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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL12RB2-SDC3 (FusionGDB2 ID:39431)

Fusion Gene Summary for IL12RB2-SDC3

check button Fusion gene summary
Fusion gene informationFusion gene name: IL12RB2-SDC3
Fusion gene ID: 39431
HgeneTgene
Gene symbol

IL12RB2

SDC3

Gene ID

3595

9672

Gene nameinterleukin 12 receptor subunit beta 2syndecan 3
Synonyms-SDCN|SYND3
Cytomap

1p31.3

1p35.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-12 receptor subunit beta-2IL-12 receptor subunit beta-2IL-12R subunit beta-2interleukin 12 receptor, beta 2interleukin-12 receptor beta-2 chainsyndecan-3N-syndecansyndecan neural typesyndecan proteoglycan 3
Modification date2020031520200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262345, ENST00000371000, 
ENST00000541374, ENST00000544434, 
ENST00000465396, 		ENST00000471567, 
ENST00000336798, ENST00000339394, 
Fusion gene scores* DoF score4 X 5 X 3=609 X 8 X 6=432
# samples 411
** MAII scorelog2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL12RB2 [Title/Abstract] AND SDC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL12RB2(67816772)-SDC3(31350012), # samples:3
Anticipated loss of major functional domain due to fusion event.IL12RB2-SDC3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
IL12RB2-SDC3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL12RB2

GO:0032729

positive regulation of interferon-gamma production

11114383


check buttonFusion gene breakpoints across IL12RB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SDC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A2NG-06AIL12RB2chr1

67816772

-SDC3chr1

31350012

-
ChimerDB4SKCMTCGA-ER-A2NG-06AIL12RB2chr1

67816772

+SDC3chr1

31350012

-


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Fusion Gene ORF analysis for IL12RB2-SDC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262345ENST00000471567IL12RB2chr1

67816772

+SDC3chr1

31350012

-
5CDS-5UTRENST00000371000ENST00000471567IL12RB2chr1

67816772

+SDC3chr1

31350012

-
5CDS-5UTRENST00000541374ENST00000471567IL12RB2chr1

67816772

+SDC3chr1

31350012

-
5CDS-5UTRENST00000544434ENST00000471567IL12RB2chr1

67816772

+SDC3chr1

31350012

-
Frame-shiftENST00000262345ENST00000336798IL12RB2chr1

67816772

+SDC3chr1

31350012

-
Frame-shiftENST00000371000ENST00000336798IL12RB2chr1

67816772

+SDC3chr1

31350012

-
Frame-shiftENST00000541374ENST00000336798IL12RB2chr1

67816772

+SDC3chr1

31350012

-
Frame-shiftENST00000544434ENST00000336798IL12RB2chr1

67816772

+SDC3chr1

31350012

-
In-frameENST00000262345ENST00000339394IL12RB2chr1

67816772

+SDC3chr1

31350012

-
In-frameENST00000371000ENST00000339394IL12RB2chr1

67816772

+SDC3chr1

31350012

-
In-frameENST00000541374ENST00000339394IL12RB2chr1

67816772

+SDC3chr1

31350012

-
In-frameENST00000544434ENST00000339394IL12RB2chr1

67816772

+SDC3chr1

31350012

-
intron-3CDSENST00000465396ENST00000336798IL12RB2chr1

67816772

+SDC3chr1

31350012

-
intron-3CDSENST00000465396ENST00000339394IL12RB2chr1

67816772

+SDC3chr1

31350012

-
intron-5UTRENST00000465396ENST00000471567IL12RB2chr1

67816772

+SDC3chr1

31350012

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371000IL12RB2chr167816772+ENST00000339394SDC3chr131350012-304718986342970778
ENST00000262345IL12RB2chr167816772+ENST00000339394SDC3chr131350012-304718986342970778
ENST00000541374IL12RB2chr167816772+ENST00000339394SDC3chr131350012-262614772132549778
ENST00000544434IL12RB2chr167816772+ENST00000339394SDC3chr131350012-24571308442380778

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371000ENST00000339394IL12RB2chr167816772+SDC3chr131350012-0.0014017670.9985983
ENST00000262345ENST00000339394IL12RB2chr167816772+SDC3chr131350012-0.0014017670.9985983
ENST00000541374ENST00000339394IL12RB2chr167816772+SDC3chr131350012-0.0008641520.9991359
ENST00000544434ENST00000339394IL12RB2chr167816772+SDC3chr131350012-0.0011513990.99884856

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Fusion Genomic Features for IL12RB2-SDC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL12RB2-SDC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:67816772/chr1:31350012)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916208_211419863.0Compositional biasNote=Poly-Ser
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915208_211419660.0Compositional biasNote=Poly-Ser
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016208_211419660.0Compositional biasNote=Poly-Ser
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914208_211419777.0Compositional biasNote=Poly-Ser
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916126_221419863.0DomainFibronectin type-III 1
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916226_319419863.0DomainFibronectin type-III 2
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916320_419419863.0DomainFibronectin type-III 3
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915126_221419660.0DomainFibronectin type-III 1
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915226_319419660.0DomainFibronectin type-III 2
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915320_419419660.0DomainFibronectin type-III 3
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016126_221419660.0DomainFibronectin type-III 1
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016226_319419660.0DomainFibronectin type-III 2
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016320_419419660.0DomainFibronectin type-III 3
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914126_221419777.0DomainFibronectin type-III 1
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914226_319419777.0DomainFibronectin type-III 2
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914320_419419777.0DomainFibronectin type-III 3
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916305_309419863.0MotifNote=WSXWS motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915305_309419660.0MotifNote=WSXWS motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016305_309419660.0MotifNote=WSXWS motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914305_309419777.0MotifNote=WSXWS motif
TgeneSDC3chr1:67816772chr1:31350012ENST0000033939415115_30285443.0Compositional biasNote=Ser/Thr-rich (mucin-like)
TgeneSDC3chr1:67816772chr1:31350012ENST0000033939415409_44285443.0Topological domainCytoplasmic
TgeneSDC3chr1:67816772chr1:31350012ENST0000033939415388_40885443.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916750_753419863.0Compositional biasNote=Poly-Pro
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915750_753419660.0Compositional biasNote=Poly-Pro
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016750_753419660.0Compositional biasNote=Poly-Pro
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914750_753419777.0Compositional biasNote=Poly-Pro
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916423_520419863.0DomainFibronectin type-III 4
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916521_620419863.0DomainFibronectin type-III 5
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915423_520419660.0DomainFibronectin type-III 4
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915521_620419660.0DomainFibronectin type-III 5
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016423_520419660.0DomainFibronectin type-III 4
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016521_620419660.0DomainFibronectin type-III 5
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914423_520419777.0DomainFibronectin type-III 4
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914521_620419777.0DomainFibronectin type-III 5
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916662_670419863.0MotifNote=Box 1 motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915662_670419660.0MotifNote=Box 1 motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016662_670419660.0MotifNote=Box 1 motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914662_670419777.0MotifNote=Box 1 motif
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916796_801419863.0RegionNote=Required for STAT4 binding
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915796_801419660.0RegionNote=Required for STAT4 binding
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016796_801419660.0RegionNote=Required for STAT4 binding
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914796_801419777.0RegionNote=Required for STAT4 binding
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+91624_622419863.0Topological domainExtracellular
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916644_862419863.0Topological domainCytoplasmic
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+91524_622419660.0Topological domainExtracellular
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915644_862419660.0Topological domainCytoplasmic
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+101624_622419660.0Topological domainExtracellular
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016644_862419660.0Topological domainCytoplasmic
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+91424_622419777.0Topological domainExtracellular
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914644_862419777.0Topological domainCytoplasmic
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000262345+916623_643419863.0TransmembraneHelical
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000371000+915623_643419660.0TransmembraneHelical
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000541374+1016623_643419660.0TransmembraneHelical
HgeneIL12RB2chr1:67816772chr1:31350012ENST00000544434+914623_643419777.0TransmembraneHelical
TgeneSDC3chr1:67816772chr1:31350012ENST00000339394151_38785443.0Topological domainExtracellular


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Fusion Gene Sequence for IL12RB2-SDC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39431_39431_1_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000262345_SDC3_chr1_31350012_ENST00000339394_length(transcript)=3047nt_BP=1898nt
TGCAGAGCACAGAGAAAGGACATCTGCGAGGAAAGTTCCCTGATGGCTGTCAACAAAGTGCCACGTCTCTATGGCTGTGAACGCTGAGCA
CACGATTTTATCGCGCCTATCATATCTTGGTGCATAAACGCACCTCACCTCGGTCAACCCTTGCTCCGTCTTATGAGACAGGCTTTATTA
TCCGCATTTTATATGAGGGGAAACTGACGGTGGAGAGAGAATTATCTTGCTCAAGGCGACACAGCAGAGCCCACAGGTGGCAGAATCCCA
CCCGAGCCCGCTTCGACCCGCGGGGTGGAAACCACGGGCGCCCGCCCGGCTGCGCTTCCAGAGCTGAACTGAGAAGCGAGTCCTCTCCGC
CCTGCGGCCACCGCCCAGCCCCGACCCCCGCCCCGGCCCGATCCTCACTCGCCGCCAGCTCCCCGCGCCCACCCCGGAGTTGGTGGCGCA
GAGGCGGGAGGCGGAGGCGGGAGGGCGGGCGCTGGCACCGGGAACGCCCGAGCGCCGGCAGAGAGCGCGGAGAGCGCGACACGTGCGGCC
CAGAGCACCGGGGCCACCCGGTCCCCGCAGGCCCGGGACCGCGCCCGCTGGCAGGCGACACGTGGAAGAATACGGAGTTCTATACCAGAG
TTGATTGTTGATGGCACATACTTTTAGAGGATGCTCATTGGCATTTATGTTTATAATCACGTGGCTGTTGATTAAAGCAAAAATAGATGC
GTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGACA
AGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAATTC
TCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCAGA
GATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAAAG
AGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATTTA
TTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTTGG
AAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAGGC
TTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTCTG
GAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCTAA
GCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGATGT
CTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAAAT
TCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTCAT
TCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTGTG
TGAGGCAGACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTCAGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGT
GCTGCCCACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTCCCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCT
GGTGGTGACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTCTCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGA
CCCGACTGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGCACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTAT
AAGGACCACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTGGCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCC
CACCACGGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTCAGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGC
CACCACCCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGGACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAAC
TCCAGAGACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTGAGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGA
GACCACACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCTGCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGG
TGCCCGCCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGCTCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAA
GGAGGTGCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTTGCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAA
AAAGGATGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTCACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTA

>39431_39431_1_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000262345_SDC3_chr1_31350012_ENST00000339394_length(amino acids)=778AA_BP=421
MLMAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQ
VTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYC
DYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWN
MVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKIL
HYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEADFEQESGIETAMRFSPDVALAVSTTPAVL
PTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIR
TTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTP
ETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKE

--------------------------------------------------------------
>39431_39431_2_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000371000_SDC3_chr1_31350012_ENST00000339394_length(transcript)=3047nt_BP=1898nt
TGCAGAGCACAGAGAAAGGACATCTGCGAGGAAAGTTCCCTGATGGCTGTCAACAAAGTGCCACGTCTCTATGGCTGTGAACGCTGAGCA
CACGATTTTATCGCGCCTATCATATCTTGGTGCATAAACGCACCTCACCTCGGTCAACCCTTGCTCCGTCTTATGAGACAGGCTTTATTA
TCCGCATTTTATATGAGGGGAAACTGACGGTGGAGAGAGAATTATCTTGCTCAAGGCGACACAGCAGAGCCCACAGGTGGCAGAATCCCA
CCCGAGCCCGCTTCGACCCGCGGGGTGGAAACCACGGGCGCCCGCCCGGCTGCGCTTCCAGAGCTGAACTGAGAAGCGAGTCCTCTCCGC
CCTGCGGCCACCGCCCAGCCCCGACCCCCGCCCCGGCCCGATCCTCACTCGCCGCCAGCTCCCCGCGCCCACCCCGGAGTTGGTGGCGCA
GAGGCGGGAGGCGGAGGCGGGAGGGCGGGCGCTGGCACCGGGAACGCCCGAGCGCCGGCAGAGAGCGCGGAGAGCGCGACACGTGCGGCC
CAGAGCACCGGGGCCACCCGGTCCCCGCAGGCCCGGGACCGCGCCCGCTGGCAGGCGACACGTGGAAGAATACGGAGTTCTATACCAGAG
TTGATTGTTGATGGCACATACTTTTAGAGGATGCTCATTGGCATTTATGTTTATAATCACGTGGCTGTTGATTAAAGCAAAAATAGATGC
GTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGACA
AGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAATTC
TCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCAGA
GATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAAAG
AGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATTTA
TTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTTGG
AAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAGGC
TTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTCTG
GAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTTACAGAATATGAATTTCAGATTTCCTCTAA
GCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGATGT
CTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAAAT
TCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATCACAGGACACACCTCCTGGACCACAGTCAT
TCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTGTG
TGAGGCAGACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTCAGCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGT
GCTGCCCACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTCCCCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCT
GGTGGTGACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTCTCCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGA
CCCGACTGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGCACCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTAT
AAGGACCACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTGGCTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCC
CACCACGGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTCAGCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGC
CACCACCCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGGACCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAAC
TCCAGAGACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTGAGTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGA
GACCACACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCTGCGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGG
TGCCCGCCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGCTCAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAA
GGAGGTGCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTTGCTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAA
AAAGGATGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTCACATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTA

>39431_39431_2_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000371000_SDC3_chr1_31350012_ENST00000339394_length(amino acids)=778AA_BP=421
MLMAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQ
VTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYC
DYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWN
MVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKIL
HYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEADFEQESGIETAMRFSPDVALAVSTTPAVL
PTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIR
TTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTP
ETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKE

--------------------------------------------------------------
>39431_39431_3_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000541374_SDC3_chr1_31350012_ENST00000339394_length(transcript)=2626nt_BP=1477nt
AGAGAGCGCGGAGAGCGCGACACGTGCGGCCCAGAGCACCGGGGCCACCCGGTCCCCGCAGGCCCGGGACCGCGCCCGCTGGCAGGCGAC
ACGTGGTCACGGTGATCCATTTGTAAAGTCGGGAATAAATGACCTCTGAAGTGTTGTCTGTATATTGATCTGCTACCAGTAAAACATATC
TCTGAAGAATACGGAGTTCTATACCAGAGTTGATTGTTGATGGCACATACTTTTAGAGGATGCTCATTGGCATTTATGTTTATAATCACG
TGGCTGTTGATTAAAGCAAAAATAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTGGATCCACTGTC
AATATTACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTGACAGAAGAATC
AATTTTCACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGGCCTGTATCAAT
AGTGATGAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATACAGAAGGGAGAA
CAGGGGACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGACCAAAAAATTTA
ACCTGGCAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAATCCAATTTCACA
GCCAAGGTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGCCTCTTCCTCCG
TGGGACATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGCTTAATCGACTC
AGATATCGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATCTGAAACCATTT
ACAGAATATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAGCACAAACACCA
GAAGAAGAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTTTCTGGAAGAAT
CTGAGTGTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGACACAGAACATC
ACAGGACACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAGGCAGTTCTCTG
CCCACTCGTATTAACATAATGAACCTGTGTGAGGCAGACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTCAGCCCAGATGTA
GCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCCCACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTCCCCTCTGAGCGC
CCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGTGACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTCTCCACTACCATG
GCTACCACTGCTGCCACAAGCACAGGGGACCCGACTGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGCACCCCTGCAGCA
CCCCCTTTTACGGCCACCACTGCTGTTATAAGGACCACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTGGCTACGGCACGG
GCCACTACCCCCGAGGCGCCCTCCCCGCCCACCACGGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTCAGCACAGCTACC
TCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCACCCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGGACCACTGCCCCT
GGACCCACAGAGGTGGCTCAGACCCCAACTCCAGAGACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTGAGTGGGGGGCCC
AGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCACACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCTGCGGCCAAGGCA
TCATCTCCACCTGGGACACTGCCCAAGGGTGCCCGCCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGCTCAGCTGCTCAG
CTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGTGCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTTGCTGCCTTCTTG
GTCACACTGCTCATCTATCGTATGAAGAAAAAGGATGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTCACATACCAGAAG
CCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAGCCACAGTGCCTCCCTGCAGCCTCAACACCACCCTGCTGTCCAGTCCCCAGCCTGG

>39431_39431_3_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000541374_SDC3_chr1_31350012_ENST00000339394_length(amino acids)=778AA_BP=421
MLMAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQ
VTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYC
DYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWN
MVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKIL
HYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEADFEQESGIETAMRFSPDVALAVSTTPAVL
PTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIR
TTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTP
ETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKE

--------------------------------------------------------------
>39431_39431_4_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000544434_SDC3_chr1_31350012_ENST00000339394_length(transcript)=2457nt_BP=1308nt
GCAGGCGACACGTGGAAGAATACGGAGTTCTATACCAGAGTTGATTGTTGATGGCACATACTTTTAGAGGATGCTCATTGGCATTTATGT
TTATAATCACGTGGCTGTTGATTAAAGCAAAAATAGATGCGTGCAAGAGAGGCGATGTGACTGTGAAGCCTTCCCATGTAATTTTACTTG
GATCCACTGTCAATATTACATGCTCTTTGAAGCCCAGACAAGGCTGCTTTCACTATTCCAGACGTAACAAGTTAATCCTGTACAAGTTTG
ACAGAAGAATCAATTTTCACCATGGCCACTCCCTCAATTCTCAAGTCACAGGTCTTCCCCTTGGTACAACCTTGTTTGTCTGCAAACTGG
CCTGTATCAATAGTGATGAAATTCAAATATGTGGAGCAGAGATCTTCGTTGGTGTTGCTCCAGAACAGCCTCAAAATTTATCCTGCATAC
AGAAGGGAGAACAGGGGACTGTGGCCTGCACCTGGGAAAGAGGACGAGACACCCACTTATACACTGAGTATACTCTACAGCTAAGTGGAC
CAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATCAACCTCACCCCTGAATCACCTGAAT
CCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCTTGGACATAGTGAGGC
CTCTTCCTCCGTGGGACATTAGAATCAAATTTCAAAAGGCTTCTGTGAGCAGATGTACCCTTTATTGGAGAGATGAGGGACTGGTACTGC
TTAATCGACTCAGATATCGGCCCAGTAACAGCAGGCTCTGGAATATGGTTAATGTTACAAAGGCCAAAGGAAGACATGATTTGCTGGATC
TGAAACCATTTACAGAATATGAATTTCAGATTTCCTCTAAGCTACATCTTTATAAGGGAAGTTGGAGTGATTGGAGTGAATCATTGAGAG
CACAAACACCAGAAGAAGAGCCTACTGGGATGTTAGATGTCTGGTACATGAAACGGCACATTGACTACAGTAGACAACAGATTTCTCTTT
TCTGGAAGAATCTGAGTGTCTCAGAGGCAAGAGGAAAAATTCTCCACTATCAGGTGACCTTGCAGGAGCTGACAGGAGGGAAAGCCATGA
CACAGAACATCACAGGACACACCTCCTGGACCACAGTCATTCCTAGAACCGGAAATTGGGCTGTGGCTGTGTCTGCAGCAAATTCAAAAG
GCAGTTCTCTGCCCACTCGTATTAACATAATGAACCTGTGTGAGGCAGACTTCGAGCAGGAGTCGGGCATTGAGACAGCCATGCGCTTCA
GCCCAGATGTAGCCCTGGCGGTGTCCACCACACCTGCGGTGCTGCCCACCACGAACATCCAGCCTGTGGGCACACCATTTGAAGAGCTCC
CCTCTGAGCGCCCCACCCTGGAGCCAGCCACCAGCCCCCTGGTGGTGACAGAAGTCCCGGAAGAGCCCAGCCAGAGAGCCACCACCGTCT
CCACTACCATGGCTACCACTGCTGCCACAAGCACAGGGGACCCGACTGTGGCCACAGTGCCTGCCACAGTGGCCACCGCCACCCCCAGCA
CCCCTGCAGCACCCCCTTTTACGGCCACCACTGCTGTTATAAGGACCACTGGCGTACGGAGGCTTCTGCCTCTCCCACTGACCACAGTGG
CTACGGCACGGGCCACTACCCCCGAGGCGCCCTCCCCGCCCACCACGGCGGCTGTCTTGGACACCGAGGCCCCAACACCCAGGCTGGTCA
GCACAGCTACCTCCCGGCCAAGAGCCCTTCCCAGGCCGGCCACCACCCAGGAGCCTGACATCCCTGAGAGGAGCACCCTGCCCCTGGGGA
CCACTGCCCCTGGACCCACAGAGGTGGCTCAGACCCCAACTCCAGAGACCTTCCTGACCACAATCCGGGATGAGCCAGAGGTTCCGGTGA
GTGGGGGGCCCAGTGGAGACTTCGAGCTGCCAGAAGAAGAGACCACACAACCAGACACAGCCAATGAGGTGGTAGCTGTGGGAGGGGCTG
CGGCCAAGGCATCATCTCCACCTGGGACACTGCCCAAGGGTGCCCGCCCGGGCCCTGGCCTCCTGGACAATGCCATCGACTCGGGCAGCT
CAGCTGCTCAGCTGCCTCAGAAGAGTATCCTGGAGCGGAAGGAGGTGCTCGTAGCTGTGATTGTGGGCGGGGTGGTGGGCGCCCTCTTTG
CTGCCTTCTTGGTCACACTGCTCATCTATCGTATGAAGAAAAAGGATGAGGGCAGCTACACGCTGGAGGAACCCAAGCAGGCGAGCGTCA
CATACCAGAAGCCTGACAAGCAGGAGGAGTTCTATGCCTAGTGGAGCCACAGTGCCTCCCTGCAGCCTCAACACCACCCTGCTGTCCAGT

>39431_39431_4_IL12RB2-SDC3_IL12RB2_chr1_67816772_ENST00000544434_SDC3_chr1_31350012_ENST00000339394_length(amino acids)=778AA_BP=421
MLMAHTFRGCSLAFMFIITWLLIKAKIDACKRGDVTVKPSHVILLGSTVNITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQ
VTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYC
DYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWN
MVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKIL
HYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLPTRINIMNLCEADFEQESGIETAMRFSPDVALAVSTTPAVL
PTTNIQPVGTPFEELPSERPTLEPATSPLVVTEVPEEPSQRATTVSTTMATTAATSTGDPTVATVPATVATATPSTPAAPPFTATTAVIR
TTGVRRLLPLPLTTVATARATTPEAPSPPTTAAVLDTEAPTPRLVSTATSRPRALPRPATTQEPDIPERSTLPLGTTAPGPTEVAQTPTP
ETFLTTIRDEPEVPVSGGPSGDFELPEEETTQPDTANEVVAVGGAAAKASSPPGTLPKGARPGPGLLDNAIDSGSSAAQLPQKSILERKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IL12RB2-SDC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL12RB2-SDC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL12RB2-SDC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource