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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IKZF3-BCAS3 (FusionGDB2 ID:39402)

Fusion Gene Summary for IKZF3-BCAS3

Fusion gene summary

Fusion gene information	Fusion gene name: IKZF3-BCAS3
	Fusion gene ID: 39402
		Hgene	Tgene
	Gene symbol	IKZF3	BCAS3
	Gene ID	22806	54828
	Gene name	IKAROS family zinc finger 3	BCAS3 microtubule associated cell migration factor
	Synonyms	AIO\|AIOLOS\|ZNFN1A3	GAOB1\|MAAB
	Cytomap	17q12-q21.1	17q23.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein Aioloszinc finger DNA binding protein Aioloszinc finger protein, subfamily 1A, 3 (Aiolos)	breast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
	Modification date	20200327	20200313
	UniProtAcc	Q9UKT9	Q9H6U6
	Ensembl transtripts involved in fusion gene	ENST00000346872, ENST00000351680, ENST00000377944, ENST00000377958, ENST00000394189, ENST00000439016, ENST00000439167, ENST00000467757, ENST00000535189, ENST00000583368, ENST00000346243, ENST00000350532, ENST00000377945, ENST00000377952,	ENST00000585744, ENST00000585812, ENST00000588874, ENST00000390652, ENST00000407086, ENST00000408905, ENST00000588462, ENST00000589222,
Fusion gene scores	* DoF score	10 X 9 X 7=630	45 X 32 X 19=27360
	# samples	11	53
	** MAII score	log2(11/630*10)=-2.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(53/27360*10)=-5.6899320603227 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IKZF3 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IKZF3(37933904)-BCAS3(58945937), # samples:2
Anticipated loss of major functional domain due to fusion event.	IKZF3-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. IKZF3-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. IKZF3-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. IKZF3-BCAS3 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. IKZF3-BCAS3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BCAS3	GO:0043085	positive regulation of catalytic activity	17505058
Tgene	BCAS3	GO:0045944	positive regulation of transcription by RNA polymerase II	17505058
Tgene	BCAS3	GO:0071391	cellular response to estrogen stimulus	17505058

Fusion gene breakpoints across IKZF3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BCAS3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A250-01A	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+

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Fusion Gene ORF analysis for IKZF3-BCAS3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000346872	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000346872	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000346872	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000351680	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000351680	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000351680	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377944	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377944	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377944	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377958	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377958	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000377958	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000394189	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000394189	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000394189	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439016	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439016	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439016	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439167	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439167	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000439167	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000467757	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000467757	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000467757	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000535189	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000535189	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000535189	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000583368	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000583368	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
5CDS-intron	ENST00000583368	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000346872	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000346872	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000346872	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000346872	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000346872	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000351680	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000351680	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000351680	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000351680	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000351680	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377944	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377944	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377944	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377944	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377944	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377958	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377958	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377958	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377958	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000377958	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000394189	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000394189	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000394189	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000394189	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000394189	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439016	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439016	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439016	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439016	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439016	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439167	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439167	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439167	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439167	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000439167	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000467757	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000467757	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000467757	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000467757	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000467757	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000535189	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000535189	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000535189	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000535189	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000535189	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000583368	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000583368	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000583368	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000583368	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
Frame-shift	ENST00000583368	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000346243	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000346243	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000346243	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000346243	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000346243	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000350532	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000350532	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000350532	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000350532	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000350532	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377945	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377945	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377945	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377945	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377945	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377952	ENST00000390652	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377952	ENST00000407086	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377952	ENST00000408905	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377952	ENST00000588462	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-3CDS	ENST00000377952	ENST00000589222	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000346243	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000346243	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000346243	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000350532	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000350532	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000350532	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377945	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377945	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377945	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377952	ENST00000585744	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377952	ENST00000585812	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+
intron-intron	ENST00000377952	ENST00000588874	IKZF3	chr17	37933904	-	BCAS3	chr17	58945937	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for IKZF3-BCAS3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IKZF3	chr17	37933903	-	BCAS3	chr17	58945936	+	4.47E-06	0.9999956
IKZF3	chr17	37933903	-	BCAS3	chr17	58945936	+	4.47E-06	0.9999956

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IKZF3-BCAS3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37933904/:58945937)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IKZF3 Q9UKT9	BCAS3 Q9H6U6
FUNCTION: Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner. {ECO:0000269\|PubMed:10369681}.	FUNCTION: Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. {ECO:0000250\|UniProtKB:Q8CCN5, ECO:0000269\|PubMed:17505058}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for IKZF3-BCAS3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IKZF3-BCAS3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IKZF3-BCAS3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IKZF3-BCAS3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source