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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGFBP3-ZNF277 (FusionGDB2 ID:38580)

Fusion Gene Summary for IGFBP3-ZNF277

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP3-ZNF277
Fusion gene ID: 38580
HgeneTgene
Gene symbol

IGFBP3

ZNF277

Gene ID

3486

11179

Gene nameinsulin like growth factor binding protein 3zinc finger protein 277
SynonymsBP-53|IBP3NRIF4|ZNF277P
Cytomap

7p12.3

7q31.1

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 3IBP-3IGF-binding protein 3IGFBP-3acid stable subunit of the 140 K IGF complexbinding protein 29binding protein 53growth hormone-dependent binding proteinzinc finger protein 277nuclear receptor-interacting factor 4zinc finger protein (C2H2 type) 277zinc finger protein 277 pseudogene
Modification date2020031520200313
UniProtAcc

P17936

.
Ensembl transtripts involved in fusion geneENST00000275521, ENST00000381083, 
ENST00000381086, ENST00000465642, 
ENST00000421043, ENST00000450657, 
ENST00000361822, 
Fusion gene scores* DoF score9 X 9 X 4=3246 X 4 X 4=96
# samples 96
** MAII scorelog2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFBP3 [Title/Abstract] AND ZNF277 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGFBP3(45956146)-ZNF277(111979897), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGFBP3

GO:0001933

negative regulation of protein phosphorylation

17591901

HgeneIGFBP3

GO:0006468

protein phosphorylation

17434920

HgeneIGFBP3

GO:0014912

negative regulation of smooth muscle cell migration

10766744

HgeneIGFBP3

GO:0045663

positive regulation of myoblast differentiation

12599210

HgeneIGFBP3

GO:0048662

negative regulation of smooth muscle cell proliferation

10766744


check buttonFusion gene breakpoints across IGFBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF277 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-R5-A7ZFIGFBP3chr7

45956146

-ZNF277chr7

111979897

+


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Fusion Gene ORF analysis for IGFBP3-ZNF277

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000275521ENST00000421043IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
5CDS-intronENST00000275521ENST00000450657IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
5CDS-intronENST00000381083ENST00000421043IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
5CDS-intronENST00000381083ENST00000450657IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
5CDS-intronENST00000381086ENST00000421043IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
5CDS-intronENST00000381086ENST00000450657IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
In-frameENST00000275521ENST00000361822IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
In-frameENST00000381083ENST00000361822IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
In-frameENST00000381086ENST00000361822IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
intron-3CDSENST00000465642ENST00000361822IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
intron-intronENST00000465642ENST00000421043IGFBP3chr7

45956146

-ZNF277chr7

111979897

+
intron-intronENST00000465642ENST00000450657IGFBP3chr7

45956146

-ZNF277chr7

111979897

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381086IGFBP3chr745956146-ENST00000361822ZNF277chr7111979897+134559124977317
ENST00000275521IGFBP3chr745956146-ENST00000361822ZNF277chr7111979897+1638884261270414
ENST00000381083IGFBP3chr745956146-ENST00000361822ZNF277chr7111979897+163387931265420

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381086ENST00000361822IGFBP3chr745956146-ZNF277chr7111979897+0.0023103620.9976896
ENST00000275521ENST00000361822IGFBP3chr745956146-ZNF277chr7111979897+0.0184015320.9815985
ENST00000381083ENST00000361822IGFBP3chr745956146-ZNF277chr7111979897+0.0111976180.9888024

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Fusion Genomic Features for IGFBP3-ZNF277


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGFBP3chr745956146-ZNF277chr7111979897+0.53728370.46271628
IGFBP3chr745956146-ZNF277chr7111979897+0.53728370.46271628

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IGFBP3-ZNF277


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:45956146/chr7:111979897)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP3

P17936

.
FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. {ECO:0000269|PubMed:20353938}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000275521-35138_161250496.6666666666667Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000275521-35192_208250496.6666666666667Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000381083-35138_161256102.0Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000381083-35192_208256102.0Compositional biasNote=Ser/Thr-rich
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000275521-3536_117250496.6666666666667DomainIGFBP N-terminal
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000381083-35210_285256102.0DomainThyroglobulin type-1
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000381083-3536_117256102.0DomainIGFBP N-terminal
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000275521-3528_134250496.6666666666667RegionIGF-binding
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000381083-3528_134256102.0RegionIGF-binding
TgeneZNF277chr7:45956146chr7:111979897ENST00000361822812355_381322451.0Zinc fingerC2H2-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGFBP3chr7:45956146chr7:111979897ENST00000275521-35210_285250496.6666666666667DomainThyroglobulin type-1
TgeneZNF277chr7:45956146chr7:111979897ENST00000361822812224_248322451.0Zinc fingerC2H2-type 1


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Fusion Gene Sequence for IGFBP3-ZNF277


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38580_38580_1_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000275521_ZNF277_chr7_111979897_ENST00000361822_length(transcript)=1638nt_BP=884nt
CCAGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCC
TGCGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGC
TGGTGCTGCTCCGCGGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGC
GTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGA
GCGAGGGCCAGCCGTGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGG
CGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAA
ATGCTAGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCC
ACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAG
ATACCCAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGT
TCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGGATGCACACGAATTTG
ATCTTCTCAAAATAAAGTCAGAACTTGGATTAAATTTCTATCAGCAAGTGAAACTGGTCAATTTTATTCGGAGGCAAGTTCACCAATGCA
GATGTTATGGCTGCCATGTGAAGTTCAAATCCAAAGCAGACTTAAGAACTCACATGGAAGAAACTAAACACACTTCGCTGCTCCCCGATA
GAAAGACGTGGGATCAACTGGAGTATTATTTTCCAACCTATGAAAATGACACTCTCCTGTGTACACTATCTGACAGTGAAAGTGACCTGA
CAGCTCAGGAACAAAATGAAAATGTTCCCATCATCAGTGAAGATACATCTAAACTGTATGCTTTGAAACAAAGCAGTATTTTGAACCAGT
TGCTACTATAAGAGTACTTGAAAACCTAGAAGAAACTACCACAGAAGCAATTTTTCATGTTTTTCTCCTATGAGACAGATATGAAAGAAC
AATTTAAATTTGAACATCAACAAAAGATTGGTCCTTGGTGAAATAAACTTTTCAAAAATGAATGTTCTTTTCAAAAAATAAAGTAGAAAA
ATGCACTTACTAAGAACATGAAAAAAAATGAAGTAGGAAAATAAGATGAAGACTTTGTATTTTGGCTGTAAAGTTTTATTGTGTGATCAT
CTTAAATTATCTCACTTCATTAAACTCATAATTATATATAGAAGTATATGTCAATTACAAAGAAATGAAATGTTCAAATTATTTATAAAC

>38580_38580_1_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000275521_ZNF277_chr7_111979897_ENST00000361822_length(amino acids)=414AA_BP=286
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDR
SAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRG
VHIPNCDKKGFYKKKQDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEY

--------------------------------------------------------------
>38580_38580_2_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000381083_ZNF277_chr7_111979897_ENST00000361822_length(transcript)=1633nt_BP=879nt
GCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTGCGCGCCCAGCCTGCCAAGCAG
CGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGCGGGCCGCCG
GTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGCGAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCT
CCGCCCGCCGTGTGCGCGGAGCTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCGTGCGGCATC
TACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTC
TGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGTGAGCCGCCCGCGCCAGGAAATGCT
AGTGAGTCGGAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCC
CTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACC
CAGAACTTCTCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGTTCCTC
AATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGGATGCACACGAATTTGATCTT
CTCAAAATAAAGTCAGAACTTGGATTAAATTTCTATCAGCAAGTGAAACTGGTCAATTTTATTCGGAGGCAAGTTCACCAATGCAGATGT
TATGGCTGCCATGTGAAGTTCAAATCCAAAGCAGACTTAAGAACTCACATGGAAGAAACTAAACACACTTCGCTGCTCCCCGATAGAAAG
ACGTGGGATCAACTGGAGTATTATTTTCCAACCTATGAAAATGACACTCTCCTGTGTACACTATCTGACAGTGAAAGTGACCTGACAGCT
CAGGAACAAAATGAAAATGTTCCCATCATCAGTGAAGATACATCTAAACTGTATGCTTTGAAACAAAGCAGTATTTTGAACCAGTTGCTA
CTATAAGAGTACTTGAAAACCTAGAAGAAACTACCACAGAAGCAATTTTTCATGTTTTTCTCCTATGAGACAGATATGAAAGAACAATTT
AAATTTGAACATCAACAAAAGATTGGTCCTTGGTGAAATAAACTTTTCAAAAATGAATGTTCTTTTCAAAAAATAAAGTAGAAAAATGCA
CTTACTAAGAACATGAAAAAAAATGAAGTAGGAAAATAAGATGAAGACTTTGTATTTTGGCTGTAAAGTTTTATTGTGTGATCATCTTAA
ATTATCTCACTTCATTAAACTCATAATTATATATAGAAGTATATGTCAATTACAAAGAAATGAAATGTTCAAATTATTTATAAACCTGAT

>38580_38580_2_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000381083_ZNF277_chr7_111979897_ENST00000361822_length(amino acids)=420AA_BP=292
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPP
PAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNAS
ESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLN
VLSPRGVHIPNCDKKGFYKKKQDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKT

--------------------------------------------------------------
>38580_38580_3_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000381086_ZNF277_chr7_111979897_ENST00000361822_length(transcript)=1345nt_BP=591nt
AGATGCGAGCACTGCGGCTGGGCGCTGAGGATCAGCCGCTTCCTGCCTGGATTCCACAGCTTCGCGCCGTGTACTGTCGCCCCATCCCTG
CGCGCCCAGCCTGCCAAGCAGCGTGCCCCGGTTGCAGGCGTCATGCAGCGGGCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTC
TGCGTCAACGCTAGTGCCGTCAGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCGGAGGAAGAC
CGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTGTCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATC
ATCATCAAGAAAGGGCATGCTAAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTCTCCTCCGAG
TCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACACTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGG
GGTGTACACATTCCCAACTGTGACAAGAAGGGATTTTATAAGAAAAAGCAGGATGCACACGAATTTGATCTTCTCAAAATAAAGTCAGAA
CTTGGATTAAATTTCTATCAGCAAGTGAAACTGGTCAATTTTATTCGGAGGCAAGTTCACCAATGCAGATGTTATGGCTGCCATGTGAAG
TTCAAATCCAAAGCAGACTTAAGAACTCACATGGAAGAAACTAAACACACTTCGCTGCTCCCCGATAGAAAGACGTGGGATCAACTGGAG
TATTATTTTCCAACCTATGAAAATGACACTCTCCTGTGTACACTATCTGACAGTGAAAGTGACCTGACAGCTCAGGAACAAAATGAAAAT
GTTCCCATCATCAGTGAAGATACATCTAAACTGTATGCTTTGAAACAAAGCAGTATTTTGAACCAGTTGCTACTATAAGAGTACTTGAAA
ACCTAGAAGAAACTACCACAGAAGCAATTTTTCATGTTTTTCTCCTATGAGACAGATATGAAAGAACAATTTAAATTTGAACATCAACAA
AAGATTGGTCCTTGGTGAAATAAACTTTTCAAAAATGAATGTTCTTTTCAAAAAATAAAGTAGAAAAATGCACTTACTAAGAACATGAAA
AAAAATGAAGTAGGAAAATAAGATGAAGACTTTGTATTTTGGCTGTAAAGTTTTATTGTGTGATCATCTTAAATTATCTCACTTCATTAA

>38580_38580_3_IGFBP3-ZNF277_IGFBP3_chr7_45956146_ENST00000381086_ZNF277_chr7_111979897_ENST00000361822_length(amino acids)=317AA_BP=189
MRISRFLPGFHSFAPCTVAPSLRAQPAKQRAPVAGVMQRARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVES
PSVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCD
KKGFYKKKQDAHEFDLLKIKSELGLNFYQQVKLVNFIRRQVHQCRCYGCHVKFKSKADLRTHMEETKHTSLLPDRKTWDQLEYYFPTYEN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IGFBP3-ZNF277


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGFBP3-ZNF277


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGFBP3-ZNF277


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource