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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IK-RAB11FIP1 (FusionGDB2 ID:39384)

Fusion Gene Summary for IK-RAB11FIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: IK-RAB11FIP1
Fusion gene ID: 39384
HgeneTgene
Gene symbol

IK

RAB11FIP1

Gene ID

3783

80223

Gene namepotassium calcium-activated channel subfamily N member 4RAB11 family interacting protein 1
SynonymsDHS2|IK|IK1|IKCA1|KCA4|KCa3.1|SK4|hIKCa1|hKCa4|hSK4NOEL1A|RCP|rab11-FIP1
Cytomap

19q13.31

8p11.23

Type of geneprotein-codingprotein-coding
Descriptionintermediate conductance calcium-activated potassium channel protein 4SKCa 4SKCa4potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4potassium intermediate/small conductance calcium-activated channel, subfamirab11 family-interacting protein 1RAB11 coupling proteinRAB11 family interacting protein 1 (class I)Rab effector proteinRab-interacting recycling protein
Modification date2020032920200313
UniProtAcc

Q13123

.
Ensembl transtripts involved in fusion geneENST00000417647, ENST00000523672, 
ENST00000523182, ENST00000524118, 
ENST00000287263, ENST00000330843, 
ENST00000522727, 
Fusion gene scores* DoF score5 X 4 X 2=4012 X 8 X 7=672
# samples 515
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/672*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IK [Title/Abstract] AND RAB11FIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIK(140039742)-RAB11FIP1(37734800), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIK

GO:0006816

calcium ion transport

18796614

HgeneIK

GO:0030322

stabilization of membrane potential

18796614

HgeneIK

GO:0050862

positive regulation of T cell receptor signaling pathway

18796614

TgeneRAB11FIP1

GO:0070164

negative regulation of adiponectin secretion

24040321


check buttonFusion gene breakpoints across IK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB11FIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE935199IKchr5

140039742

+RAB11FIP1chr8

37734800

+


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Fusion Gene ORF analysis for IK-RAB11FIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000417647ENST00000523182IKchr5

140039742

+RAB11FIP1chr8

37734800

+
5CDS-intronENST00000417647ENST00000524118IKchr5

140039742

+RAB11FIP1chr8

37734800

+
In-frameENST00000417647ENST00000287263IKchr5

140039742

+RAB11FIP1chr8

37734800

+
In-frameENST00000417647ENST00000330843IKchr5

140039742

+RAB11FIP1chr8

37734800

+
In-frameENST00000417647ENST00000522727IKchr5

140039742

+RAB11FIP1chr8

37734800

+
intron-3CDSENST00000523672ENST00000287263IKchr5

140039742

+RAB11FIP1chr8

37734800

+
intron-3CDSENST00000523672ENST00000330843IKchr5

140039742

+RAB11FIP1chr8

37734800

+
intron-3CDSENST00000523672ENST00000522727IKchr5

140039742

+RAB11FIP1chr8

37734800

+
intron-intronENST00000523672ENST00000523182IKchr5

140039742

+RAB11FIP1chr8

37734800

+
intron-intronENST00000523672ENST00000524118IKchr5

140039742

+RAB11FIP1chr8

37734800

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000417647IKchr5140039742+ENST00000287263RAB11FIP1chr837734800+703814511391503454
ENST00000417647IKchr5140039742+ENST00000330843RAB11FIP1chr837734800+8609145157267663645
ENST00000417647IKchr5140039742+ENST00000522727RAB11FIP1chr837734800+289714511391503454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000417647ENST00000287263IKchr5140039742+RAB11FIP1chr837734800+0.001402340.9985977
ENST00000417647ENST00000330843IKchr5140039742+RAB11FIP1chr837734800+0.0062741020.99372596
ENST00000417647ENST00000522727IKchr5140039742+RAB11FIP1chr837734800+0.0070964790.99290353

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Fusion Genomic Features for IK-RAB11FIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IK-RAB11FIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:140039742/chr8:37734800)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IK

Q13123

.
FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). {ECO:0000269|PubMed:22351768, ECO:0000269|PubMed:24252166, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000028726305209_2180650.0Compositional biasNote=Poly-Lys
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000028726305556_6090650.0Compositional biasNote=Ser-rich
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000033084306209_21801284.0Compositional biasNote=Poly-Lys
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000033084306556_60901284.0Compositional biasNote=Ser-rich
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000052411803209_2180440.0Compositional biasNote=Poly-Lys
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST0000052411803556_6090440.0Compositional biasNote=Ser-rich
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000287263051211_12730650.0DomainFIP-RBD
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000287263051_1260650.0DomainC2
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000330843061211_127301284.0DomainFIP-RBD
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000330843061_12601284.0DomainC2
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000524118031211_12730440.0DomainFIP-RBD
TgeneRAB11FIP1chr5:140039742chr8:37734800ENST00000524118031_1260440.0DomainC2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120182_1870558.0Compositional biasPoly-Glu
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120334_3740558.0Compositional biasArg-rich
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120342_3750558.0RegionNote=17 X 2 AA tandem repeats of R-[ED]
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120342_3430558.0RepeatNote=1
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120344_3450558.0RepeatNote=2
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120346_3470558.0RepeatNote=3
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120348_3490558.0RepeatNote=4
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120350_3510558.0RepeatNote=5
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120352_3530558.0RepeatNote=6
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120354_3550558.0RepeatNote=7
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120356_3570558.0RepeatNote=8
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120358_3590558.0RepeatNote=9
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120360_3610558.0RepeatNote=10
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120362_3630558.0RepeatNote=11
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120364_3650558.0RepeatNote=12
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120366_3670558.0RepeatNote=13
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120368_3690558.0RepeatNote=14
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120370_3710558.0RepeatNote=15
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120372_3730558.0RepeatNote=16
HgeneIKchr5:140039742chr8:37734800ENST00000417647+120374_3750558.0RepeatNote=17


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Fusion Gene Sequence for IK-RAB11FIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39384_39384_1_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000287263_length(transcript)=7038nt_BP=1451nt
GGGAAAAACAGGAAGCGGAAAGGCTGCGAACGCAAAGCAGTGTGGGTTGATTCTGAGGTGCACTGTGGGAAAGAGCTTGTCGCTGCGGTG
TTGCTGTTGGAGACTCGATTGTTGGTGACAGCGAAAGAACGATAACAAAATGCCGGAGCGAGATAGTGAGCCGTTCTCCAACCCTTTGGC
CCCCGATGGCCACGATGTGGATGATCCTCACTCCTTCCACCAATCAAAACTCACCAATGAAGACTTCAGGAAACTTCTCATGACCCCCAG
GGCTGCACCTACCTCTGCACCACCTTCTAAGTCACGTCACCATGAGATGCCAAGGGAGTACAATGAGGATGAAGACCCAGCTGCACGAAG
GAGGAAAAAGAAAAGTTATTATGCCAAGCTACGCCAACAAGAAATTGAGAGAGAGAGAGAGCTAGCAGAGAAGTACCGGGATCGTGCCAA
GGAACGGAGAGATGGAGTGAACAAAGATTATGAAGAAACCGAGCTTATCAGCACCACAGCTAACTATAGGGCTGTTGGCCCCACTGCTGA
GGCGGACAAATCAGCTGCAGAGAAGAGAAGACAGTTGATCCAGGAGTCCAAATTCTTGGGTGGTGACATGGAACACACCCATTTGGTGAA
AGGCTTGGATTTTGCTCTGCTTCAAAAGGTACGAGCTGAGATTGCCAGCAAAGAGAAAGAGGAAGAGGAACTGATGGAAAAGCCCCAGAA
AGAAACCAAGAAAGATGAGGATCCTGAAAATAAAATTGAATTTAAAACACGTCTGGGCCGCAATGTTTACCGAATGCTTTTTAAGAGCAA
AGCATATGAGCGGAATGAGTTGTTCCTGCCGGGCCGCATGGCCTATGTGGTAGACCTGGATGATGAGTATGCTGACACAGATATCCCCAC
CACTCTTATCCGCAGCAAGGCTGATTGCCCCACCATGGAGGCCCAGACCACACTGACCACAAATGACATTGTCATTAGCAAGCTGACCCA
GATCCTTTCATACCTGAGGCAGGGAACCCGTAACAAGAAGCTTAAGAAGAAGGATAAAGGGAAGCTGGAAGAGAAGAAACCTCCTGAGGC
TGACATGAATATTTTTGAAGACATTGGGGATTACGTACCCTCCACAACCAAGACACCTCGGGACAAGGAGCGGGAGAGATATCGGGAACG
GGAGCGTGATCGGGAAAGAGACAGAGACCGTGACCGAGAGCGAGAGCGAGAACGAGATCGGGAACGAGAGCGAGAGCGGGACCGAGAGAG
AGAAGAGGAAAAGAAGAGACACAGCTACTTTGAGAAGCCAAAAGTAGATGATGAGCCCATGGACGTTGACAAAGGACCTGGGTCTACCAA
GGAGTTGATCAAGTCCATCAATGAAAAGTTTGCTGGGTCTGCTGGCTGGGAAGGCACAGAATCGGCATGTCCAACAGTTATGCAGAGTGC
TACCCAGCCACAAATACAGCCCCTCGGACCCTGCATTTGCATATGCGCAGCTGACCCACGATGAGCTGATTCAGCTGGTCCTCAAACAGA
AGGAAACGATAAGCAAGAAGGAGTTCCAGGTCCGCGAGCTGGAAGACTACATTGACAACCTGCTTGTCAGGGTCATGGAAGAAACCCCCA
ATATCCTCCGCATCCCGACTCAGGTTGGCAAAAAAGCAGGAAAGATGTAAATCAGCAGAAAAAAAACACCGAGACGTTTCTGTGACTTCA
CTTTCACCTGCTCCAGGGGTCAAGGACTTGCCTTGCCTGATAACCAGCCAGCAGGCTCCGAATCACCATCTCCCTCACATGTTATCCGGC
AAGAGTGAATTCTACCAATGGAAGCCAGGTTAATGATTACAATTAATCTTTTACTGTACATTCCCAAGGCTTTAGTTTTAAATGCCACTG
TGCCTTTAACAAGGTTGTAAATATTTTATGCCCACCAGAGATGTGGTCATAAGATCTGATCCTGAGCCAGAGATTCAGATGGCACAGGAA
GTATTCATGTATTTTAACACTGGGGTTTTCTTTCTTTCATACTGAGATTTTTTTTCAGTATGTATCCTCCAGCTCTTAAAGCTTACCTGA
GAAAGCTTTAAATGAGAAAAGGACCATGCGATTGGTGCTGTGTTACATACACATACTTTCTTGGCTTCTGAGTAGCTCAGGTGTGGCTTT
TGGCTGCAGATGTTAAATTTTGATACCATGTAAACCTACCCAGCTTCTCAGACTTGGGTCTTGTTTTTTGATGGGAACAGAGGTGTTTAG
AGAAAGCCTCTGAGTATGCCTTTCAGATTTTGAACAAGCGGCCTTTTCTAAACATCGACTTCTACTACTCTCTAGCCTTAAAATACCTTC
TGCTTAGATCCAGGGCCCTTCTACTGGAGATAGGAAAAGTAGAATTCAGGAATTAAAAGAATTACTCTTTATTCAATTTGAGGAACTTGG
TGAAAGCCCCTCCTCTTATGACAGCCAGGTTCCTGCTGGCTAGACCAGCCTATTCAGCGCTTTGCTAGGGGATTGGGTGGTCCACGCACT
CGCTAATACAGTTCTCCAGGTGTGGAATGATGTCAATACGATTGCTTGGCCTTTTCCCCCTGTGCCTTTGCTCGGTGCTCTGGTTTCCTC
AGCAACACTCCTTGTAAGGGGCAGAGACAGGGTCCACCAACTCCCCAAGATGAAGAAGCCCCTTCAGGCCAGTCGTGGTGGCTCATGCCT
GTAATCCCAGCACTTTGCAAGGCCGAGGAGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGCGAAACCCCATC
TCTACTAAAAATACAAAAATTAGCTTGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGGGGCAGGAGAATTGCTTGAA
CTTGGGAGATGGAGGCTGCAGCGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAAGAGTTTTTTTAAGACTCTTAAAAAAAGAGCC
TGGGCAATTTTTTTAAGACTCTGTCTTAAAAAAAACTAAAAAGAAAAAAAGAAGCCCCTTCACTCTACAGGGGACAGGAGACCATGGATT
GGACCCCAAAGGGATTGAACTGCATCTGCATGTCTGTCCTTTGAACACTTTCTCTCCCTGCCCAAAAGGAAACCCAAATTATTTGTGGGA
TACTGGGGAAATTGTAGTGAAGGGCTTAATGTAGTTAATAAAAGTTAAAAGTCAGTAGAAAACAGGTGCCTCAGCCTTCAAATGGTTGCT
TTTTTTCCATTTTCCCTCATGAATAGACTCACCAGCATTTTACCCCCTTGTTATAAAACTGTGCAGAGCAAGAAGATGATACTTATTTTT
GAATTTGTATTTTTAAAACTAGATTTATAGACTTTTTTTTTTTTTAACTAGGGCACTTGCTTCCTTCTTAGCTAAAAGCACCAGCTGAGA
TTTTTCAGGTAATTTTGTTGTTACTCACTTAAGACTGGAATTAGAATGTTTCTGGTATTTCTCATTTTTTTCCCTGGCTATGATAGAATC
TCATCTAATCTTGACATCTCTCCTAGGGGAAGAATATCACAGGCTAATAGCGTGGTTGGGGGTGAAGATGATAGCAGTTATTAAATCAGG
AATCTCTTTTATGTGTGTCCTTGTTACATTGAGGTTAAGAGACAAAATCATTGGCAGTGCAATCTCTTTCCAGGATTTCGTTTGCTGTGG
CATTGGTTATATCAGAGCACTTTAATCTGAAGGATGATACTGTAACTTGATTTATCTAATTAGCTTTTAATTATCTACAGCTATTTTATT
TTATTTAATTCTCTCCTACAGTACTGGGACCACTGTAAACTTCTCAGATGACTTGTATTTTTGTAGTGCTATGAAATTTATTTACATACT
TATAAAGAAAACTGTATGTTCACTTGAACTCTGAAAATGTACATGTATGGCTGGACGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGG
GAGGCTGAGGCGGGTGAATCACTTGATTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAAATA
CAGAAATTAGCTGGGTGTGGTGGCAGACAGCTGTAATCTCAGCTGCTCGGGAGGCTGAGGCACAAGAATCGCTTGAGCCAGGGAGGTGGA
GGTTGCAGTGAGCTGAGATCACATCATTGCACTCCAGCCTGGGCAACGGGCGAGACTCTGTCTCAAAAAAAAGAAAGAAAGAAAAGGTAC
ATGTATATATTTGTCCTGCATTATGTTTTTTACTTGATATAAATGTATTTTTACTGTGATAGTCCAAGTGCCCTGGGGGGCAGGTGTGCT
CTATGTGGTTCTTCTTCCATTGGAGAGCTGGCGTAGAGATCTGCAGTGTTCACAAGGATGTTGGTTTGGAGATGTCTGCTGCTAGGACCT
GGGGTGTGTGACTCAGTCCATATGAGAGGGACATCTGGGTGGAGGAGTAAATTCCTGTGCTCTGAAATGCCACTTGGTAGCTCTGGACAA
TGAAGGACAATTGACTCAAGGGTGCCTGGCTTCTGCTGCTGCTGGGAAAAAATTCAGTTTATAGCATTCCTGCACCTCCCAAAGTAGATA
ACCTGGAGGTCATTCAGTTAACAACTGTCCCTGAGGACTCAGTTTTGGGGGAGGGGTTATCTGGGAGAAGCTTTAGCCTGTTCTGAGCCA
TTAGGAGACATTAGTGAATTGGAGCACTGGAGAATCCTACAAATGGCCTATGTCTCAGAAGAGCTGGGACCTCCTTCCAGCTGCTGCAGA
TGCTGACAGGCCCTGGGAGGCTGCTGTGCTCTGGAGAAGCTGGAGCAGCTCATTTCTTGGCCTAGCCTGGCTGCCTCAGAAAGAGCAGTC
AGGACTTGAGGGAAGCATCAAATTCTATACCCATAAACTGCAGTTGGAAGTCAGCTTTTTGAAATGTCCAGCCTTTGCCCAATTGTTTCA
GATCATCTCATGCCTCAGGCTTTGGCAGGTATCCTGCCCTCCATCTTATTCCAGTGTGTTCACCTCATCAAGGCAGCAGAGTGGATGAAG
GAGTAAGTCTGCCCTTTGCCATACTGAACAGCTGTGGACCCCGATTGGTGAGGGCTCTGCATATGCCTGTATGAAGGAGATACAGGTGTG
TGTGCACATGCCGGTATGAAGAAGACACAGGCATGTGCTTCTCAGTTTTGCTAACAGTGGGAGCTCAACGGGGCAGAGGGAGGAAGGTCC
ATGATGCTCAGCCACATACTGTAGAGAGAGGCAATTTAATGTTAAATGACGCACCATCCTCCCTCCCACCCTTCTCCCAGTCAACTTTTT
TTCTTTTTCTAGAACTACTAATTATCTCTCAAGGCTGAAAAATTAATTGCCTTAGGTGGAGAACTTAATTCCTAGTATCCACCAAACTTA
ACTCCGTATCTCCATATGGTGTCTCCATATCTACTGTGTGAGCTACTTAACTGACGCCCTCTTCCTCCAACTGAAGGATCGCCCAACGTT
TTTGGATTATAGAATTATTATTTCCTGCTTTCTTTCTTTGGGACTTTTGAATTTCTTTGGTTTCGTTTTTAAGAAGTAACCCAACATTTC
CTACAACACTAAATAAAATGGTACTTACCTTTCAAAGATTTGTGTCTGTAGTTTGGTATGGGTGCAATAAAAATTTATTTTGTCTTCCTG
GAAAACCTCTCTTGGTGGGGGTGGGGGGATGACCAGTGTTTCTCATCCCATGAGGGTCTCTCACTGGGATTTCTGTTGCTGCCATCTTGC
CTGGTTCCCAGGAGTCCCAAGGCCCTTTTTCTCAAAGAGGACGGACATGTCTGGTCCCTTCGGATGCACCCTTCATCTTGGCCTGAGGGA
CCATGGCACTGGCCAGAGAAACTGAGTTGGAACGTGCTGCCCCCTTTTCCTTTGCAGCCGGTACCCTTGGCTGAGCATTTGGACAGGGTC
TTTCCTCACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAACTGCCACCATCATCAGTGAGA
ACTTGAACAATGAGGTCATGATGAAGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCT
TCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCA
TGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCA
TTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGA
ATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGC
CCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAA
GAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGG
GGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAA
CCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCC
CCAGACCAGAGCTGTCAAGCCCCGAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGT
CTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGT

>39384_39384_1_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000287263_length(amino acids)=454AA_BP=
MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIE
RERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIAS
KEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKAYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQT
TLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRDRERER
ERDRERERERDREREEEKKRHSYFEKPKVDDEPMDVDKGPGSTKELIKSINEKFAGSAGWEGTESACPTVMQSATQPQIQPLGPCICICA

--------------------------------------------------------------
>39384_39384_2_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000330843_length(transcript)=8609nt_BP=1451nt
GGGAAAAACAGGAAGCGGAAAGGCTGCGAACGCAAAGCAGTGTGGGTTGATTCTGAGGTGCACTGTGGGAAAGAGCTTGTCGCTGCGGTG
TTGCTGTTGGAGACTCGATTGTTGGTGACAGCGAAAGAACGATAACAAAATGCCGGAGCGAGATAGTGAGCCGTTCTCCAACCCTTTGGC
CCCCGATGGCCACGATGTGGATGATCCTCACTCCTTCCACCAATCAAAACTCACCAATGAAGACTTCAGGAAACTTCTCATGACCCCCAG
GGCTGCACCTACCTCTGCACCACCTTCTAAGTCACGTCACCATGAGATGCCAAGGGAGTACAATGAGGATGAAGACCCAGCTGCACGAAG
GAGGAAAAAGAAAAGTTATTATGCCAAGCTACGCCAACAAGAAATTGAGAGAGAGAGAGAGCTAGCAGAGAAGTACCGGGATCGTGCCAA
GGAACGGAGAGATGGAGTGAACAAAGATTATGAAGAAACCGAGCTTATCAGCACCACAGCTAACTATAGGGCTGTTGGCCCCACTGCTGA
GGCGGACAAATCAGCTGCAGAGAAGAGAAGACAGTTGATCCAGGAGTCCAAATTCTTGGGTGGTGACATGGAACACACCCATTTGGTGAA
AGGCTTGGATTTTGCTCTGCTTCAAAAGGTACGAGCTGAGATTGCCAGCAAAGAGAAAGAGGAAGAGGAACTGATGGAAAAGCCCCAGAA
AGAAACCAAGAAAGATGAGGATCCTGAAAATAAAATTGAATTTAAAACACGTCTGGGCCGCAATGTTTACCGAATGCTTTTTAAGAGCAA
AGCATATGAGCGGAATGAGTTGTTCCTGCCGGGCCGCATGGCCTATGTGGTAGACCTGGATGATGAGTATGCTGACACAGATATCCCCAC
CACTCTTATCCGCAGCAAGGCTGATTGCCCCACCATGGAGGCCCAGACCACACTGACCACAAATGACATTGTCATTAGCAAGCTGACCCA
GATCCTTTCATACCTGAGGCAGGGAACCCGTAACAAGAAGCTTAAGAAGAAGGATAAAGGGAAGCTGGAAGAGAAGAAACCTCCTGAGGC
TGACATGAATATTTTTGAAGACATTGGGGATTACGTACCCTCCACAACCAAGACACCTCGGGACAAGGAGCGGGAGAGATATCGGGAACG
GGAGCGTGATCGGGAAAGAGACAGAGACCGTGACCGAGAGCGAGAGCGAGAACGAGATCGGGAACGAGAGCGAGAGCGGGACCGAGAGAG
AGAAGAGGAAAAGAAGAGACACAGCTACTTTGAGAAGCCAAAAGTAGATGATGAGCCCATGGACGTTGACAAAGGACCTGGGTCTACCAA
GGAGTTGATCAAGTCCATCAATGAAAAGTTTGCTGGGTCTGCTGGCTGGGAAGGCACAGAATCGGCATGTCCAACAGTTATGCAGAGTGC
TACCCAGCCACAAATACAGCCCCTCGGACCCTGCATTTGCATATGCGCAGCTGACCCACGATGAGCTGATTCAGCTGGTCCTCAAACAGA
AGGAAACGATAAGCAAGAAGGAGTTCCAGGTCCGCGAGCTGGAAGACTACATTGACAACCTGCTTGTCAGGGTCATGGAAGAAACCCCCA
ATATCCTCCGCATCCCGACTCAGGTTGGCAAAAAAGCAGGAAAGATGTAAATCAGCAGAAAAAAAACACCGAGACGTTTCTGTGACTTCA
CTTTCACCTGCTCCAGGGGTCAAGGACTTGCCTTGCCTGATAACCAGCCAGCAGGCTCCGAATCACCATCTCCCTCACATGTTATCCGGC
AAGAGTGAATTCTACCAATGGAAGCCAGGTTAATGATTACAATTAATCTTTTACTGTACATTCCCAAGGCTTTAGTTTTAAATGCCACTG
TGCCTTTAACAAGGTTGTAAATATTTTATGCCCACCAGAGATGTGGTCATAAGATCTGATCCTGAGCCAGAGATTCAGATGGCACAGGAA
GTATTCATGTATTTTAACACTGGGGTTTTCTTTCTTTCATACTGAGATTTTTTTTCAGTATGTATCCTCCAGCTCTTAAAGCTTACCTGA
GAAAGCTTTAAATGAGAAAAGGACCATGCGATTGGTGCTGTGTTACATACACATACTTTCTTGGCTTCTGAGTAGCTCAGGTGTGGCTTT
TGGCTGCAGATGTTAAATTTTGATACCATGTAAACCTACCCAGCTTCTCAGACTTGGGTCTTGTTTTTTGATGGGAACAGAGGTGTTTAG
AGAAAGCCTCTGAGTATGCCTTTCAGATTTTGAACAAGCGGCCTTTTCTAAACATCGACTTCTACTACTCTCTAGCCTTAAAATACCTTC
TGCTTAGATCCAGGGCCCTTCTACTGGAGATAGGAAAAGTAGAATTCAGGAATTAAAAGAATTACTCTTTATTCAATTTGAGGAACTTGG
TGAAAGCCCCTCCTCTTATGACAGCCAGGTTCCTGCTGGCTAGACCAGCCTATTCAGCGCTTTGCTAGGGGATTGGGTGGTCCACGCACT
CGCTAATACAGTTCTCCAGGTGTGGAATGATGTCAATACGATTGCTTGGCCTTTTCCCCCTGTGCCTTTGCTCGGTGCTCTGGTTTCCTC
AGCAACACTCCTTGTAAGGGGCAGAGACAGGGTCCACCAACTCCCCAAGATGAAGAAGCCCCTTCAGGCCAGTCGTGGTGGCTCATGCCT
GTAATCCCAGCACTTTGCAAGGCCGAGGAGGGTGGATCACTTGAGGTCAGGAGTTCGAGACCAGCCTGACCAACATGGCGAAACCCCATC
TCTACTAAAAATACAAAAATTAGCTTGGCATGGTGGTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGGGGCAGGAGAATTGCTTGAA
CTTGGGAGATGGAGGCTGCAGCGAGCCAAGATCGTGCCACTGCACTCCAGCCTGGGCAAGAGTTTTTTTAAGACTCTTAAAAAAAGAGCC
TGGGCAATTTTTTTAAGACTCTGTCTTAAAAAAAACTAAAAAGAAAAAAAGAAGCCCCTTCACTCTACAGGGGACAGGAGACCATGGATT
GGACCCCAAAGGGATTGAACTGCATCTGCATGTCTGTCCTTTGAACACTTTCTCTCCCTGCCCAAAAGGAAACCCAAATTATTTGTGGGA
TACTGGGGAAATTGTAGTGAAGGGCTTAATGTAGTTAATAAAAGTTAAAAGTCAGTAGAAAACAGGTGCCTCAGCCTTCAAATGGTTGCT
TTTTTTCCATTTTCCCTCATGAATAGACTCACCAGCATTTTACCCCCTTGTTATAAAACTGTGCAGAGCAAGAAGATGATACTTATTTTT
GAATTTGTATTTTTAAAACTAGATTTATAGACTTTTTTTTTTTTTAACTAGGGCACTTGCTTCCTTCTTAGCTAAAAGCACCAGCTGAGA
TTTTTCAGGTAATTTTGTTGTTACTCACTTAAGACTGGAATTAGAATGTTTCTGGTATTTCTCATTTTTTTCCCTGGCTATGATAGAATC
TCATCTAATCTTGACATCTCTCCTAGGGGAAGAATATCACAGGCTAATAGCGTGGTTGGGGGTGAAGATGATAGCAGTTATTAAATCAGG
AATCTCTTTTATGTGTGTCCTTGTTACATTGAGGTTAAGAGACAAAATCATTGGCAGTGCAATCTCTTTCCAGGATTTCGTTTGCTGTGG
CATTGGTTATATCAGAGCACTTTAATCTGAAGGATGATACTGTAACTTGATTTATCTAATTAGCTTTTAATTATCTACAGCTATTTTATT
TTATTTAATTCTCTCCTACAGTACTGGGACCACTGTAAACTTCTCAGATGACTTGTATTTTTGTAGTGCTATGAAATTTATTTACATACT
TATAAAGAAAACTGTATGTTCACTTGAACTCTGAAAATGTACATGTATGGCTGGACGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGG
GAGGCTGAGGCGGGTGAATCACTTGATTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAAATA
CAGAAATTAGCTGGGTGTGGTGGCAGACAGCTGTAATCTCAGCTGCTCGGGAGGCTGAGGCACAAGAATCGCTTGAGCCAGGGAGGTGGA
GGTTGCAGTGAGCTGAGATCACATCATTGCACTCCAGCCTGGGCAACGGGCGAGACTCTGTCTCAAAAAAAAGAAAGAAAGAAAAGGTAC
ATGTATATATTTGTCCTGCATTATGTTTTTTACTTGATATAAATGTATTTTTACTGTGATAGTCCAAGTGCCCTGGGGGGCAGGTGTGCT
CTATGTGGTTCTTCTTCCATTGGAGAGCTGGCGTAGAGATCTGCAGTGTTCACAAGGATGTTGGTTTGGAGATGTCTGCTGCTAGGACCT
GGGGTGTGTGACTCAGTCCATATGAGAGGGACATCTGGGTGGAGGAGTAAATTCCTGTGCTCTGAAATGCCACTTGGTAGCTCTGGACAA
TGAAGGACAATTGACTCAAGGGTGCCTGGCTTCTGCTGCTGCTGGGAAAAAATTCAGTTTATAGCATTCCTGCACCTCCCAAAGTAGATA
ACCTGGAGGTCATTCAGTTAACAACTGTCCCTGAGGACTCAGTTTTGGGGGAGGGGTTATCTGGGAGAAGCTTTAGCCTGTTCTGAGCCA
TTAGGAGACATTAGTGAATTGGAGCACTGGAGAATCCTACAAATGGCCTATGTCTCAGAAGAGCTGGGACCTCCTTCCAGCTGCTGCAGA
TGCTGACAGGCCCTGGGAGGCTGCTGTGCTCTGGAGAAGCTGGAGCAGCTCATTTCTTGGCCTAGCCTGGCTGCCTCAGAAAGAGCAGTC
AGGACTTGAGGGAAGCATCAAATTCTATACCCATAAACTGCAGTTGGAAGTCAGCTTTTTGAAATGTCCAGCCTTTGCCCAATTGTTTCA
GATCATCTCATGCCTCAGGCTTTGGCAGGTATCCTGCCCTCCATCTTATTCCAGTGTGTTCACCTCATCAAGGCAGCAGAGTGGATGAAG
GAGTAAGTCTGCCCTTTGCCATACTGAACAGCTGTGGACCCCGATTGGTGAGGGCTCTGCATATGCCTGTATGAAGGAGATACAGGTGTG
TGTGCACATGCCGGTATGAAGAAGACACAGGCATGTGCTTCTCAGTTTTGCTAACAGTGGGAGCTCAACGGGGCAGAGGGAGGAAGGTCC
ATGATGCTCAGCCACATACTGTAGAGAGAGGCAATTTAATGTTAAATGACGCACCATCCTCCCTCCCACCCTTCTCCCAGTCAACTTTTT
TTCTTTTTCTAGAACTACTAATTATCTCTCAAGGCTGAAAAATTAATTGCCTTAGGTGGAGAACTTAATTCCTAGTATCCACCAAACTTA
ACTCCGTATCTCCATATGGTGTCTCCATATCTACTGTGTGAGCTACTTAACTGACGCCCTCTTCCTCCAACTGAAGGATCGCCCAACGTT
TTTGGATTATAGAATTATTATTTCCTGCTTTCTTTCTTTGGGACTTTTGAATTTCTTTGGTTTCGTTTTTAAGAAGTAACCCAACATTTC
CTACAACACTAAATAAAATGGTACTTACCTTTCAAAACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAG
CTTGGGAACTGCCACCATCATCAGTGAGAACTTGAACAATGAGGTCATGATGAAGACTGGAAGTGTCTCCAGAGGCGCAACCCACAGCCA
GGCTTCCTTCCCCTACTGACTCCCCTTCCTCTCTTCCTCCTCTTCCTTCTAGCTCTGGCCAGGCATCTGTCCCCTCTGAATTGGGACATG
GTGCAGACACACAGTCCTCTGAGAGTCCTTCTGTCTTCTCCTCTCTCTCATCTCCCATAGCAGCTCCCATTTCCACATCCACTCCAATTG
AAAGCTGGCCTCTCGTAGACAGGGGCCAGGCCAAGTCTGAAGGACCACCCTTGCTCCCTAAGGCAGAGTTGCAAACTGAGAGTTTAACAC
CGGTTCCAAATTCTGGTTCTTCTGCCCTGGGATCACTTTTCAAACAGCCATCCTTTCCAGCAAATAAAGGGACAGAAGATTCTCTGATGG
GCAGGACCCGTGAGACAGGCACAGAGAAGAACACCAGCAGCCTTGAGTTGGAGGAGTCTCTCCCAGAGCAGCCTGAAACAGGGCGACAAG
AGGAAGAACTTCCGAGATTCCCCTGCAAAAAACAAGACTACAGCCCATCATCTGGAGAAGCCCAGGAAGTACCGTTTGCCCTTTCACTCA
GCAGTGATGGAGCTGTGAGCCCTGTTGGGGAGCTTGCAGCAGGAGGAGACAGAGACTTGGAGAGTCAGGCTGGGTCTCTTGTGGAGAGCA
AAGCCAGGGATGCAGCTGAAGAAGTGGCGCCCCCTCTTCCCATGGGAGCATCAGTCCCTTCCATTGATTCCATGATGCGGAAGCTGGAAG
AGATGGGTCTGAACCTCCGCAAGGACCAGAAGAAAACCAAGAAGCGTGTGTCATTTTCTGAGCAGCTCTTCACGGAAGAGGCAGTGGCGG
GGGCTGCCTTGCTGGTGGAAGGACACAGCAGTTGTCCCCAGGAGCTGAACCCTGCATGGTCTGTTGCTGGAAACGCGTCTGACGGAGAGC
CTCCTGAGTCTCCCCACGCAGAGGACTCAGAAAGGGAATCGGTGACCACACCTGGGCCAGCGACGTGTGGTGCGCCAGCCTCCCCAGCGG
ATCACCTCCTCCTCCCCTCCCAGGAGGAGAGTTTCTCCGAAGTCCCCATGAGTGAAGCAAGCTCAGCGAAAGACACTCCACTCTTTAGGA
TGGAGGGAGAGGATGCCCTTGTGACTCAGTATCAGAGCAAAGCCAGTGACCACGAAGGTTTATTGTCTGACCCCTTGAGTGACCTTCAGT
TGGTCTCAGATTTTAAATCTCCAATCATGGCCGATCTGAACTTAAGCCTTCCTTCCATTCCTGAAGTCGCATCGGATGATGAAAGAATAG
ATCAGGTTGAAGATGACGGAGATCAGGTTGAAGATGATGGAGAGACAGCAAAGTCGTCAACTCTGGACATAGGAGCTTTGTCCTTGGGCT
TGGTAGTCCCCTGTCCTGAGAGGGGAAAGGGGCCCAGTGGCGAGGCAGATAGGTTGGTACTGGGGGAGGGCCTGTGTGATTTCAGGCTGC
AAGCACCCCAGGCATCTGTGACAGCTCCTTCAGAGCAGACCACAGAGTTCGGAATTCACAAACCACATCTTGGCAAGAGCTCAAGCTTGG
ATAAACAGCTGCCAGGCCCCAGTGGTGGTGAGGAAGAAAAACCGATGGGAAATGGGAGTCCAAGCCCGCCTCCTGGCACATCCCTGGACA
ATCCTGTACCCAGCCCCTCCCCTTCTGAGATCTTTCCTGTCACACACTCTTTCCCCAGCTCTGCACATTCTGACACTCACCACACCAGCA
CAGCAGAATCTCAAAAAAAAGCCACAGCAGAGGGCTCCGCTGGTAGAGTTGAAAATTTTGGCAAGAGGAAGCCACTCCTCCAGGCCTGGG
TCTCACCCTCGGAGACACATCCAGTCTCAGCTCAGCCAGGCGCTGGAACTGGGTCAGCCAAGCACAGTCATGTCTCACAAGAGAACAGCG
AGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTTCCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAAT
GATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCATGTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGC
CCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCATTTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCT
GCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAATCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGA
CCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCCCCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCA
GAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAGAAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCA
GGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGGGAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAA
GATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAACCTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCC
AAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCCCAGACCAGAGCTGTCAAGCCCCGAATCAAAGATCAAGACCTTACTTTC
CAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTCTGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGA

>39384_39384_2_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000330843_length(amino acids)=645AA_BP=
MEVSPEAQPTARLPSPTDSPSSLPPLPSSSGQASVPSELGHGADTQSSESPSVFSSLSSPIAAPISTSTPIESWPLVDRGQAKSEGPPLL
PKAELQTESLTPVPNSGSSALGSLFKQPSFPANKGTEDSLMGRTRETGTEKNTSSLELEESLPEQPETGRQEEELPRFPCKKQDYSPSSG
EAQEVPFALSLSSDGAVSPVGELAAGGDRDLESQAGSLVESKARDAAEEVAPPLPMGASVPSIDSMMRKLEEMGLNLRKDQKKTKKRVSF
SEQLFTEEAVAGAALLVEGHSSCPQELNPAWSVAGNASDGEPPESPHAEDSERESVTTPGPATCGAPASPADHLLLPSQEESFSEVPMSE
ASSAKDTPLFRMEGEDALVTQYQSKASDHEGLLSDPLSDLQLVSDFKSPIMADLNLSLPSIPEVASDDERIDQVEDDGDQVEDDGETAKS
STLDIGALSLGLVVPCPERGKGPSGEADRLVLGEGLCDFRLQAPQASVTAPSEQTTEFGIHKPHLGKSSSLDKQLPGPSGGEEEKPMGNG
SPSPPPGTSLDNPVPSPSPSEIFPVTHSFPSSAHSDTHHTSTAESQKKATAEGSAGRVENFGKRKPLLQAWVSPSETHPVSAQPGAGTGS

--------------------------------------------------------------
>39384_39384_3_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000522727_length(transcript)=2897nt_BP=1451nt
GGGAAAAACAGGAAGCGGAAAGGCTGCGAACGCAAAGCAGTGTGGGTTGATTCTGAGGTGCACTGTGGGAAAGAGCTTGTCGCTGCGGTG
TTGCTGTTGGAGACTCGATTGTTGGTGACAGCGAAAGAACGATAACAAAATGCCGGAGCGAGATAGTGAGCCGTTCTCCAACCCTTTGGC
CCCCGATGGCCACGATGTGGATGATCCTCACTCCTTCCACCAATCAAAACTCACCAATGAAGACTTCAGGAAACTTCTCATGACCCCCAG
GGCTGCACCTACCTCTGCACCACCTTCTAAGTCACGTCACCATGAGATGCCAAGGGAGTACAATGAGGATGAAGACCCAGCTGCACGAAG
GAGGAAAAAGAAAAGTTATTATGCCAAGCTACGCCAACAAGAAATTGAGAGAGAGAGAGAGCTAGCAGAGAAGTACCGGGATCGTGCCAA
GGAACGGAGAGATGGAGTGAACAAAGATTATGAAGAAACCGAGCTTATCAGCACCACAGCTAACTATAGGGCTGTTGGCCCCACTGCTGA
GGCGGACAAATCAGCTGCAGAGAAGAGAAGACAGTTGATCCAGGAGTCCAAATTCTTGGGTGGTGACATGGAACACACCCATTTGGTGAA
AGGCTTGGATTTTGCTCTGCTTCAAAAGGTACGAGCTGAGATTGCCAGCAAAGAGAAAGAGGAAGAGGAACTGATGGAAAAGCCCCAGAA
AGAAACCAAGAAAGATGAGGATCCTGAAAATAAAATTGAATTTAAAACACGTCTGGGCCGCAATGTTTACCGAATGCTTTTTAAGAGCAA
AGCATATGAGCGGAATGAGTTGTTCCTGCCGGGCCGCATGGCCTATGTGGTAGACCTGGATGATGAGTATGCTGACACAGATATCCCCAC
CACTCTTATCCGCAGCAAGGCTGATTGCCCCACCATGGAGGCCCAGACCACACTGACCACAAATGACATTGTCATTAGCAAGCTGACCCA
GATCCTTTCATACCTGAGGCAGGGAACCCGTAACAAGAAGCTTAAGAAGAAGGATAAAGGGAAGCTGGAAGAGAAGAAACCTCCTGAGGC
TGACATGAATATTTTTGAAGACATTGGGGATTACGTACCCTCCACAACCAAGACACCTCGGGACAAGGAGCGGGAGAGATATCGGGAACG
GGAGCGTGATCGGGAAAGAGACAGAGACCGTGACCGAGAGCGAGAGCGAGAACGAGATCGGGAACGAGAGCGAGAGCGGGACCGAGAGAG
AGAAGAGGAAAAGAAGAGACACAGCTACTTTGAGAAGCCAAAAGTAGATGATGAGCCCATGGACGTTGACAAAGGACCTGGGTCTACCAA
GGAGTTGATCAAGTCCATCAATGAAAAGTTTGCTGGGTCTGCTGGCTGGGAAGGCACAGAATCGGCATGTCCAACAGTTATGCAGAGTGC
TACCCAGCCACAAATACAGCCCCTCGGACCCTGCATTTGCATATGCGCAGCTGACCCACGATGAGCTGATTCAGCTGGTCCTCAAACAGA
AGGAAACGATAAGCAAGAAGGAGTTCCAGGTCCGCGAGCTGGAAGACTACATTGACAACCTGCTTGTCAGGGTCATGGAAGAAACCCCCA
ATATCCTCCGCATCCCGACTCAGGTTGGCAAAAAAGCAGGAAAGATGTAAATCAGCAGAAAAAAAACACCGAGACGTTTCTGTGACTTCA
CTTTCACCTGCTCCAGGGGTCAAGGACTTGCCTTGCCTGATAACCAGCCAGCAGGCTCCGAATCACCATCTCCCTCACATGTTATCCGGC
AAGAGTACTTCATCCTGTGAAGCCAATGAATGCAATGGCCACCAAGGTTGCTAACTGCAGCTTGGGAACTGCCACCATCATCAGTGAGAA
CTTGAACAATGAGGTCATGATGAAGTCATGTCTCACAAGAGAACAGCGAGTACGGATCTTAAGCAACTGAACCAGGTCAACTTTACCCTT
CCCAAGAAGGAAGGACTTTCCTTTCTTGGTGGCCTTCGGTCTAAGAATGATGTCCTTTCCCGCTCTAATGTCTGCATCAATGGGAACCAT
GTTTACCTGGAGCAGCCAGAAGCCAAGGGTGAGATCAAGGATAGCAGCCCGTCCTCCTCCCCATCCCCCAAGGGCTTCAGAAAGAAGCAT
TTGTTCTCTTCTACAGAGAACCTGGCGGCTGGGTCTTGGAAGGAGCCTGCTGAAGGAGGTGGGCTGTCTTCTGACAGGCAGCTCTCCGAA
TCTTCCACCAAGGACTCCTTGAAGTCTATGACCCTGCCGTCCTACCGACCTGCCCCACTGGTCAGTGGGGACCTCAGGGAAAACATGGCC
CCCGCAAACTCAGAGGCCACAAAAGAAGCTAAGGAGAGCAAGAAGCCAGAGAGCAGGAGGTCCTCTTTGCTGTCTCTGATGACGGGGAAG
AAGGATGTGGCTAAGGGCAGTGAAGGTGAAAACCCTCTCACGGTCCCAGGGAGGGAGAAGGAAGGCATGCTGATGGGGGTTAAGCCGGGG
GAGGACGCATCGGGGCCTGCTGAAGACCTTGTGAGAAGATCTGAGAAAGATACTGCAGCTGTTGTCTCCAGACAGGGCAGCTCCCTGAAC
CTCTTTGAAGATGTGCAGATCACAGAACCAGAAGCTGAGCCAGAGTCCAAGTCTGAACCGAGACCTCCAATTTCCTCTCCGAGGGCTCCC
CAGACCAGAGCTGTCAAGCCCCGAATCAAAGATCAAGACCTTACTTTCCAAGTCAAATTTGCAGAAGACGCCTCTTTCCCAGTCCATGTC
TGTCCTGCCGACTTCAAAGCCAGAAAAAGTGCTGCTTCGTCCCGGAGACTTTCAGTCCCAGTGGGATGAAGATGACAATGAGGATGAGTC

>39384_39384_3_IK-RAB11FIP1_IK_chr5_140039742_ENST00000417647_RAB11FIP1_chr8_37734800_ENST00000522727_length(amino acids)=454AA_BP=
MPERDSEPFSNPLAPDGHDVDDPHSFHQSKLTNEDFRKLLMTPRAAPTSAPPSKSRHHEMPREYNEDEDPAARRRKKKSYYAKLRQQEIE
RERELAEKYRDRAKERRDGVNKDYEETELISTTANYRAVGPTAEADKSAAEKRRQLIQESKFLGGDMEHTHLVKGLDFALLQKVRAEIAS
KEKEEEELMEKPQKETKKDEDPENKIEFKTRLGRNVYRMLFKSKAYERNELFLPGRMAYVVDLDDEYADTDIPTTLIRSKADCPTMEAQT
TLTTNDIVISKLTQILSYLRQGTRNKKLKKKDKGKLEEKKPPEADMNIFEDIGDYVPSTTKTPRDKERERYRERERDRERDRDRDRERER
ERDRERERERDREREEEKKRHSYFEKPKVDDEPMDVDKGPGSTKELIKSINEKFAGSAGWEGTESACPTVMQSATQPQIQPLGPCICICA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IK-RAB11FIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IK-RAB11FIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IK-RAB11FIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource