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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABHD16A-LY6G6F (FusionGDB2 ID:395)

Fusion Gene Summary for ABHD16A-LY6G6F

Fusion gene summary

Fusion gene information	Fusion gene name: ABHD16A-LY6G6F
	Fusion gene ID: 395
		Hgene	Tgene
	Gene symbol	ABHD16A	LY6G6F
	Gene ID	7920	259215
	Gene name	abhydrolase domain containing 16A, phospholipase	lymphocyte antigen 6 family member G6F
	Synonyms	BAT5\|D6S82E\|NG26\|PP199\|hBAT5	C6orf21\|G6f\|LY6G6\|LY6G6D\|NG32
	Cytomap	6p21.33	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylserine lipase ABHD16AHLA-B associated transcript 5abhydrolase domain containing 16Aabhydrolase domain-containing protein 16Aalpha/beta hydrolase domain-containing protein 16Amonoacylglycerol lipase ABHD16Aprotein ABHD16Aprotein G5	lymphocyte antigen 6 complex locus protein G6flymphocyte antigen 6 complex, locus G6Dlymphocyte antigen 6 complex, locus G6F
	Modification date	20200327	20200313
	UniProtAcc	O95870	.
	Ensembl transtripts involved in fusion gene	ENST00000395952, ENST00000440843, ENST00000538874, ENST00000375842, ENST00000413853, ENST00000429735, ENST00000432617, ENST00000444818, ENST00000446529, ENST00000457366, ENST00000464268, ENST00000471644, ENST00000475067, ENST00000482058, ENST00000488103, ENST00000494438, ENST00000495335, ENST00000546528, ENST00000547161, ENST00000547325, ENST00000548592, ENST00000549543, ENST00000549722, ENST00000549853, ENST00000550556, ENST00000550719, ENST00000551038, ENST00000552042,	ENST00000383420, ENST00000442105, ENST00000446062, ENST00000447811, ENST00000453044, ENST00000455632, ENST00000554860, ENST00000556331, ENST00000557698, ENST00000375832, ENST00000556581,
Fusion gene scores	* DoF score	4 X 3 X 5=60	1 X 1 X 1=1
	# samples	5	1
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: ABHD16A [Title/Abstract] AND LY6G6F [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABHD16A(31668719)-LY6G6F(31675235), # samples:2
Anticipated loss of major functional domain due to fusion event.	ABHD16A-LY6G6F seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABHD16A	GO:0052651	monoacylglycerol catabolic process	25290914
Hgene	ABHD16A	GO:1905344	prostaglandin catabolic process	25290914

Fusion gene breakpoints across ABHD16A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LY6G6F (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-NC-A5HK-01A	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+

Top

Fusion Gene ORF analysis for ABHD16A-LY6G6F

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000395952	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000395952	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000440843	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5CDS-intron	ENST00000538874	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-3CDS	ENST00000375842	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-3CDS	ENST00000375842	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
5UTR-intron	ENST00000375842	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
Frame-shift	ENST00000538874	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
Frame-shift	ENST00000538874	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
In-frame	ENST00000395952	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
In-frame	ENST00000395952	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
In-frame	ENST00000440843	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
In-frame	ENST00000440843	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000413853	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000413853	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000429735	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000429735	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000432617	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000432617	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000444818	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000444818	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000446529	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000446529	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000457366	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000457366	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000464268	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000464268	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000471644	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000471644	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000475067	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000475067	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000482058	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000482058	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000488103	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000488103	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000494438	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000494438	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000495335	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000495335	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000546528	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000546528	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000547161	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000547161	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000547325	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000547325	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000548592	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000548592	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549543	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549543	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549722	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549722	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549853	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000549853	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000550556	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000550556	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000550719	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000550719	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000551038	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000551038	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000552042	ENST00000375832	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-3CDS	ENST00000552042	ENST00000556581	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000413853	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000429735	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000432617	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000444818	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000446529	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000457366	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000464268	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000471644	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000475067	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000482058	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000488103	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000494438	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000495335	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000546528	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547161	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000547325	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000548592	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549543	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549722	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000549853	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550556	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000550719	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000551038	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000383420	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000442105	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000446062	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000447811	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000453044	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000455632	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000554860	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000556331	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+
intron-intron	ENST00000552042	ENST00000557698	ABHD16A	chr6	31668719	-	LY6G6F	chr6	31675235	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for ABHD16A-LY6G6F

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ABHD16A	chr6	31668718	-	LY6G6F	chr6	31675234	+	1.28E-10	1
ABHD16A	chr6	31668718	-	LY6G6F	chr6	31675234	+	1.28E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ABHD16A-LY6G6F

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31668719/chr6:31675235)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABHD16A O95870	.
FUNCTION: Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914). {ECO:0000250\|UniProtKB:Q9Z1Q2, ECO:0000269\|PubMed:25290914}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000395952

60_80

114

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000395952

93_113

114

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000440843

60_80

526.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000375832

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000383420

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000442105

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000446062

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000447811

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000453044

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000455632

17_122

298.0

Domain

Note=Ig-like V-type

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000375832

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000375832

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000383420

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000383420

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000442105

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000442105

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000446062

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000446062

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000447811

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000447811

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000453044

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000453044

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000455632

17_235

298.0

Topological domain

Extracellular

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000455632

257_297

298.0

Topological domain

Cytoplasmic

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000375832

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000383420

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000442105

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000446062

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000447811

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000453044

236_256

298.0

Transmembrane

Helical

Tgene

LY6G6F

chr6:31668719

chr6:31675235

ENST00000455632

236_256

298.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000395952

281_407

114

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000440843

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000446529

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000546528

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547161

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547325

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000548592

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549543

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549722

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549853

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550556

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550719

281_407

559.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000551038

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000552042

281_407

526.0

Domain

AB hydrolase-1

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000395952

114_558

114

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000440843

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000446529

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000546528

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547161

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547325

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000548592

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549543

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549722

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549853

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550556

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550719

114_558

559.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000551038

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000552042

114_558

526.0

Topological domain

Cytoplasmic

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000440843

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000446529

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000446529

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000546528

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000546528

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547161

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547161

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547325

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000547325

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000548592

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000548592

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549543

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549543

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549722

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549722

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549853

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000549853

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550556

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550556

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550719

60_80

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000550719

93_113

559.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000551038

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000551038

93_113

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000552042

60_80

526.0

Transmembrane

Helical

Hgene

ABHD16A

chr6:31668719

chr6:31675235

ENST00000552042

93_113

526.0

Transmembrane

Helical

Top

Fusion Gene Sequence for ABHD16A-LY6G6F

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ABHD16A-LY6G6F

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ABHD16A-LY6G6F

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ABHD16A-LY6G6F

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source