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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALDOA-CLCN7 (FusionGDB2 ID:3941)

Fusion Gene Summary for ALDOA-CLCN7

check button Fusion gene summary
Fusion gene informationFusion gene name: ALDOA-CLCN7
Fusion gene ID: 3941
HgeneTgene
Gene symbol

ALDOA

CLCN7

Gene ID

112694756

1186

Gene nameuncharaterized LOC112694756chloride voltage-gated channel 7
SynonymsALDA|ALDOACLC-7|CLC7|HOD|OPTA2|OPTB4|PPP1R63
Cytomap

-

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionuncharaterized LOC112694756Fructose-bisphosphate aldolase ALung cancer antigen NY-LU-1Muscle-type aldolaseH(+)/Cl(-) exchange transporter 7chloride channel 7 alpha subunitchloride channel protein 7chloride channel, voltage-sensitive 7protein phosphatase 1, regulatory subunit 63
Modification date2020030320200315
UniProtAcc

P04075

P51798

Ensembl transtripts involved in fusion geneENST00000338110, ENST00000395248, 
ENST00000412304, ENST00000563060, 
ENST00000566897, ENST00000569545, 
ENST00000395240, ENST00000564546, 
ENST00000564595, ENST00000569798, 
ENST00000575627, 		ENST00000262318, 
ENST00000382745, ENST00000448525, 
ENST00000566812, 
Fusion gene scores* DoF score37 X 23 X 12=102128 X 5 X 6=240
# samples 428
** MAII scorelog2(42/10212*10)=-4.603732304741
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALDOA [Title/Abstract] AND CLCN7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALDOA(30075826)-CLCN7(1499328), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ALDOA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLCN7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-MS-A51UALDOAchr16

30075826

+CLCN7chr16

1499328

-


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Fusion Gene ORF analysis for ALDOA-CLCN7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000338110ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000338110ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000338110ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000395248ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000395248ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000395248ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000412304ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000412304ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000412304ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000563060ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000563060ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000563060ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000566897ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000566897ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000566897ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000569545ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000569545ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-3CDSENST00000569545ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000338110ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000395248ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000412304ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000563060ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000566897ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
5UTR-intronENST00000569545ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000395240ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000395240ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000395240ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564546ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564546ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564546ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564595ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564595ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000564595ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000569798ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000569798ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000569798ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000575627ENST00000262318ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000575627ENST00000382745ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-3CDSENST00000575627ENST00000448525ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-intronENST00000395240ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-intronENST00000564546ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-intronENST00000564595ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-intronENST00000569798ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-
intron-intronENST00000575627ENST00000566812ALDOAchr16

30075826

+CLCN7chr16

1499328

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ALDOA-CLCN7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ALDOA-CLCN7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30075826/:1499328)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDOA

P04075

CLCN7

P51798

FUNCTION: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189, PubMed:21527911). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:18449189, PubMed:21527911, PubMed:31155284). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189, ECO:0000269|PubMed:21527911, ECO:0000269|PubMed:31155284}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ALDOA-CLCN7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ALDOA-CLCN7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALDOA-CLCN7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALDOA-CLCN7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource