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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDH3A2-EIF5A (FusionGDB2 ID:3897)

Fusion Gene Summary for ALDH3A2-EIF5A

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDH3A2-EIF5A
Fusion gene ID: 3897
HgeneTgene
Gene symbol

ALDH3A2

EIF5A

Gene ID

224

143244

Gene namealdehyde dehydrogenase 3 family member A2eukaryotic translation initiation factor 5A like 1
SynonymsALDH10|FALDH|SLSEIF5A|EIF5AP1|bA342M3.3|eIF-4D|eIF-5A|eIF-5A-1|eIF-5A1
Cytomap

17p11.2

10q22.3

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase family 3 member A2aldehyde dehydrogenase 10fatty aldehyde dehydrogenasemicrosomal aldehyde dehydrogenaseeukaryotic translation initiation factor 5A-1-likeEukaryotic translation initiation factor 5A-1Rev-binding factoreukaryotic translation initiation factor 5A pseudogene 1
Modification date2020031520200313
UniProtAcc

P51648

Q6IS14

Ensembl transtripts involved in fusion geneENST00000176643, ENST00000339618, 
ENST00000395575, ENST00000579855, 
ENST00000581518, ENST00000571163, 
ENST00000574597, 		ENST00000336458, 
ENST00000416016, ENST00000419711, 
ENST00000571955, ENST00000572815, 
ENST00000573542, ENST00000576930, 
ENST00000336452, 
Fusion gene scores* DoF score6 X 5 X 5=1509 X 5 X 8=360
# samples 69
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDH3A2 [Title/Abstract] AND EIF5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDH3A2(19575269)-EIF5A(7212934), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALDH3A2

GO:0006081

cellular aldehyde metabolic process

9133646

HgeneALDH3A2

GO:0046458

hexadecanal metabolic process

25047030

HgeneALDH3A2

GO:0055114

oxidation-reduction process

9133646


check buttonFusion gene breakpoints across ALDH3A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5KY-01AALDH3A2chr17

19575269

+EIF5Achr17

7212934

+


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Fusion Gene ORF analysis for ALDH3A2-EIF5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000176643ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000176643ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000339618ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000395575ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000579855ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
5CDS-5UTRENST00000581518ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
In-frameENST00000176643ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
In-frameENST00000339618ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
In-frameENST00000395575ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
In-frameENST00000579855ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
In-frameENST00000581518ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-3CDSENST00000571163ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-3CDSENST00000574597ENST00000336452ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000571163ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000336458ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000416016ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000419711ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000571955ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000572815ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000573542ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+
intron-5UTRENST00000574597ENST00000576930ALDH3A2chr17

19575269

+EIF5Achr17

7212934

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000176643ALDH3A2chr1719575269+ENST00000336452EIF5Achr177212934+302018892122374720
ENST00000581518ALDH3A2chr1719575269+ENST00000336452EIF5Achr177212934+28231692152177720
ENST00000395575ALDH3A2chr1719575269+ENST00000336452EIF5Achr177212934+273216011132086657
ENST00000339618ALDH3A2chr1719575269+ENST00000336452EIF5Achr177212934+27951664982149683
ENST00000579855ALDH3A2chr1719575269+ENST00000336452EIF5Achr177212934+26731542572027656

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000176643ENST00000336452ALDH3A2chr1719575269+EIF5Achr177212934+0.0019688060.9980312
ENST00000581518ENST00000336452ALDH3A2chr1719575269+EIF5Achr177212934+0.0017132590.99828666
ENST00000395575ENST00000336452ALDH3A2chr1719575269+EIF5Achr177212934+0.0016919440.99830806
ENST00000339618ENST00000336452ALDH3A2chr1719575269+EIF5Achr177212934+0.0016897730.9983102
ENST00000579855ENST00000336452ALDH3A2chr1719575269+EIF5Achr177212934+0.0016545050.9983455

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Fusion Genomic Features for ALDH3A2-EIF5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ALDH3A2chr1719575269+EIF5Achr177212933+6.39E-080.9999999
ALDH3A2chr1719575269+EIF5Achr177212933+6.39E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ALDH3A2-EIF5A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:19575269/chr17:7212934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH3A2

P51648

EIF5A

Q6IS14

FUNCTION: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). {ECO:0000269|PubMed:18035827, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:25047030, ECO:0000269|PubMed:9133646, ECO:0000269|PubMed:9662422}.FUNCTION: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000176643+910185_190481486.0Nucleotide bindingNAD
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000339618+911185_1904811064.0Nucleotide bindingNAD
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000395575+1011185_190481486.0Nucleotide bindingNAD
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000579855+1011185_190481486.0Nucleotide bindingNAD
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000581518+912185_190481620.3333333333334Nucleotide bindingNAD
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000176643+9101_463481486.0Topological domainNote=Cytoplasmic
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000339618+9111_4634811064.0Topological domainNote=Cytoplasmic
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000395575+10111_463481486.0Topological domainNote=Cytoplasmic
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000579855+10111_463481486.0Topological domainNote=Cytoplasmic
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000581518+9121_463481620.3333333333334Topological domainNote=Cytoplasmic
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000176643+910464_484481486.0TransmembraneHelical
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000339618+911464_4844811064.0TransmembraneHelical
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000395575+1011464_484481486.0TransmembraneHelical
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000579855+1011464_484481486.0TransmembraneHelical
HgeneALDH3A2chr17:19575269chr17:7212934ENST00000581518+912464_484481620.3333333333334TransmembraneHelical
TgeneEIF5Achr17:19575269chr17:7212934ENST000003364520620_9023357.3333333333333RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000003364580620_900239.66666666666666RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000004160160620_900298.0RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000004197110620_900319.6666666666667RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000005719551720_900319.6666666666667RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000005735420620_900245.66666666666666RegionNote=DOHH-binding
TgeneEIF5Achr17:19575269chr17:7212934ENST000005769301720_900295.3333333333333RegionNote=DOHH-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ALDH3A2-EIF5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3897_3897_1_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000176643_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=3020nt_BP=1889nt
CCGGGGCGCTCTCAGCAGGATGGCCAACACCTTCCCTCCATCCCTACACCCCGCCGCCCCCTGGCCCGTGGCCGCGCTCGGCTCCCGCAC
TGCTCACTCCACCCCCTACATCCCAGCCCGCTGCCAGAGCCGGGGAGAGGGCGGGGGCCGCGTGGGCGAGGCCGTGAACAGCGGCTGTCA
CGTGGGCCGCCCAGGCCAATAGGGGTGAGGCTTTGGGTCGAGCTCAGTCCTCCCCCGGCGCCTCCGACTGGCAGTGGGACTCAGCGGGCG
TGGAGGTCGCGGCTGAGCGAGCGAGCCCTGGGCGAGTGAATTGTGGCTGTGGGTTGACGGTGGAGACACCCCCCGGAGGGAGGCGGAGGG
AAGGGAGGCGAGGCCTGCACCTGCATGCTTCCCGCCTCCCACTCCCCAGCGCCCCCGGACCGTGCAGTTCTCTGCAGGACCAGGCCATGG
AGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTGCGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGA
GGATGGTGCAGGAGCGCGAGAAGGATATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAAGTCA
TTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACTGCTAAACCAGTTAAGAAGAACGTGCTCACCATGC
TGGATGAGGCCTATATTCAGCCACAGCCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAGCCAC
TGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGTGAAAATACAGCCAAGATCTTGGCAAAGCTTCTCC
CTCAGTATTTAGACCAGGATCTCTATATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCACATTT
TCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCATCTGACCCCTGTGACTCTTGAACTGGGAGGGAAAA
GTCCATGTTATATTGATAAAGATTGTGACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACCTGCA
TTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAGATTAAGGAAACAGTGAAGGAATTTTATGGAGAAA
ATATAAAAGAGTCTCCTGATTATGAAAGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATAGCTT
TTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGATGTTGATCCTAAAACCAAGGTGATGCAAGAAGAAA
TTTTTGGACCAATTCTTCCAATAGTGCCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCTCTTT
ATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGTGGAGGTGTCACAGGCAATGACGTCATTATGCACT
TCACGCTCAACTCTTTCCCATTTGGAGGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCTCATC
AGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATATCCTCCCAACAGCCAGTCAAAGGTGGATTGGGGAA
AATTTTTTCTCTTGAAACGGTTCAACAAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTCAAGT
TGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAG
CATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACG
CCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACA
TCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTC
TCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGG
AGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCC
CCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCAC
CCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCT
CTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCA
ATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCT
TTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAG
GAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCC

>3897_3897_1_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000176643_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=720AA_BP=559
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKE
KLGLLLLTFLGIVAAVLVKLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIF
TGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK

--------------------------------------------------------------
>3897_3897_2_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000339618_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=2795nt_BP=1664nt
AGTCCTCCCCCGGCGCCTCCGACTGGCAGTGGGACTCAGCGGGCGTGGAGGTCGCGGCTGAGCGAGCGAGCCCTGGGCGAGTGAATTGTG
GCTGTGGGTTGACGGTGGAGACACCCCCCGGAGGGAGGCGGAGGGAAGGGAGGCGAGGCCTGCACCTGCATGCTTCCCGCCTCCCACTCC
CCAGCGCCCCCGGACCGTGCAGTTCTCTGCAGGACCAGGCCATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGT
CGCGACCTCTGCGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGATATCCTGACGGCCATCGCCG
CCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAAGTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTG
AATGGGTTACTGCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAGCCTCTGGGAGTGGTGCTGA
TAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAGCCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTT
CTGAACTGAGTGAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTATATTGTTATTAATGGTGGTG
TTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCACATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTG
CTGCCAAGCATCTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGTGACCTGGACATTGTTTGCA
GACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACCTGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAA
TTGTATGGAAGATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAAAGGATCATCAATCTTCGTC
ATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATAGCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAG
TACTTACCGATGTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTGCCTGTGAAAAATGTAGATG
AGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCTCTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATG
AGACATCCAGTGGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGAGGAGTGGGTTCCAGTGGGA
TGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCTCATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACA
AACTCAGATATCCTCCCAACAGCCAGTCAAAGGTGGATTGGGGAAAATTTTTTCTCTTGAAACGGTTCAACAAAGAAAAACTCGGTCTCC
TGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTCAAGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGA
CAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTA
AGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAAT
ATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACC
TATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACT
GTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCA
GGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGAC
TCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTT
GGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGG
TGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGC
CCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGC
CTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGG
GCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTGTTAAAATCAAACCTGAATAAAACTACAAGTTTAAT

>3897_3897_2_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000339618_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=683AA_BP=522
MTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADL
CKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSEL
SENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRI
TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLT
DVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGA
YHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKLESKPLKMADDLDFETGD
AGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSL

--------------------------------------------------------------
>3897_3897_3_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000395575_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=2732nt_BP=1601nt
AATAGGGGTGAGGCTTTGGGTCGAGCTCAGTCCTCCCCCGGCGCCTCCGACTGGCAGTGGGACTCAGCGGGCGTGGAGGTCGCGGCTGAG
CGAGCGAGCCCTGGGCGAGTGAATTGTGGCTCGCCCCCGGACCGTGCAGTTCTCTGCAGGACCAGGCCATGGAGCTCGAAGTCCGGCGGG
TCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTGCGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGCG
AGAAGGATATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAAGTCATTACTGTCCTTGGGGAAA
TTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACTGCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATTC
AGCCACAGCCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAGCCACTGATAGGAGCCATCGCTG
CAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGTGAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAGG
ATCTCTATATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCACATTTTCTATACGGGAAACACTG
CGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCATCTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGATA
AAGATTGTGACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACCTGCATTGCACCCGACTATATTC
TCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAGATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCTG
ATTATGAAAGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATAGCTTTTGGTGGGGAGACTGATG
AGGCCACACGCTACATAGCCCCAACAGTACTTACCGATGTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTTC
CAATAGTGCCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCTCTTTATGTATTTTCGCATAACC
ATAAGCTCATCAAACGGATGATTGATGAGACATCCAGTGGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTCC
CATTTGGAGGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCTCATCAGCGTCCCTGTTTATTAA
AAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATATCCTCCCAACAGCCAGTCAAAGGTGGATTGGGGAAAATTTTTTCTCTTGAAAC
GGTTCAACAAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTCAAGTTGGAATCGAAGCCTCTTA
AAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAAGAATGGCT
TTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTTG
GTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAATGACTTCC
AGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTTG
GCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGTTGCAATCA
AGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGCC
TGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGGG
AGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTAC
AGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATCAGAAAGCG
GTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAGCACCACCC
CAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGAC
CTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTGTTAAAATC

>3897_3897_3_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000395575_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=657AA_BP=496
MWLAPGPCSSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENL
PEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVING
GVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN
QIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNV
DEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGA
NKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRP
CKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKY

--------------------------------------------------------------
>3897_3897_4_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000579855_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=2673nt_BP=1542nt
AGTCCTCCCCCGGCGCCTCCGACTGGCAGTGGGACTCAGCGGGCGTGGAGGTCGCGGCTGAGCGAGCGAGCCCTGGGCGATTCTCTGCAG
GACCAGGCCATGGAGCTCGAAGTCCGGCGGGTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTGCGGTTTCGGCTGCAGCAGCTG
GAGGCCCTGCGGAGGATGGTGCAGGAGCGCGAGAAGGATATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTAC
AGTCAGGAAGTCATTACTGTCCTTGGGGAAATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACTGCTAAACCAGTTAAGAAGAAC
GTGCTCACCATGCTGGATGAGGCCTATATTCAGCCACAGCCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTC
ACCATTCAGCCACTGATAGGAGCCATCGCTGCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGTGAAAATACAGCCAAGATCTTG
GCAAAGCTTCTCCCTCAGTATTTAGACCAGGATCTCTATATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGA
TTTGACCACATTTTCTATACGGGAAACACTGCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCATCTGACCCCTGTGACTCTTGAA
CTGGGAGGGAAAAGTCCATGTTATATTGATAAAGATTGTGACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGT
GGCCAAACCTGCATTGCACCCGACTATATTCTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAGATTAAGGAAACAGTGAAGGAA
TTTTATGGAGAAAATATAAAAGAGTCTCCTGATTATGAAAGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGA
CAAAAGATAGCTTTTGGTGGGGAGACTGATGAGGCCACACGCTACATAGCCCCAACAGTACTTACCGATGTTGATCCTAAAACCAAGGTG
ATGCAAGAAGAAATTTTTGGACCAATTCTTCCAATAGTGCCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAG
CCTCTGGCTCTTTATGTATTTTCGCATAACCATAAGCTCATCAAACGGATGATTGATGAGACATCCAGTGGAGGTGTCACAGGCAATGAC
GTCATTATGCACTTCACGCTCAACTCTTTCCCATTTGGAGGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGAT
ACTTTTTCTCATCAGCGTCCCTGTTTATTAAAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATATCCTCCCAACAGCCAGTCAAAG
GTGGATTGGGGAAAATTTTTTCTCTTGAAACGGTTCAACAAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCT
GTGCTTGTCAAGTTGGAATCGAAGCCTCTTAAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCA
ATGCAGTGCTCAGCATTACGTAAGAATGGCTTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGC
AAGCACGGCCACGCCAAGGTCCATCTGGTTGGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATG
GATGTCCCCAACATCAAAAGGAATGACTTCCAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGA
GAGGACCTTCGTCTCCCTGAGGGAGACCTTGGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCT
GCCATGACAGAGGAGGCAGCTGTTGCAATCAAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGA
ACCTGCAGAGGCCCCCTCCCCGAGCCTGGCCTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTT
TGGTTTTCCCCACCCCCTCAATCTGTCGGGGAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTG
AAGCTGCCCTCCTCTTCTCCCCTCACACTACAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTT
TTTTTTTAATTCAATCTGGAATCAGAAAGCGGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGT
TGCCTATAGCCCTTTACCCTGAGCACCACCCCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGAT
GGGGAGGGAAGAGGAGGAGAGGGGAGGGGACCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGC

>3897_3897_4_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000579855_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=656AA_BP=495
MSERALGDSLQDQAMELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLP
EWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGG
VEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQ
IVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVD
EAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGAN
KLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPC
KIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYD

--------------------------------------------------------------
>3897_3897_5_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000581518_EIF5A_chr17_7212934_ENST00000336452_length(transcript)=2823nt_BP=1692nt
AATAGGGGTGAGGCTTTGGGTCGAGCTCAGTCCTCCCCCGGCGCCTCCGACTGGCAGTGGGACTCAGCGGGCGTGGAGGTCGCGGCTGAG
CGAGCGAGCCCTGGGCGAGTGAATTGTGGCTGTGGGTTGACGGTGGAGACACCCCCCGGAGGGAGGCGGAGGGAAGGGAGGCGAGGCCTG
CACCTGCATGCTTCCCGCCTCCCACTCCCCAGCGCCCCCGGACCGTGCAGTTCTCTGCAGGACCAGGCCATGGAGCTCGAAGTCCGGCGG
GTCCGACAGGCGTTCCTGTCCGGCCGGTCGCGACCTCTGCGGTTTCGGCTGCAGCAGCTGGAGGCCCTGCGGAGGATGGTGCAGGAGCGC
GAGAAGGATATCCTGACGGCCATCGCCGCCGACCTGTGCAAGAGTGAATTCAATGTGTACAGTCAGGAAGTCATTACTGTCCTTGGGGAA
ATTGATTTTATGCTTGAGAATCTTCCTGAATGGGTTACTGCTAAACCAGTTAAGAAGAACGTGCTCACCATGCTGGATGAGGCCTATATT
CAGCCACAGCCTCTGGGAGTGGTGCTGATAATCGGAGCTTGGAATTACCCCTTCGTTCTCACCATTCAGCCACTGATAGGAGCCATCGCT
GCAGGAAATGCTGTGATTATAAAGCCTTCTGAACTGAGTGAAAATACAGCCAAGATCTTGGCAAAGCTTCTCCCTCAGTATTTAGACCAG
GATCTCTATATTGTTATTAATGGTGGTGTTGAGGAAACCACGGAGCTCCTGAAGCAGCGATTTGACCACATTTTCTATACGGGAAACACT
GCGGTTGGCAAAATTGTCATGGAAGCTGCTGCCAAGCATCTGACCCCTGTGACTCTTGAACTGGGAGGGAAAAGTCCATGTTATATTGAT
AAAGATTGTGACCTGGACATTGTTTGCAGACGCATAACCTGGGGAAAATACATGAATTGTGGCCAAACCTGCATTGCACCCGACTATATT
CTCTGTGAAGCATCCCTCCAAAATCAAATTGTATGGAAGATTAAGGAAACAGTGAAGGAATTTTATGGAGAAAATATAAAAGAGTCTCCT
GATTATGAAAGGATCATCAATCTTCGTCATTTTAAGAGGATACTAAGTTTGCTTGAAGGACAAAAGATAGCTTTTGGTGGGGAGACTGAT
GAGGCCACACGCTACATAGCCCCAACAGTACTTACCGATGTTGATCCTAAAACCAAGGTGATGCAAGAAGAAATTTTTGGACCAATTCTT
CCAATAGTGCCTGTGAAAAATGTAGATGAGGCCATAAATTTCATAAATGAACGTGAAAAGCCTCTGGCTCTTTATGTATTTTCGCATAAC
CATAAGCTCATCAAACGGATGATTGATGAGACATCCAGTGGAGGTGTCACAGGCAATGACGTCATTATGCACTTCACGCTCAACTCTTTC
CCATTTGGAGGAGTGGGTTCCAGTGGGATGGGAGCTTATCACGGAAAACATAGTTTTGATACTTTTTCTCATCAGCGTCCCTGTTTATTA
AAAAGTTTAAAGAGAGAAGGTGCTAACAAACTCAGATATCCTCCCAACAGCCAGTCAAAGGTGGATTGGGGAAAATTTTTTCTCTTGAAA
CGGTTCAACAAAGAAAAACTCGGTCTCCTGTTGCTCACTTTCCTGGGTATTGTAGCCGCTGTGCTTGTCAAGTTGGAATCGAAGCCTCTT
AAAATGGCAGATGACTTGGACTTCGAGACAGGAGATGCAGGGGCCTCAGCCACCTTCCCAATGCAGTGCTCAGCATTACGTAAGAATGGC
TTTGTGGTGCTCAAAGGCCGGCCATGTAAGATCGTCGAGATGTCTACTTCGAAGACTGGCAAGCACGGCCACGCCAAGGTCCATCTGGTT
GGTATTGACATCTTTACTGGGAAGAAATATGAAGATATCTGCCCGTCAACTCATAATATGGATGTCCCCAACATCAAAAGGAATGACTTC
CAGCTGATTGGCATCCAGGATGGGTACCTATCACTGCTCCAGGACAGCGGGGAGGTACGAGAGGACCTTCGTCTCCCTGAGGGAGACCTT
GGCAAGGAGATTGAGCAGAAGTACGACTGTGGAGAAGAGATCCTGATCACGGTGCTGTCTGCCATGACAGAGGAGGCAGCTGTTGCAATC
AAGGCCATGGCAAAATAACTGGCTCCCAGGGTGGCGGTGGTGGCAGCAGTGATCCTCTGAACCTGCAGAGGCCCCCTCCCCGAGCCTGGC
CTGGCTCTGGCCCGGTCCTAAGCTGGACTCCTCCTACACAATTTATTTGACGTTTTATTTTGGTTTTCCCCACCCCCTCAATCTGTCGGG
GAGCCCCTGCCCTTCACCTAGCTCCCTTGGCCAGGAGCGAGCGAAGCTGTGGCCTTGGTGAAGCTGCCCTCCTCTTCTCCCCTCACACTA
CAGCCCTGGTGGGGGAGAAGGGGGTGGGTGCTGCTTGTGGTTTAGTCTTTTTTTTTTTTTTTTTTTTAATTCAATCTGGAATCAGAAAGC
GGTGGATTCTGGCAAATGGTCCTTGTGCCCTCCCCACTCATCCCTGGTCTGGTCCCCTGTTGCCTATAGCCCTTTACCCTGAGCACCACC
CCAACAGACTGGGGACCAGCCCCCTCGCCTGCCTGTGTCTCTCCCCAAACCCCTTTAGATGGGGAGGGAAGAGGAGGAGAGGGGAGGGGA
CCTGCCCCCTCCTCAGGCATCTGGGAGGGCCCTGCCCCCATGGGCTTTACCCTTCCCTGCGGGCTCTCTCCCCGACACATTTGTTAAAAT

>3897_3897_5_ALDH3A2-EIF5A_ALDH3A2_chr17_19575269_ENST00000581518_EIF5A_chr17_7212934_ENST00000336452_length(amino acids)=720AA_BP=559
MGRAQSSPGASDWQWDSAGVEVAAERASPGRVNCGCGLTVETPPGGRRREGRRGLHLHASRLPLPSAPGPCSSLQDQAMELEVRRVRQAF
LSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPL
GVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKI
VMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERI
INLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIK
RMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKE
KLGLLLLTFLGIVAAVLVKLESKPLKMADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIF
TGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALDH3A2-EIF5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDH3A2-EIF5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALDH3A2-EIF5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource