FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:IGFL2-NNMT (FusionGDB2 ID:38632)

Fusion Gene Summary for IGFL2-NNMT

check button Fusion gene summary
Fusion gene informationFusion gene name: IGFL2-NNMT
Fusion gene ID: 38632
HgeneTgene
Gene symbol

IGFL2

NNMT

Gene ID

147920

4837

Gene nameIGF like family member 2nicotinamide N-methyltransferase
SynonymsUNQ645|VPRI645-
Cytomap

19q13.32

11q23.2

Type of geneprotein-codingprotein-coding
Descriptioninsulin growth factor-like family member 2nicotinamide N-methyltransferase
Modification date2020031320200329
UniProtAcc

Q6UWQ7

P40261

Ensembl transtripts involved in fusion geneENST00000434646, ENST00000377693, 
ENST00000600243, 		ENST00000541754, 
ENST00000542647, ENST00000545255, 
ENST00000299964, ENST00000535185, 
ENST00000535401, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 7 X 6=336
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGFL2 [Title/Abstract] AND NNMT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGFL2(46652294)-NNMT(114182766), # samples:1
Anticipated loss of major functional domain due to fusion event.IGFL2-NNMT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGFL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NNMT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0911IGFL2chr19

46652294

+NNMTchr11

114182766

+


Top

Fusion Gene ORF analysis for IGFL2-NNMT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000434646ENST00000541754IGFL2chr19

46652294

+NNMTchr11

114182766

+
5CDS-5UTRENST00000434646ENST00000542647IGFL2chr19

46652294

+NNMTchr11

114182766

+
5CDS-5UTRENST00000434646ENST00000545255IGFL2chr19

46652294

+NNMTchr11

114182766

+
5CDS-intronENST00000434646ENST00000299964IGFL2chr19

46652294

+NNMTchr11

114182766

+
5CDS-intronENST00000434646ENST00000535185IGFL2chr19

46652294

+NNMTchr11

114182766

+
Frame-shiftENST00000434646ENST00000535401IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-3CDSENST00000377693ENST00000535401IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-3CDSENST00000600243ENST00000535401IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000377693ENST00000541754IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000377693ENST00000542647IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000377693ENST00000545255IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000600243ENST00000541754IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000600243ENST00000542647IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-5UTRENST00000600243ENST00000545255IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-intronENST00000377693ENST00000299964IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-intronENST00000377693ENST00000535185IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-intronENST00000600243ENST00000299964IGFL2chr19

46652294

+NNMTchr11

114182766

+
intron-intronENST00000600243ENST00000535185IGFL2chr19

46652294

+NNMTchr11

114182766

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for IGFL2-NNMT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGFL2chr1946652294+NNMTchr11114182766+2.36E-070.99999976
IGFL2chr1946652294+NNMTchr11114182766+2.36E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for IGFL2-NNMT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:46652294/:114182766)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGFL2

Q6UWQ7

NNMT

P40261

FUNCTION: Potential ligand of the IGFLR1 cell membrane receptor. {ECO:0000269|PubMed:21454693}.FUNCTION: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for IGFL2-NNMT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for IGFL2-NNMT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for IGFL2-NNMT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for IGFL2-NNMT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource