FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ALDOA-CCT5 (FusionGDB2 ID:3940)

Fusion Gene Summary for ALDOA-CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDOA-CCT5
Fusion gene ID: 3940
HgeneTgene
Gene symbol

ALDOA

CCT5

Gene ID

112694756

22948

Gene nameuncharaterized LOC112694756chaperonin containing TCP1 subunit 5
SynonymsALDA|ALDOACCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

-

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionuncharaterized LOC112694756Fructose-bisphosphate aldolase ALung cancer antigen NY-LU-1Muscle-type aldolaseT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2020030320200313
UniProtAcc

P04075

P48643

Ensembl transtripts involved in fusion geneENST00000395248, ENST00000564546, 
ENST00000338110, ENST00000412304, 
ENST00000563060, ENST00000564595, 
ENST00000566897, ENST00000395240, 
ENST00000569545, ENST00000569798, 
ENST00000575627, 		ENST00000280326, 
ENST00000503026, ENST00000506600, 
ENST00000515390, ENST00000515676, 
Fusion gene scores* DoF score37 X 23 X 12=1021258 X 14 X 17=13804
# samples 4261
** MAII scorelog2(42/10212*10)=-4.603732304741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(61/13804*10)=-4.50013332598527
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDOA [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDOA(30081734)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.ALDOA-CCT5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDOA-CCT5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ALDOA-CCT5 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDOA-CCT5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALDOA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N6-A4VD-01AALDOAchr16

30081734

-CCT5chr5

10250033

+


Top

Fusion Gene ORF analysis for ALDOA-CCT5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000395248ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-3CDSENST00000564546ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000395248ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000395248ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000395248ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000395248ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000564546ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000564546ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000564546ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
3UTR-intronENST00000564546ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000338110ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000338110ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000338110ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000338110ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000412304ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000412304ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000412304ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000412304ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000563060ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000563060ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000563060ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000563060ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000564595ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000564595ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000564595ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000564595ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000566897ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000566897ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000566897ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
5CDS-intronENST00000566897ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
Frame-shiftENST00000338110ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
Frame-shiftENST00000412304ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
Frame-shiftENST00000563060ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
Frame-shiftENST00000564595ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
In-frameENST00000566897ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-3CDSENST00000395240ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-3CDSENST00000569545ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-3CDSENST00000569798ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-3CDSENST00000575627ENST00000280326ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000395240ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000395240ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000395240ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000395240ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569545ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569545ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569545ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569545ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569798ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569798ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569798ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000569798ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000575627ENST00000503026ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000575627ENST00000506600ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000575627ENST00000515390ALDOAchr16

30081734

-CCT5chr5

10250033

+
intron-intronENST00000575627ENST00000515676ALDOAchr16

30081734

-CCT5chr5

10250033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000566897ALDOAchr1630081734-ENST00000280326CCT5chr510250033+6123244828384493551

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000566897ENST00000280326ALDOAchr1630081734-CCT5chr510250033+0.0023116460.9976884

Top

Fusion Genomic Features for ALDOA-CCT5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ALDOA-CCT5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:30081734/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDOA

P04075

CCT5

P48643

FUNCTION: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ALDOA-CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3940_3940_1_ALDOA-CCT5_ALDOA_chr16_30081734_ENST00000566897_CCT5_chr5_10250033_ENST00000280326_length(transcript)=6123nt_BP=2448nt
CGCGAACGGCTTCTGGGCGGGGCCGGTCCCTCGGACGATTGGACCTAGCTTGGCGCGGAATCCGTGAATTGCCCGCGGCCCGAGGGTGCA
GGTGATGGGTGCTGACCGACTGGGGAAGCCCGGAGTGTGGGGACTGAGGAGGGGAGTGGCCTGGGGCGCGCTGGAGCCTGCGAGGAAGGC
GCCGCCTCGGATCCCCCGCCCCCCATTCCCCTTCCCGAATTCCACCCTCCGGCCCAGCCATGGCCTCAGTTTCCCCAAACAGGAAAGGGA
AGGAGGGTGGGCACCCCGGTCTAACGGTGCCTCTCAGCCTCTGAGACCCAGAACCTTCCTTCTGCAGCTCCCGGACTGACTGGCTCTGCC
CTTCCCCATGGACGCCCAGGGCTGCTGCGCGGACGGTAGCTCCCCCTGCAGGAAGCAAGGTTCCTCCGGGCCCCCAGACTGCTGCTGGAC
CTGTGCAGAAGCCTGCAACTTTCCTCTGCCTAGCCCGGCCCACTTCCTGGATGCTTGCTGCCCCCAGCCCACCAGAGCTGACTGGGCACC
TCGCTGCCCCCGCTGCTGCCCACTCTGCGACTGTGCCTGTACGTGCCAGCTCCCCGACTGCCAGAGCCTCAACTGTCTCTGCTTCGAGAT
CAAGCTCCGATGAGGACCCAGGGCCCCTGCCCTCTGGGGAGCGGCCAGCCCCCAGGGCCCATGTGCCCTCCTCCCTGAAGAGCCTTTCCC
CACGCCACTGGAACCACAGATGGCCTGCCGAGCACCCAGGCCTGGGAACTGGAAGTGGCAGCGCAGGGCCTGGCTCCCTGCAGGGCAGGA
CTCTTGGCCGGCTGGACGGCAGCTCCTCTGGAGGGCCAGAAAAGAGAGGGGCTAGTGCTCGGGCAGGTGCCCTGGCTTCCCTTCCCCTCC
ACACGTCAACGATTCTATTTGAAGTTGGGCAGGGGGGTGGCGCTGCTCACCACACACAAGTGTTATAGGAGGAGTCTGGCCCTTGAGTAC
CGGGTACGCAGGGGTGCCTCAACCACACTCCGTCCACGGACTCTCCGTTATTTTAGGAGGTCCCTGGCCAAAGATTTATTTCTCTTGACA
ACCAAGGGCCTCCGTCTGGATTTCCAAGGAAGAATTTCCTCTGAAGCACCGGAACTTGCTACTACCAGCACCATGCCCTACCAATATCCA
GCACTGACCCCGGAGCAGAAGAAGGAGCTGTCTGACATCGCTCACCGCATCGTGGCACCTGGCAAGGGCATCCTGGCTGCAGATGAGTCC
ACTGGGAGCATTGCCAAGCGGCTGCAGTCCATTGGCACCGAGAACACCGAGGAGAACCGGCGCTTCTACCGCCAGCTGCTGCTGACAGCT
GACGACCGCGTGAACCCCTGCATTGGGGGTGTCATCCTCTTCCATGAGACACTCTACCAGAAGGCGGATGATGGGCGTCCCTTCCCCCAA
GTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGGTAGACAAGGGCGTGGTCCCCCTGGCAGGGACAAATGGCGAGACTACCACCCAA
GGGTTGGATGGGCTGTCTGAGCGCTGTGCCCAGTACAAGAAGGACGGAGCTGACTTCGCCAAGTGGCGTTGTGTGCTGAAGATTGGGGAA
CACACCCCCTCAGCCCTCGCCATCATGGAAAATGCCAATGTTCTGGCCCGTTATGCCAGTATCTGCCAGCAGAATGGCATTGTGCCCATC
GTGGAGCCTGAGATCCTCCCTGATGGGGACCATGACTTGAAGCGCTGCCAGTATGTGACCGAGAAGGTGCTGGCTGCTGTCTACAAGGCT
CTGAGTGACCACCACATCTACCTGGAAGGCACCTTGCTGAAGCCCAACATGGTCACCCCAGGCCATGCTTGCACTCAGAAGTTTTCTCAT
GAGGAGATTGCCATGGCGACCGTCACAGCGCTGCGCCGCACAGTGCCCCCCGCTGTCACTGGGATCACCTTCCTGTCTGGAGGCCAGAGT
GAGGAGGAGGCGTCCATCAACCTCAATGCCATTAACAAGTGCCCCCTGCTGAAGCCCTGGGCCCTGACCTTCTCCTACGGCCGAGCCCTG
CAGGCCTCTGCCCTGAAGGCCTGGGGCGGGAAGAAGGAGAACCTGAAGGCTGCGCAGGAGGAGTATGTCAAGCGAGCCCTGGCCAACAGC
CTTGCCTGTCAAGGAAAGTACACTCCGAGCGGTCAGGCTGGGGCTGCTGCCAGCGAGTCCCTCTTCGTCTCTAACCACGCCTATTAAGCG
GAGGTGTTCCCAGGCTGCCCCCAACACTCCAGGCCCTGCCCCCTCCCACTCTTGAAGAGGAGGCCGCCTCCTCGGGGCTCCAGGCTGGCT
TGCCCGCGCTCTTTCTTCCCTCGTGACAGTGGTGTGTGGTGTCGTCTGTGAATGCTAAGTCCATCACCCTTTCCGGCACACTGCCAAATA
AACAGCTATTTAAGGGGGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGT
GCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTT
GACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGAT
TCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCC
TCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATG
GGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTC
AAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAG
GATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTG
TCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTA
GACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGC
GTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAG
ATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAA
GTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAA
GATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTAT
AAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGG
GGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCC
ATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTT
GGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATC
ATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCT
GCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCA
CTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAG
ATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAG
CAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACAT
TGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTT
CCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTC
AACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAA
TTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCT
CTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCA
CAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGC
CTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGG
CTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAAT
CTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCC
GAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAAT
TGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGT
TATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTT
ATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTC
ATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTG
TGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAG
TTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATC
AGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGG
AAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCACGTGATGTCTTTTATTTTTCACGTT

>3940_3940_1_ALDOA-CCT5_ALDOA_chr16_30081734_ENST00000566897_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ALDOA-CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ALDOA-CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ALDOA-CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource