTGTTTGGGGGAAAGACTTGGGTCTGCCGCTACCCACAGGGGACTCTCAGGAACCCGAGAGCTTGGGGAGATGA AATGGGGGTGCATAGGGGCCACCTGTTGGCTCAGGGCCCTGTGGGGGCCGCTGAACCTGCTGGAACTCTCCTGCCTGCCACATGCCAGGG GCAGGGCTGAGGGAGTGTGAGGGATGCACAGCTGTTCAGGGCTGAGACATTCTGGGCTGGGGCTGTCCCAGCGTGGGAGGCGTGCGGGCT GTAGGGCCCCGAAGCTGACCTCCACCTTTCTGCTTCTCTCTCACGGACGCCGCGGCCCGCAGGGGGCGGATTGGCACCTGCACCCGTGGA TGGGGGCGGCGTGGCCAGCCTTGGGTGCCTCCTGGGCTGCACCTGTGCCACCTTGGCCGCCCGGAGGACCGCCCACCACTGCGGGCCCCC TGGAGCCAGGCCGCCGGGGCACCCCCACGCGGGGCCATGTGCCGCCTGCACTTGGCTGCCTCCAGTCTTTTCCCCAGCCTCTCGGGGCCC TAGCAGGATGACAAGTAGGCGGCTCTGGGGCCCAGGACAGCCCAGCTGGGGACCCAGGAGGTCAGACTGCAGTGGACCCTGGGGCAGGGC TGGGGGTGGGCTGGGCTCTCTGCTCCACCAGCCACAGCTTGACAGATTCCCAGCCTGCCAGGGCCTGAGACCCTGTGTCCACATGACCTC AGGGAGTCCCCCACCTGCTGCAGGGGGTCCAGCACCCCACAGGGGGGCAGTCCCAGAGCTGTGGGGACCGGCACGACCTTTGCCCAGCCT CCCTACCCAACCAAGCACTTTAGACTAAGCCACTTCCTCCTCGGGGAGCCCAGGCCTCCGTGGGTTGGGCTGGGTGGGGGGGGGGTCTCA GGTTGCCCCTGAAGGTCTCTGCACTCCTCCTGCCCTTCCCCTGACACATGAACAGATGCCTTAACTTCCTGGAGCCACCAGCCTGGTGAG CCATTGGCCTCTGCCTGCCACCAAGGTCCTGTGGTCTTGGCCAGCTCCGCCTGGGCCCCACTGGGGCTGCCTGCACCCAGAGACGATGCC GGCGGGATCTCAGAGGGCCTGAGGCCCAAGCCCTGTGTCCTCCAGCAGTGGTACGGCCTGCGGCAGGGTGGCACTCCGGCCAGCCCTTCT CCGTCACAGGGTCCCTGTCCCTGGGTCCACCCTGGGCTGTGGCTCTACATCTCCCATTTGGGGACGAGAAAGCCACAAAACCATTCTCTA >38579_38579_2_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000334554_length(amino acids)=791AA_BP=246 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI -------------------------------------------------------------- >38579_38579_3_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000405930_length(transcript)=3216nt_BP=764nt CCAGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCC TGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGC TGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGC GTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGA GCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGG CGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAA ATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCC ACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAG ATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCT GCTGTGGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGA AGCCGCCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCC GTAGCAAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGT TCAGCAGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACA AGTTTAGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGG ACGACAGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGC CATCCCCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATG TGGCCCTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCA GCCTGTCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACT CACCCTACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGC CCTCGCCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGC GCTCCCAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGG GCCCCCGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGA CGTCACTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCC CGGGGCCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACG CGGGCCCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGGGCGGATTGGCACCTGCA CCCGTGGATGGGGGCGGCGTGGCCAGCCTTGGGTGCCTCCTGGGCTGCACCTGTGCCACCTTGGCCGCCCGGAGGACCGCCCACCACTGC GGGCCCCCTGGAGCCAGGCCGCCGGGGCACCCCCACGCGGGGCCATGTGCCGCCTGCACTTGGCTGCCTCCAGTCTTTTCCCCAGCCTCT CGGGGCCCTAGCAGGATGACAAGTAGGCGGCTCTGGGGCCCAGGACAGCCCAGCTGGGGACCCAGGAGGTCAGACTGCAGTGGACCCTGG GGCAGGGCTGGGGGTGGGCTGGGCTCTCTGCTCCACCAGCCACAGCTTGACAGATTCCCAGCCTGCCAGGGCCTGAGACCCTGTGTCCAC ATGACCTCAGGGAGTCCCCCACCTGCTGCAGGGGGTCCAGCACCCCACAGGGGGGCAGTCCCAGAGCTGTGGGGACCGGCACGACCTTTG CCCAGCCTCCCTACCCAACCAAGCACTTTAGACTAAGCCACTTCCTCCTCGGGGAGCCCAGGCCTCCGTGGGTTGGGCTGGGTGGGGGGG GGGTCTCAGGTTGCCCCTGAAGGTCTCTGCACTCCTCCTGCCCTTCCCCTGACACATGAACAGATGCCTTAACTTCCTGGAGCCACCAGC CTGGTGAGCCATTGGCCTCTGCCTGCCACCAAGGTCCTGTGGTCTTGGCCAGCTCCGCCTGGGCCCCACTGGGGCTGCCTGCACCCAGAG ACGATGCCGGCGGGATCTCAGAGGGCCTGAGGCCCAAGCCCTGTGTCCTCCAGCAGTGGTACGGCCTGCGGCAGGGTGGCACTCCGGCCA GCCCTTCTCCGTCACAGGGTCCCTGTCCCTGGGTCCACCCTGGGCTGTGGCTCTACATCTCCCATTTGGGGACGAGAAAGCCACAAAACC >38579_38579_3_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000275521_ZDHHC8_chr22_20128140_ENST00000405930_length(amino acids)=804AA_BP=246 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCGNVEHVL CSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSSDLQTPR PGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSPPLSASD AFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPYLHPGAT GDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPRGPALRY GSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGPKAVAFI -------------------------------------------------------------- >38579_38579_4_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000320602_length(transcript)=3447nt_BP=759nt GCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAG CGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCG GTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCT CCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATC TACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTC TGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGAAATGCT AGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCC CTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACC CAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCTGCTGT GGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGAAGCCG CCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCCGTAGC AAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGTTCAGC AGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACAAGTTT AGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGGACGAC AGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGCCATCC CCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATGTGGCC CTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCAGCCTG TCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACTCACCC TACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGCCCTCG CCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGCGCTCC CAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGGGCCCC CGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGACGTCA CTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCCCGGGG CCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACGCGGGC CCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGACCACCCTCAGCTGAAGACTCCC CCAAGTAAGCTTAATGGGCAGTCCCCGGGCCTGGCCCGGCTGGGACCTGCCACCGGCCCCCCAGGGCCCTCTGCCAGCCCTACACGGCAC ACGCTGGTTAAGAAGGTGTCCGGCGTGGGTGGGACCACCTACGAGATCTCGGTGTGAGGACTGACTGCCACACATCCGCCATGGTGCCAC GGGGACCAGGACCCCACAGCGCACCCCCCCTCCCCACCAACTTCTCTGCCCCAGGGACCCGAGGCCACCCCAGCCTGGTGTGGACCCATC GGCGGGAGAGAGTGCCACGCCTCCACAGCTTGCCCCAAGCGCTCTGCCTGCCCGTCCACTCATCTGCCCATGGGGAAGTCGGCTCACTGG GACAAGGGCCACTGGGCTGGTCTGTGTCTGGGCCTGTCCCATGGCTGGGGCAGTGAGGGGGCCCAGTCAGCCTCTTTGGGGCACCCTCTC TCAGCCAGGCTTGGCCCACTGCCATCACCCAGCACCCCAGATCACCGCCAGGCCAGCCCCCAATGGTCCCCTTACGGACAGGTCCCAGAG ATGGACAGAGGCACCCAGGGCCCCCACCGTCCTTCTGACACAGCCTGTGGGCTCCCGGACCGAGTGTCCCCCGCCAGGCTACTCCTAACT AACGCGTTGCCTTTCACGGACCCCGCTGGAAGCTTGTAGCTTGGCAAGGCTGATGCTTCTGCCCTGGCCTGCTCTGGGTGGTGGTGGATA GGTGGACAGACGGCCAGCCAGCCAGCTGTGGCCGGGGGCCCGGCTCCATGTGTCCCGTGTCTGTGTGCTGTGCTGCCGCGCCGTGTCTGA TGTGTCAGTGCTCCGGCCGCCGCTGTCCCTTTCATCAAAGCCTTAACCTTTGCTTTATGCTCTTGTGGGAGGCGACGGGGGGGCAGGCGG GAGCAGGCACGGGGGTGATGCTGCCACAGGGGGCTGGTGACACCCAGAGCCCCCTCCCCAGCCCTCAGGCCCTCCCTGCCAAACTGGAGA ACCCCACCCCAAGGCATGCCACGTCCGCAGCCCCGGCCTGGCTGCGGTGCTCGCGCCGTGGGAAAGCACACTGGGGAGGGGTCAGTGCTT CCCTTGGTGTCAGGGACCTGAGAGTAAGCACATGACAGCGTCTGCTTGCGTTGTGTCTGTTTTATGTTTTTATATCTACATCTATATATC >38579_38579_4_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000320602_length(amino acids)=797AA_BP=252 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP -------------------------------------------------------------- >38579_38579_5_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000334554_length(transcript)=5004nt_BP=759nt GCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAG CGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCG GTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCT CCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATC TACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTC TGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGAAATGCT AGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCC CTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACC CAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCTGCTGT GGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGAAGCCG CCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCCGTAGC AAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGTTCAGC AGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACAAGTTT AGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGGACGAC AGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGCCATCC CCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATGTGGCC CTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCAGCCTG TCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACTCACCC TACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGCCCTCG CCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGCGCTCC CAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGGGCCCC CGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGACGTCA CTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCCCGGGG CCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACGCGGGC CCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGACCACCCTCAGCTGAAGACTCCC CCAAGTAAGCTTAATGGGCAGTCCCCGGGCCTGGCCCGGCTGGGACCTGCCACCGGCCCCCCAGGGCCCTCTGCCAGCCCTACACGGCAC ACGCTGGTTAAGAAGGTGTCCGGCGTGGGTGGGACCACCTACGAGATCTCGGTGTGAGGACTGACTGCCACACATCCGCCATGGTGCCAC GGGGACCAGGACCCCACAGCGCACCCCCCCTCCCCACCAACTTCTCTGCCCCAGGGACCCGAGGCCACCCCAGCCTGGTGTGGACCCATC GGCGGGAGAGAGTGCCACGCCTCCACAGCTTGCCCCAAGCGCTCTGCCTGCCCGTCCACTCATCTGCCCATGGGGAAGTCGGCTCACTGG GACAAGGGCCACTGGGCTGGTCTGTGTCTGGGCCTGTCCCATGGCTGGGGCAGTGAGGGGGCCCAGTCAGCCTCTTTGGGGCACCCTCTC TCAGCCAGGCTTGGCCCACTGCCATCACCCAGCACCCCAGATCACCGCCAGGCCAGCCCCCAATGGTCCCCTTACGGACAGGTCCCAGAG ATGGACAGAGGCACCCAGGGCCCCCACCGTCCTTCTGACACAGCCTGTGGGCTCCCGGACCGAGTGTCCCCCGCCAGGCTACTCCTAACT AACGCGTTGCCTTTCACGGACCCCGCTGGAAGCTTGTAGCTTGGCAAGGCTGATGCTTCTGCCCTGGCCTGCTCTGGGTGGTGGTGGATA GGTGGACAGACGGCCAGCCAGCCAGCTGTGGCCGGGGGCCCGGCTCCATGTGTCCCGTGTCTGTGTGCTGTGCTGCCGCGCCGTGTCTGA TGTGTCAGTGCTCCGGCCGCCGCTGTCCCTTTCATCAAAGCCTTAACCTTTGCTTTATGCTCTTGTGGGAGGCGACGGGGGGGCAGGCGG GAGCAGGCACGGGGGTGATGCTGCCACAGGGGGCTGGTGACACCCAGAGCCCCCTCCCCAGCCCTCAGGCCCTCCCTGCCAAACTGGAGA ACCCCACCCCAAGGCATGCCACGTCCGCAGCCCCGGCCTGGCTGCGGTGCTCGCGCCGTGGGAAAGCACACTGGGGAGGGGTCAGTGCTT CCCTTGGTGTCAGGGACCTGAGAGTAAGCACATGACAGCGTCTGCTTGCGTTGTGTCTGTTTTATGTTTTTATATCTACATCTATATATC TATAATTTTATTAAAAAAAAGAAAAAGAGTTATTTTGATTCTTTCCTTGGGCAAGGCCAGGGCTATTGCTGCAGGATCCCGAGTTAGGGG AGGGCAGGGGCCGGGCCCCAGAAGAGGGAGTGGCTGCTGTCTGGTGTGCAGGGGTCGGTGGGTTCCTCAGGGGCATTTCTGCCGACTTGG GCTGAGTCAGAGGCTTGGGAAGAGGGGGCGGCCGATGGTCTGTGGCTGGGAAGTGTGAGGGTCTCTCGCCTTGGGTCTGTGTCAGTTCTG GCAGTGACAGGGTGTTTGGGGGAAAGACTTGGGTCTGCCGCTACCCACAGGGGACTCTCAGGAACCCGAGAGCTTGGGGAGATGAAATGG GGGTGCATAGGGGCCACCTGTTGGCTCAGGGCCCTGTGGGGGCCGCTGAACCTGCTGGAACTCTCCTGCCTGCCACATGCCAGGGGCAGG GCTGAGGGAGTGTGAGGGATGCACAGCTGTTCAGGGCTGAGACATTCTGGGCTGGGGCTGTCCCAGCGTGGGAGGCGTGCGGGCTGTAGG GCCCCGAAGCTGACCTCCACCTTTCTGCTTCTCTCTCACGGACGCCGCGGCCCGCAGGGGGCGGATTGGCACCTGCACCCGTGGATGGGG GCGGCGTGGCCAGCCTTGGGTGCCTCCTGGGCTGCACCTGTGCCACCTTGGCCGCCCGGAGGACCGCCCACCACTGCGGGCCCCCTGGAG CCAGGCCGCCGGGGCACCCCCACGCGGGGCCATGTGCCGCCTGCACTTGGCTGCCTCCAGTCTTTTCCCCAGCCTCTCGGGGCCCTAGCA GGATGACAAGTAGGCGGCTCTGGGGCCCAGGACAGCCCAGCTGGGGACCCAGGAGGTCAGACTGCAGTGGACCCTGGGGCAGGGCTGGGG GTGGGCTGGGCTCTCTGCTCCACCAGCCACAGCTTGACAGATTCCCAGCCTGCCAGGGCCTGAGACCCTGTGTCCACATGACCTCAGGGA GTCCCCCACCTGCTGCAGGGGGTCCAGCACCCCACAGGGGGGCAGTCCCAGAGCTGTGGGGACCGGCACGACCTTTGCCCAGCCTCCCTA CCCAACCAAGCACTTTAGACTAAGCCACTTCCTCCTCGGGGAGCCCAGGCCTCCGTGGGTTGGGCTGGGTGGGGGGGGGGTCTCAGGTTG CCCCTGAAGGTCTCTGCACTCCTCCTGCCCTTCCCCTGACACATGAACAGATGCCTTAACTTCCTGGAGCCACCAGCCTGGTGAGCCATT GGCCTCTGCCTGCCACCAAGGTCCTGTGGTCTTGGCCAGCTCCGCCTGGGCCCCACTGGGGCTGCCTGCACCCAGAGACGATGCCGGCGG GATCTCAGAGGGCCTGAGGCCCAAGCCCTGTGTCCTCCAGCAGTGGTACGGCCTGCGGCAGGGTGGCACTCCGGCCAGCCCTTCTCCGTC ACAGGGTCCCTGTCCCTGGGTCCACCCTGGGCTGTGGCTCTACATCTCCCATTTGGGGACGAGAAAGCCACAAAACCATTCTCTATTGTT >38579_38579_5_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000334554_length(amino acids)=797AA_BP=252 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP -------------------------------------------------------------- >38579_38579_6_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000405930_length(transcript)=3211nt_BP=759nt GCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAG CGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCG GTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCT CCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATC TACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTC TGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGAAATGCT AGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCC CTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACC CAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGTGACTGGGAAGTTCCGCGGGGGTGTGAACCCTTTCACCCGAGGCTGCTGT GGGAATGTGGAGCACGTGCTGTGTAGCCCCCTGGCGCCCCGGTACGTGGTGGAGCCACCCCGGCTGCCGCTCGCGGTGAGTTTGAAGCCG CCTTTCCTTAGGCCTGAACTCCTGGACCGAGCTGCACCGCTCAAGGTCAAGCTTAGTGACAACGGGCTGAAGGCTGGCCTGGGCCGTAGC AAGTCCAAGGGCAGCCTGGACCGGCTGGATGAGAAGCCACTGGACTTGGGGCCACCACTGCCCCCCAAGATAGAGGCTGGCACGTTCAGC AGTGACCTGCAGACCCCGCGCCCAGGCAGTGCTGAGAGTGCCCTGTCGGTGCAGAGGACCAGCCCCCCGACACCTGCCATGTACAAGTTT AGGCCGGCTTTCCCCACGGGTCCCAAGGTGCCCTTCTGTGGACCAGGCGAGCAGGTTCCAGGCCCTGATTCCCTGACCCTGGGGGACGAC AGCATCCGTAGCCTGGACTTTGTGTCCGAGCCGAGCCTGGACCTCCCTGACTATGGGCCAGGGGGCCTGCATGCAGCCTACCCGCCATCC CCACCGCTCAGCGCCTCTGATGCCTTCTCGGGCGCTTTGCGCTCCCTGAGCCTCAAGGCCTCGAGCCGGCGGGGCGGGGATCATGTGGCC CTGCAGCCCCTGCGCTCTGAGGGGGGGCCCCCCACGCCCCACCGTAGCATTTTTGCCCCCCATGCACTGCCCAACCGCAACGGCAGCCTG TCCTATGACAGCCTGCTCAATCCTGGCTCGCCTGGTGGCCACGCCTGCCCTGCCCACCCAGCAGTTGGCGTGGCCGGATACCACTCACCC TACCTGCATCCTGGGGCAACGGGCGACCCGCCACGGCCCCTACCCCGCAGCTTCAGCCCCGTGCTGGGCCCCCGCCCCCGGGAGCCCTCG CCTGTGCGCTACGACAACCTGTCCAGGACCATCATGGCATCCATCCAGGAGCGCAAGGACAGGGAGGAGCGTGAGCGCCTGCTGCGCTCC CAGGCCGACTCACTCTTCGGCGACTCAGGCGTCTATGACGCTCCCAGCTCCTACAGCCTGCAGCAGGCCAGTGTGCTGTCCGAGGGCCCC CGAGGTCCCGCGCTGCGCTATGGCTCCAGAGACGACCTTGTGGCTGGGCCCGGCTTCGGTGGCGCCCGCAACCCTGCCCTGCAGACGTCA CTGTCCTCGCTGTCCAGCTCCGTGAGCCGTGCACCGCGGACGTCGTCCTCCTCCCTGCAGGCTGATCAGGCCAGCAGCAACGCCCCGGGG CCCCGGCCCAGCAGTGGCTCACACAGGTCACCTGCACGCCAGGGCCTGCCCTCCCCGCCCGGCACTCCCCACTCACCATCCTACGCGGGC CCCAAAGCTGTCGCCTTCATCCACACGGACCTCCCAGAGCCACCGCCCTCGCTGACCGTGCAGAGGGGGCGGATTGGCACCTGCACCCGT GGATGGGGGCGGCGTGGCCAGCCTTGGGTGCCTCCTGGGCTGCACCTGTGCCACCTTGGCCGCCCGGAGGACCGCCCACCACTGCGGGCC CCCTGGAGCCAGGCCGCCGGGGCACCCCCACGCGGGGCCATGTGCCGCCTGCACTTGGCTGCCTCCAGTCTTTTCCCCAGCCTCTCGGGG CCCTAGCAGGATGACAAGTAGGCGGCTCTGGGGCCCAGGACAGCCCAGCTGGGGACCCAGGAGGTCAGACTGCAGTGGACCCTGGGGCAG GGCTGGGGGTGGGCTGGGCTCTCTGCTCCACCAGCCACAGCTTGACAGATTCCCAGCCTGCCAGGGCCTGAGACCCTGTGTCCACATGAC CTCAGGGAGTCCCCCACCTGCTGCAGGGGGTCCAGCACCCCACAGGGGGGCAGTCCCAGAGCTGTGGGGACCGGCACGACCTTTGCCCAG CCTCCCTACCCAACCAAGCACTTTAGACTAAGCCACTTCCTCCTCGGGGAGCCCAGGCCTCCGTGGGTTGGGCTGGGTGGGGGGGGGGTC TCAGGTTGCCCCTGAAGGTCTCTGCACTCCTCCTGCCCTTCCCCTGACACATGAACAGATGCCTTAACTTCCTGGAGCCACCAGCCTGGT GAGCCATTGGCCTCTGCCTGCCACCAAGGTCCTGTGGTCTTGGCCAGCTCCGCCTGGGCCCCACTGGGGCTGCCTGCACCCAGAGACGAT GCCGGCGGGATCTCAGAGGGCCTGAGGCCCAAGCCCTGTGTCCTCCAGCAGTGGTACGGCCTGCGGCAGGGTGGCACTCCGGCCAGCCCT TCTCCGTCACAGGGTCCCTGTCCCTGGGTCCACCCTGGGCTGTGGCTCTACATCTCCCATTTGGGGACGAGAAAGCCACAAAACCATTCT >38579_38579_6_IGFBP3-ZDHHC8_IGFBP3_chr7_45956812_ENST00000381083_ZDHHC8_chr22_20128140_ENST00000405930_length(amino acids)=810AA_BP=252 MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYVTGKFRGGVNPFTRGCCG NVEHVLCSPLAPRYVVEPPRLPLAVSLKPPFLRPELLDRAAPLKVKLSDNGLKAGLGRSKSKGSLDRLDEKPLDLGPPLPPKIEAGTFSS DLQTPRPGSAESALSVQRTSPPTPAMYKFRPAFPTGPKVPFCGPGEQVPGPDSLTLGDDSIRSLDFVSEPSLDLPDYGPGGLHAAYPPSP PLSASDAFSGALRSLSLKASSRRGGDHVALQPLRSEGGPPTPHRSIFAPHALPNRNGSLSYDSLLNPGSPGGHACPAHPAVGVAGYHSPY LHPGATGDPPRPLPRSFSPVLGPRPREPSPVRYDNLSRTIMASIQERKDREERERLLRSQADSLFGDSGVYDAPSSYSLQQASVLSEGPR GPALRYGSRDDLVAGPGFGGARNPALQTSLSSLSSSVSRAPRTSSSSLQADQASSNAPGPRPSSGSHRSPARQGLPSPPGTPHSPSYAGP KAVAFIHTDLPEPPPSLTVQRGRIGTCTRGWGRRGQPWVPPGLHLCHLGRPEDRPPLRAPWSQAAGAPPRGAMCRLHLAASSLFPSLSGP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for IGFBP3-ZDHHC8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IGFBP3-ZDHHC8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IGFBP3-ZDHHC8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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