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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGFBP4-DCN (FusionGDB2 ID:38581)

Fusion Gene Summary for IGFBP4-DCN

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFBP4-DCN
Fusion gene ID: 38581
HgeneTgene
Gene symbol

IGFBP4

DCN

Gene ID

3487

1634

Gene nameinsulin like growth factor binding protein 4decorin
SynonymsBP-4|HT29-IGFBP|IBP4|IGFBP-4CSCD|DSPG2|PG40|PGII|PGS2|SLRR1B
Cytomap

17q21.2

12q21.33

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor-binding protein 4IBP-4IGF-binding protein 4decorinbone proteoglycan IIdermatan sulphate proteoglycans IIproteoglycan core proteinsmall leucine-rich protein 1B
Modification date2020031520200313
UniProtAcc

P22692

P07585

Ensembl transtripts involved in fusion geneENST00000269593, ENST00000542955, 
ENST00000393155, ENST00000548768, 
ENST00000550099, ENST00000551354, 
ENST00000552962, ENST00000052754, 
ENST00000228329, ENST00000303320, 
ENST00000420120, ENST00000425043, 
ENST00000441303, ENST00000456569, 
ENST00000546370, ENST00000546745, 
ENST00000547568, 
Fusion gene scores* DoF score7 X 9 X 3=18912 X 9 X 6=648
# samples 912
** MAII scorelog2(9/189*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFBP4 [Title/Abstract] AND DCN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGFBP4(38613815)-DCN(91573256), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDCN

GO:0010508

positive regulation of autophagy

23798385

TgeneDCN

GO:0010596

negative regulation of endothelial cell migration

23798385

TgeneDCN

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

23798385

TgeneDCN

GO:0016239

positive regulation of macroautophagy

23798385

TgeneDCN

GO:0016525

negative regulation of angiogenesis

23978385

TgeneDCN

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

23798385


check buttonFusion gene breakpoints across IGFBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DCN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP289909IGFBP4chr17

38613815

+DCNchr12

91573256

-


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Fusion Gene ORF analysis for IGFBP4-DCN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-5UTRENST00000269593ENST00000393155IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-5UTRENST00000269593ENST00000548768IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-5UTRENST00000269593ENST00000550099IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-5UTRENST00000269593ENST00000551354IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-5UTRENST00000269593ENST00000552962IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000052754IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000228329IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000303320IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000420120IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000425043IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000441303IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000456569IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000546370IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000546745IGFBP4chr17

38613815

+DCNchr12

91573256

-
3UTR-intronENST00000269593ENST00000547568IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-5UTRENST00000542955ENST00000393155IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-5UTRENST00000542955ENST00000548768IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-5UTRENST00000542955ENST00000550099IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-5UTRENST00000542955ENST00000551354IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-5UTRENST00000542955ENST00000552962IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000052754IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000228329IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000303320IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000420120IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000425043IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000441303IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000456569IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000546370IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000546745IGFBP4chr17

38613815

+DCNchr12

91573256

-
intron-intronENST00000542955ENST00000547568IGFBP4chr17

38613815

+DCNchr12

91573256

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IGFBP4-DCN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IGFBP4-DCN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:38613815/:91573256)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFBP4

P22692

DCN

P07585

FUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.FUNCTION: May affect the rate of fibrils formation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IGFBP4-DCN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IGFBP4-DCN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGFBP4-DCN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGFBP4-DCN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource