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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH3A1-ASPH (FusionGDB2 ID:3891)

Fusion Gene Summary for ALDH3A1-ASPH

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH3A1-ASPH
Fusion gene ID: 3891
HgeneTgene
Gene symbol

ALDH3A1

ASPH

Gene ID

218

444

Gene namealdehyde dehydrogenase 3 family member A1aspartate beta-hydroxylase
SynonymsALDH3|ALDHIIIAAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap

17p11.2

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, dimeric NADP-preferringaldehyde dehydrogenase isozyme 3aldehyde dehydrogenase type IIIstomach aldehyde dehydrogenaseaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2020032020200315
UniProtAcc

P30838

Q6ICH7

Ensembl transtripts involved in fusion geneENST00000225740, ENST00000395555, 
ENST00000444455, ENST00000457500, 
ENST00000485231, ENST00000494157, 
ENST00000379454, ENST00000541428, 
ENST00000356457, ENST00000379449, 
ENST00000389204, ENST00000445642, 
ENST00000517661, ENST00000517847, 
ENST00000517856, ENST00000517903, 
ENST00000518068, ENST00000522603, 
ENST00000522835, ENST00000522919, 
ENST00000523897, 
Fusion gene scores* DoF score5 X 5 X 4=10017 X 17 X 5=1445
# samples 719
** MAII scorelog2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1445*10)=-2.92699816905709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH3A1 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH3A1(19641367)-ASPH(62596725), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDH3A1

GO:0006081

cellular aldehyde metabolic process

1737758

HgeneALDH3A1

GO:0055114

oxidation-reduction process

1737758

TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across ALDH3A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABU679486ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
ChiTaRS5.0N/ABU685263ALDH3A1chr17

19641367

+ASPHchr8

62596725

-


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Fusion Gene ORF analysis for ALDH3A1-ASPH

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000225740ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000225740ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000395555ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000395555ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000444455ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000444455ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000457500ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000457500ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000485231ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000485231ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000494157ENST00000379454ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-3CDSENST00000494157ENST00000541428ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000225740ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000395555ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000444455ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000457500ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000485231ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000356457ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000379449ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000389204ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000445642ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000517661ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000517847ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000517856ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000517903ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000518068ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000522603ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000522835ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000522919ALDH3A1chr17

19641367

+ASPHchr8

62596725

-
intron-intronENST00000494157ENST00000523897ALDH3A1chr17

19641367

+ASPHchr8

62596725

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ALDH3A1-ASPH


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ALDH3A1-ASPH


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19641367/:62596725)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH3A1

P30838

ASPH

Q6ICH7

FUNCTION: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). {ECO:0000250|UniProtKB:P47739, ECO:0000269|PubMed:1737758, ECO:0000305}.FUNCTION: May function as 2-oxoglutarate-dependent dioxygenase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ALDH3A1-ASPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ALDH3A1-ASPH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH3A1-ASPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALDH3A1-ASPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource