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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IL6R-ATP8B2 (FusionGDB2 ID:39572) |
Fusion Gene Summary for IL6R-ATP8B2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IL6R-ATP8B2 | Fusion gene ID: 39572 | Hgene | Tgene | Gene symbol | IL6R | ATP8B2 | Gene ID | 3570 | 57198 |
| Gene name | interleukin 6 receptor | ATPase phospholipid transporting 8B2 | |
| Synonyms | CD126|IL-6R-1|IL-6RA|IL6Q|IL6RA|IL6RQ|gp80 | ATPID | |
| Cytomap | 1q21.3 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-6 receptor subunit alphaCD126 antigenIL-6 receptor subunit alphaIL-6R 1membrane glycoprotein 80 | phospholipid-transporting ATPase ID36/8-9 fusion protein with epitope for anti-lectin antibodyATPase, aminophospholipid transporter, class I, type 8B, member 2ATPase, class I, type 8B, member 2P4-ATPase flippase complex alpha subunit ATP8B2probable p | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P98198 | |
| Ensembl transtripts involved in fusion gene | ENST00000507256, ENST00000344086, ENST00000368485, | ENST00000368487, ENST00000368489, ENST00000341822, ENST00000426445, | |
| Fusion gene scores | * DoF score | 5 X 6 X 5=150 | 2 X 3 X 2=12 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: IL6R [Title/Abstract] AND ATP8B2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | |||
| Anticipated loss of major functional domain due to fusion event. | IL6R-ATP8B2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. IL6R-ATP8B2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. IL6R-ATP8B2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IL6R | GO:0008284 | positive regulation of cell proliferation | 2261637 |
| Hgene | IL6R | GO:0019221 | cytokine-mediated signaling pathway | 2261637 |
| Hgene | IL6R | GO:0032722 | positive regulation of chemokine production | 10510402 |
| Hgene | IL6R | GO:0032755 | positive regulation of interleukin-6 production | 10510402 |
| Hgene | IL6R | GO:0034097 | response to cytokine | 2261637 |
| Hgene | IL6R | GO:0048661 | positive regulation of smooth muscle cell proliferation | 10510402 |
| Hgene | IL6R | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 11884403 |
| Fusion gene breakpoints across IL6R (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across ATP8B2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerKB3 | . | . | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| ChimerKB3 | . | . | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
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Fusion Gene ORF analysis for IL6R-ATP8B2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000507256 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 3UTR-3CDS | ENST00000507256 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 3UTR-3CDS | ENST00000507256 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 3UTR-3CDS | ENST00000507256 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 3UTR-3UTR | ENST00000507256 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 3UTR-3UTR | ENST00000507256 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 3UTR-3UTR | ENST00000507256 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 3UTR-3UTR | ENST00000507256 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 5CDS-3UTR | ENST00000344086 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 5CDS-3UTR | ENST00000344086 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 5CDS-3UTR | ENST00000344086 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 5CDS-3UTR | ENST00000344086 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 5CDS-3UTR | ENST00000368485 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 5CDS-3UTR | ENST00000368485 | ENST00000341822 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| 5CDS-3UTR | ENST00000368485 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| 5CDS-3UTR | ENST00000368485 | ENST00000426445 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| Frame-shift | ENST00000344086 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| Frame-shift | ENST00000344086 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| Frame-shift | ENST00000368485 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| Frame-shift | ENST00000368485 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154302871 | + |
| In-frame | ENST00000344086 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| In-frame | ENST00000344086 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| In-frame | ENST00000368485 | ENST00000368487 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| In-frame | ENST00000368485 | ENST00000368489 | IL6R | chr1 | 154420647 | + | ATP8B2 | chr1 | 154303290 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368485 | IL6R | chr1 | 154420647 | + | ENST00000368487 | ATP8B2 | chr1 | 154303290 | + | 2679 | 1433 | 311 | 2506 | 731 |
| ENST00000368485 | IL6R | chr1 | 154420647 | + | ENST00000368489 | ATP8B2 | chr1 | 154303290 | + | 7105 | 1433 | 311 | 4915 | 1534 |
| ENST00000344086 | IL6R | chr1 | 154420647 | + | ENST00000368487 | ATP8B2 | chr1 | 154303290 | + | 2649 | 1403 | 281 | 2476 | 731 |
| ENST00000344086 | IL6R | chr1 | 154420647 | + | ENST00000368489 | ATP8B2 | chr1 | 154303290 | + | 7075 | 1403 | 281 | 4885 | 1534 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IL6R-ATP8B2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IL6R-ATP8B2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:/chr1:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | ATP8B2 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. {ECO:0000269|PubMed:25315773}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IL6R-ATP8B2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >39572_39572_1_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000344086_ATP8B2_chr1_154303290_ENST00000368487_length(transcript)=2649nt_BP=1403nt GGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCCGCTCCGGCTTTCGTAACCGCACCCTGGGAC GGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCCGCCGCTCTGAGTCATGTGCGAGTGGGAAGT CGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCT GCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGTTCCCATTA GCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCG CGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTC TGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGG CTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCCAGCTGGGA CTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGG GTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGCCGT GCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCG CCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCA CTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGC TCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCACGACGCCTGGAGCG GCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTT GGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGAGTAACTGCATCAAGACCTCCAAGTACAATATTCTCA CCTTCCTGCCTGTCAACCTCTTTGAGCAGTTCCAGGAAGTTGCCAACACTTACTTCCTGTTCCTCCTCATTCTGCAGTTGATCCCCCAGA TCTCTTCCCTGTCCTGGTTCACCACCATTGTGCCTTTGGTTCTTGTCCTCACCATCACAGCTGTTAAAGATGCCACTGATGACTATTTCC GCCACAAGAGCGATAACCAGGTGAATAACCGCCAGTCTCAGGTGCTGATCAATGGAATCCTCCAGCAGGAGCAGTGGATGAATGTCTGTG TTGGTGATATTATCAAGCTAGAAAATAACCAGTTTGTGGCGGCGGATCTCCTCCTCCTTTCCAGCAGTGAGCCCCATGGGCTGTGTTACA TAGAGACAGCAGAACTTGATGGCGAGACCAACATGAAAGTACGTCAGGCGATTCCAGTCACCTCAGAATTGGGAGACATCAGTAAGCTTG CCAAGTTTGACGGTGAAGTGATCTGTGAACCTCCCAACAACAAACTGGACAAATTCAGCGGAACCCTCTACTGGAAGGAAAATAAGTTCC CTCTGAGCAACCAGAACATGCTGCTGCGGGGCTGTGTGCTGCGAAACACCGAGTGGTGCTTCGGGCTGGTCATCTTTGCAGGTCCCGACA CTAAGCTGATGCAAAACAGCGGCAGAACAAAGTTCAAAAGAACGAGTATCGATCGCCTAATGAATACCCTGGTGCTCTGGATTTTTGGAT TCCTGGTTTGCATGGGGGTGATCCTGGCCATTGGCAATGCCATCTGGGAGCACGAGGTGGGGATGCGTTTCCAGGTCTACCTGCCGTGGG ATGAGGCAGTGGACAGTGCCTTCTTCTCTGGCTTCCTCTCCTTCTGGTCCTACATCATCATCCTCAACACCGTTGTGCCCATTTCACTCT ATGTCAGGTATGTGCCTTCTCTGACCTGGGGTCTCTCCAGGGAGTCAGGCGGTCCCATAGAACTTTTCTTTTCTATGAAGATGAAGTCCT TGAGAAGTAACGAGAAGTCCTCTTCTTCCTGTACTGTAAACATTTGATGTTATCTGTTTATCTTTGTGGGCAGAGCAAACTTTTTACCAC AGTTTCCTGGTACTTGGGACTGTATTAGAGAAAAAAAAATATTGATTTATTCAGCACCTATTTATTACATGCCTACTGTGTACAAAGAAG >39572_39572_1_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000344086_ATP8B2_chr1_154303290_ENST00000368487_length(amino acids)=731AA_BP=374 MPPGPEPACPPTAPPRPCHPCRPVPISLSASAGPWSGSRGGSMLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCP GVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRS TPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA RNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES RSPPAENEVSTPMQSNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKS DNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFD GEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVC MGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVRYVPSLTWGLSRESGGPIELFFSMKMKSLRSN -------------------------------------------------------------- >39572_39572_2_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000344086_ATP8B2_chr1_154303290_ENST00000368489_length(transcript)=7075nt_BP=1403nt GGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCCGCTCCGGCTTTCGTAACCGCACCCTGGGAC GGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCCGCCGCTCTGAGTCATGTGCGAGTGGGAAGT CGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCT GCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGTTCCCATTA GCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCG CGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTC TGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGG CTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCCAGCTGGGA CTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGG GTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGCCGT GCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCG CCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCA CTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGC TCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCACGACGCCTGGAGCG GCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTT GGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGAGTAACTGCATCAAGACCTCCAAGTACAATATTCTCA CCTTCCTGCCTGTCAACCTCTTTGAGCAGTTCCAGGAAGTTGCCAACACTTACTTCCTGTTCCTCCTCATTCTGCAGTTGATCCCCCAGA TCTCTTCCCTGTCCTGGTTCACCACCATTGTGCCTTTGGTTCTTGTCCTCACCATCACAGCTGTTAAAGATGCCACTGATGACTATTTCC GCCACAAGAGCGATAACCAGGTGAATAACCGCCAGTCTCAGGTGCTGATCAATGGAATCCTCCAGCAGGAGCAGTGGATGAATGTCTGTG TTGGTGATATTATCAAGCTAGAAAATAACCAGTTTGTGGCGGCGGATCTCCTCCTCCTTTCCAGCAGTGAGCCCCATGGGCTGTGTTACA TAGAGACAGCAGAACTTGATGGCGAGACCAACATGAAAGTACGTCAGGCGATTCCAGTCACCTCAGAATTGGGAGACATCAGTAAGCTTG CCAAGTTTGACGGTGAAGTGATCTGTGAACCTCCCAACAACAAACTGGACAAATTCAGCGGAACCCTCTACTGGAAGGAAAATAAGTTCC CTCTGAGCAACCAGAACATGCTGCTGCGGGGCTGTGTGCTGCGAAACACCGAGTGGTGCTTCGGGCTGGTCATCTTTGCAGGTCCCGACA CTAAGCTGATGCAAAACAGCGGCAGAACAAAGTTCAAAAGAACGAGTATCGATCGCCTAATGAATACCCTGGTGCTCTGGATTTTTGGAT TCCTGGTTTGCATGGGGGTGATCCTGGCCATTGGCAATGCCATCTGGGAGCACGAGGTGGGGATGCGTTTCCAGGTCTACCTGCCGTGGG ATGAGGCAGTGGACAGTGCCTTCTTCTCTGGCTTCCTCTCCTTCTGGTCCTACATCATCATCCTCAACACCGTTGTGCCCATTTCACTCT ATGTCAGTGTGGAGGTCATCCGTCTGGGCCACAGCTACTTCATCAACTGGGATAAGAAGATGTTCTGCATGAAGAAGCGGACGCCTGCAG AAGCCCGCACCACCACCCTAAACGAGGAGCTGGGCCAGGTGGAGTACATCTTCTCCGACAAGACGGGCACCCTCACCCAGAACATCATGG TTTTCAACAAGTGCTCCATCAATGGCCACAGCTATGGTGATGTGTTTGACGTCCTGGGACACAAAGCTGAATTGGGAGAGAGGCCTGAAC CTGTTGACTTCTCCTTCAATCCTCTGGCTGACAAGAAGTTCTTATTTTGGGACCCCAGCCTGCTGGAGGCTGTCAAGATCGGGGACCCCC ACACGCATGAGTTCTTCCGCCTCCTTTCCCTGTGTCATACTGTCATGTCAGAAGAAAAGAACGAAGGAGAGCTGTACTACAAAGCTCAGT CCCCAGATGAGGGGGCCCTGGTCACCGCAGCCAGGAACTTTGGTTTTGTTTTCCGCTCTCGCACCCCCAAAACAATCACCGTCCATGAGA TGGGCACAGCCATCACCTACCAGCTGCTGGCCATCCTGGACTTCAACAACATCCGCAAGCGGATGTCGGTCATAGTGCGGAATCCAGAGG GGAAGATCCGACTCTACTGCAAAGGGGCTGACACTATCCTACTGGACAGACTGCACCACTCCACTCAAGAGCTGCTCAACACCACCATGG ACCACCTTAATGAGTACGCAGGGGAAGGGCTGAGGACCCTGGTGCTGGCCTACAAGGATCTGGATGAAGAGTACTACGAGGAGTGGGCTG AGCGACGCCTCCAGGCCAGCCTGGCCCAGGACAGCCGGGAGGACAGGCTGGCTAGCATCTATGAGGAGGTTGAGAACAACATGATGCTGC TGGGTGCAACGGCCATTGAGGACAAACTTCAGCAAGGGGTTCCAGAGACCATTGCCCTCCTGACACTGGCCAACATCAAGATTTGGGTGC TAACCGGAGACAAGCAAGAGACGGCTGTGAACATCGGCTATTCCTGCAAGATGCTGACGGATGACATGACTGAGGTTTTCATAGTCACTG GCCATACTGTCCTGGAGGTGCGGGAGGAGCTCAGGAAAGCCCGGGAGAAGATGATGGACTCATCCCGCTCCGTAGGCAACGGCTTCACCT ATCAGGACAAGCTTTCTTCTTCCAAGCTAACTTCTGTCCTGGAGGCCGTTGCTGGGGAGTACGCCCTGGTCATAAATGGTCACAGCCTGG CCCACGCACTGGAGGCAGACATGGAGCTGGAGTTTCTGGAGACAGCGTGTGCCTGCAAAGCTGTCATCTGCTGCCGGGTGACCCCCTTGC AGAAGGCACAGGTGGTAGAACTGGTCAAGAAGTACAAGAAGGCTGTGACGCTTGCCATTGGAGACGGAGCCAATGATGTCAGCATGATCA AAACGGCTCACATTGGTGTGGGGATCAGTGGGCAGGAAGGGATCCAGGCTGTCTTGGCCTCCGATTACTCCTTCTCCCAGTTCAAGTTCC TGCAGCGCCTCCTGCTGGTGCATGGGCGCTGGTCCTACCTGCGAATGTGCAAGTTTCTTTGCTATTTCTTCTACAAAAACTTTGCTTTCA CCATGGTCCACTTCTGGTTTGGCTTCTTCTGTGGCTTCTCAGCCCAGACCGTCTATGACCAGTATTTCATCACCCTGTATAACATCGTGT ACACCTCCCTGCCAGTCCTGGCTATGGGGGTCTTTGATCAGGATGTCCCCGAGCAGCGGAGCATGGAGTACCCTAAGCTGTATGAGCCGG GCCAGCTGAACCTTCTCTTCAACAAGCGGGAGTTCTTCATCTGCATCGCCCAGGGCATCTACACCTCCGTGCTCATGTTCTTCATTCCCT ATGGGGTGTTTGCTGATGCCACCCGGGATGATGGCACTCAGCTGGCTGACTACCAGTCCTTTGCAGTCACTGTGGCCACATCCTTGGTCA TTGTGGTTAGCGTGCAGATTGGGCTCGACACAGGCTACTGGACGGCCATCAACCACTTCTTCATCTGGGGAAGCCTTGCTGTTTACTTTG CCATCCTCTTTGCCATGCACAGCAATGGGCTCTTCGACATGTTTCCCAACCAGTTCCGGTTTGTGGGGAATGCCCAGAACACCTTGGCCC AGCCCACGGTGTGGCTGACCATTGTGCTCACCACAGTCGTCTGCATCATGCCCGTGGTTGCCTTCCGATTCCTCAGGCTCAACCTGAAGC CGGATCTCTCCGACACGGTCCGCTACACACAGCTCGTGAGGAAGAAGCAGAAGGCCCAGCACCGCTGCATGCGGCGGGTTGGCCGCACTG GCTCCCGGCGCTCCGGCTATGCCTTCTCCCATCAGGAGGGCTTCGGGGAGCTCATCATGTCTGGCAAGAACATGCGGCTGAGCTCTCTCG CGCTCTCCAGCTTCACCACCCGCTCCAGCTCCAGCTGGATTGAGAGCCTGCGCAGGAAGAAGAGTGACAGTGCCAGTAGCCCCAGTGGCG GTGCCGACAAGCCCCTCAAGGGCTGAAGGCCGAGGATGGATGCCCTGTGCCAGTGACCAGAGCACCCAGGGCTGGCCAGTCACTGAGGGA ACAGCGTCTCGGAACTGCTGGTCCTCATTCCTTGCTTCCCGTCCCCCCGGTAGACTCTGTCCTGCTGGTCCCACCACACATGGCTGGGAC ATCTGTTCCCAGCTGTAGGCCCTTCCACCAGCTGGGGAGCTAGAGGGAGCAGGCCCAAGGGCAGAGCAGAGGCTGAGGCACGGGGAGCCA GCCCCACTCGGGGACCAGAAGTGGAACCAAAAACAAGAAAAAACTGTGAGAGATTGTGTCTGCCCCTGCCCTGCCTGGGACCCACAGGGA GACTATAATCTCCTTATTTTTTTACTCCTACTCCCCAGAGGGGCCCTAGTGCCTCTGTTCCTGAATTACATAAGAATGTACCATGCCGGG AAGCCAGAGACCTGCAGGGGCCTCGGCCCCTCACATCGTGTATGTCTCTCCTTGATTTGTGTTGTGTCCAGTTTGGTTTTGTCTTTTTTT ATTTGGCAAGTGGAGGAGGCTTTTATGTGACTTTTATGTTGTGGTTGGTGTCTTAACTCTCCTGGGAAAAGGAGGCTGGCACACACTGGG ATGCCGCAGCCTGGCCGGCTGTGGGGTGGTTTGGGAGGATCCATGTCGGCTCTGCCTGCAGTGACCAGTGCTCTGTGGGGCAGAGGAGCT GACCAGGGAGGGAGGTACCCATGAGCAGAGGGTAGTGGGAGAGTGTAAAGGAGGGTTTGGTCCTGTCTGCTTCCTCACCTTGAGAGTAAA GTGCTGCCCTCTGCCCCCAACACACACACATATCAATTCCTGGATTCCTTAGTCCTGCTGGCCTTGGGCTGGAGCCTAGGAAAGTGGCCC CCAAATCCTTAGTGAGCTAAAGCTGGGTCTGAAATTTGGTCAGTGGGGAGGGGTAGTTTTCTTTTCTTTTTTCTTTTTCTTTTTTTCTTT TTTTTTTTGAGATGGAGTCTCACTCTTGTCACCTAGGCAAGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTC AAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACACCACCACGCTTGGTTAATTTTTGTATTTTTAGTAGAGAT GTTTCACCATGTTGGCCAGGCTAGTCTTGAATTCCTGACCTCCTGACCTGCCCACCTCAACCTCCCAAAGTGCTGAGATTACAGGCGTGA GCCACCACACCCAGCTCAGGGAGGCGTAGTTTTCTTTAATTTTAAATTTAAACCCAAGTTTATTGGCAGACTCCCTTTTGACCTCCCTTT GCCTCCCCATCTGGTGCTTTCTTGCATCTACACCCCAGGGCCCTGTGGTGGGGCTGCAGGGGGAAGCTGTGCACCTGAGATGAGGCTGGA ACGGGAATTGGCCTCTCTGCTCCCTTCTTCAGTAAGCAAGGAGCCCCGCCCCTCAGGCCCAGCCTCTGGCAAGAGGTGGTGGAATCCTTG TGCCGGGTAGTAGAGGAGGATAAGGGCAAAACCAGGCCCAGGCCAGTGCCTGGCTTGGTCTGGATGGGACACTGTCAGAGTTTGGCCACA GCCTGTCCTTTACTTCATCCACACCTATGAAGCTATTCCCTAAATAAGGCATTTCCCAAGTTAGTCGCTACCTAATCAGCCTTGAGAAGA ATCCTTTCCTCTTCTTTGATAGTGGGTCGGGGGATTCTTCAGGAATGGTTTGGAGCTGGGAGTGGGTAGGGGGATTTTAAATGTTCCATA TGGGAGCCCCAAAGGAACTGGATGGGCTGCAGTGAGGTGGGGGCGGGTGGGCAGGGAATGGGAGAGGGGAAGTCTTGGCAGGGAAATCCC TTTTGGCCACACAGTTTACAAACCCAGTATCATGTCTGTCTGTGTGTCTCTCAAGGTGAGAGTCTGATTTTTATACCAAAGAGGAAATGA TTTTTTTTCATATTTTGTTTGTCTATATTATATAAATATATATATACAGTTATATATATATATATTATTTTTTGGTTCTCTCTCGTTTTT TAGGGAGGGAAGAAAGTACCAAGTTGCATTGAGCTGTAATTAAGGAACATTATAATTTATGACACATTTCTATACTTGCAAAAATTATAT >39572_39572_2_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000344086_ATP8B2_chr1_154303290_ENST00000368489_length(amino acids)=1534AA_BP=374 MPPGPEPACPPTAPPRPCHPCRPVPISLSASAGPWSGSRGGSMLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCP GVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRS TPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA RNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES RSPPAENEVSTPMQSNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKS DNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFD GEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVC MGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEART TTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHE FFRLLSLCHTVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIR LYCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNMMLLGAT AIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDK LSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAH IGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSL PVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVS VQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLS DTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADK -------------------------------------------------------------- >39572_39572_3_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000368485_ATP8B2_chr1_154303290_ENST00000368487_length(transcript)=2679nt_BP=1433nt GGCGGTCCCCTGTTCTCCCCGCTCAGGTGCGGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCC GCTCCGGCTTTCGTAACCGCACCCTGGGACGGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCC GCCGCTCTGAGTCATGTGCGAGTGGGAAGTCGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGA CTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCC CCTGCCACCCCTGCCGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCG GCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGC TGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGC CGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATT CATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGA GCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGA ACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACA GCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGC AGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGA ACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGC ATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCG AGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGAGTAACT GCATCAAGACCTCCAAGTACAATATTCTCACCTTCCTGCCTGTCAACCTCTTTGAGCAGTTCCAGGAAGTTGCCAACACTTACTTCCTGT TCCTCCTCATTCTGCAGTTGATCCCCCAGATCTCTTCCCTGTCCTGGTTCACCACCATTGTGCCTTTGGTTCTTGTCCTCACCATCACAG CTGTTAAAGATGCCACTGATGACTATTTCCGCCACAAGAGCGATAACCAGGTGAATAACCGCCAGTCTCAGGTGCTGATCAATGGAATCC TCCAGCAGGAGCAGTGGATGAATGTCTGTGTTGGTGATATTATCAAGCTAGAAAATAACCAGTTTGTGGCGGCGGATCTCCTCCTCCTTT CCAGCAGTGAGCCCCATGGGCTGTGTTACATAGAGACAGCAGAACTTGATGGCGAGACCAACATGAAAGTACGTCAGGCGATTCCAGTCA CCTCAGAATTGGGAGACATCAGTAAGCTTGCCAAGTTTGACGGTGAAGTGATCTGTGAACCTCCCAACAACAAACTGGACAAATTCAGCG GAACCCTCTACTGGAAGGAAAATAAGTTCCCTCTGAGCAACCAGAACATGCTGCTGCGGGGCTGTGTGCTGCGAAACACCGAGTGGTGCT TCGGGCTGGTCATCTTTGCAGGTCCCGACACTAAGCTGATGCAAAACAGCGGCAGAACAAAGTTCAAAAGAACGAGTATCGATCGCCTAA TGAATACCCTGGTGCTCTGGATTTTTGGATTCCTGGTTTGCATGGGGGTGATCCTGGCCATTGGCAATGCCATCTGGGAGCACGAGGTGG GGATGCGTTTCCAGGTCTACCTGCCGTGGGATGAGGCAGTGGACAGTGCCTTCTTCTCTGGCTTCCTCTCCTTCTGGTCCTACATCATCA TCCTCAACACCGTTGTGCCCATTTCACTCTATGTCAGGTATGTGCCTTCTCTGACCTGGGGTCTCTCCAGGGAGTCAGGCGGTCCCATAG AACTTTTCTTTTCTATGAAGATGAAGTCCTTGAGAAGTAACGAGAAGTCCTCTTCTTCCTGTACTGTAAACATTTGATGTTATCTGTTTA TCTTTGTGGGCAGAGCAAACTTTTTACCACAGTTTCCTGGTACTTGGGACTGTATTAGAGAAAAAAAAATATTGATTTATTCAGCACCTA >39572_39572_3_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000368485_ATP8B2_chr1_154303290_ENST00000368487_length(amino acids)=731AA_BP=374 MPPGPEPACPPTAPPRPCHPCRPVPISLSASAGPWSGSRGGSMLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCP GVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRS TPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA RNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES RSPPAENEVSTPMQSNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKS DNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFD GEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVC MGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVRYVPSLTWGLSRESGGPIELFFSMKMKSLRSN -------------------------------------------------------------- >39572_39572_4_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000368485_ATP8B2_chr1_154303290_ENST00000368489_length(transcript)=7105nt_BP=1433nt GGCGGTCCCCTGTTCTCCCCGCTCAGGTGCGGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCC GCTCCGGCTTTCGTAACCGCACCCTGGGACGGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCC GCCGCTCTGAGTCATGTGCGAGTGGGAAGTCGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGA CTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCC CCTGCCACCCCTGCCGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCG GCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGC TGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGC CGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATT CATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGA GCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGA ACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACA GCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGC AGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGA ACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGC ATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCG AGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGAGTAACT GCATCAAGACCTCCAAGTACAATATTCTCACCTTCCTGCCTGTCAACCTCTTTGAGCAGTTCCAGGAAGTTGCCAACACTTACTTCCTGT TCCTCCTCATTCTGCAGTTGATCCCCCAGATCTCTTCCCTGTCCTGGTTCACCACCATTGTGCCTTTGGTTCTTGTCCTCACCATCACAG CTGTTAAAGATGCCACTGATGACTATTTCCGCCACAAGAGCGATAACCAGGTGAATAACCGCCAGTCTCAGGTGCTGATCAATGGAATCC TCCAGCAGGAGCAGTGGATGAATGTCTGTGTTGGTGATATTATCAAGCTAGAAAATAACCAGTTTGTGGCGGCGGATCTCCTCCTCCTTT CCAGCAGTGAGCCCCATGGGCTGTGTTACATAGAGACAGCAGAACTTGATGGCGAGACCAACATGAAAGTACGTCAGGCGATTCCAGTCA CCTCAGAATTGGGAGACATCAGTAAGCTTGCCAAGTTTGACGGTGAAGTGATCTGTGAACCTCCCAACAACAAACTGGACAAATTCAGCG GAACCCTCTACTGGAAGGAAAATAAGTTCCCTCTGAGCAACCAGAACATGCTGCTGCGGGGCTGTGTGCTGCGAAACACCGAGTGGTGCT TCGGGCTGGTCATCTTTGCAGGTCCCGACACTAAGCTGATGCAAAACAGCGGCAGAACAAAGTTCAAAAGAACGAGTATCGATCGCCTAA TGAATACCCTGGTGCTCTGGATTTTTGGATTCCTGGTTTGCATGGGGGTGATCCTGGCCATTGGCAATGCCATCTGGGAGCACGAGGTGG GGATGCGTTTCCAGGTCTACCTGCCGTGGGATGAGGCAGTGGACAGTGCCTTCTTCTCTGGCTTCCTCTCCTTCTGGTCCTACATCATCA TCCTCAACACCGTTGTGCCCATTTCACTCTATGTCAGTGTGGAGGTCATCCGTCTGGGCCACAGCTACTTCATCAACTGGGATAAGAAGA TGTTCTGCATGAAGAAGCGGACGCCTGCAGAAGCCCGCACCACCACCCTAAACGAGGAGCTGGGCCAGGTGGAGTACATCTTCTCCGACA AGACGGGCACCCTCACCCAGAACATCATGGTTTTCAACAAGTGCTCCATCAATGGCCACAGCTATGGTGATGTGTTTGACGTCCTGGGAC ACAAAGCTGAATTGGGAGAGAGGCCTGAACCTGTTGACTTCTCCTTCAATCCTCTGGCTGACAAGAAGTTCTTATTTTGGGACCCCAGCC TGCTGGAGGCTGTCAAGATCGGGGACCCCCACACGCATGAGTTCTTCCGCCTCCTTTCCCTGTGTCATACTGTCATGTCAGAAGAAAAGA ACGAAGGAGAGCTGTACTACAAAGCTCAGTCCCCAGATGAGGGGGCCCTGGTCACCGCAGCCAGGAACTTTGGTTTTGTTTTCCGCTCTC GCACCCCCAAAACAATCACCGTCCATGAGATGGGCACAGCCATCACCTACCAGCTGCTGGCCATCCTGGACTTCAACAACATCCGCAAGC GGATGTCGGTCATAGTGCGGAATCCAGAGGGGAAGATCCGACTCTACTGCAAAGGGGCTGACACTATCCTACTGGACAGACTGCACCACT CCACTCAAGAGCTGCTCAACACCACCATGGACCACCTTAATGAGTACGCAGGGGAAGGGCTGAGGACCCTGGTGCTGGCCTACAAGGATC TGGATGAAGAGTACTACGAGGAGTGGGCTGAGCGACGCCTCCAGGCCAGCCTGGCCCAGGACAGCCGGGAGGACAGGCTGGCTAGCATCT ATGAGGAGGTTGAGAACAACATGATGCTGCTGGGTGCAACGGCCATTGAGGACAAACTTCAGCAAGGGGTTCCAGAGACCATTGCCCTCC TGACACTGGCCAACATCAAGATTTGGGTGCTAACCGGAGACAAGCAAGAGACGGCTGTGAACATCGGCTATTCCTGCAAGATGCTGACGG ATGACATGACTGAGGTTTTCATAGTCACTGGCCATACTGTCCTGGAGGTGCGGGAGGAGCTCAGGAAAGCCCGGGAGAAGATGATGGACT CATCCCGCTCCGTAGGCAACGGCTTCACCTATCAGGACAAGCTTTCTTCTTCCAAGCTAACTTCTGTCCTGGAGGCCGTTGCTGGGGAGT ACGCCCTGGTCATAAATGGTCACAGCCTGGCCCACGCACTGGAGGCAGACATGGAGCTGGAGTTTCTGGAGACAGCGTGTGCCTGCAAAG CTGTCATCTGCTGCCGGGTGACCCCCTTGCAGAAGGCACAGGTGGTAGAACTGGTCAAGAAGTACAAGAAGGCTGTGACGCTTGCCATTG GAGACGGAGCCAATGATGTCAGCATGATCAAAACGGCTCACATTGGTGTGGGGATCAGTGGGCAGGAAGGGATCCAGGCTGTCTTGGCCT CCGATTACTCCTTCTCCCAGTTCAAGTTCCTGCAGCGCCTCCTGCTGGTGCATGGGCGCTGGTCCTACCTGCGAATGTGCAAGTTTCTTT GCTATTTCTTCTACAAAAACTTTGCTTTCACCATGGTCCACTTCTGGTTTGGCTTCTTCTGTGGCTTCTCAGCCCAGACCGTCTATGACC AGTATTTCATCACCCTGTATAACATCGTGTACACCTCCCTGCCAGTCCTGGCTATGGGGGTCTTTGATCAGGATGTCCCCGAGCAGCGGA GCATGGAGTACCCTAAGCTGTATGAGCCGGGCCAGCTGAACCTTCTCTTCAACAAGCGGGAGTTCTTCATCTGCATCGCCCAGGGCATCT ACACCTCCGTGCTCATGTTCTTCATTCCCTATGGGGTGTTTGCTGATGCCACCCGGGATGATGGCACTCAGCTGGCTGACTACCAGTCCT TTGCAGTCACTGTGGCCACATCCTTGGTCATTGTGGTTAGCGTGCAGATTGGGCTCGACACAGGCTACTGGACGGCCATCAACCACTTCT TCATCTGGGGAAGCCTTGCTGTTTACTTTGCCATCCTCTTTGCCATGCACAGCAATGGGCTCTTCGACATGTTTCCCAACCAGTTCCGGT TTGTGGGGAATGCCCAGAACACCTTGGCCCAGCCCACGGTGTGGCTGACCATTGTGCTCACCACAGTCGTCTGCATCATGCCCGTGGTTG CCTTCCGATTCCTCAGGCTCAACCTGAAGCCGGATCTCTCCGACACGGTCCGCTACACACAGCTCGTGAGGAAGAAGCAGAAGGCCCAGC ACCGCTGCATGCGGCGGGTTGGCCGCACTGGCTCCCGGCGCTCCGGCTATGCCTTCTCCCATCAGGAGGGCTTCGGGGAGCTCATCATGT CTGGCAAGAACATGCGGCTGAGCTCTCTCGCGCTCTCCAGCTTCACCACCCGCTCCAGCTCCAGCTGGATTGAGAGCCTGCGCAGGAAGA AGAGTGACAGTGCCAGTAGCCCCAGTGGCGGTGCCGACAAGCCCCTCAAGGGCTGAAGGCCGAGGATGGATGCCCTGTGCCAGTGACCAG AGCACCCAGGGCTGGCCAGTCACTGAGGGAACAGCGTCTCGGAACTGCTGGTCCTCATTCCTTGCTTCCCGTCCCCCCGGTAGACTCTGT CCTGCTGGTCCCACCACACATGGCTGGGACATCTGTTCCCAGCTGTAGGCCCTTCCACCAGCTGGGGAGCTAGAGGGAGCAGGCCCAAGG GCAGAGCAGAGGCTGAGGCACGGGGAGCCAGCCCCACTCGGGGACCAGAAGTGGAACCAAAAACAAGAAAAAACTGTGAGAGATTGTGTC TGCCCCTGCCCTGCCTGGGACCCACAGGGAGACTATAATCTCCTTATTTTTTTACTCCTACTCCCCAGAGGGGCCCTAGTGCCTCTGTTC CTGAATTACATAAGAATGTACCATGCCGGGAAGCCAGAGACCTGCAGGGGCCTCGGCCCCTCACATCGTGTATGTCTCTCCTTGATTTGT GTTGTGTCCAGTTTGGTTTTGTCTTTTTTTATTTGGCAAGTGGAGGAGGCTTTTATGTGACTTTTATGTTGTGGTTGGTGTCTTAACTCT CCTGGGAAAAGGAGGCTGGCACACACTGGGATGCCGCAGCCTGGCCGGCTGTGGGGTGGTTTGGGAGGATCCATGTCGGCTCTGCCTGCA GTGACCAGTGCTCTGTGGGGCAGAGGAGCTGACCAGGGAGGGAGGTACCCATGAGCAGAGGGTAGTGGGAGAGTGTAAAGGAGGGTTTGG TCCTGTCTGCTTCCTCACCTTGAGAGTAAAGTGCTGCCCTCTGCCCCCAACACACACACATATCAATTCCTGGATTCCTTAGTCCTGCTG GCCTTGGGCTGGAGCCTAGGAAAGTGGCCCCCAAATCCTTAGTGAGCTAAAGCTGGGTCTGAAATTTGGTCAGTGGGGAGGGGTAGTTTT CTTTTCTTTTTTCTTTTTCTTTTTTTCTTTTTTTTTTTGAGATGGAGTCTCACTCTTGTCACCTAGGCAAGAGTGCAATGGCACAATCTC AGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCACACACCACCACGC TTGGTTAATTTTTGTATTTTTAGTAGAGATGTTTCACCATGTTGGCCAGGCTAGTCTTGAATTCCTGACCTCCTGACCTGCCCACCTCAA CCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCACACCCAGCTCAGGGAGGCGTAGTTTTCTTTAATTTTAAATTTAAACCCAAGTT TATTGGCAGACTCCCTTTTGACCTCCCTTTGCCTCCCCATCTGGTGCTTTCTTGCATCTACACCCCAGGGCCCTGTGGTGGGGCTGCAGG GGGAAGCTGTGCACCTGAGATGAGGCTGGAACGGGAATTGGCCTCTCTGCTCCCTTCTTCAGTAAGCAAGGAGCCCCGCCCCTCAGGCCC AGCCTCTGGCAAGAGGTGGTGGAATCCTTGTGCCGGGTAGTAGAGGAGGATAAGGGCAAAACCAGGCCCAGGCCAGTGCCTGGCTTGGTC TGGATGGGACACTGTCAGAGTTTGGCCACAGCCTGTCCTTTACTTCATCCACACCTATGAAGCTATTCCCTAAATAAGGCATTTCCCAAG TTAGTCGCTACCTAATCAGCCTTGAGAAGAATCCTTTCCTCTTCTTTGATAGTGGGTCGGGGGATTCTTCAGGAATGGTTTGGAGCTGGG AGTGGGTAGGGGGATTTTAAATGTTCCATATGGGAGCCCCAAAGGAACTGGATGGGCTGCAGTGAGGTGGGGGCGGGTGGGCAGGGAATG GGAGAGGGGAAGTCTTGGCAGGGAAATCCCTTTTGGCCACACAGTTTACAAACCCAGTATCATGTCTGTCTGTGTGTCTCTCAAGGTGAG AGTCTGATTTTTATACCAAAGAGGAAATGATTTTTTTTCATATTTTGTTTGTCTATATTATATAAATATATATATACAGTTATATATATA TATATTATTTTTTGGTTCTCTCTCGTTTTTTAGGGAGGGAAGAAAGTACCAAGTTGCATTGAGCTGTAATTAAGGAACATTATAATTTAT >39572_39572_4_IL6R-ATP8B2_IL6R_chr1_154420647_ENST00000368485_ATP8B2_chr1_154303290_ENST00000368489_length(amino acids)=1534AA_BP=374 MPPGPEPACPPTAPPRPCHPCRPVPISLSASAGPWSGSRGGSMLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCP GVEPEDNATVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRS TPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA RNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTES RSPPAENEVSTPMQSNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKS DNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFD GEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVC MGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEART TTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHE FFRLLSLCHTVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIR LYCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNMMLLGAT AIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDK LSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAH IGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSL PVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVS VQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLS DTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for IL6R-ATP8B2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IL6R-ATP8B2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IL6R-ATP8B2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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