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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IL7R-LRPPRC (FusionGDB2 ID:39599)

Fusion Gene Summary for IL7R-LRPPRC

check button Fusion gene summary
Fusion gene informationFusion gene name: IL7R-LRPPRC
Fusion gene ID: 39599
HgeneTgene
Gene symbol

IL7R

LRPPRC

Gene ID

3575

10128

Gene nameinterleukin 7 receptorleucine rich pentatricopeptide repeat containing
SynonymsCD127|CDW127|IL-7R-alpha|IL7RA|ILRACLONE-23970|GP130|LRP130|LSFC
Cytomap

5p13.2

2p21

Type of geneprotein-codingprotein-coding
Descriptioninterleukin-7 receptor subunit alphaCD127 antigenIL-7 receptor subunit alphaIL-7R subunit alphainterleukin 7 receptor alpha chaininterleukin 7 receptor isoform H5-6leucine-rich PPR motif-containing protein, mitochondrial130 kDa leucine-rich proteinLRP 130leucine-rich PPR-motif containingmitochondrial leucine-rich PPR motif-containing protein
Modification date2020031320200329
UniProtAcc.

P42704

Ensembl transtripts involved in fusion geneENST00000303115, ENST00000343305, 
ENST00000506850, ENST00000511031, 
ENST00000511982, 		ENST00000409659, 
ENST00000409946, ENST00000260665, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 13 X 4=676
# samples 113
** MAII scorelog2(1/1*10)=3.32192809488736log2(13/676*10)=-2.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IL7R [Title/Abstract] AND LRPPRC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL7R(35867565)-LRPPRC(44171033), # samples:1
Anticipated loss of major functional domain due to fusion event.IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
IL7R-LRPPRC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
IL7R-LRPPRC seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIL7R

GO:0008284

positive regulation of cell proliferation

11418668

HgeneIL7R

GO:1904894

positive regulation of STAT cascade

11418668


check buttonFusion gene breakpoints across IL7R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRPPRC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GY-01AIL7Rchr5

35867565

+LRPPRCchr2

44171033

-


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Fusion Gene ORF analysis for IL7R-LRPPRC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000303115ENST00000409659IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000303115ENST00000409946IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000343305ENST00000409659IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000343305ENST00000409946IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000506850ENST00000409659IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000506850ENST00000409946IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000511031ENST00000409659IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000511031ENST00000409946IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000511982ENST00000409659IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
5CDS-intronENST00000511982ENST00000409946IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
Frame-shiftENST00000511031ENST00000260665IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
In-frameENST00000303115ENST00000260665IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
In-frameENST00000343305ENST00000260665IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
In-frameENST00000506850ENST00000260665IL7Rchr5

35867565

+LRPPRCchr2

44171033

-
In-frameENST00000511982ENST00000260665IL7Rchr5

35867565

+LRPPRCchr2

44171033

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000303115IL7Rchr535867565+ENST00000260665LRPPRCchr244171033-44895081292396755
ENST00000343305IL7Rchr535867565+ENST00000260665LRPPRCchr244171033-4449468892356755
ENST00000506850IL7Rchr535867565+ENST00000260665LRPPRCchr244171033-4447466872354755
ENST00000511982IL7Rchr535867565+ENST00000260665LRPPRCchr244171033-44354544682342624

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000303115ENST00000260665IL7Rchr535867565+LRPPRCchr244171033-0.0010161180.9989839
ENST00000343305ENST00000260665IL7Rchr535867565+LRPPRCchr244171033-0.0010365580.9989635
ENST00000506850ENST00000260665IL7Rchr535867565+LRPPRCchr244171033-0.0010409870.99895895
ENST00000511982ENST00000260665IL7Rchr535867565+LRPPRCchr244171033-0.0001642290.9998357

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Fusion Genomic Features for IL7R-LRPPRC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IL7R-LRPPRC


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:35867565/chr2:44171033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LRPPRC

