FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:IL4R-S100A16 (FusionGDB2 ID:39566)

Fusion Gene Summary for IL4R-S100A16

check button Fusion gene summary
Fusion gene informationFusion gene name: IL4R-S100A16
Fusion gene ID: 39566
HgeneTgene
Gene symbol

IL4R

S100A16

Gene ID

3566

388697

Gene nameinterleukin 4 receptorhornerin
SynonymsCD124|IL-4RA|IL4RAFLG3|S100A16|S100a18
Cytomap

16p12.1

1q21.3

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-4 receptor subunit alphaIL-4 receptor subunit alphaIL4R nirs variant 1interleukin 13 receptorinterleukin-4 receptor alpha chainhornerinfilaggrin family member 3intermediate filament-associated protein
Modification date2020032220200313
UniProtAcc

P24394

.
Ensembl transtripts involved in fusion geneENST00000170630, ENST00000380922, 
ENST00000395762, ENST00000543915, 
ENST00000449195, ENST00000565915, 
ENST00000368703, ENST00000368704, 
ENST00000368705, ENST00000368706, 
ENST00000474991, 
Fusion gene scores* DoF score9 X 8 X 5=3605 X 6 X 2=60
# samples 106
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/60*10)=0
Context

PubMed: IL4R [Title/Abstract] AND S100A16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL4R(27373850)-S100A16(153579953), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneS100A16

GO:0043163

cell envelope organization

21282207


check buttonFusion gene breakpoints across IL4R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across S100A16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE717238IL4Rchr16

27373850

+S100A16chr1

153579953

+


Top

Fusion Gene ORF analysis for IL4R-S100A16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000170630ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000170630ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000170630ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000170630ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000380922ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000380922ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000380922ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000380922ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000395762ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000395762ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000395762ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000395762ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000543915ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000543915ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000543915ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-3UTRENST00000543915ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-5UTRENST00000170630ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-5UTRENST00000380922ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-5UTRENST00000395762ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+
5CDS-5UTRENST00000543915ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000449195ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000449195ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000449195ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000449195ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000565915ENST00000368703IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000565915ENST00000368704IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000565915ENST00000368705IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-3UTRENST00000565915ENST00000368706IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-5UTRENST00000449195ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+
intron-5UTRENST00000565915ENST00000474991IL4Rchr16

27373850

+S100A16chr1

153579953

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for IL4R-S100A16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IL4R-S100A16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:27373850/:153579953)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IL4R

P24394

.
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. {ECO:0000269|PubMed:8124718}.; FUNCTION: Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. {ECO:0000269|PubMed:8124718}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for IL4R-S100A16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for IL4R-S100A16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for IL4R-S100A16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for IL4R-S100A16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource