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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IL1RAP-TP63 (FusionGDB2 ID:39489)

Fusion Gene Summary for IL1RAP-TP63

Fusion gene summary

Fusion gene information	Fusion gene name: IL1RAP-TP63
	Fusion gene ID: 39489
		Hgene	Tgene
	Gene symbol	IL1RAP	TP63
	Gene ID	3556	8626
	Gene name	interleukin 1 receptor accessory protein	tumor protein p63
	Synonyms	C3orf13\|IL-1RAcP\|IL1R3	AIS\|B(p51A)\|B(p51B)\|EEC3\|KET\|LMS\|NBP\|OFC8\|RHS\|SHFM4\|TP53CP\|TP53L\|TP73L\|p40\|p51\|p53CP\|p63\|p73H\|p73L
	Cytomap	3q28	3q28
	Type of gene	protein-coding	protein-coding
	Description	interleukin-1 receptor accessory proteinIL-1 receptor accessory proteininterleukin-1 receptor 3interleukin-1 receptor accessory protein beta	tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
	Modification date	20200313	20200329
	UniProtAcc	Q9NPH3	.
	Ensembl transtripts involved in fusion gene	ENST00000465496, ENST00000072516, ENST00000317757, ENST00000412504, ENST00000422485, ENST00000422940, ENST00000434491, ENST00000439062, ENST00000443369, ENST00000447382,	ENST00000264731, ENST00000320472, ENST00000354600, ENST00000382063, ENST00000392460, ENST00000392461, ENST00000392463, ENST00000418709, ENST00000437221, ENST00000440651, ENST00000449992, ENST00000456148,
Fusion gene scores	* DoF score	7 X 5 X 4=140	13 X 11 X 8=1144
	# samples	10	15
	** MAII score	log2(10/140*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1144*10)=-2.93105264628251 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IL1RAP [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IL1RAP(190232008)-TP63(189526061), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TP63	GO:0045747	positive regulation of Notch signaling pathway	11641404
Tgene	TP63	GO:0045892	negative regulation of transcription, DNA-templated	12446784
Tgene	TP63	GO:0045893	positive regulation of transcription, DNA-templated	12446784\|16343436
Tgene	TP63	GO:0045944	positive regulation of transcription by RNA polymerase II	22521434
Tgene	TP63	GO:2000271	positive regulation of fibroblast apoptotic process	9774969

Fusion gene breakpoints across IL1RAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TP63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-39-5035-01A	IL1RAP	chr3	190232008	-	TP63	chr3	189526061	+
ChimerDB4	LUSC	TCGA-39-5035-01A	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
ChimerDB4	LUSC	TCGA-39-5035	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
ChimerDB4	LUSC	TCGA-39-5035	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+

Top

Fusion Gene ORF analysis for IL1RAP-TP63

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000465496	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-3CDS	ENST00000465496	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
3UTR-intron	ENST00000465496	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
3UTR-intron	ENST00000465496	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000072516	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000072516	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000317757	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000317757	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000412504	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000412504	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000422485	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000422485	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000422940	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000422940	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000434491	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000434491	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000439062	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000439062	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000443369	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000443369	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-3CDS	ENST00000447382	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-3CDS	ENST00000447382	ENST00000264731	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000072516	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000072516	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000317757	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000317757	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000412504	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000412504	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422485	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422485	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000422940	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000422940	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000434491	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000434491	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000439062	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000439062	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000443369	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000443369	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000320472	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000354600	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000382063	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392460	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392461	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000392463	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000418709	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000437221	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000440651	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000449992	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+
5UTR-intron	ENST00000447382	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526061	+
5UTR-intron	ENST00000447382	ENST00000456148	IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for IL1RAP-TP63

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+	0.00026081	0.9997392
IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+	0.00026081	0.9997392
IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+	0.00026081	0.9997392
IL1RAP	chr3	190232008	+	TP63	chr3	189526060	+	0.00026081	0.9997392

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL1RAP-TP63

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:190232008/:189526061)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IL1RAP Q9NPH3	.
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). {ECO:0000250\|UniProtKB:Q61730, ECO:0000269\|PubMed:10799889, ECO:0000269\|PubMed:9371760, ECO:0000305\|PubMed:10653850, ECO:0000305\|PubMed:19836339}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity). {ECO:0000250\|UniProtKB:Q61730, ECO:0000269\|PubMed:12530978}.; FUNCTION: [Isoform 4]: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity). {ECO:0000250\|UniProtKB:Q61730, ECO:0000269\|PubMed:19481478}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for IL1RAP-TP63

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL1RAP-TP63

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IL1RAP-TP63

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IL1RAP-TP63

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source