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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL1RAP-TMEM207 (FusionGDB2 ID:39488)

Fusion Gene Summary for IL1RAP-TMEM207

check button Fusion gene summary
Fusion gene informationFusion gene name: IL1RAP-TMEM207
Fusion gene ID: 39488
HgeneTgene
Gene symbol

IL1RAP

TMEM207

Gene ID

3556

131920

Gene nameinterleukin 1 receptor accessory proteintransmembrane protein 207
SynonymsC3orf13|IL-1RAcP|IL1R3UNQ846
Cytomap

3q28

3q28

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-1 receptor accessory proteinIL-1 receptor accessory proteininterleukin-1 receptor 3interleukin-1 receptor accessory protein betatransmembrane protein 207SRSR846
Modification date2020031320200313
UniProtAcc

Q9NPH3

.
Ensembl transtripts involved in fusion geneENST00000072516, ENST00000317757, 
ENST00000412504, ENST00000422485, 
ENST00000422940, ENST00000434491, 
ENST00000439062, ENST00000443369, 
ENST00000447382, ENST00000465496, 
ENST00000354905, 
Fusion gene scores* DoF score7 X 5 X 4=1404 X 2 X 2=16
# samples 104
** MAII scorelog2(10/140*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IL1RAP [Title/Abstract] AND TMEM207 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL1RAP(190326970)-TMEM207(190165616), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IL1RAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM207 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-5491-01AIL1RAPchr3

190326970

-TMEM207chr3

190165616

-
ChimerDB4LUSCTCGA-22-5491-01AIL1RAPchr3

190326970

+TMEM207chr3

190165616

-


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Fusion Gene ORF analysis for IL1RAP-TMEM207

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000072516ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000317757ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000412504ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000422485ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000422940ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000434491ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000439062ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000443369ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
In-frameENST00000447382ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-
intron-3CDSENST00000465496ENST00000354905IL1RAPchr3

190326970

+TMEM207chr3

190165616

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000412504IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-20957892521154300
ENST00000072516IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-2013707501072340
ENST00000443369IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-2013707501072340
ENST00000439062IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-22569503861315309
ENST00000447382IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-20927862221151309
ENST00000422485IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-20537471831112309
ENST00000434491IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-161130529670213
ENST00000422940IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-1962656291021330
ENST00000317757IL1RAPchr3190326970+ENST00000354905TMEM207chr3190165616-20497431791108309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000412504ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0027525210.9972474
ENST00000072516ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0024293130.9975707
ENST00000443369ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0024293130.9975707
ENST00000439062ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0029605230.9970395
ENST00000447382ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0029938270.99700624
ENST00000422485ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0023290030.99767095
ENST00000434491ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0088299940.99117005
ENST00000422940ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0021544010.99784565
ENST00000317757ENST00000354905IL1RAPchr3190326970+TMEM207chr3190165616-0.0023139360.997686

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Fusion Genomic Features for IL1RAP-TMEM207


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL1RAP-TMEM207


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:190326970/chr3:190165616)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL1RAP

Q9NPH3

.
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+41121_128179571.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+51221_128179688.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+41121_128179571.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+5921_128179357.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+4821_128179357.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+61321_128179571.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+41121_128179688.0DomainNote=Ig-like C2-type 1
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+51221_128179571.0DomainNote=Ig-like C2-type 1
TgeneTMEM207chr3:190326970chr3:190165616ENST000003549050552_7225147.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+411141_230179571.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+411242_348179571.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+411403_546179571.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+512141_230179688.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+512242_348179688.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+512403_546179688.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+411141_230179571.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+411242_348179571.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+411403_546179571.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+59141_230179357.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+59242_348179357.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+59403_546179357.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+48141_230179357.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+48242_348179357.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+48403_546179357.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+613141_230179571.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+613242_348179571.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+613403_546179571.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+411141_230179688.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+411242_348179688.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+411403_546179688.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+512141_230179571.0DomainNote=Ig-like C2-type 2
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+512242_348179571.0DomainNote=Ig-like C2-type 3
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+512403_546179571.0DomainTIR
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+41121_367179571.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+411389_570179571.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+51221_367179688.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+512389_570179688.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+41121_367179571.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+411389_570179571.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+5921_367179357.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+59389_570179357.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+4821_367179357.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+48389_570179357.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+61321_367179571.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+613389_570179571.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+41121_367179688.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+411389_570179688.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+51221_367179571.0Topological domainExtracellular
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+512389_570179571.0Topological domainCytoplasmic
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000072516+411368_388179571.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000317757+512368_388179688.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000412504+411368_388179571.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422485+59368_388179357.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000422940+48368_388179357.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000439062+613368_388179571.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000443369+411368_388179688.0TransmembraneHelical
HgeneIL1RAPchr3:190326970chr3:190165616ENST00000447382+512368_388179571.0TransmembraneHelical


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Fusion Gene Sequence for IL1RAP-TMEM207


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39488_39488_1_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000072516_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2013nt_BP=707nt
AAAGGGGGAAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAG
GCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGATGACACTTC
TGTGGTGTGTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGC
AAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAG
CTGGCCTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTA
AGGAGAAAGATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGCAGCA
AAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATG
GCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGG
ACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTT
TGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGG
CAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCC
CTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGG
TGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAG
AGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAA
GTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAAC
AATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCAT
GGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAAT
GAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTC
AGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATA
TAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGG
GCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTC
AAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCATCACAGATGACATATGATCTTCAGCTGACAAATTTGTTG

>39488_39488_1_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000072516_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=340AA_BP=219
MPGSRSPGSALARGAEGSSARRHCTHPGCFCCALSASQERMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLF
EHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNS
PMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCW

--------------------------------------------------------------
>39488_39488_2_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000317757_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2049nt_BP=743nt
TGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTT
GCTGCGCCCTCTCAGCTTCCCAAGAAAGGCATCGTCATGTGATCATCACCTAAGAACTAGAACATCAGCAGGCCCTAGAAGCCTCACTCT
TGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAG
AACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTGAAC
ACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGC
CAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCAACT
ATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCCA
TGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCA
AACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACCCTA
ATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGCTGA
GGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTGTGA
GTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCACCTC
CATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCAAAT
TTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGTTGG
AAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAACCA
AATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTATACA
GCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCAACA
TGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAAAGG
ATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGATAG
AAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATGTGG
CCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTGTTC
CCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCATCA

>39488_39488_2_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000317757_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=309AA_BP=188
MPLPLISQRMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEE
PINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV
KPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAV

--------------------------------------------------------------
>39488_39488_3_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000412504_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2095nt_BP=789nt
AAAGGGGGAAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAG
GCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGTGAGTCTCGC
GCCGCCGTGAGGGCTCAGAAGTCACCAAGCCGCAGAATCTCAGGGTAGACGGATTCTTAGAGATCTTACAGGATGACACTTCTGTGGTGT
GTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAA
GTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTT
ACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAA
GATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCA
TTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAG
AGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCA
TGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCA
GCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTT
GCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTA
TATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATT
ATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTAT
TCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGG
CTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGT
GCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCA
TAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGA
GGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAA
CAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCA
ACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCA
TTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCA
TTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCATCACAGATGACATATGATCTTCAGCTGACAAATTTGTTGAACAAAAC

>39488_39488_3_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000412504_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=300AA_BP=179
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPEN
RISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYML
VLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAVSPTVGIHLQ

--------------------------------------------------------------
>39488_39488_4_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000422485_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2053nt_BP=747nt
AGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGC
TTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGCATCGTCATGTGATCATCACCTAAGAACTAGAACATCAGCAGGCCCTAGAAGCCTCA
CTCTTGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCC
TCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTT
GAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAG
GAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGC
AACTATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCC
CCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGT
GTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACAC
CCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGG
CTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCT
GTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCA
CCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATC
AAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATG
TTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACA
ACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTA
TACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCC
AACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTA
AAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAG
ATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAAT
GTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCT
GTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCC

>39488_39488_4_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000422485_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=309AA_BP=188
MPLPLISQRMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEE
PINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV
KPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAV

--------------------------------------------------------------
>39488_39488_5_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000422940_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=1962nt_BP=656nt
TGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTT
GCTGCGCCCTCTCAGCTTCCCAAGAAAGGATGACACTTCTGTGGTGTGTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCT
CAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTG
AACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGG
AGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCA
ACTATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCC
CCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTG
TCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACC
CTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGC
TGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTG
TGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCAC
CTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCA
AATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGT
TGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAA
CCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTAT
ACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCA
ACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAA
AGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGA
TAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATG
TGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTG
TTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCA

>39488_39488_5_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000422940_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=330AA_BP=209
MARGAEGSSARRHCTHPGCFCCALSASQERMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLY
IEYGIQRITCPNVDGYFPSSVKPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHR

--------------------------------------------------------------
>39488_39488_6_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000434491_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=1611nt_BP=305nt
TGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTT
GCTGCGCCCTCTCAGCTTCCCAAGAAAGGAACACTACATATTGCAGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTT
TCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTC
CTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATG
ACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCC
AGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAG
AAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAG
GCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCC
AAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAG
AATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTAT
GCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCA
CTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCC
GAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTT
GAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGA
AATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAG
TAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCAT
AGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAA

>39488_39488_6_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000434491_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=213AA_BP=92
MARGAEGSSARRHCTHPGCFCCALSASQERNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITW
YMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAVSPTVGI

--------------------------------------------------------------
>39488_39488_7_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000439062_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2256nt_BP=950nt
AAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAA
GGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGGCTTTGACCTGAAGCTTG
AAATTGAGTTTGGGACAATAATGTGTCTCATGGGGAATTGCATGGACTCCTTATCATAAGCCAAATGCTGAGGTAAAGCTGCGGAATTGA
GTCGTCCTCCAAGAAGGGAGAGAAAATGATGTCTTGTGACATTTCCAGATAACTGGCATCGTCATGTGATCATCACCTAAGAACTAGAAC
ATCAGCAGGCCCTAGAAGCCTCACTCTTGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTAGTGAGTCTCTACTTTT
ATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAG
CTCGCATCAAGTGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTTACTCTGATCTGGTATTGGA
CTAGGCAGGACCGGGACCTTGAGGAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGC
CCACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCATTTCCCTTGGAAGTTGTTC
AAAAAGACAGCTGTTTCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGTCCAAATG
TAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGCGAAGAAGATGAAATGT
GTGTAAATTATAATGACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCTCTTCTCTGTGGAGCTG
TGGTCCTCTGCCTCCAGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCTGTTGGAGACTTGGACT
CTATTTATGGGACAGAAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATATCCTGTTCCTGCTCCAT
GTTTTGGCCCTTTAGGCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATCAATTTAAAGTATTAAC
GACATCTGTAATTCCAAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCATATAGTCTGAGGAAGG
ACAATTCGACAAAAGAATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTTTTGATGTGTCACTGCT
GTATCATACTTTTATGCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCTGGAAGTAGTTTCCATC
ACATTTAGGACTCCACTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAAAAATTATTATAATTTA
ACAATAGCCCAAGCCGAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGGGAGAGAGTAGGAAAAA
GAAAAGTTTGGAGTTGAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAAGAGGTTTTATGCCCCA
ACCTGAAGAGGAAGAAATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACACGGGGAGAAAAGAAAA
GTTCCCCTTTTACAGTAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTTATTGCAGCATCATGCT
AAGAACCTTCGGCATAGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTTTGGCAGTGGCCATCAG
CAGGGGGACAGACAAAAACATCCATCACAGATGACATATGATCTTCAGCTGACAAATTTGTTGAACAAAACAATAAACATCAATAGATAT

>39488_39488_7_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000439062_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=309AA_BP=188
MPLPLISQRMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEE
PINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV
KPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAV

--------------------------------------------------------------
>39488_39488_8_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000443369_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2013nt_BP=707nt
AAAGGGGGAAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAG
GCGCGGAAGGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGATGACACTTC
TGTGGTGTGTAGTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGC
AAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAG
CTGGCCTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTA
AGGAGAAAGATGTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGCAGCA
AAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATG
GCATTCAGAGGATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGG
ACCTACCATGCGAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTT
TGGTGGCAGCTCTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGG
CAGTTTTTGCTGTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCC
CTGACCTATATCCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGG
TGTGGATTATCAATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAG
AGATCTATTCATATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAA
GTAGCAGGCTTTTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAAC
AATTAGGTGCTGGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCAT
GGGGTCCATAAAAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAAT
GAAGGTGAGGGGAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTC
AGCAAAAACAAGAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATA
TAATGCCAACACGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGG
GCTTGGCATTTATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTC
AAGTGGCATTTTGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCATCACAGATGACATATGATCTTCAGCTGACAAATTTGTTG

>39488_39488_8_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000443369_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=340AA_BP=219
MPGSRSPGSALARGAEGSSARRHCTHPGCFCCALSASQERMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLF
EHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNS
PMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCW

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>39488_39488_9_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000447382_TMEM207_chr3_190165616_ENST00000354905_length(transcript)=2092nt_BP=786nt
AAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCCGGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAA
GGAAGCAGTGCCCGGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAAGGCATCGTCATGTGATCATC
ACCTAAGAACTAGAACATCAGCAGGCCCTAGAAGCCTCACTCTTGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTA
GTGAGTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGGGACTAGACACCATGAGGCAAATCCAAGTG
TTTGAAGATGAGCCAGCTCGCATCAAGTGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGCCTTACT
CTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAACTTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGAT
GTGCTGTGGTTCCGGCCCACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGCAGCAAAGTTGCATTT
CCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCCATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGG
ATCACTTGTCCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATGTTGGTGCTCTCGGACCTACCATGC
GAAGAAGATGAAATGTGTGTAAATTATAATGACCAACACCCTAATGGCTGGTATATCTGGATCCTCCTGCTGCTGGTTTTGGTGGCAGCT
CTTCTCTGTGGAGCTGTGGTCCTCTGCCTCCAGTGCTGGCTGAGGAGACCCCGAATTGATTCTCACAGGCGCACCATGGCAGTTTTTGCT
GTTGGAGACTTGGACTCTATTTATGGGACAGAAGCAGCTGTGAGTCCAACTGTTGGAATTCACCTTCAAACTCAAACCCCTGACCTATAT
CCTGTTCCTGCTCCATGTTTTGGCCCTTTAGGCTCCCCACCTCCATATGAAGAAATTGTAAAAACAACCTGATTTTAGGTGTGGATTATC
AATTTAAAGTATTAACGACATCTGTAATTCCAAAACATCAAATTTAGGAATAGTTATTTCAGTTGTTGGAAATGTCCAGAGATCTATTCA
TATAGTCTGAGGAAGGACAATTCGACAAAAGAATGGATGTTGGAAAAAATTTTGGTCATGGAGATGTTTAAATAGTAAAGTAGCAGGCTT
TTGATGTGTCACTGCTGTATCATACTTTTATGCTACACAACCAAATTAATGCTTCTCCACTAGTATCCAAACAGGCAACAATTAGGTGCT
GGAAGTAGTTTCCATCACATTTAGGACTCCACTGCAGTATACAGCACACCATTTTCTGCTTTAAACTCTTTCCTAGCATGGGGTCCATAA
AAATTATTATAATTTAACAATAGCCCAAGCCGAGAATCCAACATGTCCAGAACCAGAACCAGAAAGATAGTATTTGAATGAAGGTGAGGG
GAGAGAGTAGGAAAAAGAAAAGTTTGGAGTTGAAGGGTAAAGGATAAATGAAGAGGAAAAGGAAAAGATTACAAGTCTCAGCAAAAACAA
GAGGTTTTATGCCCCAACCTGAAGAGGAAGAAATTGTAGATAGAAGGTGAAGGAGATTGCTGAAGATATAGAGCACATATAATGCCAACA
CGGGGAGAAAAGAAAAGTTCCCCTTTTACAGTAATGAATGTGGCCTCCATAGTCCATAGTGTTTCTCTGGAGCCTCAGGGCTTGGCATTT
ATTGCAGCATCATGCTAAGAACCTTCGGCATAGGTATCTGTTCCCATGAGGACTGCAGAAGTAGCAATGAGACATCTTCAAGTGGCATTT
TGGCAGTGGCCATCAGCAGGGGGACAGACAAAAACATCCATCACAGATGACATATGATCTTCAGCTGACAAATTTGTTGAACAAAACAAT

>39488_39488_9_IL1RAP-TMEM207_IL1RAP_chr3_190326970_ENST00000447382_TMEM207_chr3_190165616_ENST00000354905_length(amino acids)=309AA_BP=188
MPLPLISQRMTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEE
PINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSV
KPTITWYMLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAV

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Fusion Gene PPI Analysis for IL1RAP-TMEM207


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL1RAP-TMEM207


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL1RAP-TMEM207


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource