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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IKBKB-GOT1L1 (FusionGDB2 ID:39366)

Fusion Gene Summary for IKBKB-GOT1L1

Fusion gene summary

Fusion gene information	Fusion gene name: IKBKB-GOT1L1
	Fusion gene ID: 39366
		Hgene	Tgene
	Gene symbol	IKBKB	GOT1L1
	Gene ID	3551	137362
	Gene name	inhibitor of nuclear factor kappa B kinase subunit beta	glutamic-oxaloacetic transaminase 1 like 1
	Synonyms	IKK-beta\|IKK2\|IKKB\|IMD15\|IMD15A\|IMD15B\|NFKBIKB	-
	Cytomap	8p11.21	8p11.23
	Type of gene	protein-coding	protein-coding
	Description	inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betainhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase beta	putative aspartate aminotransferase, cytoplasmic 2glutamate oxaloacetate transaminase 1-like protein 1transaminase A-like protein 1
	Modification date	20200313	20200313
	UniProtAcc	O14920	.
	Ensembl transtripts involved in fusion gene	ENST00000416505, ENST00000519735, ENST00000520810, ENST00000520835, ENST00000379708, ENST00000518983, ENST00000522147, ENST00000522785,	ENST00000518826, ENST00000307599,
Fusion gene scores	* DoF score	9 X 7 X 6=378	3 X 4 X 2=24
	# samples	13	2
	** MAII score	log2(13/378*10)=-1.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/24*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IKBKB [Title/Abstract] AND GOT1L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IKBKB(42151030)-GOT1L1(37796399), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IKBKB	GO:0006468	protein phosphorylation	15084260\|20434986
Hgene	IKBKB	GO:0018105	peptidyl-serine phosphorylation	21399639
Hgene	IKBKB	GO:0042325	regulation of phosphorylation	26212789
Hgene	IKBKB	GO:0045944	positive regulation of transcription by RNA polymerase II	23091055\|23453807
Hgene	IKBKB	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15790681
Hgene	IKBKB	GO:0071356	cellular response to tumor necrosis factor	23091055

Fusion gene breakpoints across IKBKB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOT1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-69-8255-01A	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-

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Fusion Gene ORF analysis for IKBKB-GOT1L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000416505	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
5CDS-intron	ENST00000519735	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
5CDS-intron	ENST00000520810	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
5CDS-intron	ENST00000520835	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
In-frame	ENST00000416505	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
In-frame	ENST00000519735	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
In-frame	ENST00000520810	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
In-frame	ENST00000520835	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-3CDS	ENST00000379708	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-3CDS	ENST00000518983	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-3CDS	ENST00000522147	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-3CDS	ENST00000522785	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-intron	ENST00000379708	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-intron	ENST00000518983	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-intron	ENST00000522147	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-
intron-intron	ENST00000522785	ENST00000518826	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000520810	IKBKB	chr8	42151030	+	ENST00000307599	GOT1L1	chr8	37796399	-	1737	574	186	1724	512
ENST00000416505	IKBKB	chr8	42151030	+	ENST00000307599	GOT1L1	chr8	37796399	-	1628	465	233	1615	460
ENST00000519735	IKBKB	chr8	42151030	+	ENST00000307599	GOT1L1	chr8	37796399	-	1721	558	170	1708	512
ENST00000520835	IKBKB	chr8	42151030	+	ENST00000307599	GOT1L1	chr8	37796399	-	1598	435	53	1585	510

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000520810	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-	0.001555264	0.99844474
ENST00000416505	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-	0.001869676	0.9981304
ENST00000519735	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-	0.00143779	0.9985623
ENST00000520835	ENST00000307599	IKBKB	chr8	42151030	+	GOT1L1	chr8	37796399	-	0.003944134	0.99605584

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Fusion Genomic Features for IKBKB-GOT1L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IKBKB-GOT1L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42151030/chr8:37796399)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IKBKB O14920	.
FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:20410276). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NCOA3, BCL10 and IRS1 (PubMed:17213322). Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). {ECO:0000250\|UniProtKB:O88351, ECO:0000269\|PubMed:11297557, ECO:0000269\|PubMed:15084260, ECO:0000269\|PubMed:17213322, ECO:0000269\|PubMed:19716809, ECO:0000269\|PubMed:20410276, ECO:0000269\|PubMed:20434986, ECO:0000269\|PubMed:20797629, ECO:0000269\|PubMed:21138416, ECO:0000269\|PubMed:25326418, ECO:0000269\|PubMed:30337470}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000416505

21_29

698.0

Nucleotide binding

ATP

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000519735

21_29

129

257.0

Nucleotide binding

ATP

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520810

21_29

129

757.0

Nucleotide binding

ATP

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520835

21_29

127

755.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000416505

15_300

698.0

Domain

Protein kinase

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000519735

15_300

129

257.0

Domain

Protein kinase

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520810

15_300

129

757.0

Domain

Protein kinase

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520835

15_300

127

755.0

Domain

Protein kinase

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000416505

458_479

698.0

Region

Note=Leucine-zipper

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000416505

737_742

698.0

Region

Note=NEMO-binding

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000519735

458_479

129

257.0

Region

Note=Leucine-zipper

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000519735

737_742

129

257.0

Region

Note=NEMO-binding

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520810

458_479

129

757.0

Region

Note=Leucine-zipper

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520810

737_742

129

757.0

Region

Note=NEMO-binding

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520835

458_479

127

755.0

Region

Note=Leucine-zipper

Hgene

IKBKB

chr8:42151030

chr8:37796399

ENST00000520835

737_742

127

755.0

Region

Note=NEMO-binding

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Fusion Gene Sequence for IKBKB-GOT1L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>39366_39366_1_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000416505_GOT1L1_chr8_37796399_ENST00000307599_length(transcript)=1628nt_BP=465nt
GGAAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGG
CCGCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGACATCAGTATGAGCTG
GTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCA
CAATCAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGG
CCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCACCT
TGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGGATC
CCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCCAAG
CCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGCATA
AGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAATACT
CTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGATGG
GGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTGATA
TTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCTGCA
GCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGTGTG
TCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCAACC
CTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGC
TCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACC
TGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGG
GCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGTCTT

>39366_39366_1_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000416505_GOT1L1_chr8_37796399_ENST00000307599_length(amino acids)=460AA_BP=77
MGQGDLEMSSDGTIRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSL
VVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFGKHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGL
VFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGCVLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRIL
QYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENI
MLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYITEGINEAVLLTESSEMCLPK

--------------------------------------------------------------
>39366_39366_2_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000519735_GOT1L1_chr8_37796399_ENST00000307599_length(transcript)=1721nt_BP=558nt
AAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCC
GCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGACATCAGTATGAGCTGGT
CACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAATGTCATCCGATGGCACA
ATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTGGAGATCCAGA
TCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGC
TGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCA
CCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGG
ATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCC
AAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGC
ATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAAT
ACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGA
TGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTG
ATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCT
GCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGT
GTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCA
ACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCC
AGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAAT
ACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTG
AGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATTGGAATAAAACTTTAGT

>39366_39366_2_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000519735_GOT1L1_chr8_37796399_ENST00000307599_length(amino acids)=512AA_BP=129
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPND
LPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFG
KHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGC
VLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQ
QLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQ

--------------------------------------------------------------
>39366_39366_3_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000520810_GOT1L1_chr8_37796399_ENST00000307599_length(transcript)=1737nt_BP=574nt
GTGACGTCAGAGCAGGAAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCAT
AGCCCCGGGTTTGGCCGCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGAGTTAGCACGAC
ATCAGTATGAGCTGGTCACCTTCCCTGACAACGCAGACATGTGGGGCCTGGGAAATGAAAGAGCGCCTTGGGACAGGGGGATTTGGAAAT
GTCATCCGATGGCACAATCAGGAAACAGGTGAGCAGATTGCCATCAAGCAGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGG
TGCCTGGAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGGCTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCC
AATGACCTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCCGGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGG
GAAGGTGCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATGAAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGA
CTACAGATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCATGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTC
TTTGGAAAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTACACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAG
TTTCTCAGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTTCTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGC
TTTACAGTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGGACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACAT
GGCTGTGTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAAGTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAG
ATATTCCCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACTTGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAA
GGCTTTGAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTTATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAAC
AACCAGCAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGGCCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATC
ACCTCCATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTCTAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAA
GTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACATCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAAC
TCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCAAGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAAC
ATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGAGCTCAGAGATGTGTCTTCCAAAGGAAAAAAAAACACTGATT

>39366_39366_3_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000520810_GOT1L1_chr8_37796399_ENST00000307599_length(amino acids)=512AA_BP=129
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPND
LPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFG
KHSQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGC
VLVMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQ
QLLCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQ

--------------------------------------------------------------
>39366_39366_4_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000520835_GOT1L1_chr8_37796399_ENST00000307599_length(transcript)=1598nt_BP=435nt
AAGTGTTTGAGGAAGTCGCGCCGCGCTGCCCGCGTTAAGATTCCCGCATTTTAATGTTTTCAGGGGGGTGTCATAGCCCCGGGTTTGGCC
GCCCCAGCCCCGCCTTCCCCGCCCCGGGGAGCCCGCCCCCTGCCCCGCGTCCCTGCCGACAGGAAACAGGTGAGCAGATTGCCATCAAGC
AGTGCCGGCAGGAGCTCAGCCCCCGGAACCGAGAGCGGTGGTGCCTGGAGATCCAGATCATGAGAAGGCTGACCCACCCCAATGTGGTGG
CTGCCCGAGATGTCCCTGAGGGGATGCAGAACTTGGCGCCCAATGACCTGCCCCTGCTGGCCATGGAGTACTGCCAAGGAGGAGATCTCC
GGAAGTACCTGAACCAGTTTGAGAACTGCTGTGGTCTGCGGGAAGGTGCCATCCTCACCTTGCTGAGTGACATTGTCTGCATGACAAATG
AAGGCCATCCCTGGGTTTCTCTCGTGGTGCAGAAGACTCGACTACAGATTTCACAGGATCCCTCCCTGAATTATGAGTACTTGCCCACCA
TGGGCCTGAAATCATTCATCCAGGCCTCTCTAGCACTCCTCTTTGGAAAGCACAGCCAAGCCATTGTGGAGAACAGGGTAGGGGGTGTAC
ACACTGTTGGTGACAGTGGTGCCTTCCAGCTTGGCGTCCAGTTTCTCAGAGCTTGGCATAAGGATGCTCGTATAGTTTACATCATCTCTT
CTCAAAAAGAACTGCATGGACTCGTCTTCCAGGACATGGGCTTTACAGTTTATGAATACTCTGTCTGGGACCCCAAGAAGCTATGCATGG
ACCCCGACATACTCCTCAATGTGGTGGAGCAGATCCCACATGGCTGTGTCCTTGTGATGGGGAACATTATCGACTGCAAGTTGACACCAA
GTGGGTGGGCAAAGTTGATGTCCATGATAAAGAGCAAGCAGATATTCCCATTTTTTGATATTCCCTGTCAAGGTTTATACACCAGTGACT
TGGAAGAAGATACTAGAATCTTACAATACTTTGTGTCTCAAGGCTTTGAGTTCTTCTGCAGCCAGTCTCTGTCCAAGAATTTTGGCATTT
ATGATGAAGGAGTGGGGATGCTAGTGGTGGTGGCAGTCAACAACCAGCAGCTGCTGTGTGTCCTCTCCCAGCTGGAAGGATTAGCCCAGG
CCCTGTGGCTAAACCCCCCCAACACGGGTGCACGTGTCATCACCTCCATCCTCTGCAACCCTGCTCTGCTGGGAGAATGGAAGCAGAGTC
TAAAAGAAGTTGTAGAGAACATCATGCTAACCAAGGAAAAAGTGAAGGAGAAACTCCAGCTCCTGGGAACCCCTGGGTCCTGGGGTCACA
TCACCGAGCAGAGTGGGACCCACGGCTATCTTGGACTCAACTCCCAGCAGGTGGAATACCTGGTCAGGAAGAAGCACATCTATATCCCCA
AGAACGGTCAGATTAACTTCAGCTGTATCAATGCCAACAACATAAATTACATCACTGAGGGCATCAATGAGGCTGTCCTCCTCACAGAGA

>39366_39366_4_IKBKB-GOT1L1_IKBKB_chr8_42151030_ENST00000520835_GOT1L1_chr8_37796399_ENST00000307599_length(amino acids)=510AA_BP=127
MFSGGCHSPGFGRPSPAFPAPGSPPPAPRPCRQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLP
LLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIVCMTNEGHPWVSLVVQKTRLQISQDPSLNYEYLPTMGLKSFIQASLALLFGKH
SQAIVENRVGGVHTVGDSGAFQLGVQFLRAWHKDARIVYIISSQKELHGLVFQDMGFTVYEYSVWDPKKLCMDPDILLNVVEQIPHGCVL
VMGNIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRILQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQL
LCVLSQLEGLAQALWLNPPNTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGTHGYLGLNSQQV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IKBKB-GOT1L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IKBKB-GOT1L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IKBKB-GOT1L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source