P42704

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:11585913, ECO:0000269|PubMed:12832482, ECO:0000269|PubMed:15081402, ECO:0000269|PubMed:15139850, ECO:0000269|PubMed:15272088, ECO:0000269|PubMed:17050673}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381121_13947651395.0RegionNote=RNA-binding
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141121_13940532.0RegionNote=RNA-binding
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381031_10657651395.0RepeatNote=PPR 15
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381066_11027651395.0RepeatNote=PPR 16
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381103_11377651395.0RepeatNote=PPR 17
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381138_11757651395.0RepeatNote=PPR 18
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381176_12107651395.0RepeatNote=PPR 19
TgeneLRPPRCchr5:35867565chr2:44171033ENST0000026066521381317_13517651395.0RepeatNote=PPR 20
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138785_8207651395.0RepeatNote=PPR 12
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138821_8567651395.0RepeatNote=PPR 13
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138954_9887651395.0RepeatNote=PPR 14
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141031_10650532.0RepeatNote=PPR 15
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141066_11020532.0RepeatNote=PPR 16
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141103_11370532.0RepeatNote=PPR 17
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141138_11750532.0RepeatNote=PPR 18
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141176_12100532.0RepeatNote=PPR 19
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014126_1600532.0RepeatNote=PPR 1
TgeneLRPPRCchr5:35867565chr2:44171033ENST000004099460141317_13510532.0RepeatNote=PPR 20
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014161_1950532.0RepeatNote=PPR 2
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014196_2300532.0RepeatNote=PPR 3
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014231_2650532.0RepeatNote=PPR 4
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014266_3000532.0RepeatNote=PPR 5
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014301_3350532.0RepeatNote=PPR 6
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014403_4370532.0RepeatNote=PPR 7
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014438_4720532.0RepeatNote=PPR 8
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014678_7090532.0RepeatNote=PPR 9
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014710_7460532.0RepeatNote=PPR 10
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014747_7840532.0RepeatNote=PPR 11
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014785_8200532.0RepeatNote=PPR 12
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014821_8560532.0RepeatNote=PPR 13
TgeneLRPPRCchr5:35867565chr2:44171033ENST00000409946014954_9880532.0RepeatNote=PPR 14

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38184_189126460.0Compositional biasNote=Ser/Thr-rich
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38131_231126460.0DomainFibronectin type-III
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38217_221126460.0MotifNote=WSXWS motif
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38272_280126460.0MotifNote=Box 1 motif
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+3821_239126460.0Topological domainExtracellular
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38265_459126460.0Topological domainCytoplasmic
HgeneIL7Rchr5:35867565chr2:44171033ENST00000303115+38240_264126460.0TransmembraneHelical
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138126_1607651395.0RepeatNote=PPR 1
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138161_1957651395.0RepeatNote=PPR 2
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138196_2307651395.0RepeatNote=PPR 3
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138231_2657651395.0RepeatNote=PPR 4
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138266_3007651395.0RepeatNote=PPR 5
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138301_3357651395.0RepeatNote=PPR 6
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138403_4377651395.0RepeatNote=PPR 7
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138438_4727651395.0RepeatNote=PPR 8
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138678_7097651395.0RepeatNote=PPR 9
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138710_7467651395.0RepeatNote=PPR 10
TgeneLRPPRCchr5:35867565chr2:44171033ENST000002606652138747_7847651395.0RepeatNote=PPR 11


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Fusion Gene Sequence for IL7R-LRPPRC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39599_39599_1_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000303115_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4489nt_BP=508nt
GTGGTTAGATAAGTATAAAGCCCTAGATCTAAGCTTCTCTGTCTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACAC
TGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATGACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTC
GTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAAGATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAA
GTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGACCCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTC
GTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGATATATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATA
TGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAATAGACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAG
AAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTCCACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAA
CAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCATCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGC
GACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAAAAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTA
GAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTTGTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTT
GCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATCATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTT
TGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAAAAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAG
ATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTT
ATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTAT
GAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAAC
CAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTA
CTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCC
AACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTGAAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACC
CCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCCATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAAT
GGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATCAATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCA
ATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTCATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATA
GAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATGGCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGAT
TTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCCAGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATT
TTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAGGCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAA
AAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCAGAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCA
AAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCATCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCT
GAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGGGAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATT
TGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGGGAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCA
TGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTATTGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTC
TTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTCTTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCA
TTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTGCTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTT
CTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTGTGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAG
TCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAGACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATG
CCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGCCACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAG
TCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCTCTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTT
GTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTATGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTG
ATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTAAGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGC
CATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAACTGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAAC
TCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTGACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCAC
ATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTGCAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCAT
CTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCGGGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTT
CAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCATGGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTG
AGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGCCAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTG
TTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCAC
GTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATTTTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCG
AACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAA
GAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCTCATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAAT
TGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTTGGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGT
ACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTATATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGAC

>39599_39599_1_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000303115_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE
IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE
PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK
IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI
LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV
KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF
INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD
ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY

--------------------------------------------------------------
>39599_39599_2_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000343305_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4449nt_BP=468nt
GTCTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAA
TGACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGG
AAGATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGG
ACCCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTCGTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGA
TATATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATATGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAA
TAGACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTT
TCCACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAAC
CATCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATG
AAAAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACT
TTGTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGA
TCATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGG
AAAAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTG
ACTGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCC
TTAGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAA
CCACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAG
AGCAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGA
AAGCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATT
TGAAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGG
CCATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCA
TCAATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAG
TCATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCA
TGGCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATG
CCAGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAA
AGGCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCT
CAGAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACG
CATCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGA
GGGAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGA
GGGAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTT
ATTGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGAT
TCTTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTC
TGCTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATG
TGTGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAG
AGACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCT
GCCACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTC
CTCTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATC
TATGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTG
TAAGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTA
ACTGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGG
TGACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCT
TGCAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGG
CGGGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGC
ATGGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTT
GCCAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACT
GCAACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAA
TTTTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTC
AGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGC
CTCATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACG
TTGGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGT
ATATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTA

>39599_39599_2_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000343305_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE
IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE
PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK
IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI
LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV
KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF
INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD
ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY

--------------------------------------------------------------
>39599_39599_3_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000506850_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4447nt_BP=466nt
CTTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATG
ACAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAA
GATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGAC
CCAGATGTCAACATCACCAATCTGGAATTTGAAATATGTGGGGCCCTCGTGGAGGTAAAGTGCCTGAATTTCAGGAAACTACAAGAGATA
TATTTCATCGAGACAAAGAAATTCTTACTGATTGGAAAGAGCAATATATGTGTGAAGGTTGGAGAAAAGAGTCTAACCTGCAAAAAAATA
GACCTAACCACTATAGATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTC
CACATGCTAAATGGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCA
TCCACCAACATAAGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAA
AAGTATAAAGTATTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTT
GTGAGCCAAGAACAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATC
ATTGAGACTCCAGGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAA
AAATTAGTGGAGCTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGAC
TGGCAAAGAGCTGATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTT
AGAGAGGGTAACCAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACC
ACAGAACCTGATTTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAG
CAAAACATTGTGTTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAA
GCATTCGCGGAGACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTG
AAAGAGGCTGTGACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCC
ATGAAGGGTGATGTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATC
AATAACATTGCTTTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTC
ATTGAACCCCAATACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATG
GCGGAGAGATTGGCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCC
AGAGCTCTCCTACAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAG
GCATCAACTGTGAAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCA
GAGAAAGATGTCACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCA
TCTTTGCTGAAGTATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGG
GAAAACTCTTCTTGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGG
GAAAAATAAATGAAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTAT
TGGACATTTTTGGAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTC
TTCCCCTAATTGGCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTG
CTGTTTCTCTGAAAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTG
TGAAGTCCTGCATAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAG
ACCCAAAGGGCCTGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGC
CACTGTGGCTTCAAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCT
CTCATTGTAGTTTCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTA
TGAAGGGGTAAAATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTA
AGTAGTGACTTCAAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAAC
TGGAGATGAGGTAATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTG
ACTCCCTACTGTTCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTG
CAACTTGTGCTGTTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCG
GGAAGCCAGGAAGTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCAT
GGCCAACGTTGAGTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGC
CAAAAGCATCTTTTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGC
AACCTCCGCCTCCTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATT
TTTGTATGGTAAAGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAG
CCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCT
CATTTTTTTGCAGTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTT
GGGGTGTAATCTGGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTAT
ATGGACTCTGGTAAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTACA

>39599_39599_3_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000506850_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=755AA_BP=126
MTILGTTFGMVFSLLQVVSGESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQE
IYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAE
PSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKK
IIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEI
LREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEV
KAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVF
INNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDD
ARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRY

--------------------------------------------------------------
>39599_39599_4_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000511982_LRPPRC_chr2_44171033_ENST00000260665_length(transcript)=4435nt_BP=454nt
TTCCTCCCTCCCTCCCTTCCTCTTACTCTCATTCATTTCATACACACTGGCTCACACATCTACTCTCTCTCTCTATCTCTCTCAGAATGA
CAATTCTAGGTACAACTTTTGGCATGGTTTTTTCTTTACTTCAAGTCGTTTCTGGAGAAAGTGGCTATGCTCAAAATGGAGACTTGGAAG
ATGCAGAACTGGATGACTACTCATTCTCATGCTATAGCCAGTTGGAAGTGAATGGATCGCAGCACTCACTGACCTGTGCTTTTGAGGACC
CAGATGTCAACATCACCAATCTGGAATTTGAAATATGGTAAGAAGTTGTATATAAAAGTATGGTTGTCACTTTTGGGCTACCTGAAAACA
CTGTGTCTGGACATTCTGTAGGTTAAAAGTAGACAAATAGTGGAAACAACTGGCAATAGATAATAGCTAATTCCCTACTGTAAATTTTTA
TAATATGCTATTAACATTCTGAAGGAGATGAAAGAGAAGGATGTTCTTATCAAAGATACAACAGCCTTGTCCTTTTTCCACATGCTAAAT
GGCGCAGCTTTAAGAGGTGAAATTGAAACAGTAAAACAGTTGCATGAAGCCATCGTGACTCTAGGGTTAGCAGAACCATCCACCAACATA
AGTTTCCCATTGGTCACTGTACACTTGGAAAAGGGCGACCTATCTACTGCTCTTGAGGTCGCCATTGACTGCTATGAAAAGTATAAAGTA
TTACCAAGGATTCATGATGTCTTGTGTAAACTGGTAGAGAAAGGCGAGACTGATCTAATTCAGAAAGCAATGGACTTTGTGAGCCAAGAA
CAAGGTGAAATGGTGATGCTCTATGATCTCTTCTTTGCCTTCCTACAAACAGGAAATTACAAAGAGGCCAAGAAGATCATTGAGACTCCA
GGGATTAGAGCTCGATCTGCAAGGCTTCAGTGGTTTTGTGACAGATGTGTTGCAAATAATCAGGTTGAAACTCTGGAAAAATTAGTGGAG
CTGACACAGAAGCTATTTGAATGTGATAGAGACCAGATGTACTACAATCTGCTAAAACTGTATAAAATAAACGGTGACTGGCAAAGAGCT
GATGCAGTCTGGAATAAAATCCAAGAAGAAAATGTTATTCCTCGTGAAAAGACATTAAGATTATTAGCAGAAATCCTTAGAGAGGGTAAC
CAGGAAGTTCCGTTTGACGTACCTGAGTTGTGGTATGAAGATGAAAAACATTCCCTGAATTCTTCGTCAGCCTCAACCACAGAACCTGAT
TTCCAGAAAGATATATTGATTGCCTGCCGATTGAACCAAAAAAAAGGGGCATATGATATTTTCCTGAATGCAAAAGAGCAAAACATTGTG
TTTAATGCTGAAACCTACAGCAATCTCATTAAATTACTGATGTCAGAAGATTATTTTACACAAGCAATGGAAGTGAAAGCATTCGCGGAG
ACCCACATCAAGGGCTTCACACTGAACGATGCTGCCAACAGCCGCCTCATCATAACGCAAGTTAGGCGGGATTATTTGAAAGAGGCTGTG
ACAACACTGAAAACAGTATTGGATCAGCAGCAGACCCCTTCTAGGTTAGCAGTGACCCGTGTCATCCAGGCATTGGCCATGAAGGGTGAT
GTTGAAAACATAGAAGTAGTTCAGAAGATGTTAAATGGACTCGAAGACTCCATTGGACTTTCAAAAATGGTTTTCATCAATAACATTGCT
TTGGCTCAAATAAAGAATAATAACATAGATGCCGCAATAGAAAACATTGAAAATATGCTTACTTCAGAGAATAAAGTCATTGAACCCCAA
TACTTCGGCTTGGCATACTTATTCAGAAAAGTAATAGAGGAGCAGTTGGAACCAGCAGTTGAAAAGATAAGCATCATGGCGGAGAGATTG
GCCAATCAGTTTGCAATTTATAAACCTGTCACTGATTTTTTCCTTCAACTTGTGGATGCAGGCAAGGTGGATGATGCCAGAGCTCTCCTA
CAGAGATGTGGTGCAATTGCTGAACAAACCCCGATTTTGTTGTTGTTCCTCCTTAGGAATTCTAGGAAACAAGGAAAGGCATCAACTGTG
AAATCTGTGTTAGAATTGATTCCTGAATTAAATGAAAAGGAAGAAGCATACAATTCCCTCATGAAAAGCTATGTCTCAGAGAAAGATGTC
ACATCTGCTAAAGCACTGTATGAACATTTGACTGCAAAGAATACAAAATTGGATGATCTGTTTCTAAAGCGTTACGCATCTTTGCTGAAG
TATGCTGGAGAGCCTGTCCCTTTCATTGAACCCCCTGAAAGCTTTGAATTTTATGCACAGCAGCTAAGAAAATTGAGGGAAAACTCTTCT
TGAAATAACCAGGCGATACTTTGTTTTGTATATATTTGTGATTCTGTGTCTACATGTTATTTTGAAGTATATCTGAGGGAAAAATAAATG
AAAATTTTCTTTATGTACTTATGTATGTGTGATGCATGTTCAAAGTCTTATTGACCATAACTCTGTGCACTTGGTTATTGGACATTTTTG
GAGTTTTTTTCTCTGGGAAAAATCGATAGTGTTTTCTTCAATGCTGCTGCTGTGTGAAGCCATACTTTTTCAGGATTCTTCCCCTAATTG
GCTCTTTGGTTTCCCTGCTCTGTTTCATTTATTTCATTAAAATGTTATTCCTTTATTTAAGATTCACTTATTAGTCTGCTGTTTCTCTGA
AAAATTTTAGAGCTAGGTATAGTGACCGTGAACTTTCTAACGCATAATATTCTGTGATACAGCCATTCCGTACATGTGTGAAGTCCTGCA
TAACTTTCGAACTTTGTTAAATGTTGGCACTAGGAGTCATCAGATCTAGGCTTCATCATTTTCCAGTGAGAAGCAGAGACCCAAAGGGCC
TGTTACTTGTGCTTGGTCAGGGGACTGTCTGTCATGCCTGGAGGCTCTTCGGCACACTTCCCCATCTTTCCCTTCTGCCACTGTGGCTTC
AAGCACCTCTGTTCATAGAGCGTCTCTGAAATTGAGTCTCGGTCATGACTTATCCCGAAGTAGAGCAATGTGTTTCCTCTCATTGTAGTT
TCAGGACTTTGTCAGTACAAGCTCTGCCCTAGGCTTGTTACTTTATACTCATATCCTGAAAAGATGTGATTTCATCTATGAAGGGGTAAA
ATATTGGTTTGTATTTAATTGTTTGAAATAAAAGTGATCCCTATATTGAATCTCATGCCTGTTAATATCTACACTGTAAGTAGTGACTTC
AAAAAAATTCTAAGATAGGTAGTCAGGAGAGTTTGCCATTATAAAAGGTGTCTTAATAATATGGAATATTGACCTAACTGGAGATGAGGT
AATTAATTACCGAAATGTTGAAAATGTTTTGAGAACTCTCCCCATTTTGGGGTATTCCTTGTTCATTTGAATTTGGTGACTCCCTACTGT
TCCAGTTTCAGTGCCAACTTGGGTCACACTGTTCACATCAGGGGAGACCTTGCCTTGGGGACGTAGGCGGGCCTCTTGCAACTTGTGCTG
TTGACCTTCTGTCTTGTGGAACTCTCTCTCCTGCATCTGCTACCTGCCCGCAGATGGTGTGAGGGAGGGTTGATGGCGGGAAGCCAGGAA
GTAGATGTCATCATGGTATTGGCCAGGCTTTTACTTCAACTCTTTTTGTGGCGTTAGATTTAAGGAAGCAGGGGGCATGGCCAACGTTGA
GTCTTGGCCCAGTGGACATAGTGCGGCTTTCCCTTGAGCACTGCCCAGATGCAGGACCTGCACATGTTACAGGTTTGCCAAAAGCATCTT
TTTTTTTTTTTTTTTTTTTGAGATAGTCTTGCTCTGTTGCTTAAGCCAGAGTGCAGTGGCGCAATCTCAGCTCACTGCAACCTCCGCCTC
CTGGGTTCAAGTGATTCTTGTGCCTCAGCCTCCCACGTAGCTGAGATTACAGGCTTGCACCACCATGTTCAGCTAATTTTTGTATGGTAA
AGACGGAGTTTCACCATGTTGGCCAGGTTGGTCTCGAACTCCTGGCCCCAAGTGATCCTCCCCCTGCGCTCGCTTCAGCCTCCCAAAGTG
CTGGGATTACAGGTGTGAGCCACCACGCCTGGCCAAGAGCCTCACTCCTGTCTTTAGTGATTGCACTGAAGCAGGCCTCATTTTTTTGCA
GTCATGCTAACCACAAGTTAGTCAACATTCACTAATTGACATTCATTAGAATAGGTCTCCAAGGTGAGGCATAACGTTGGGGTGTAATCT
GGATTTCGCAGTCATCTTTTTGGGGAAACTGAAAGTACCATCTCATTTGCATGAAGTGACTCCACACTGGCCCTGTATATGGACTCTGGT
AAAATGTGAGTGTGGTACAGAGGAAATAGGTAAGACCCCCTTATCTAGCCCTCTCGGCAGCAGCGGGGGGGTGTTACAAAGGACTAGCTG

>39599_39599_4_IL7R-LRPPRC_IL7R_chr5_35867565_ENST00000511982_LRPPRC_chr2_44171033_ENST00000260665_length(amino acids)=624AA_BP=
MKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHD
VLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLF
ECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDIL
IACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTV
LDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAY
LFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLEL

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Fusion Gene PPI Analysis for IL7R-LRPPRC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IL7R-LRPPRC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IL7R-LRPPRC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource