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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IL4R-FCHO1 (FusionGDB2 ID:39561)

Fusion Gene Summary for IL4R-FCHO1

Fusion gene summary

Fusion gene information	Fusion gene name: IL4R-FCHO1
	Fusion gene ID: 39561
		Hgene	Tgene
	Gene symbol	IL4R	FCHO1
	Gene ID	3566	23149
	Gene name	interleukin 4 receptor	FCH and mu domain containing endocytic adaptor 1
	Synonyms	CD124\|IL-4RA\|IL4RA	-
	Cytomap	16p12.1	19p13.11
	Type of gene	protein-coding	protein-coding
	Description	interleukin-4 receptor subunit alphaIL-4 receptor subunit alphaIL4R nirs variant 1interleukin 13 receptorinterleukin-4 receptor alpha chain	F-BAR domain only protein 1FCH domain only 1FCH domain only protein 1
	Modification date	20200322	20200313
	UniProtAcc	P24394	O14526
	Ensembl transtripts involved in fusion gene	ENST00000170630, ENST00000380922, ENST00000395762, ENST00000449195, ENST00000543915, ENST00000565915,	ENST00000252771, ENST00000389133, ENST00000539407, ENST00000594202, ENST00000595033, ENST00000596536, ENST00000596951, ENST00000597512, ENST00000599236, ENST00000600676,
Fusion gene scores	* DoF score	9 X 8 X 5=360	5 X 6 X 3=90
	# samples	10	5
	** MAII score	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IL4R [Title/Abstract] AND FCHO1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IL4R(27357787)-FCHO1(17893203), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across IL4R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FCHO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF896822	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+

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Fusion Gene ORF analysis for IL4R-FCHO1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000170630	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000170630	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000380922	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000395762	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000449195	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000543915	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000252771	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000389133	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000539407	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000594202	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000595033	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000596536	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000596951	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000597512	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000599236	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+
intron-intron	ENST00000565915	ENST00000600676	IL4R	chr16	27357787	-	FCHO1	chr19	17893203	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for IL4R-FCHO1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL4R-FCHO1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27357787/:17893203)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
IL4R P24394	FCHO1 O14526
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269\|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269\|PubMed:8124718}.	FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. {ECO:0000269\|PubMed:20448150}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for IL4R-FCHO1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for IL4R-FCHO1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for IL4R-FCHO1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for IL4R-FCHO1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source