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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL6R-IL6ST (FusionGDB2 ID:39574)

Fusion Gene Summary for IL6R-IL6ST

check button Fusion gene summary
Fusion gene informationFusion gene name: IL6R-IL6ST
Fusion gene ID: 39574
HgeneTgene
Gene symbol

IL6R

IL6ST

Gene ID

3570

3572

Gene nameinterleukin 6 receptorinterleukin 6 signal transducer
SynonymsCD126|IL-6R-1|IL-6RA|IL6Q|IL6RA|IL6RQ|gp80CD130|CDW130|GP130|HIES4|IL-6RB|sGP130
Cytomap

1q21.3

5q11.2

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-6 receptor subunit alphaCD126 antigenIL-6 receptor subunit alphaIL-6R 1membrane glycoprotein 80interleukin-6 receptor subunit betaCD130 antigenIL-6 receptor subunit betaIL-6R subunit betagp130 of the rheumatoid arthritis antigenic peptide-bearing soluble formgp130, oncostatin M receptorinterleukin receptor beta chainmembrane glycoprotein 130
Modification date2020031320200327
UniProtAcc.

P40189

Ensembl transtripts involved in fusion geneENST00000507256, ENST00000344086, 
ENST00000368485, 		ENST00000336909, 
ENST00000381287, ENST00000381293, 
ENST00000381294, ENST00000381298, 
ENST00000502326, ENST00000536319, 
ENST00000381286, ENST00000396816, 
ENST00000522633, ENST00000577363, 
Fusion gene scores* DoF score5 X 6 X 5=1507 X 8 X 3=168
# samples 68
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL6R [Title/Abstract] AND IL6ST [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL6R(154420644)-IL6ST(55265681), # samples:2
Anticipated loss of major functional domain due to fusion event.IL6R-IL6ST seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
IL6R-IL6ST seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
IL6R-IL6ST seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL6R

GO:0008284

positive regulation of cell proliferation

2261637

HgeneIL6R

GO:0019221

cytokine-mediated signaling pathway

2261637

HgeneIL6R

GO:0032722

positive regulation of chemokine production

10510402

HgeneIL6R

GO:0032755

positive regulation of interleukin-6 production

10510402

HgeneIL6R

GO:0034097

response to cytokine

2261637

HgeneIL6R

GO:0048661

positive regulation of smooth muscle cell proliferation

10510402

HgeneIL6R

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

11884403

TgeneIL6ST

GO:0008284

positive regulation of cell proliferation

2261637

TgeneIL6ST

GO:0019221

cytokine-mediated signaling pathway

2261637

TgeneIL6ST

GO:0034097

response to cytokine

2261637|8999038

TgeneIL6ST

GO:0048861

leukemia inhibitory factor signaling pathway

8999038|12643274

TgeneIL6ST

GO:0070120

ciliary neurotrophic factor-mediated signaling pathway

12643274


check buttonFusion gene breakpoints across IL6R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IL6ST (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX503599IL6Rchr1

154420644

+IL6STchr5

55265681

-
ChiTaRS5.0N/ACQ796429IL6Rchr1

154420644

+IL6STchr5

55265681

-


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Fusion Gene ORF analysis for IL6R-IL6ST

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000507256ENST00000336909IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000381287IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000381293IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000381294IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000381298IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000502326IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-3CDSENST00000507256ENST00000536319IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-intronENST00000507256ENST00000381286IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-intronENST00000507256ENST00000396816IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-intronENST00000507256ENST00000522633IL6Rchr1

154420644

+IL6STchr5

55265681

-
3UTR-intronENST00000507256ENST00000577363IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000344086ENST00000381286IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000344086ENST00000396816IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000344086ENST00000522633IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000344086ENST00000577363IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000368485ENST00000381286IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000368485ENST00000396816IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000368485ENST00000522633IL6Rchr1

154420644

+IL6STchr5

55265681

-
5CDS-intronENST00000368485ENST00000577363IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000344086ENST00000336909IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000344086ENST00000381293IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000344086ENST00000381294IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000344086ENST00000381298IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000344086ENST00000502326IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000368485ENST00000336909IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000368485ENST00000381293IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000368485ENST00000381294IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000368485ENST00000381298IL6Rchr1

154420644

+IL6STchr5

55265681

-
Frame-shiftENST00000368485ENST00000502326IL6Rchr1

154420644

+IL6STchr5

55265681

-
In-frameENST00000344086ENST00000381287IL6Rchr1

154420644

+IL6STchr5

55265681

-
In-frameENST00000344086ENST00000536319IL6Rchr1

154420644

+IL6STchr5

55265681

-
In-frameENST00000368485ENST00000381287IL6Rchr1

154420644

+IL6STchr5

55265681

-
In-frameENST00000368485ENST00000536319IL6Rchr1

154420644

+IL6STchr5

55265681

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368485IL6Rchr1154420644+ENST00000381287IL6STchr555265681-10000143322824042586
ENST00000368485IL6Rchr1154420644+ENST00000536319IL6STchr555265681-3860143322823859526
ENST00000344086IL6Rchr1154420644+ENST00000381287IL6STchr555265681-9970140322524012586
ENST00000344086IL6Rchr1154420644+ENST00000536319IL6STchr555265681-3830140322523829526

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368485ENST00000381287IL6Rchr1154420644+IL6STchr555265681-0.0002938730.9997061
ENST00000368485ENST00000536319IL6Rchr1154420644+IL6STchr555265681-0.0023571390.9976428
ENST00000344086ENST00000381287IL6Rchr1154420644+IL6STchr555265681-0.0002959020.99970406
ENST00000344086ENST00000536319IL6Rchr1154420644+IL6STchr555265681-0.0023276560.9976724

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Fusion Genomic Features for IL6R-IL6ST


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL6R-IL6ST


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154420644/chr5:55265681)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IL6ST

P40189

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Signal-transducing molecule (PubMed:2261637). The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activate the intracellular JAK-MAPK and JAK-STAT3 signaling pathways (PubMed:2261637, PubMed:19915009, PubMed:23294003). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003, PubMed:25731159). In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop (By similarity). Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3 (By similarity). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). {ECO:0000250|UniProtKB:Q00560, ECO:0000269|PubMed:19915009, ECO:0000269|PubMed:2261637, ECO:0000269|PubMed:23294003, ECO:0000269|PubMed:25731159, ECO:0000269|PubMed:28747427, ECO:0000269|PubMed:30309848}.; FUNCTION: [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response (PubMed:11121117, PubMed:21990364, PubMed:30279168). Also blocks IL11 cluster signaling through IL11R (PubMed:30279168). {ECO:0000269|PubMed:11121117, ECO:0000269|PubMed:21990364, ECO:0000269|PubMed:30279168}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+79113_217332366.0DomainFibronectin type-III 1
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+79218_316332366.0DomainFibronectin type-III 2
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+7926_112332366.0DomainNote=Ig-like C2-type
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+710113_217332469.0DomainFibronectin type-III 1
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+710218_316332469.0DomainFibronectin type-III 2
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+71026_112332469.0DomainNote=Ig-like C2-type
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+79303_307332366.0MotifNote=WSXWS motif
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+710303_307332469.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015725_75521919.0Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014725_755212415.0Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014725_75521858.0Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217725_75521919.0Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116725_75521919.0Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113725_75521299.3333333333333Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013725_75521441.3333333333333Compositional biasNote=Ser-rich
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015125_21621919.0DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015224_32421919.0DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000033690901526_12021919.0DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015329_42421919.0DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015426_51721919.0DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015518_61321919.0DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014125_216212415.0DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014224_324212415.0DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000038128701426_120212415.0DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014329_424212415.0DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014426_517212415.0DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014518_613212415.0DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014125_21621858.0DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014224_32421858.0DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000038129401426_12021858.0DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014329_42421858.0DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014426_51721858.0DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014518_61321858.0DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217125_21621919.0DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217224_32421919.0DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000038129821726_12021919.0DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217329_42421919.0DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217426_51721919.0DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217518_61321919.0DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116125_21621919.0DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116224_32421919.0DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000050232611626_12021919.0DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116329_42421919.0DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116426_51721919.0DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116518_61321919.0DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113125_21621299.3333333333333DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113224_32421299.3333333333333DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000052263311326_12021299.3333333333333DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113329_42421299.3333333333333DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113426_51721299.3333333333333DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113518_61321299.3333333333333DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013125_21621441.3333333333333DomainFibronectin type-III 1
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013224_32421441.3333333333333DomainFibronectin type-III 2
TgeneIL6STchr1:154420644chr5:55265681ENST0000053631901326_12021441.3333333333333DomainNote=Ig-like C2-type
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013329_42421441.3333333333333DomainFibronectin type-III 3
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013426_51721441.3333333333333DomainFibronectin type-III 4
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013518_61321441.3333333333333DomainFibronectin type-III 5
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015310_31421919.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015651_65921919.0MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014310_314212415.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014651_659212415.0MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014310_31421858.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014651_65921858.0MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217310_31421919.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217651_65921919.0MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116310_31421919.0MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116651_65921919.0MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113310_31421299.3333333333333MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113651_65921299.3333333333333MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013310_31421441.3333333333333MotifNote=WSXWS motif
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013651_65921441.3333333333333MotifNote=Box 1 motif
TgeneIL6STchr1:154420644chr5:55265681ENST0000033690901523_61921919.0Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015642_91821919.0Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000038128701423_619212415.0Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014642_918212415.0Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000038129401423_61921858.0Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014642_91821858.0Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000038129821723_61921919.0Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217642_91821919.0Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000050232611623_61921919.0Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116642_91821919.0Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000052263311323_61921299.3333333333333Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113642_91821299.3333333333333Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST0000053631901323_61921441.3333333333333Topological domainExtracellular
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013642_91821441.3333333333333Topological domainCytoplasmic
TgeneIL6STchr1:154420644chr5:55265681ENST00000336909015620_64121919.0TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000381287014620_641212415.0TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000381294014620_64121858.0TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000381298217620_64121919.0TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000502326116620_64121919.0TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000522633113620_64121299.3333333333333TransmembraneHelical
TgeneIL6STchr1:154420644chr5:55265681ENST00000536319013620_64121441.3333333333333TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+7920_365332366.0Topological domainExtracellular
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+79387_468332366.0Topological domainCytoplasmic
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+71020_365332469.0Topological domainExtracellular
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+710387_468332469.0Topological domainCytoplasmic
HgeneIL6Rchr1:154420644chr5:55265681ENST00000344086+79366_386332366.0TransmembraneHelical
HgeneIL6Rchr1:154420644chr5:55265681ENST00000368485+710366_386332469.0TransmembraneHelical


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Fusion Gene Sequence for IL6R-IL6ST


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39574_39574_1_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000344086_IL6ST_chr5_55265681_ENST00000381287_length(transcript)=9970nt_BP=1403nt
GGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCCGCTCCGGCTTTCGTAACCGCACCCTGGGAC
GGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCCGCCGCTCTGAGTCATGTGCGAGTGGGAAGT
CGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCT
GCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGTTCCCATTA
GCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCG
CGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTC
TGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGG
CTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCCAGCTGGGA
CTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGG
GTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGCCGT
GCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCG
CCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCA
CTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGC
TCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCACGACGCCTGGAGCG
GCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTT
GGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGA
ATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTA
CATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATAT
AGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTT
GCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTT
GGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGT
TGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTT
TGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATG
GACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCC
TGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGA
AGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGATAACATTGCCTCCTTTTGAAGCCAATGGAA
AAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCA
CAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTC
AAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGATAACATGCTTTGGGTGGAATGGACTACTCCAAGGGAATCTGTAAAGA
AATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTGTATCACAGACTGGCAACAAGAAGATGGTACCGTGCATCGCACCTATT
TAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGG
CATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAAC
TTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATT
CTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGG
ATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGCTCAAGGAGAAATTGAAGCCATAGTCGTGCCTGTTTGCTTAGCATTCCTATTGA
CAACTCTTCTGGGAGTGCTGTTCTGCTTTAATAAGCGAGACCTAATTAAAAAACACATCTGGCCTAATGTTCCAGATCCTTCAAAGAGTC
ATATTGCCCAGTGGTCACCTCACACTCCTCCAAGGCACAATTTTAATTCAAAAGATCAAATGTATTCAGATGGCAATTTCACTGATGTAA
GTGTTGTGGAAATAGAAGCAAATGACAAAAAGCCTTTTCCAGAAGATCTGAAATCATTGGACCTGTTCAAAAAGGAAAAAATTAATACTG
AAGGACACAGCAGTGGTATTGGGGGGTCTTCATGCATGTCATCTTCTAGGCCAAGCATTTCTAGCAGTGATGAAAATGAATCTTCACAAA
ACACTTCGAGCACTGTCCAGTATTCTACCGTGGTACACAGTGGCTACAGACACCAAGTTCCGTCAGTCCAAGTCTTCTCAAGATCCGAGT
CTACCCAGCCCTTGTTAGATTCAGAGGAGCGGCCAGAAGATCTACAATTAGTAGATCATGTAGATGGCGGTGATGGTATTTTGCCCAGGC
AACAGTACTTCAAACAGAACTGCAGTCAGCATGAATCCAGTCCAGATATTTCACATTTTGAAAGGTCAAAGCAAGTTTCATCAGTCAATG
AGGAAGATTTTGTTAGACTTAAACAGCAGATTTCAGATCATATTTCACAATCCTGTGGATCTGGGCAAATGAAAATGTTTCAGGAAGTTT
CTGCAGCAGATGCTTTTGGTCCAGGTACTGAGGGACAAGTAGAAAGATTTGAAACAGTTGGCATGGAGGCTGCGACTGATGAAGGCATGC
CTAAAAGTTACTTACCACAGACTGTACGGCAAGGCGGCTACATGCCTCAGTGAAGGACTAGTAGTTCCTGCTACAACTTCAGCAGTACCT
ATAAAGTAAAGCTAAAATGATTTTATCTGTGAATTCAGATTTTAAAAAGTCTTCACTCTCTGAAGATGATCATTTGCCCTTAAGGACAAA
AATGAACTGAAGTTTCACATGAGCTATTTCCATTCCAGAATATCTGGGATTCTACTTTAAGCACTACATAAACTGACTTTATCCTCAGAC
TAGCTGAATGATTTTGTGCTGTTTCAGGATGTTTGCACTGAAGAAAAACAGAAAGCTTATCTGAAATTTATAAAACTTTTTGTTTTGCTA
CATAGAAAACAGAAGGTATTTGAATAATAAGCAGTGATATGCTTAGTGAGCACAGCTATACTGATTTTGATTAGAATAGTCATCAGAGTG
GCTTAGGGACAGTTAATATAAAAGAGGAGCAAGGTGTAGACCATCATCTACTTCTGCTAAAATAACTTAAAAAGAGGTCCATAGGCCATA
ACTACATGAGCCCAGCTTTTGTAATCTGACAAAAAAATGAGGAGCAGCTTCGTGTATATCAGTGTACACGGTATTCCTTAGGTCCCTTCC
ATTGGTAGTGATGCTGCGAGTTATTACTGGAGAAAAGGAATTCTAGAGCTTTAACTTGGCAGATTAAAAGTACTCATTTTTTATTCATCA
ATAATTAGTAATCTCACTAGTTTTCAAAAATTTGCATATTATTGACAACCTCTTTGAAGATGCATTTCACAAACTCAACAGAGTGCCATG
ATAAGAGCTAGGGATCCCCCAAACTATCTCAAGCATCTAAAAAATTGCCATTTTTAAAGGCTTAAATTGTAGTAGTAAAGGGGAAAACAG
GAAGTAGTAGTAAAGGGGAAAAAAAACCAATAAAGCATCTAAAAAATTGGCATGTTAAAAGGCTTAAATTGCTAATGTGTGTATATATAT
ATATATATATACACACACATATCATTGACTTTTCTTAAGACTTCAGAGTACTGGGTAGATGAACACTTTATACAGTATATATCTTCAGCT
TAAATTTGTTTTGAGTATTTTTTTTATTTTTAAATAAGTAGGCAAAGATTTAAATTTTTTTATTTTTAGTAAATGTTTGAGGCACACTAA
GACAACTTGGGCAATATTTGCCAAAACAAAACAGAACCCCAAAAAATGTACATCTTGTTCTTAGCAAATATCATTATTGTAGAGACACTT
AATAAAGAGATGGTATTTTAATGTCTGCAGTTCTGAGGTAGGGTGGAACTTAGTTCTACATTGTGATTTAGGAATTTTTAAAACCTTTTT
TCTTCAAGGGAGAAGTGACCCAGGCCTCGAGTTTAGTGCTAAAGCCGCTAGTGTACTTATGCTGTCCCCTAACCACCACGTGCGATATGG
AAGCAGATGCTAAATATAGGGGTTTTCTTAGAAAGTAAGAGGAAATTAGCAAGCGTTATTAGTGATTGACTACTGCTATCAAGTGAATTC
AAAGGAAACAGGTTTTTATGCCATATTTAAGTTACAGAAACCAGGCATGCTTAGAATAGTTTCTAGAGGTTATTGGAGAATAGAAAGCTA
AGAAAACTTGGTATACATTTACAATGGAAATATAATTACACTTTTTACTCTCAGAATATTGTTCACATTAGACTTCCTGTTTATCTTTTA
TATTCTTGCATTTATATAATGCCTCATCCTTTCAAAGTTCTTTCACATATTATATGATCTTCTTTATGAAAAAAATAGATGTTTCATTCT
GATATATTCAGTTTCCCACTTTAGGCAAAAGTAGATTAATAGAATGACGAATTCAAAGTAGATGAGGAAAATCAGGCACAGAGAAGTAAA
GGTAGGGATAGACCCAAATTTACACAACAAGATAATGACATCTCCAGCTTTTAAGTTGATCATCAAAGGCTGGGCTGGATTTGTCTTGCT
GTATGTGTCAGGAAATTTATACCTATTACATTTTCCATTTTCTCAAAATTTAAGTCACATGACTAATATTTAGCTGCAACTTTCCTCATA
ACAAATAGTGTCATGAAGAATGTTGTAGTGTGAAGTTTGTACATTTCAGGGTCAGATATACAATATGAACTCTTAATCTACAGGAATGAG
AATGGAGGATCATTGAAGGCCATGATATAAACAAATTTGCATGTTGAAGCCTGTATAAAACATGGTACAGTGAGTGAATATACCCCCATC
CCCAAGAACACTTTATACATATTAAATGGATATATGATTACTGTGCAAAAATTCATTCTGGAAATGAACATATATTTGAGCACTAATATG
TAATGTACACCTGCCCTAAGGAGAAAATAAATTATAAAACTTTTTACATTCAAAATTACTTTCCCAAGCATGTCTTAGAATAATCTATGT
GTTGATGCATGTAAATTGTACTTTAGGTAGGCAAAGAAATCTGGTTATTTATGTAAAAACTAGTCTAATAAAGTTAGTTAGTGGCTTTAT
CACTTTAAATCTTTAGTGTCCAAAAGTGGTGTTTAAAGTAATAGCACATCAGAAAACCTTGTCTGGACAAAACTAGTTCACTCACTGCTT
CTGCACCTGCAGTTGCTCCCTTTAGGGTTATAAAATAATGACCCAAATGTTACATGTGTTGATATTATAACTTGTCAGTTACTGATGTCT
GTGGTATCCTACCCTCATCTCTGAAAGGGATAATACTGAATAATTATTAGAAAACTATAAAACTTCACACTTTGTACCATTAAAACCTAA
AATTTTAATCTTGTCCTTTTTTACTATGGATCAGTCGGCACTCGGGAACAGCAGCAAGGAAAAAAAGCAAATTTCATTCACATGTTCTGT
GTTCATACCTCTTCTCTACCTAATTGTTCATTTAAATTTCAGCCTTATTCCTTGATAAGGGATTTTACCACATGAAGTCATCCAGTGACC
CTAGCTCTTATTGTGAAGTTAGTGGAGTATACTTAGAAATGTTACAACTTTAAAATGTTACAAAACATTCATTAAAGCTCATATTTAAAG
TAGAGCATCTAGTTTGAGAAATAGAAATCAATTATTAAAGATGTCTTTTTTCTACCCATTTAACTAGTTAAAACCATGACATGTAAATGT
AGAAGTAGAATAATCATAGAATTCCCTAAAATATTTCTGTTTACTAACATATATTGACCAAGTACATCAAGCAGGAGAGATCTTCCTTCA
TTCTGTTATAGTCCACATCATTCTAATTTTGCTCAGTTGTTATTAAGAGCATATTCCTAAACCATACACTTTTGTTTCAATAAAGTTTTA
TTTTGTTGAGATGAATAAAATAACAAAGTTATAAGCTGCATAAGACAAAAGTTCAATTGTTCAAAAAAAATTTACTGGGATAGCTTTCTA
TTACAGGTATTGTTAGATTATATTGTGCTGATAAGATTACTTTCTAAAAAATTTGTACTTTTCTGTAAATTAAAAGAATATGGAGTCATA
AAATGGCAAGTGTTTTAGGATTAGCCTAAAATTGGACATTGTCATTGATTTCAAAGAAGGTATGAACTAGCAGTCTTACAGCCTAATTCT
TCTTTGGACTGGTCCTTGGCAGCAGTTCCTTTTCAGACTCGATAAACAGAATTCAGATGATGTAAGTCAAAACAAAACTTTACAAAGCCA
AGCGTATTATCTTTTGCATTAACCTATTTTTTTCCATCATACATGCTACTAGTATGTGCATTAGCATGATATTCTCATATACATTGCATT
AAAAATTAAAAGGTGGCAGCTCAGGGTGAGCTCTTCTGTTGCTCATTTGTTCCTAAATTTTTAAGGGCTTTTTCTCAGTCAATAGTTTGT
ACAAACTGGTTAGTTTAACTTCATTACCCATTTCATTAAAGTTGATGGGTCGTGTGATGAGATGCATTTAAGGCCGATAGTGATAGATGT
TTTTTTTATTTCTTGAACACAGGCTTTGTCTGAATGATGTTCTTTTATCTCTTGAACACAAGCTTTGAATGATAACTACAGGTTTTAAGT
GCTGTTACATTAATACCATAATGTGATGTGTTAGAAACAAAGGGATATTTCAAAGGTAGATATTTGAAAATTCTCTAGTCTCAATATGTA
TGTGTATTGAATATACTCTAAAAATAAATGTGCAATTTGCTAGTAGGACAATGCAGTGACTGACTAGCATTAGGTATGTTTCTTTTATAT
CCTAGCTATGTCCCACTTTCTTCTAAGTGCAATCCTTTCATGTTCACTTGCTGTTTTACCCCATCTACTCTAACTTCATTTGGAAGGCTT
GTCTAGAGTATAGCATGTATTTTTACCTTTGCAGTGAATTGCATGTGCTAATTGTAACCACAGCTATTTTTATGTTGACATAACTCCAAA
TGTTATATTAAATGTTCTATTATATATTAGCTCTAATCCCTTAAGTAAATTTTAAGAAATAAATACTTGTTCAAATTTTTTTTCTGTATG
TGGTTACTATCATCTGACTATGCATATTTGTAACAGCATTTATCATTAGTGGTGTTAGCTAAATAAGCATCTTAGTGTAAATGAGATGCT
TCGTGTGGGTTTTGTGACATTTTAAATGACATAATGGAATGTGATTTAAAAGAAAACCAGTACACTATCTTGGTCTTAATAACATAGAAT
GGAGATGGCAAATTTATCCACTAGTTTTCCAGATTTACTATTTAATAGCTGAGGTCTGAAATCGTAGCATCCTCCCTCCTAGTGGACATT
AAAAAAAAAAAAAAAAAAAAAAACCTACTTGGTTGTCAAGAGCCCAAGTATGGAGGTGCTGCGCCATCTTGTGGCCTGTCTGTGCCCACC
CTGCACTCTGCTGGAGTCTCCATCCTTGTTGCAGTGAGACTTGAAGTTCAAGATTGATACATGGCATCCTCCTGCTACTTCTTGAGGTTA
CTAAGTAGTATATGAAACTAATCAGTCAGCAAGTCCACCTGGAAGGAAAAGAAAATCTCAACTATTAATGTGCCTTCACATTGTGATTTT
GTCTAAAAAAATGTAGTGAGTCAAAAAACCCACAAGCCAGCCAACAGTAACTCCTTCACATATATACCAGAGTTTATAGAAATAACATGT
CAGCTTTGGGCTATGTGCTCCTTTGTTTAAAATCTTCTATTTGGTTATGGCTTGTATAGGCTCAAGCCTGATTTCTTTAAGGTGTGGTGG
CTCATCTTATCCTAATGTGTATGATAGATACAGTCCATCCTGCTTTGGAAAAGATTATGTAACTCCTTGAGAGCATACTCTTTCTCTAGC
CCAAAGGCAGTGAGAGAGTTTTCTTGTTCAGGATTGCTTAACTTTCCATTTAAGCTTTTTCTTTTTAAATTAATACAAACTTCTACACTT
TCAAAATACGAAATATATTACAACTGCGTATAGGCTCTTCCATACTTAAGTCCAGTGCTTGGGCAAGTTAATGGAGTGAAAGACTACAAG
CAAAGAGGAACTGAGGTAGAAAAAGAAGAATGTGTGAAAGCAGCAGGAAGCTCAGCCAACTCGAAAGCAGGGTGAACAGCTTGAGTCCTG
TTGCTGCTGATCGGGGTTGGCTCTTGGACAACTTAGTAAGATCATGGAAAGGCTGCTTGGGTTCTCCATAGAAAAGTTCTGTCTCCATCA
AGGGAGGAAAATGTACCTTTCAACTCAAAATTCAATATTTGTTTTTAAATATAGCTATTTTCCCCAACCGCTAAAGATTTTCAACAGATA
CGAAGCCAGAGCTTAGTTTTAGAAACCTGTGGACATTCAAACCTGATTCTTTATTCCCTGTGACTATGGTTATGTCATTTTACATGTCAA
AAAAGTGTATCTAGAATTGTCATTTCTTATTTTTGAGCTTTTTTTAGTGAGAATTATCCCCTCACTTAAATGGCTTTTTATTTAAACATC

>39574_39574_1_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000344086_IL6ST_chr5_55265681_ENST00000381287_length(amino acids)=586AA_BP=
MVRDTGVTGVKKQVGSPMKITLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKA
YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKD
GPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVS
VVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSES
TQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVS

--------------------------------------------------------------
>39574_39574_2_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000344086_IL6ST_chr5_55265681_ENST00000536319_length(transcript)=3830nt_BP=1403nt
GGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCCGCTCCGGCTTTCGTAACCGCACCCTGGGAC
GGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCCGCCGCTCTGAGTCATGTGCGAGTGGGAAGT
CGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGACTCGCAGTGTGTGTAGAGAGCCGGGCTCCT
GCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCCCCTGCCACCCCTGCCGCCCGGTTCCCATTA
GCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCG
CGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTC
TGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCACCCCAGCAGATGGG
CTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATTCATGCTACCGGGCCGGCCGCCCAGCTGGGA
CTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGG
GTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGCCGT
GCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTTCTACATAGTGTCCATGTGCGTCG
CCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCA
CTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGC
TCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCACGACGCCTGGAGCG
GCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCGAGTGGAGCCCGGAGGCCATGGGCACGCCTT
GGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGTGAACTTCTAGATCCATGTGGTTATATCAGTCCTGA
ATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATGTATGGATTATTTTCATGTAAATGCTAATTA
CATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAGAACAGCATCCAGTGTCACCTTTACAGATAT
AGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAATGTTTATGGAATCACAATAATTTCAGGCTT
GCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTGTGAGTGGGATGGTGGAAGGGAAACACACTT
GGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGCAAAACGTGACACCCCCACCTCATGCACTGT
TGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCTTGGGAAGGTTACATCAGATCATATCAATTT
TGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGAGGAACTGTCTAGTATCTTAAAATTGACATG
GACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAAAGATGCCTCAACTTGGAGCCAGATTCCTCC
TGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGAATATGTGTTTAGGATTCGCTGTATGAAGGA
AGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGATAACATTGCCTCCTTTTGAAGCCAATGGAA
AAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAGTTAATGCCACAAAACTGACAGTAAATCTCA
CAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAGCTGTTTTAACTATCCCTGCCTGTGACTTTC
AAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTGATGGACCAGGAAGCCCTGAATCCATAAAGGCAT
ACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGAAAAACGAAGCTGTCTTAGAGTGGGACCAACTTC
CTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCATTGGAAATGAAACTGCTGTGAATGTGGATTCTT
CCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAATGGCAGCATACACAGATGAAGGTGGGAAGGATG
GTCCAGAATTCACTTTTACTACCCCAAAGTTTGCTCAAGGAGAAATTGAAGCCATAGTCGTGCCTGTTTGCTTAGCATTCCTATTGACAA
CTCTTCTGGGAGTGCTGTTCTGCTTTAATAAGCGAGACCTAATTAAAAAACACATCTGGCCTAATGTTCCAGATCCTTCAAAGAGTCATA
TTGCCCAGTGGTCACCTCACACTCCTCCAAGGCACAATTTTAATTCAAAAGATCAAATGTATTCAGATGGCAATTTCACTGATGTAAGTG
TTGTGGAAATAGAAGCAAATGACAAAAAGCCTTTTCCAGAAGATCTGAAATCATTGGACCTGTTCAAAAAGGAAAAAATTAATACTGAAG
GACACAGCAGTGGTATTGGGGGGTCTTCATGCATGTCATCTTCTAGGCCAAGCATTTCTAGCAGTGATGAAAATGAATCTTCACAAAACA
CTTCGAGCACTGTCCAGTATTCTACCGTGGTACACAGTGGCTACAGACACCAAGTTCCGTCAGTCCAAGTCTTCTCAAGATCCGAGTCTA
CCCAGCCCTTGTTAGATTCAGAGGAGCGGCCAGAAGATCTACAATTAGTAGATCATGTAGATGGCGGTGATGGTATTTTGCCCAGGCAAC
AGTACTTCAAACAGAACTGCAGTCAGCATGAATCCAGTCCAGATATTTCACATTTTGAAAGGTCAAAGCAAGTTTCATCAGTCAATGAGG
AAGATTTTGTTAGACTTAAACAGCAGATTTCAGATCATATTTCACAATCCTGTGGATCTGGGCAAATGAAAATGTTTCAGGAAGTTTCTG
CAGCAGATGCTTTTGGTCCAGGTACTGAGGGACAAGTAGAAAGATTTGAAACAGTTGGCATGGAGGCTGCGACTGATGAAGGCATGCCTA

>39574_39574_2_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000344086_IL6ST_chr5_55265681_ENST00000536319_length(amino acids)=526AA_BP=
MVRDTGVTGVKKQVGSPMKITLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSS
HTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHI
AQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNT
SSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEE

--------------------------------------------------------------
>39574_39574_3_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000368485_IL6ST_chr5_55265681_ENST00000381287_length(transcript)=10000nt_BP=1433nt
GGCGGTCCCCTGTTCTCCCCGCTCAGGTGCGGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCC
GCTCCGGCTTTCGTAACCGCACCCTGGGACGGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCC
GCCGCTCTGAGTCATGTGCGAGTGGGAAGTCGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGA
CTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCC
CCTGCCACCCCTGCCGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCG
GCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGC
TGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGC
CGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATT
CATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGA
GCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGA
ACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACA
GCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGC
AGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGA
ACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGC
ATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCG
AGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGTGAACT
TCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATG
TATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAG
AACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAA
TGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTG
TGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGC
AAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCT
TGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGA
GGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAA
AGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGA
ATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGA
TAACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAG
TTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAG
CTGTTTTAACTATCCCTGCCTGTGACTTTCAAGCTACTCACCCTGTAATGGATCTTAAAGCATTCCCCAAAGATAACATGCTTTGGGTGG
AATGGACTACTCCAAGGGAATCTGTAAAGAAATATATACTTGAGTGGTGTGTGTTATCAGATAAAGCACCCTGTATCACAGACTGGCAAC
AAGAAGATGGTACCGTGCATCGCACCTATTTAAGAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTG
ATGGACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGA
AAAACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCA
TTGGAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAA
TGGCAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGCTCAAGGAGAAATTGAAGCCATAG
TCGTGCCTGTTTGCTTAGCATTCCTATTGACAACTCTTCTGGGAGTGCTGTTCTGCTTTAATAAGCGAGACCTAATTAAAAAACACATCT
GGCCTAATGTTCCAGATCCTTCAAAGAGTCATATTGCCCAGTGGTCACCTCACACTCCTCCAAGGCACAATTTTAATTCAAAAGATCAAA
TGTATTCAGATGGCAATTTCACTGATGTAAGTGTTGTGGAAATAGAAGCAAATGACAAAAAGCCTTTTCCAGAAGATCTGAAATCATTGG
ACCTGTTCAAAAAGGAAAAAATTAATACTGAAGGACACAGCAGTGGTATTGGGGGGTCTTCATGCATGTCATCTTCTAGGCCAAGCATTT
CTAGCAGTGATGAAAATGAATCTTCACAAAACACTTCGAGCACTGTCCAGTATTCTACCGTGGTACACAGTGGCTACAGACACCAAGTTC
CGTCAGTCCAAGTCTTCTCAAGATCCGAGTCTACCCAGCCCTTGTTAGATTCAGAGGAGCGGCCAGAAGATCTACAATTAGTAGATCATG
TAGATGGCGGTGATGGTATTTTGCCCAGGCAACAGTACTTCAAACAGAACTGCAGTCAGCATGAATCCAGTCCAGATATTTCACATTTTG
AAAGGTCAAAGCAAGTTTCATCAGTCAATGAGGAAGATTTTGTTAGACTTAAACAGCAGATTTCAGATCATATTTCACAATCCTGTGGAT
CTGGGCAAATGAAAATGTTTCAGGAAGTTTCTGCAGCAGATGCTTTTGGTCCAGGTACTGAGGGACAAGTAGAAAGATTTGAAACAGTTG
GCATGGAGGCTGCGACTGATGAAGGCATGCCTAAAAGTTACTTACCACAGACTGTACGGCAAGGCGGCTACATGCCTCAGTGAAGGACTA
GTAGTTCCTGCTACAACTTCAGCAGTACCTATAAAGTAAAGCTAAAATGATTTTATCTGTGAATTCAGATTTTAAAAAGTCTTCACTCTC
TGAAGATGATCATTTGCCCTTAAGGACAAAAATGAACTGAAGTTTCACATGAGCTATTTCCATTCCAGAATATCTGGGATTCTACTTTAA
GCACTACATAAACTGACTTTATCCTCAGACTAGCTGAATGATTTTGTGCTGTTTCAGGATGTTTGCACTGAAGAAAAACAGAAAGCTTAT
CTGAAATTTATAAAACTTTTTGTTTTGCTACATAGAAAACAGAAGGTATTTGAATAATAAGCAGTGATATGCTTAGTGAGCACAGCTATA
CTGATTTTGATTAGAATAGTCATCAGAGTGGCTTAGGGACAGTTAATATAAAAGAGGAGCAAGGTGTAGACCATCATCTACTTCTGCTAA
AATAACTTAAAAAGAGGTCCATAGGCCATAACTACATGAGCCCAGCTTTTGTAATCTGACAAAAAAATGAGGAGCAGCTTCGTGTATATC
AGTGTACACGGTATTCCTTAGGTCCCTTCCATTGGTAGTGATGCTGCGAGTTATTACTGGAGAAAAGGAATTCTAGAGCTTTAACTTGGC
AGATTAAAAGTACTCATTTTTTATTCATCAATAATTAGTAATCTCACTAGTTTTCAAAAATTTGCATATTATTGACAACCTCTTTGAAGA
TGCATTTCACAAACTCAACAGAGTGCCATGATAAGAGCTAGGGATCCCCCAAACTATCTCAAGCATCTAAAAAATTGCCATTTTTAAAGG
CTTAAATTGTAGTAGTAAAGGGGAAAACAGGAAGTAGTAGTAAAGGGGAAAAAAAACCAATAAAGCATCTAAAAAATTGGCATGTTAAAA
GGCTTAAATTGCTAATGTGTGTATATATATATATATATATACACACACATATCATTGACTTTTCTTAAGACTTCAGAGTACTGGGTAGAT
GAACACTTTATACAGTATATATCTTCAGCTTAAATTTGTTTTGAGTATTTTTTTTATTTTTAAATAAGTAGGCAAAGATTTAAATTTTTT
TATTTTTAGTAAATGTTTGAGGCACACTAAGACAACTTGGGCAATATTTGCCAAAACAAAACAGAACCCCAAAAAATGTACATCTTGTTC
TTAGCAAATATCATTATTGTAGAGACACTTAATAAAGAGATGGTATTTTAATGTCTGCAGTTCTGAGGTAGGGTGGAACTTAGTTCTACA
TTGTGATTTAGGAATTTTTAAAACCTTTTTTCTTCAAGGGAGAAGTGACCCAGGCCTCGAGTTTAGTGCTAAAGCCGCTAGTGTACTTAT
GCTGTCCCCTAACCACCACGTGCGATATGGAAGCAGATGCTAAATATAGGGGTTTTCTTAGAAAGTAAGAGGAAATTAGCAAGCGTTATT
AGTGATTGACTACTGCTATCAAGTGAATTCAAAGGAAACAGGTTTTTATGCCATATTTAAGTTACAGAAACCAGGCATGCTTAGAATAGT
TTCTAGAGGTTATTGGAGAATAGAAAGCTAAGAAAACTTGGTATACATTTACAATGGAAATATAATTACACTTTTTACTCTCAGAATATT
GTTCACATTAGACTTCCTGTTTATCTTTTATATTCTTGCATTTATATAATGCCTCATCCTTTCAAAGTTCTTTCACATATTATATGATCT
TCTTTATGAAAAAAATAGATGTTTCATTCTGATATATTCAGTTTCCCACTTTAGGCAAAAGTAGATTAATAGAATGACGAATTCAAAGTA
GATGAGGAAAATCAGGCACAGAGAAGTAAAGGTAGGGATAGACCCAAATTTACACAACAAGATAATGACATCTCCAGCTTTTAAGTTGAT
CATCAAAGGCTGGGCTGGATTTGTCTTGCTGTATGTGTCAGGAAATTTATACCTATTACATTTTCCATTTTCTCAAAATTTAAGTCACAT
GACTAATATTTAGCTGCAACTTTCCTCATAACAAATAGTGTCATGAAGAATGTTGTAGTGTGAAGTTTGTACATTTCAGGGTCAGATATA
CAATATGAACTCTTAATCTACAGGAATGAGAATGGAGGATCATTGAAGGCCATGATATAAACAAATTTGCATGTTGAAGCCTGTATAAAA
CATGGTACAGTGAGTGAATATACCCCCATCCCCAAGAACACTTTATACATATTAAATGGATATATGATTACTGTGCAAAAATTCATTCTG
GAAATGAACATATATTTGAGCACTAATATGTAATGTACACCTGCCCTAAGGAGAAAATAAATTATAAAACTTTTTACATTCAAAATTACT
TTCCCAAGCATGTCTTAGAATAATCTATGTGTTGATGCATGTAAATTGTACTTTAGGTAGGCAAAGAAATCTGGTTATTTATGTAAAAAC
TAGTCTAATAAAGTTAGTTAGTGGCTTTATCACTTTAAATCTTTAGTGTCCAAAAGTGGTGTTTAAAGTAATAGCACATCAGAAAACCTT
GTCTGGACAAAACTAGTTCACTCACTGCTTCTGCACCTGCAGTTGCTCCCTTTAGGGTTATAAAATAATGACCCAAATGTTACATGTGTT
GATATTATAACTTGTCAGTTACTGATGTCTGTGGTATCCTACCCTCATCTCTGAAAGGGATAATACTGAATAATTATTAGAAAACTATAA
AACTTCACACTTTGTACCATTAAAACCTAAAATTTTAATCTTGTCCTTTTTTACTATGGATCAGTCGGCACTCGGGAACAGCAGCAAGGA
AAAAAAGCAAATTTCATTCACATGTTCTGTGTTCATACCTCTTCTCTACCTAATTGTTCATTTAAATTTCAGCCTTATTCCTTGATAAGG
GATTTTACCACATGAAGTCATCCAGTGACCCTAGCTCTTATTGTGAAGTTAGTGGAGTATACTTAGAAATGTTACAACTTTAAAATGTTA
CAAAACATTCATTAAAGCTCATATTTAAAGTAGAGCATCTAGTTTGAGAAATAGAAATCAATTATTAAAGATGTCTTTTTTCTACCCATT
TAACTAGTTAAAACCATGACATGTAAATGTAGAAGTAGAATAATCATAGAATTCCCTAAAATATTTCTGTTTACTAACATATATTGACCA
AGTACATCAAGCAGGAGAGATCTTCCTTCATTCTGTTATAGTCCACATCATTCTAATTTTGCTCAGTTGTTATTAAGAGCATATTCCTAA
ACCATACACTTTTGTTTCAATAAAGTTTTATTTTGTTGAGATGAATAAAATAACAAAGTTATAAGCTGCATAAGACAAAAGTTCAATTGT
TCAAAAAAAATTTACTGGGATAGCTTTCTATTACAGGTATTGTTAGATTATATTGTGCTGATAAGATTACTTTCTAAAAAATTTGTACTT
TTCTGTAAATTAAAAGAATATGGAGTCATAAAATGGCAAGTGTTTTAGGATTAGCCTAAAATTGGACATTGTCATTGATTTCAAAGAAGG
TATGAACTAGCAGTCTTACAGCCTAATTCTTCTTTGGACTGGTCCTTGGCAGCAGTTCCTTTTCAGACTCGATAAACAGAATTCAGATGA
TGTAAGTCAAAACAAAACTTTACAAAGCCAAGCGTATTATCTTTTGCATTAACCTATTTTTTTCCATCATACATGCTACTAGTATGTGCA
TTAGCATGATATTCTCATATACATTGCATTAAAAATTAAAAGGTGGCAGCTCAGGGTGAGCTCTTCTGTTGCTCATTTGTTCCTAAATTT
TTAAGGGCTTTTTCTCAGTCAATAGTTTGTACAAACTGGTTAGTTTAACTTCATTACCCATTTCATTAAAGTTGATGGGTCGTGTGATGA
GATGCATTTAAGGCCGATAGTGATAGATGTTTTTTTTATTTCTTGAACACAGGCTTTGTCTGAATGATGTTCTTTTATCTCTTGAACACA
AGCTTTGAATGATAACTACAGGTTTTAAGTGCTGTTACATTAATACCATAATGTGATGTGTTAGAAACAAAGGGATATTTCAAAGGTAGA
TATTTGAAAATTCTCTAGTCTCAATATGTATGTGTATTGAATATACTCTAAAAATAAATGTGCAATTTGCTAGTAGGACAATGCAGTGAC
TGACTAGCATTAGGTATGTTTCTTTTATATCCTAGCTATGTCCCACTTTCTTCTAAGTGCAATCCTTTCATGTTCACTTGCTGTTTTACC
CCATCTACTCTAACTTCATTTGGAAGGCTTGTCTAGAGTATAGCATGTATTTTTACCTTTGCAGTGAATTGCATGTGCTAATTGTAACCA
CAGCTATTTTTATGTTGACATAACTCCAAATGTTATATTAAATGTTCTATTATATATTAGCTCTAATCCCTTAAGTAAATTTTAAGAAAT
AAATACTTGTTCAAATTTTTTTTCTGTATGTGGTTACTATCATCTGACTATGCATATTTGTAACAGCATTTATCATTAGTGGTGTTAGCT
AAATAAGCATCTTAGTGTAAATGAGATGCTTCGTGTGGGTTTTGTGACATTTTAAATGACATAATGGAATGTGATTTAAAAGAAAACCAG
TACACTATCTTGGTCTTAATAACATAGAATGGAGATGGCAAATTTATCCACTAGTTTTCCAGATTTACTATTTAATAGCTGAGGTCTGAA
ATCGTAGCATCCTCCCTCCTAGTGGACATTAAAAAAAAAAAAAAAAAAAAAAACCTACTTGGTTGTCAAGAGCCCAAGTATGGAGGTGCT
GCGCCATCTTGTGGCCTGTCTGTGCCCACCCTGCACTCTGCTGGAGTCTCCATCCTTGTTGCAGTGAGACTTGAAGTTCAAGATTGATAC
ATGGCATCCTCCTGCTACTTCTTGAGGTTACTAAGTAGTATATGAAACTAATCAGTCAGCAAGTCCACCTGGAAGGAAAAGAAAATCTCA
ACTATTAATGTGCCTTCACATTGTGATTTTGTCTAAAAAAATGTAGTGAGTCAAAAAACCCACAAGCCAGCCAACAGTAACTCCTTCACA
TATATACCAGAGTTTATAGAAATAACATGTCAGCTTTGGGCTATGTGCTCCTTTGTTTAAAATCTTCTATTTGGTTATGGCTTGTATAGG
CTCAAGCCTGATTTCTTTAAGGTGTGGTGGCTCATCTTATCCTAATGTGTATGATAGATACAGTCCATCCTGCTTTGGAAAAGATTATGT
AACTCCTTGAGAGCATACTCTTTCTCTAGCCCAAAGGCAGTGAGAGAGTTTTCTTGTTCAGGATTGCTTAACTTTCCATTTAAGCTTTTT
CTTTTTAAATTAATACAAACTTCTACACTTTCAAAATACGAAATATATTACAACTGCGTATAGGCTCTTCCATACTTAAGTCCAGTGCTT
GGGCAAGTTAATGGAGTGAAAGACTACAAGCAAAGAGGAACTGAGGTAGAAAAAGAAGAATGTGTGAAAGCAGCAGGAAGCTCAGCCAAC
TCGAAAGCAGGGTGAACAGCTTGAGTCCTGTTGCTGCTGATCGGGGTTGGCTCTTGGACAACTTAGTAAGATCATGGAAAGGCTGCTTGG
GTTCTCCATAGAAAAGTTCTGTCTCCATCAAGGGAGGAAAATGTACCTTTCAACTCAAAATTCAATATTTGTTTTTAAATATAGCTATTT
TCCCCAACCGCTAAAGATTTTCAACAGATACGAAGCCAGAGCTTAGTTTTAGAAACCTGTGGACATTCAAACCTGATTCTTTATTCCCTG
TGACTATGGTTATGTCATTTTACATGTCAAAAAAGTGTATCTAGAATTGTCATTTCTTATTTTTGAGCTTTTTTTAGTGAGAATTATCCC
CTCACTTAAATGGCTTTTTATTTAAACATCTGTGCATTCTGTATGAAATTGTAGTCTTTCTGGGATAACATGGTGAGCTATATGGTGGTA

>39574_39574_3_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000368485_IL6ST_chr5_55265681_ENST00000381287_length(amino acids)=586AA_BP=
MVRDTGVTGVKKQVGSPMKITLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
ATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKA
YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKD
GPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVS
VVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSES
TQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVS

--------------------------------------------------------------
>39574_39574_4_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000368485_IL6ST_chr5_55265681_ENST00000536319_length(transcript)=3860nt_BP=1433nt
GGCGGTCCCCTGTTCTCCCCGCTCAGGTGCGGCGCTGTGGCAGGAAGCCACCCCCTCGGTCGGCCGGTGCGCGGGGCTGTTGCGCCATCC
GCTCCGGCTTTCGTAACCGCACCCTGGGACGGCCCAGAGACGCTCCAGCGCGAGTTCCTCAAATGTTTTCCTGCGTTGCCAGGACCGTCC
GCCGCTCTGAGTCATGTGCGAGTGGGAAGTCGCACTGACACTGAGCCGGGCCAGAGGGAGAGGAGCCGAGCGCGGCGCGGGGCCGAGGGA
CTCGCAGTGTGTGTAGAGAGCCGGGCTCCTGCGGATGGGGGCTGCCCCCGGGGCCTGAGCCCGCCTGCCCGCCCACCGCCCCGCCCCGCC
CCTGCCACCCCTGCCGCCCGGTTCCCATTAGCCTGTCCGCCTCTGCGGGACCATGGAGTGGTAGCCGAGGAGGAAGCATGCTGGCCGTCG
GCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGCGCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGC
TGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTGCCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGC
CGGCTGCAGGCTCCCACCCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACTATT
CATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCCCCAGCTCTCCTGCTTCCGGAAGA
GCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCATCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGA
ACAGTCCGGCCGAAGACTTCCAGGAGCCGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACA
GCTCTTTCTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGTTGTGGAATCTTGC
AGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGCTCAGTGTCACCTGGCAAGACCCCCACTCCTGGA
ACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATATCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGC
ATCACTGTGTCATCCACGACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGAGCG
AGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGTGTCCACCCCCATGCAGGTGAACT
TCTAGATCCATGTGGTTATATCAGTCCTGAATCTCCAGTTGTACAACTTCATTCTAATTTCACTGCAGTTTGTGTGCTAAAGGAAAAATG
TATGGATTATTTTCATGTAAATGCTAATTACATTGTCTGGAAAACAAACCATTTTACTATTCCTAAGGAGCAATATACTATCATAAACAG
AACAGCATCCAGTGTCACCTTTACAGATATAGCTTCATTAAATATTCAGCTCACTTGCAACATTCTTACATTCGGACAGCTTGAACAGAA
TGTTTATGGAATCACAATAATTTCAGGCTTGCCTCCAGAAAAACCTAAAAATTTGAGTTGCATTGTGAACGAGGGGAAGAAAATGAGGTG
TGAGTGGGATGGTGGAAGGGAAACACACTTGGAGACAAACTTCACTTTAAAATCTGAATGGGCAACACACAAGTTTGCTGATTGCAAAGC
AAAACGTGACACCCCCACCTCATGCACTGTTGATTATTCTACTGTGTATTTTGTCAACATTGAAGTCTGGGTAGAAGCAGAGAATGCCCT
TGGGAAGGTTACATCAGATCATATCAATTTTGATCCTGTATATAAAGTGAAGCCCAATCCGCCACATAATTTATCAGTGATCAACTCAGA
GGAACTGTCTAGTATCTTAAAATTGACATGGACCAACCCAAGTATTAAGAGTGTTATAATACTAAAATATAACATTCAATATAGGACCAA
AGATGCCTCAACTTGGAGCCAGATTCCTCCTGAAGACACAGCATCCACCCGATCTTCATTCACTGTCCAAGACCTTAAACCTTTTACAGA
ATATGTGTTTAGGATTCGCTGTATGAAGGAAGATGGTAAGGGATACTGGAGTGACTGGAGTGAAGAAGCAAGTGGGATCACCTATGAAGA
TAACATTGCCTCCTTTTGAAGCCAATGGAAAAATCTTGGATTATGAAGTGACTCTCACAAGATGGAAATCACATTTACAAAATTACACAG
TTAATGCCACAAAACTGACAGTAAATCTCACAAATGATCGCTATCTAGCAACCCTAACAGTAAGAAATCTTGTTGGCAAATCAGATGCAG
CTGTTTTAACTATCCCTGCCTGTGACTTTCAAGGGAACTTAGCAGAGAGCAAATGCTATTTGATAACAGTTACTCCAGTATATGCTGATG
GACCAGGAAGCCCTGAATCCATAAAGGCATACCTTAAACAAGCTCCACCTTCCAAAGGACCTACTGTTCGGACAAAAAAAGTAGGGAAAA
ACGAAGCTGTCTTAGAGTGGGACCAACTTCCTGTTGATGTTCAGAATGGATTTATCAGAAATTATACTATATTTTATAGAACCATCATTG
GAAATGAAACTGCTGTGAATGTGGATTCTTCCCACACAGAATATACATTGTCCTCTTTGACTAGTGACACATTGTACATGGTACGAATGG
CAGCATACACAGATGAAGGTGGGAAGGATGGTCCAGAATTCACTTTTACTACCCCAAAGTTTGCTCAAGGAGAAATTGAAGCCATAGTCG
TGCCTGTTTGCTTAGCATTCCTATTGACAACTCTTCTGGGAGTGCTGTTCTGCTTTAATAAGCGAGACCTAATTAAAAAACACATCTGGC
CTAATGTTCCAGATCCTTCAAAGAGTCATATTGCCCAGTGGTCACCTCACACTCCTCCAAGGCACAATTTTAATTCAAAAGATCAAATGT
ATTCAGATGGCAATTTCACTGATGTAAGTGTTGTGGAAATAGAAGCAAATGACAAAAAGCCTTTTCCAGAAGATCTGAAATCATTGGACC
TGTTCAAAAAGGAAAAAATTAATACTGAAGGACACAGCAGTGGTATTGGGGGGTCTTCATGCATGTCATCTTCTAGGCCAAGCATTTCTA
GCAGTGATGAAAATGAATCTTCACAAAACACTTCGAGCACTGTCCAGTATTCTACCGTGGTACACAGTGGCTACAGACACCAAGTTCCGT
CAGTCCAAGTCTTCTCAAGATCCGAGTCTACCCAGCCCTTGTTAGATTCAGAGGAGCGGCCAGAAGATCTACAATTAGTAGATCATGTAG
ATGGCGGTGATGGTATTTTGCCCAGGCAACAGTACTTCAAACAGAACTGCAGTCAGCATGAATCCAGTCCAGATATTTCACATTTTGAAA
GGTCAAAGCAAGTTTCATCAGTCAATGAGGAAGATTTTGTTAGACTTAAACAGCAGATTTCAGATCATATTTCACAATCCTGTGGATCTG
GGCAAATGAAAATGTTTCAGGAAGTTTCTGCAGCAGATGCTTTTGGTCCAGGTACTGAGGGACAAGTAGAAAGATTTGAAACAGTTGGCA

>39574_39574_4_IL6R-IL6ST_IL6R_chr1_154420644_ENST00000368485_IL6ST_chr5_55265681_ENST00000536319_length(amino acids)=526AA_BP=
MVRDTGVTGVKKQVGSPMKITLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQ
GNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSS
HTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHI
AQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNT
SSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEE

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Fusion Gene PPI Analysis for IL6R-IL6ST


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL6R-IL6ST


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL6R-IL6ST


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource