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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL20RB-NR4A1 (FusionGDB2 ID:39508)

Fusion Gene Summary for IL20RB-NR4A1

check button Fusion gene summary
Fusion gene informationFusion gene name: IL20RB-NR4A1
Fusion gene ID: 39508
HgeneTgene
Gene symbol

IL20RB

NR4A1

Gene ID

53833

3164

Gene nameinterleukin 20 receptor subunit betanuclear receptor subfamily 4 group A member 1
SynonymsDIRS1|FNDC6|IL-20R2GFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3
Cytomap

3q22.3

12q13.13

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-20 receptor subunit betaIL-20 receptor subunit betaIL-20R-betaIL-20RBfibronectin type III domain containing 6interleukin 20 receptor beta subunitinterleukin-20 receptor IInuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucle
Modification date2020031320200329
UniProtAcc

Q6UXL0

P22736

Ensembl transtripts involved in fusion geneENST00000484501, ENST00000329582, 
ENST00000309741, 		ENST00000360284, 
ENST00000545748, ENST00000550082, 
ENST00000547206, ENST00000243050, 
ENST00000394824, ENST00000394825, 
ENST00000548232, 
Fusion gene scores* DoF score5 X 3 X 3=4515 X 14 X 4=840
# samples 516
** MAII scorelog2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/840*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL20RB [Title/Abstract] AND NR4A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNR4A1(52435713)-IL20RB(136699308), # samples:3
IL20RB(136677043)-NR4A1(52448111), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR4A1

GO:0002042

cell migration involved in sprouting angiogenesis

18059339

TgeneNR4A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22427340


check buttonFusion gene breakpoints across IL20RB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NR4A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BA-6871-01AIL20RBchr3

136677043

-NR4A1chr12

52448111

+


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Fusion Gene ORF analysis for IL20RB-NR4A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000484501ENST00000360284IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-3CDSENST00000484501ENST00000545748IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-3CDSENST00000484501ENST00000550082IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-3UTRENST00000484501ENST00000547206IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-5UTRENST00000484501ENST00000243050IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-5UTRENST00000484501ENST00000394824IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-5UTRENST00000484501ENST00000394825IL20RBchr3

136677043

-NR4A1chr12

52448111

+
3UTR-5UTRENST00000484501ENST00000548232IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5CDS-3UTRENST00000329582ENST00000547206IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5CDS-5UTRENST00000329582ENST00000243050IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5CDS-5UTRENST00000329582ENST00000394824IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5CDS-5UTRENST00000329582ENST00000394825IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5CDS-5UTRENST00000329582ENST00000548232IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-3CDSENST00000309741ENST00000360284IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-3CDSENST00000309741ENST00000545748IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-3CDSENST00000309741ENST00000550082IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-3UTRENST00000309741ENST00000547206IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-5UTRENST00000309741ENST00000243050IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-5UTRENST00000309741ENST00000394824IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-5UTRENST00000309741ENST00000394825IL20RBchr3

136677043

-NR4A1chr12

52448111

+
5UTR-5UTRENST00000309741ENST00000548232IL20RBchr3

136677043

-NR4A1chr12

52448111

+
In-frameENST00000329582ENST00000360284IL20RBchr3

136677043

-NR4A1chr12

52448111

+
In-frameENST00000329582ENST00000545748IL20RBchr3

136677043

-NR4A1chr12

52448111

+
In-frameENST00000329582ENST00000550082IL20RBchr3

136677043

-NR4A1chr12

52448111

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000329582IL20RBchr3136677043-ENST00000360284NR4A1chr1252448111+22413372492135628
ENST00000329582IL20RBchr3136677043-ENST00000545748NR4A1chr1252448111+26933372492135628
ENST00000329582IL20RBchr3136677043-ENST00000550082NR4A1chr1252448111+22413372492135628

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000329582ENST00000360284IL20RBchr3136677043-NR4A1chr1252448111+0.079385720.9206143
ENST00000329582ENST00000545748IL20RBchr3136677043-NR4A1chr1252448111+0.0362582360.9637418
ENST00000329582ENST00000550082IL20RBchr3136677043-NR4A1chr1252448111+0.079385720.9206143

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Fusion Genomic Features for IL20RB-NR4A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL20RB-NR4A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52435713/chr12:136699308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL20RB

Q6UXL0

NR4A1

P22736

FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.FUNCTION: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P12813, ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000002430501882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418583_58612612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003602841882_9212612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003948241882_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507583_5860599.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000003948250782_920599.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202583_5860326.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000005482320282_920326.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207583_58612612.0Compositional biasNote=Poly-Pro
TgeneNR4A1chr3:136677043chr12:52448111ENST000005500820782_9212612.0Compositional biasNote=Poly-Ser
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418264_33912612.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507264_3390599.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202264_3390326.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207264_33912612.0DNA bindingNuclear receptor
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418360_59512612.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507360_5950599.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202360_5950326.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207360_59512612.0DomainNR LBD
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418171_46612612.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507171_4660599.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202171_4660326.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207171_46612612.0RegionRequired for nuclear import
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000024305018303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418267_28712612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000036028418303_32712612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482418303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507267_2870599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000039482507303_3270599.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202267_2870326.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000054823202303_3270326.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207267_28712612.0Zinc fingerNR C4-type
TgeneNR4A1chr3:136677043chr12:52448111ENST0000055008207303_32712612.0Zinc fingerNR C4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17144_22829312.0DomainFibronectin type-III 2
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-1737_13629312.0DomainFibronectin type-III 1
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17255_31129312.0Topological domainCytoplasmic
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-1730_23329312.0Topological domainExtracellular
HgeneIL20RBchr3:136677043chr12:52448111ENST00000329582-17234_25429312.0TransmembraneHelical


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Fusion Gene Sequence for IL20RB-NR4A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39508_39508_1_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000360284_length(transcript)=2241nt_BP=337nt
AAAGTTACATTTTCTCTGGAACTCTCCTAGGCCACTCCCTGCTGATGCAACATCTGGGTTTGGGCAGAAAGGAGGGTGCTTCGGAGCCCG
CCCTTTCTGAGCTTCCTGGGCCGGCTCTAGAACAATTCAGGCTTCGCTGCGACTCAGACCTCAGCTCCAACATATGCATTCTGAAGAAAG
ATGGCTGAGATGGACAGAATGCTTTATTTTGGAAAGAAACAATGTTCTAGGTCAAACTGAGTCTACCAAATGCAGACTTTCACAATGGTT
CTAGAAGAAATCTGGACAAGTCTTTTCATGTGGTTTTTCTACGCATTGATTCCATGTTTGCTCACAGAGATGCCCTGTATCCAAGCCCAA
TATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTG
GCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTC
CTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCC
TCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGT
GGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCC
TTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCA
GCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAG
CTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGAT
ACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAG
CATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAG
GACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTC
CGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCC
CTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAG
GAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTT
GCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCA
GGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTG
GCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGG
CTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAG
CCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAG
CTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCA

>39508_39508_1_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000360284_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------
>39508_39508_2_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000545748_length(transcript)=2693nt_BP=337nt
AAAGTTACATTTTCTCTGGAACTCTCCTAGGCCACTCCCTGCTGATGCAACATCTGGGTTTGGGCAGAAAGGAGGGTGCTTCGGAGCCCG
CCCTTTCTGAGCTTCCTGGGCCGGCTCTAGAACAATTCAGGCTTCGCTGCGACTCAGACCTCAGCTCCAACATATGCATTCTGAAGAAAG
ATGGCTGAGATGGACAGAATGCTTTATTTTGGAAAGAAACAATGTTCTAGGTCAAACTGAGTCTACCAAATGCAGACTTTCACAATGGTT
CTAGAAGAAATCTGGACAAGTCTTTTCATGTGGTTTTTCTACGCATTGATTCCATGTTTGCTCACAGAGATGCCCTGTATCCAAGCCCAA
TATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTG
GCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTC
CTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCC
TCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGT
GGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCC
TTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCA
GCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAG
CTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGAT
ACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAG
CATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAG
GACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTC
CGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCC
CTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAG
GAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTT
GCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCA
GGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTG
GCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGG
CTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAG
CCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAG
CTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCA
CATGCGCACTCTCATATGCCACCCCATGTGCCTTTAGTCCACGGACCCCCAGAGCACCCCCAAGCCTGGGCTTGAGCTGCAGAATGACTC
CACCTTCTCACCTGCTCCAGGAGGTTTGCAGGGAGCTCAAGCCCTTGGGGAGGGGGATGCCTTCATGGGGGTGACCCCACGATTTGTCTT
ATCCCCCCCAGCCTGGCCCCGGCCTTTATGTTTTTTGTAAGATAAACCGTTTTTAACACATAGCGCCGTGCTGTAAATAAGCCCAGTGCT
GCTGTAAATACAGGAAGAAAGAGCTTGAGGTGGGAGCGGGGCTGGGAGGAAGGGATGGGCCCCGCCTTCCTGGGCAGCCTTTCCAGCCTC
CTGCTGGCTCTCTCTTCCTACCCTCCTTCCACATGTACATAAACTGTCACTCTAGGAAGAAGACAAATGACAGATTCTGACATTTATATT

>39508_39508_2_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000545748_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------
>39508_39508_3_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000550082_length(transcript)=2241nt_BP=337nt
AAAGTTACATTTTCTCTGGAACTCTCCTAGGCCACTCCCTGCTGATGCAACATCTGGGTTTGGGCAGAAAGGAGGGTGCTTCGGAGCCCG
CCCTTTCTGAGCTTCCTGGGCCGGCTCTAGAACAATTCAGGCTTCGCTGCGACTCAGACCTCAGCTCCAACATATGCATTCTGAAGAAAG
ATGGCTGAGATGGACAGAATGCTTTATTTTGGAAAGAAACAATGTTCTAGGTCAAACTGAGTCTACCAAATGCAGACTTTCACAATGGTT
CTAGAAGAAATCTGGACAAGTCTTTTCATGTGGTTTTTCTACGCATTGATTCCATGTTTGCTCACAGAGATGCCCTGTATCCAAGCCCAA
TATGGGACACCAGCACCGAGTCCGGGACCCCGTGACCACCTGGCAAGCGACCCCCTGACCCCTGAGTTCATCAAGCCCACCATGGACCTG
GCCAGCCCCGAGGCAGCCCCCGCTGCCCCCACTGCCCTGCCCAGCTTCAGCACCTTCATGGACGGCTACACAGGAGAGTTTGACACCTTC
CTCTACCAGCTGCCAGGAACAGTCCAGCCATGCTCCTCAGCCTCCTCCTCGGCCTCCTCCACATCCTCGTCCTCAGCCACCTCCCCTGCC
TCTGCCTCCTTCAAGTTCGAGGACTTCCAGGTGTACGGCTGCTACCCCGGCCCCCTGAGCGGCCCAGTGGATGAGGCCCTGTCCTCCAGT
GGCTCTGACTACTATGGCAGCCCCTGCTCGGCCCCGTCGCCCTCCACGCCCAGCTTCCAGCCGCCCCAGCTCTCTCCCTGGGATGGCTCC
TTCGGCCACTTCTCGCCCAGCCAGACTTACGAAGGCCTGCGGGCATGGACAGAGCAGCTGCCCAAAGCCTCTGGGCCCCCACAGCCTCCA
GCCTTCTTTTCCTTCAGTCCTCCCACCGGCCCCAGCCCCAGCCTGGCCCAGAGCCCCCTGAAGTTGTTCCCCTCACAGGCCACCCACCAG
CTGGGGGAGGGAGAGAGCTATTCCATGCCTACGGCCTTCCCAGGTTTGGCACCCACTTCTCCACACCTTGAGGGCTCGGGGATACTGGAT
ACACCCGTGACCTCAACCAAGGCCCGGAGCGGGGCCCCAGGTGGAAGTGAAGGCCGCTGTGCTGTGTGTGGGGACAACGCTTCATGCCAG
CATTATGGTGTCCGCACATGTGAGGGCTGCAAGGGCTTCTTCAAGCGCACAGTGCAGAAAAACGCCAAGTACATCTGCCTGGCTAACAAG
GACTGCCCTGTGGACAAGAGGCGGCGAAACCGCTGCCAGTTCTGCCGCTTCCAGAAGTGCCTGGCGGTGGGCATGGTGAAGGAAGTTGTC
CGAACAGACAGCCTGAAGGGGCGGCGGGGCCGGCTACCTTCAAAACCCAAGCAGCCCCCAGATGCCTCCCCTGCCAATCTCCTCACTTCC
CTGGTCCGTGCACACCTGGACTCAGGGCCCAGCACTGCCAAACTGGACTACTCCAAGTTCCAGGAGCTGGTGCTGCCCCACTTTGGGAAG
GAAGATGCTGGGGATGTACAGCAGTTCTACGACCTGCTCTCCGGTTCTCTGGAGGTCATCCGCAAGTGGGCGGAGAAGATCCCTGGCTTT
GCTGAGCTGTCACCGGCTGACCAGGACCTGTTGCTGGAGTCGGCCTTCCTGGAGCTCTTCATCCTCCGCCTGGCGTACAGGTCTAAGCCA
GGCGAGGGCAAGCTCATCTTCTGCTCAGGCCTGGTGCTACACCGGCTGCAGTGTGCCCGTGGCTTCGGGGACTGGATTGACAGTATCCTG
GCCTTCTCAAGGTCCCTGCACAGCTTGCTTGTCGATGTCCCTGCCTTCGCCTGCCTCTCTGCCCTTGTCCTCATCACCGACCGGCATGGG
CTGCAGGAGCCGCGGCGGGTGGAGGAGCTGCAGAACCGCATCGCCAGCTGCCTGAAGGAGCACGTGGCAGCTGTGGCGGGCGAGCCCCAG
CCAGCCAGCTGCCTGTCACGTCTGTTGGGCAAACTGCCCGAGCTGCGGACCCTGTGCACCCAGGGCCTGCAGCGCATCTTCTACCTCAAG
CTGGAGGACTTGGTGCCCCCTCCACCCATCATTGACAAGATCTTCATGGACACGCTGCCCTTCTGACCCCTGCCTGGGAACACGTGTGCA

>39508_39508_3_IL20RB-NR4A1_IL20RB_chr3_136677043_ENST00000329582_NR4A1_chr12_52448111_ENST00000550082_length(amino acids)=628AA_BP=29
MQTFTMVLEEIWTSLFMWFFYALIPCLLTEMPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGY
TGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQ
LSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHL
EGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAV
GMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKW
AEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for IL20RB-NR4A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL20RB-NR4A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL20RB-NR4A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource