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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL32-DOK6 (FusionGDB2 ID:39527)

Fusion Gene Summary for IL32-DOK6

check button Fusion gene summary
Fusion gene informationFusion gene name: IL32-DOK6
Fusion gene ID: 39527
HgeneTgene
Gene symbol

IL32

DOK6

Gene ID

9235

220164

Gene nameinterleukin 32docking protein 6
SynonymsIL-32alpha|IL-32beta|IL-32delta|IL-32gamma|NK4|TAIF|TAIFa|TAIFb|TAIFc|TAIFdDOK5L|HsT3226
Cytomap

16p13.3

18q22.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-32interleukin-32 etainterleukin-32 smallinterleukin-32 thetanatural killer cell transcript 4natural killer cells protein 4tumor necrosis factor alpha-inducing factordocking protein 6downstream of tyrosine kinase 6
Modification date2020031320200313
UniProtAcc

P24001

Q6PKX4

Ensembl transtripts involved in fusion geneENST00000008180, ENST00000325568, 
ENST00000382213, ENST00000396887, 
ENST00000396890, ENST00000440815, 
ENST00000444393, ENST00000525643, 
ENST00000526464, ENST00000528163, 
ENST00000530890, ENST00000534507, 
ENST00000548652, ENST00000549213, 
ENST00000551122, ENST00000533097, 
ENST00000529550, ENST00000529699, 
ENST00000530538, ENST00000531965, 
ENST00000548246, ENST00000548476, 
ENST00000551513, ENST00000552356, 
ENST00000552664, ENST00000552936, 
ENST00000382713, ENST00000584435, 
Fusion gene scores* DoF score2 X 2 X 1=410 X 8 X 5=400
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL32 [Title/Abstract] AND DOK6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL32(3119530)-DOK6(67138489), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IL32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across DOK6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF341230IL32chr16

3119530

+DOK6chr18

67138489

+


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Fusion Gene ORF analysis for IL32-DOK6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000008180ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000008180ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000325568ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000325568ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000382213ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000382213ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000396887ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000396887ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000396890ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000396890ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000440815ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000440815ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000444393ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000444393ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000525643ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000525643ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000526464ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000526464ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000528163ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000528163ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000530890ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000530890ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000534507ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000534507ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000548652ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000548652ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000549213ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000549213ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000551122ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
3UTR-intronENST00000551122ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
5CDS-intronENST00000533097ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
5CDS-intronENST00000533097ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000529550ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000529550ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000529699ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000529699ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000530538ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000530538ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000531965ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000531965ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000548246ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000548246ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000548476ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000548476ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000551513ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000551513ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552356ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552356ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552664ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552664ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552936ENST00000382713IL32chr16

3119530

+DOK6chr18

67138489

+
intron-intronENST00000552936ENST00000584435IL32chr16

3119530

+DOK6chr18

67138489

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for IL32-DOK6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL32-DOK6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:3119530/:67138489)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL32

P24001

DOK6

Q6PKX4

FUNCTION: Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. {ECO:0000269|PubMed:15664165}.FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. {ECO:0000269|PubMed:15286081}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IL32-DOK6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL32-DOK6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL32-DOK6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL32-DOK6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource