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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABHD14B-ABHD14B (FusionGDB2 ID:386)

Fusion Gene Summary for ABHD14B-ABHD14B

check button Fusion gene summary
Fusion gene informationFusion gene name: ABHD14B-ABHD14B
Fusion gene ID: 386
HgeneTgene
Gene symbol

ABHD14B

ABHD14B

Gene ID

84836

84836

Gene nameabhydrolase domain containing 14Babhydrolase domain containing 14B
SynonymsCIB|HEL-S-299CIB|HEL-S-299
Cytomap

3p21.2

3p21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ABHD14BCCG1-interacting factor Babhydrolase domain-containing protein 14Balpha/beta hydrolase domain-containing protein 14Bcell cycle gene 1-interacting factor Bepididymis secretory protein Li 299epididymis secretory sperm binding proteinprotein ABHD14BCCG1-interacting factor Babhydrolase domain-containing protein 14Balpha/beta hydrolase domain-containing protein 14Bcell cycle gene 1-interacting factor Bepididymis secretory protein Li 299epididymis secretory sperm binding protein
Modification date2020032020200320
UniProtAcc

Q96IU4

Q96IU4

Ensembl transtripts involved in fusion geneENST00000315877, ENST00000361143, 
ENST00000395008, ENST00000461108, 
ENST00000483233, ENST00000487005, 
ENST00000525795, 		ENST00000315877, 
ENST00000361143, ENST00000395008, 
ENST00000461108, ENST00000483233, 
ENST00000525795, ENST00000487005, 
Fusion gene scores* DoF score6 X 6 X 5=1802 X 2 X 1=4
# samples 82
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: ABHD14B [Title/Abstract] AND ABHD14B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABHD14B(52003386)-ABHD14B(52003425), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABHD14B

GO:0045944

positive regulation of transcription by RNA polymerase II

14672934

TgeneABHD14B

GO:0045944

positive regulation of transcription by RNA polymerase II

14672934


check buttonFusion gene breakpoints across ABHD14B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ABHD14B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA484849ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+


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Fusion Gene ORF analysis for ABHD14B-ABHD14B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000315877ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000315877ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000315877ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000315877ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000315877ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000315877ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000361143ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000395008ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000461108ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000483233ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000487005ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000315877ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000361143ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000395008ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000461108ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000483233ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-3UTRENST00000525795ENST00000525795ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000315877ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000361143ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000395008ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000461108ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000483233ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000487005ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+
intron-5UTRENST00000525795ENST00000487005ABHD14Bchr3

52003386

-ABHD14Bchr3

52003425

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ABHD14B-ABHD14B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABHD14B-ABHD14B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52003386/:52003425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABHD14B

Q96IU4

ABHD14B

Q96IU4

FUNCTION: Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription. {ECO:0000269|PubMed:14672934}.FUNCTION: Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription. {ECO:0000269|PubMed:14672934}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ABHD14B-ABHD14B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABHD14B-ABHD14B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABHD14B-ABHD14B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABHD14B-ABHD14B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource