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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IKZF2-MICU2 (FusionGDB2 ID:39399)

Fusion Gene Summary for IKZF2-MICU2

check button Fusion gene summary
Fusion gene informationFusion gene name: IKZF2-MICU2
Fusion gene ID: 39399
HgeneTgene
Gene symbol

IKZF2

MICU2

Gene ID

22807

221154

Gene nameIKAROS family zinc finger 2mitochondrial calcium uptake 2
SynonymsANF1A2|HELIOS|ZNF1A2|ZNFN1A21110008L20Rik|EFHA1
Cytomap

2q34

13q12.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein Heliosikaros family zinc finger protein 2zinc finger DNA binding protein Helioszinc finger protein, subfamily 1A, 2 (Helios)calcium uptake protein 2, mitochondrialEF hand domain family A1EF hand domain family, member A1EF-hand domain-containing family member A1Smhs2 homolog
Modification date2020031320200315
UniProtAcc

Q9UKS7

Q8IYU8

Ensembl transtripts involved in fusion geneENST00000342002, ENST00000374319, 
ENST00000413091, ENST00000421754, 
ENST00000434687, ENST00000451136, 
ENST00000457361, ENST00000374327, 
ENST00000442445, 		ENST00000479790, 
ENST00000382374, 
Fusion gene scores* DoF score7 X 7 X 5=24513 X 13 X 6=1014
# samples 713
** MAII scorelog2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1014*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IKZF2 [Title/Abstract] AND MICU2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIKZF2(213914437)-MICU2(22069457), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMICU2

GO:0006851

mitochondrial calcium ion transmembrane transport

24560927

TgeneMICU2

GO:0051562

negative regulation of mitochondrial calcium ion concentration

24560927


check buttonFusion gene breakpoints across IKZF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MICU2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-5512-01AIKZF2chr2

213914437

-MICU2chr13

22069457

-
ChimerDB4PRADTCGA-EJ-5512IKZF2chr2

213914437

-MICU2chr13

22069457

-


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Fusion Gene ORF analysis for IKZF2-MICU2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000342002ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000374319ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000413091ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000421754ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000434687ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000451136ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
5CDS-5UTRENST00000457361ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000342002ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000374319ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000413091ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000421754ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000434687ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000451136ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
In-frameENST00000457361ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
intron-3CDSENST00000374327ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
intron-3CDSENST00000442445ENST00000382374IKZF2chr2

213914437

-MICU2chr13

22069457

-
intron-5UTRENST00000374327ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-
intron-5UTRENST00000442445ENST00000479790IKZF2chr2

213914437

-MICU2chr13

22069457

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457361IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-15557431451005286
ENST00000342002IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-15557431451005286
ENST00000434687IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-16968843041146280
ENST00000374319IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-16188063041068254
ENST00000451136IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-13084960758252
ENST00000413091IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-13865740836278
ENST00000421754IKZF2chr2213914437-ENST00000382374MICU2chr1322069457-13084960758252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457361ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0006026820.9993973
ENST00000342002ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0006026820.9993973
ENST00000434687ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0009323560.9990677
ENST00000374319ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0013084770.9986915
ENST00000451136ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0013855580.99861443
ENST00000413091ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0009135860.9990864
ENST00000421754ENST00000382374IKZF2chr2213914437-MICU2chr1322069457-0.0013855580.99861443

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Fusion Genomic Features for IKZF2-MICU2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IKZF2-MICU2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:213914437/chr13:22069457)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IKZF2

Q9UKS7

MICU2

Q8IYU8

FUNCTION: Associates with Ikaros at centromeric heterochromatin.FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:26903221}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69112_134165501.0Zinc fingerC2H2-type 1
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69140_162165501.0Zinc fingerC2H2-type 2
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69112_134191527.0Zinc fingerC2H2-type 1
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69140_162191527.0Zinc fingerC2H2-type 2
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69168_190191527.0Zinc fingerC2H2-type 3
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58112_134191527.0Zinc fingerC2H2-type 1
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58140_162191527.0Zinc fingerC2H2-type 2
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58168_190191527.0Zinc fingerC2H2-type 3
TgeneMICU2chr2:213914437chr13:22069457ENST00000382374912362_397347435.0DomainEF-hand 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69168_190165501.0Zinc fingerC2H2-type 3
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69196_219165501.0Zinc fingerC2H2-type 4
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69471_493165501.0Zinc fingerC2H2-type 5
HgeneIKZF2chr2:213914437chr13:22069457ENST00000374319-69499_523165501.0Zinc fingerC2H2-type 6
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69196_219191527.0Zinc fingerC2H2-type 4
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69471_493191527.0Zinc fingerC2H2-type 5
HgeneIKZF2chr2:213914437chr13:22069457ENST00000434687-69499_523191527.0Zinc fingerC2H2-type 6
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58196_219191527.0Zinc fingerC2H2-type 4
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58471_493191527.0Zinc fingerC2H2-type 5
HgeneIKZF2chr2:213914437chr13:22069457ENST00000457361-58499_523191527.0Zinc fingerC2H2-type 6
TgeneMICU2chr2:213914437chr13:22069457ENST000003823749122_50347435.0Compositional biasNote=Ala-rich
TgeneMICU2chr2:213914437chr13:22069457ENST00000382374912172_207347435.0DomainEF-hand 1
TgeneMICU2chr2:213914437chr13:22069457ENST00000382374912227_262347435.0DomainEF-hand 2
TgeneMICU2chr2:213914437chr13:22069457ENST00000382374912293_328347435.0DomainEF-hand 3


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Fusion Gene Sequence for IKZF2-MICU2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39399_39399_1_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000342002_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1555nt_BP=743nt
GGGCTTGGCTTGGAGGGGGCAAGGGAGGGAAAGAGAGAAGGGGGAAACACAAAAAACTTCTTTCTTTCTCCCTCCGTTTATCTTCAGCCC
GACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGCATTGCACTTTGACTATGGAAACAGA
GGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACC
CAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACC
CCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAG
GAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCC
CAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAA
CCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCAC
AGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGT
CTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATG
GGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGG
AAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTAT
TTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGT
AGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAA
CTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGAC
CAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTT
ATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAATGTTCTATCTGG

>39399_39399_1_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000342002_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=286AA_BP=199
MEMHCTLTMETEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEE
PLIESSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPF
CSYACRRRDALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKES

--------------------------------------------------------------
>39399_39399_2_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000374319_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1618nt_BP=806nt
GCTCCTCGCTGAAGATGGAGGAAGTAAAAACAGGATTACCCTTAGCTACAGATCCACTGCCTTAGTTTCCACCACCAACTGCAGTGCACA
AACACACGTTAGGCACAGGAAAGAAAGAAAGACAGAGGACACATTAACAGTAAACACAAACAAAAGGGTGATGGGATTATTTTACTGCAT
GCACTGCTGAGCCCGACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGGTGATGAATCTT
TTTTAATCAAAGGACAATTTCTTTTCATTGCACTTTGACTATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTC
ACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCAC
AAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGG
TAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCT
TCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTC
TGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGA
GTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGA
TGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGA
ATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATA
ATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATT
CTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGA
TATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACA
CTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCT
TCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTT

>39399_39399_2_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000374319_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=254AA_BP=167
MTMETEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESS
EVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQ

--------------------------------------------------------------
>39399_39399_3_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000413091_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1386nt_BP=574nt
ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC
TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT
GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG
GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTT
TGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACT
CAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGG
GACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATT
TTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCAT
CGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGG
AAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAA
GTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTA
AAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGT
AAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAA
GTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTC
ATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAAT

>39399_39399_3_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000413091_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=278AA_BP=191
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV
ADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRR
DALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKEVW

--------------------------------------------------------------
>39399_39399_4_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000421754_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1308nt_BP=496nt
ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC
TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT
GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG
GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA
GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC
TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC
TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA
AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA
AAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGT
GATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTC
ATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTT
TTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATAC
ATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTT
CAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACAT

>39399_39399_4_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000421754_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=252AA_BP=165
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV
ADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQEL

--------------------------------------------------------------
>39399_39399_5_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000434687_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1696nt_BP=884nt
GCTCCTCGCTGAAGATGGAGGAAGTAAAAACAGGATTACCCTTAGCTACAGATCCACTGCCTTAGTTTCCACCACCAACTGCAGTGCACA
AACACACGTTAGGCACAGGAAAGAAAGAAAGACAGAGGACACATTAACAGTAAACACAAACAAAAGGGTGATGGGATTATTTTACTGCAT
GCACTGCTGAGCCCGACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGGTGATGAATCTT
TTTTAATCAAAGGACAATTTCTTTTCATTGCACTTTGACTATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTC
ACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCAC
AAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGG
TAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCT
TCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCCCAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGA
ACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCC
GTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGC
TGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAG
TCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTG
TGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAA
TTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATA
AGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTG
TCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGAT
ATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAA
TAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCT

>39399_39399_5_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000434687_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=280AA_BP=193
MTMETEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESS
EVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACR
RRDALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKESIKGVKE

--------------------------------------------------------------
>39399_39399_6_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000451136_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1308nt_BP=496nt
ATGGAAACAGAGGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACC
TCAAGCACACCCAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGT
GACAGGAAACCCCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTG
GCTGACAACAGGAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTGAACGCCCCTTCCACTGTAACCAGTGTGGA
GCTTCTTTTACTCAGAAGGGCAACCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCC
TGTAGAAGAAGGGACGCCCTCACAGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTC
TCAAACAATATTTTGGACACTGTCTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAA
AACAGAATGCATCGAGGTTTATGGGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTA
AAAGAAGTCTGGAAACAAGCTGGAAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGT
GATTTTTTAGAAGTACTTGCTATTTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTC
ATAATTTTATTAAAGAACTTAGTAGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTT
TTGTACTTCGGTAAGATGGAAAACTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATAC
ATATGGGAAAAAGTACTTGAGACCAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTT
CAGATTTTTCTCATCTGTACCTTATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACAT

>39399_39399_6_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000451136_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=252AA_BP=165
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEV
ADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSAEFKRAVKVATGQEL

--------------------------------------------------------------
>39399_39399_7_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000457361_MICU2_chr13_22069457_ENST00000382374_length(transcript)=1555nt_BP=743nt
GGGCTTGGCTTGGAGGGGGCAAGGGAGGGAAAGAGAGAAGGGGGAAACACAAAAAACTTCTTTCTTTCTCCCTCCGTTTATCTTCAGCCC
GACATTGTCACCTCCTCTTTGAGGGGTTAGAAGAAGCTGAGATCTCCCGACAGAGCTGGAAATGCATTGCACTTTGACTATGGAAACAGA
GGCTATTGATGGCTATATAACGTGTGACAATGAGCTTTCACCCGAAAGGGAGCACTCCAATATGGCAATTGACCTCACCTCAAGCACACC
CAATGGACAGCATGCCTCACCAAGTCACATGACAAGCACAAATTCAGTAAAGCTAGAAATGCAGAGTGATGAAGAGTGTGACAGGAAACC
CCTGAGCCGTGAAGATGAGATCAGGGGCCATGATGAGGGTAGCAGCCTAGAAGAACCCCTAATTGAGAGCAGCGAGGTGGCTGACAACAG
GAAAGTCCAGGAGCTTCAAGGCGAGGGAGGAATCCGGCTTCCGAATGGTAAACTGAAATGTGACGTCTGTGGCATGGTTTGCATTGGGCC
CAATGTGCTTATGGTACATAAAAGGAGTCACACTGGTGAACGCCCCTTCCACTGTAACCAGTGTGGAGCTTCTTTTACTCAGAAGGGCAA
CCTTCTGAGACACATAAAGTTACACTCTGGAGAGAAGCCGTTCAAATGTCCTTTCTGTAGCTACGCCTGTAGAAGAAGGGACGCCCTCAC
AGGACACCTCAGGACCCATTCTGCGGAGTTTAAGAGAGCTGTGAAAGTAGCAACAGGACAAGAACTCTCAAACAATATTTTGGACACTGT
CTTTAAGATCTTTGATTTGGATGGTGATGAATGTCTTAGTCATGAAGAGTTTCTTGGGGTGTTAAAAAACAGAATGCATCGAGGTTTATG
GGTACCACAACATCAGAGTATACAAGAATACTGGAAGTGTGTGAAGAAAGAAAGCATTAAAGGAGTAAAAGAAGTCTGGAAACAAGCTGG
AAAAGGTCTTTTTTAATAAAAGATATAATAGTATGGCAATTATATTGTTCCAAATGTCAAAATTTGTGATTTTTTAGAAGTACTTGCTAT
TTATCTTCTTAAGTCTTCATTGATATTCTGTGTGAAATAAGCATGTCTTGTACTTGCTTTCTGATTCATAATTTTATTAAAGAACTTAGT
AGAAAGAAAAGTAAGTATAAAAATAGATATTGGATTCTGTCAGAAGGCCTAGATTTGAAATAATGTTTTGTACTTCGGTAAGATGGAAAA
CTTAGTGATTCACTGATTTCTTAGACACTCTAATATGATATGCTTTCTGGAAGGATAAAACAAATACATATGGGAAAAAGTACTTGAGAC
CAAGGCCAGCATCAATTCCAGACATCTTCATGTTCCTAATAGGCTAAATGAAGTTAAAAACTTATTTCAGATTTTTCTCATCTGTACCTT
ATATCTCATAAATTTATTGCATATTTTATGTCAGTAGCTTAGCTGTTTATTGTCTTTAAAATAACATGTAAACTTCAATGTTCTATCTGG

>39399_39399_7_IKZF2-MICU2_IKZF2_chr2_213914437_ENST00000457361_MICU2_chr13_22069457_ENST00000382374_length(amino acids)=286AA_BP=199
MEMHCTLTMETEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEE
PLIESSEVADNRKVQELQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPF
CSYACRRRDALTGHLRTHSAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNRMHRGLWVPQHQSIQEYWKCVKKES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IKZF2-MICU2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IKZF2-MICU2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IKZF2-MICU2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource