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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABHD16A-FAM19A1 (FusionGDB2 ID:394)

Fusion Gene Summary for ABHD16A-FAM19A1

Fusion gene summary

Fusion gene information	Fusion gene name: ABHD16A-FAM19A1
	Fusion gene ID: 394
		Hgene	Tgene
	Gene symbol	ABHD16A	FAM19A1
	Gene ID	7920	407738
	Gene name	abhydrolase domain containing 16A, phospholipase	TAFA chemokine like family member 1
	Synonyms	BAT5\|D6S82E\|NG26\|PP199\|hBAT5	FAM19A1\|TAFA-1
	Cytomap	6p21.33	3p14.1
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylserine lipase ABHD16AHLA-B associated transcript 5abhydrolase domain containing 16Aabhydrolase domain-containing protein 16Aalpha/beta hydrolase domain-containing protein 16Amonoacylglycerol lipase ABHD16Aprotein ABHD16Aprotein G5	chemokine-like protein TAFA-1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1family with sequence similarity 19 member A1, C-C motif chemokine likeprotein FAM19A1
	Modification date	20200327	20200313
	UniProtAcc	O95870	.
	Ensembl transtripts involved in fusion gene	ENST00000375842, ENST00000395952, ENST00000413853, ENST00000429735, ENST00000432617, ENST00000440843, ENST00000444818, ENST00000446529, ENST00000457366, ENST00000464268, ENST00000471644, ENST00000475067, ENST00000482058, ENST00000488103, ENST00000494438, ENST00000495335, ENST00000538874, ENST00000546528, ENST00000547161, ENST00000547325, ENST00000548592, ENST00000549543, ENST00000549722, ENST00000549853, ENST00000550556, ENST00000550719, ENST00000551038, ENST00000552042,	ENST00000478136, ENST00000491017, ENST00000496687,
Fusion gene scores	* DoF score	4 X 3 X 5=60	9 X 8 X 5=360
	# samples	5	10
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABHD16A [Title/Abstract] AND FAM19A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABHD16A(31654740)-FAM19A1(68173021), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABHD16A	GO:0052651	monoacylglycerol catabolic process	25290914
Hgene	ABHD16A	GO:1905344	prostaglandin catabolic process	25290914

Fusion gene breakpoints across ABHD16A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FAM19A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AV682461	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+

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Fusion Gene ORF analysis for ABHD16A-FAM19A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000375842	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
5CDS-intron	ENST00000375842	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
5CDS-intron	ENST00000375842	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000395952	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000395952	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000395952	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000413853	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000413853	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000413853	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000429735	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000429735	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000429735	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000432617	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000432617	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000432617	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000440843	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000440843	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000440843	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000444818	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000444818	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000444818	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000446529	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000446529	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000446529	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000457366	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000457366	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000457366	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000464268	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000464268	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000464268	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000471644	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000471644	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000471644	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000475067	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000475067	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000475067	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000482058	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000482058	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000482058	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000488103	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000488103	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000488103	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000494438	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000494438	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000494438	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000495335	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000495335	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000495335	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000538874	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000538874	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000538874	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000546528	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000546528	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000546528	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547161	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547161	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547161	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547325	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547325	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000547325	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000548592	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000548592	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000548592	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549543	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549543	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549543	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549722	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549722	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549722	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549853	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549853	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000549853	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550556	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550556	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550556	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550719	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550719	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000550719	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000551038	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000551038	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000551038	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000552042	ENST00000478136	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000552042	ENST00000491017	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+
intron-intron	ENST00000552042	ENST00000496687	ABHD16A	chr6	31654740	-	FAM19A1	chr3	68173021	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ABHD16A-FAM19A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ABHD16A-FAM19A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31654740/:68173021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABHD16A O95870	.
FUNCTION: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250\|UniProtKB:Q9Z1Q2, ECO:0000269\|PubMed:25290914}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ABHD16A-FAM19A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ABHD16A-FAM19A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ABHD16A-FAM19A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ABHD16A-FAM19A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source