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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:IL6-TMED10 (FusionGDB2 ID:39597) |
Fusion Gene Summary for IL6-TMED10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IL6-TMED10 | Fusion gene ID: 39597 | Hgene | Tgene | Gene symbol | IL6 | TMED10 | Gene ID | 3569 | 10972 |
| Gene name | interleukin 6 | transmembrane p24 trafficking protein 10 | |
| Synonyms | BSF-2|BSF2|CDF|HGF|HSF|IFN-beta-2|IFNB2|IL-6 | P24(DELTA)|S31I125|S31III125|TMP21|Tmp-21-I|p23|p24d1 | |
| Cytomap | 7p15.3 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | interleukin-6B-cell differentiation factorB-cell stimulatory factor 2CTL differentiation factorhybridoma growth factorinterferon beta-2interleukin BSF-2 | transmembrane emp24 domain-containing protein 1021 kDa transmembrane trafficking proteinp24 family protein delta-1p24deltap24delta1testicular tissue protein Li 206transmembrane emp24-like trafficking protein 10transmembrane protein Tmp21 | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P05231 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000258743, ENST00000401630, ENST00000404625, ENST00000407492, ENST00000401651, ENST00000406575, ENST00000420258, | ENST00000303575, ENST00000557670, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 9 X 4=324 |
| # samples | 1 | 11 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/324*10)=-1.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IL6 [Title/Abstract] AND TMED10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | IL6(22771050)-TMED10(75598821), # samples:1 TMED10(75598821)-IL6(22771050), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IL6 | GO:0001781 | neutrophil apoptotic process | 7595060 |
| Hgene | IL6 | GO:0002384 | hepatic immune response | 2444978 |
| Hgene | IL6 | GO:0002675 | positive regulation of acute inflammatory response | 2444978 |
| Hgene | IL6 | GO:0006954 | inflammatory response | 10443688 |
| Hgene | IL6 | GO:0008284 | positive regulation of cell proliferation | 2261637 |
| Hgene | IL6 | GO:0010574 | regulation of vascular endothelial growth factor production | 8557680 |
| Hgene | IL6 | GO:0010628 | positive regulation of gene expression | 19390056 |
| Hgene | IL6 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 25916550 |
| Hgene | IL6 | GO:0019221 | cytokine-mediated signaling pathway | 2261637|12643274 |
| Hgene | IL6 | GO:0032722 | positive regulation of chemokine production | 10510402 |
| Hgene | IL6 | GO:0032755 | positive regulation of interleukin-6 production | 10510402 |
| Hgene | IL6 | GO:0032966 | negative regulation of collagen biosynthetic process | 12419823 |
| Hgene | IL6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 7508917 |
| Hgene | IL6 | GO:0042102 | positive regulation of T cell proliferation | 3130269 |
| Hgene | IL6 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 12643274|19390056 |
| Hgene | IL6 | GO:0043065 | positive regulation of apoptotic process | 9949178 |
| Hgene | IL6 | GO:0043066 | negative regulation of apoptotic process | 7595060 |
| Hgene | IL6 | GO:0043410 | positive regulation of MAPK cascade | 7508917|12419823 |
| Hgene | IL6 | GO:0045669 | positive regulation of osteoblast differentiation | 30545407 |
| Hgene | IL6 | GO:0045727 | positive regulation of translation | 16732314 |
| Hgene | IL6 | GO:0045893 | positive regulation of transcription, DNA-templated | 7749983|16606666 |
| Hgene | IL6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7508917|16946298|17324931 |
| Hgene | IL6 | GO:0046427 | positive regulation of JAK-STAT cascade | 12419823|12552091|17324931 |
| Hgene | IL6 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 10510402 |
| Hgene | IL6 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 7508917 |
| Hgene | IL6 | GO:0050871 | positive regulation of B cell activation | 3491322 |
| Hgene | IL6 | GO:0051024 | positive regulation of immunoglobulin secretion | 3491322 |
| Hgene | IL6 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 7749983 |
| Hgene | IL6 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 12419823 |
| Hgene | IL6 | GO:0051384 | response to glucocorticoid | 10443688 |
| Hgene | IL6 | GO:0051607 | defense response to virus | 3023045 |
| Hgene | IL6 | GO:0060252 | positive regulation of glial cell proliferation | 2104886 |
| Hgene | IL6 | GO:0070102 | interleukin-6-mediated signaling pathway | 12552091|16946298 |
| Hgene | IL6 | GO:0070301 | cellular response to hydrogen peroxide | 19168699 |
| Tgene | TMED10 | GO:0006886 | intracellular protein transport | 20427317 |
| Tgene | TMED10 | GO:0035964 | COPI-coated vesicle budding | 10052452 |
| Fusion gene breakpoints across IL6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across TMED10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE619286 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
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Fusion Gene ORF analysis for IL6-TMED10 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000258743 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-3UTR | ENST00000401630 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-3UTR | ENST00000404625 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-3UTR | ENST00000407492 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-intron | ENST00000258743 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-intron | ENST00000401630 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-intron | ENST00000404625 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| 5CDS-intron | ENST00000407492 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-3UTR | ENST00000401651 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-3UTR | ENST00000406575 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-3UTR | ENST00000420258 | ENST00000303575 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-intron | ENST00000401651 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-intron | ENST00000406575 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| intron-intron | ENST00000420258 | ENST00000557670 | IL6 | chr7 | 22771050 | + | TMED10 | chr14 | 75598821 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for IL6-TMED10 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for IL6-TMED10 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22771050/:75598821) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IL6 | . |
| FUNCTION: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable). {ECO:0000305|PubMed:30995492}.; FUNCTION: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000305|PubMed:30995492}.; FUNCTION: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability (PubMed:17075861, PubMed:12794819). Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF (PubMed:12794819). Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (PubMed:20823453). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis (By similarity). Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (PubMed:15124018). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity). {ECO:0000250|UniProtKB:P08505, ECO:0000269|PubMed:12794819, ECO:0000269|PubMed:15124018, ECO:0000269|PubMed:17075861, ECO:0000269|PubMed:20823453, ECO:0000305|PubMed:30995492}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for IL6-TMED10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for IL6-TMED10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for IL6-TMED10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for IL6-TMED10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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