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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ILK-ILK (FusionGDB2 ID:39640)

Fusion Gene Summary for ILK-ILK

check button Fusion gene summary
Fusion gene informationFusion gene name: ILK-ILK
Fusion gene ID: 39640
HgeneTgene
Gene symbol

ILK

ILK

Gene ID

3611

3611

Gene nameintegrin linked kinaseintegrin linked kinase
SynonymsHEL-S-28|ILK-1|ILK-2|P59|p59ILKHEL-S-28|ILK-1|ILK-2|P59|p59ILK
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionintegrin-linked protein kinase59 kDa serine/threonine-protein kinaseepididymis secretory protein Li 28integrin-linked kinase-2integrin-linked protein kinase59 kDa serine/threonine-protein kinaseepididymis secretory protein Li 28integrin-linked kinase-2
Modification date2020032020200320
UniProtAcc

Q13418

Q9H0C8

Ensembl transtripts involved in fusion geneENST00000526711, ENST00000299421, 
ENST00000396751, ENST00000420936, 
ENST00000528995, ENST00000537806, 
ENST00000299421, ENST00000396751, 
ENST00000420936, ENST00000528995, 
ENST00000537806, ENST00000526711, 
Fusion gene scores* DoF score4 X 6 X 2=484 X 5 X 2=40
# samples 75
** MAII scorelog2(7/48*10)=0.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ILK [Title/Abstract] AND ILK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointILK(6630619)-ILK(6630588), # samples:1
ILK(6630776)-ILK(6630793), # samples:1
Anticipated loss of major functional domain due to fusion event.ILK-ILK seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ILK-ILK seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ILK-ILK seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ILK-ILK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ILK-ILK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
ILK-ILK seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneILK

GO:0006468

protein phosphorylation

10871859

HgeneILK

GO:0007229

integrin-mediated signaling pathway

9366252

TgeneILK

GO:0006468

protein phosphorylation

10871859

TgeneILK

GO:0007229

integrin-mediated signaling pathway

9366252


check buttonFusion gene breakpoints across ILK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ILK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA230229ILKchr11

6630619

+ILKchr11

6630588

-
ChiTaRS5.0N/ABE770002ILKchr11

6630776

-ILKchr11

6630793

+


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Fusion Gene ORF analysis for ILK-ILK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000526711ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3CDSENST00000526711ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
3UTR-3CDSENST00000526711ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3CDSENST00000526711ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
3UTR-3CDSENST00000526711ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3CDSENST00000526711ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
3UTR-3CDSENST00000526711ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3CDSENST00000526711ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
3UTR-3CDSENST00000526711ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3CDSENST00000526711ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+
3UTR-3UTRENST00000526711ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
3UTR-3UTRENST00000526711ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
5CDS-3UTRENST00000299421ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
5CDS-3UTRENST00000299421ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
5CDS-3UTRENST00000396751ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
5CDS-3UTRENST00000396751ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
5CDS-3UTRENST00000420936ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
5CDS-3UTRENST00000420936ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
5CDS-3UTRENST00000528995ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
5CDS-3UTRENST00000528995ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
5CDS-3UTRENST00000537806ENST00000526711ILKchr11

6630619

+ILKchr11

6630588

-
5CDS-3UTRENST00000537806ENST00000526711ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000299421ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000299421ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000299421ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000299421ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000299421ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000299421ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000299421ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000299421ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000299421ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000299421ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000396751ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000396751ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000396751ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000396751ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000396751ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000396751ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000396751ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000396751ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000396751ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000396751ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000420936ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000420936ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000420936ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000420936ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000420936ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000420936ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000420936ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000420936ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000420936ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000420936ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000528995ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000528995ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000528995ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000528995ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000528995ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000528995ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000528995ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000528995ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000528995ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000528995ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000537806ENST00000299421ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000537806ENST00000299421ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000537806ENST00000396751ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000537806ENST00000396751ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000537806ENST00000420936ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000537806ENST00000420936ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000537806ENST00000528995ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000537806ENST00000528995ILKchr11

6630776

-ILKchr11

6630793

+
Frame-shiftENST00000537806ENST00000537806ILKchr11

6630619

+ILKchr11

6630588

-
Frame-shiftENST00000537806ENST00000537806ILKchr11

6630776

-ILKchr11

6630793

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ILK-ILK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ILK-ILK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:6630619/:6630588)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ILK

Q13418

ILK

Q9H0C8

FUNCTION: Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling (PubMed:10712922). Focal adhesion protein part of the complex ILK-PINCH (PubMed:10712922). This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway (PubMed:10712922). Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells (PubMed:10712922). Regulates cell motility by forming a complex with PARVB (PubMed:32528174). Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). {ECO:0000269|PubMed:32528174, ECO:0000269|PubMed:8538749, ECO:0000269|PubMed:9736715, ECO:0000303|PubMed:10712922}.FUNCTION: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. {ECO:0000269|PubMed:14990992}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ILK-ILK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ILK-ILK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ILK-ILK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ILK-ILK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource