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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IKBKG-ATP2B3 (FusionGDB2 ID:39375)

Fusion Gene Summary for IKBKG-ATP2B3

Fusion gene summary

Fusion gene information	Fusion gene name: IKBKG-ATP2B3
	Fusion gene ID: 39375
		Hgene	Tgene
	Gene symbol	IKBKG	ATP2B3
	Gene ID	8517	492
	Gene name	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	ATPase plasma membrane Ca2+ transporting 3
	Synonyms	AMCBX1\|EDAID1\|FIP-3\|FIP3\|Fip3p\|IKK-gamma\|IKKAP1\|IKKG\|IMD33\|IP\|IP1\|IP2\|IPD2\|NEMO\|ZC2HC9	CFAP39\|CLA2\|OPCA\|PMCA3\|PMCA3a\|SCAX1
	Cytomap	Xq28	Xq28
	Type of gene	protein-coding	protein-coding
	Description	NF-kappa-B essential modulatorI-kappa-B kinase subunit gammaNF-kappa-B essential modifierikB kinase subunit gammaikB kinase-associated protein 1incontinentia pigmentiinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammainhibit	plasma membrane calcium-transporting ATPase 3ATPase, Ca++ transporting, plasma membrane 3cilia and flagella associated protein 39plasma membrane calcium ATPaseplasma membrane calcium pump
	Modification date	20200327	20200313
	UniProtAcc	Q9Y6K9	Q16720
	Ensembl transtripts involved in fusion gene	ENST00000263518, ENST00000369602, ENST00000369606, ENST00000393549, ENST00000455588, ENST00000470142, ENST00000369601, ENST00000369607, ENST00000369609, ENST00000492469,	ENST00000263519, ENST00000349466, ENST00000359149, ENST00000370181, ENST00000370186, ENST00000393842, ENST00000460549,
Fusion gene scores	* DoF score	4 X 3 X 3=36	3 X 5 X 3=45
	# samples	5	5
	** MAII score	log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: IKBKG [Title/Abstract] AND ATP2B3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IKBKG(153775960)-ATP2B3(152806816), # samples:1 IKBKG(153775960)-ATP2B3(152806817), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	IKBKG	GO:0006974	cellular response to DNA damage stimulus	14651848
Hgene	IKBKG	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	17702576
Hgene	IKBKG	GO:0045944	positive regulation of transcription by RNA polymerase II	23091055
Hgene	IKBKG	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15620648
Hgene	IKBKG	GO:0065003	protein-containing complex assembly	11113112
Tgene	ATP2B3	GO:0051480	regulation of cytosolic calcium ion concentration	18029012
Tgene	ATP2B3	GO:1990034	calcium ion export across plasma membrane	18029012

Fusion gene breakpoints across IKBKG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP2B3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-FI-A2CY-01A	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
ChimerDB4	UCEC	TCGA-FI-A2CY	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+

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Fusion Gene ORF analysis for IKBKG-ATP2B3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000263518	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000263518	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000263518	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000263518	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000263518	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000263518	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000263518	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369602	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369602	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000369606	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000369606	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000393549	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000393549	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000455588	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000455588	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-3CDS	ENST00000470142	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-3CDS	ENST00000470142	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000263518	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000263518	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000369602	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000369602	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000369606	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000369606	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000393549	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000393549	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000455588	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000455588	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
5UTR-intron	ENST00000470142	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
5UTR-intron	ENST00000470142	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369601	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369601	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369607	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369607	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000369609	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000369609	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000263519	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000349466	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000359149	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000370181	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000370186	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-3CDS	ENST00000492469	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-3CDS	ENST00000492469	ENST00000393842	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-intron	ENST00000369601	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-intron	ENST00000369601	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-intron	ENST00000369607	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-intron	ENST00000369607	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-intron	ENST00000369609	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-intron	ENST00000369609	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+
intron-intron	ENST00000492469	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806817	+
intron-intron	ENST00000492469	ENST00000460549	IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for IKBKG-ATP2B3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+	5.79E-06	0.99999416
IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+	5.79E-06	0.99999416
IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+	5.79E-06	0.99999416
IKBKG	chrX	153775960	+	ATP2B3	chrX	152806816	+	5.79E-06	0.99999416

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IKBKG-ATP2B3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:153775960/:152806816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IKBKG Q9Y6K9	ATP2B3 Q16720
FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. {ECO:0000269\|PubMed:14695475, ECO:0000269\|PubMed:19854139, ECO:0000269\|PubMed:20724660}.	FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for IKBKG-ATP2B3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IKBKG-ATP2B3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IKBKG-ATP2B3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IKBKG-ATP2B3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source