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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ILVBL-TECR (FusionGDB2 ID:39652)

Fusion Gene Summary for ILVBL-TECR

check button Fusion gene summary
Fusion gene informationFusion gene name: ILVBL-TECR
Fusion gene ID: 39652
HgeneTgene
Gene symbol

ILVBL

TECR

Gene ID

10994

9524

Gene nameilvB acetolactate synthase liketrans-2,3-enoyl-CoA reductase
Synonyms209L8|AHAS|HACL1L|ILV2HGPSN2|MRT14|SC2|TER
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionacetolactate synthase-like protein2-hydroxyacyl-CoA lyase 1 likeacetolactate synthase homologilvB (bacterial acetolactate synthase)-likeilvB-like proteinvery-long-chain enoyl-CoA reductaseepididymis secretory sperm binding proteinglycoprotein, synaptic 2synaptic glycoprotein SC2
Modification date2020032720200320
UniProtAcc

A1L0T0

.
Ensembl transtripts involved in fusion geneENST00000263383, ENST00000534378, 
ENST00000531635, 		ENST00000596164, 
ENST00000436007, ENST00000596073, 
ENST00000600083, ENST00000215567, 
Fusion gene scores* DoF score8 X 9 X 5=3609 X 3 X 7=189
# samples 1013
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/189*10)=-0.539874611192618
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ILVBL [Title/Abstract] AND TECR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointILVBL(15226661)-TECR(14673337), # samples:2
TECR(14640523)-ILVBL(15227333), # samples:2
Anticipated loss of major functional domain due to fusion event.TECR-ILVBL seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
TECR-ILVBL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
TECR-ILVBL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ILVBL-TECR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ILVBL-TECR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ILVBL-TECR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTECR

GO:0030497

fatty acid elongation

12482854

TgeneTECR

GO:0042761

very long-chain fatty acid biosynthetic process

12482854


check buttonFusion gene breakpoints across ILVBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TECR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1319-01AILVBLchr19

15226661

-TECRchr19

14673337

+
ChimerDB4OVTCGA-25-1319ILVBLchr19

15226962

-TECRchr19

14673336

+


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Fusion Gene ORF analysis for ILVBL-TECR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000263383ENST00000596164ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-3UTRENST00000263383ENST00000596164ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-3UTRENST00000534378ENST00000596164ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-3UTRENST00000534378ENST00000596164ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000263383ENST00000436007ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000263383ENST00000436007ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000263383ENST00000596073ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000263383ENST00000596073ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000263383ENST00000600083ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000263383ENST00000600083ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000534378ENST00000436007ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000534378ENST00000436007ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000534378ENST00000596073ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000534378ENST00000596073ILVBLchr19

15226962

-TECRchr19

14673336

+
5CDS-5UTRENST00000534378ENST00000600083ILVBLchr19

15226661

-TECRchr19

14673337

+
5CDS-5UTRENST00000534378ENST00000600083ILVBLchr19

15226962

-TECRchr19

14673336

+
Frame-shiftENST00000263383ENST00000215567ILVBLchr19

15226661

-TECRchr19

14673337

+
Frame-shiftENST00000534378ENST00000215567ILVBLchr19

15226962

-TECRchr19

14673336

+
In-frameENST00000263383ENST00000215567ILVBLchr19

15226962

-TECRchr19

14673336

+
In-frameENST00000534378ENST00000215567ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-3CDSENST00000531635ENST00000215567ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-3CDSENST00000531635ENST00000215567ILVBLchr19

15226962

-TECRchr19

14673336

+
intron-3UTRENST00000531635ENST00000596164ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-3UTRENST00000531635ENST00000596164ILVBLchr19

15226962

-TECRchr19

14673336

+
intron-5UTRENST00000531635ENST00000436007ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-5UTRENST00000531635ENST00000436007ILVBLchr19

15226962

-TECRchr19

14673336

+
intron-5UTRENST00000531635ENST00000596073ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-5UTRENST00000531635ENST00000596073ILVBLchr19

15226962

-TECRchr19

14673336

+
intron-5UTRENST00000531635ENST00000600083ILVBLchr19

15226661

-TECRchr19

14673337

+
intron-5UTRENST00000531635ENST00000600083ILVBLchr19

15226962

-TECRchr19

14673336

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534378ILVBLchr1915226661-ENST00000215567TECRchr1914673337+25651546552457800
ENST00000263383ILVBLchr1915226962-ENST00000215567TECRchr1914673336+263016111401708522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534378ENST00000215567ILVBLchr1915226661-TECRchr1914673337+0.0031407050.9968593
ENST00000263383ENST00000215567ILVBLchr1915226962-TECRchr1914673336+0.0096892860.99031067

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Fusion Genomic Features for ILVBL-TECR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ILVBLchr1915226660-TECRchr1914673336+0.0009195660.9990804
ILVBLchr1915226962-TECRchr1914673336+1.31E-060.9999987
ILVBLchr1915226660-TECRchr1914673336+0.0009195660.9990804
ILVBLchr1915226962-TECRchr1914673336+1.31E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ILVBL-TECR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:15226661/chr19:14673337)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ILVBL

A1L0T0

.
FUNCTION: Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. {ECO:0000269|PubMed:28289220}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneILVBLchr19:15226661chr19:14673337ENST00000263383-141613_33538633.0TransmembraneHelical
HgeneILVBLchr19:15226962chr19:14673336ENST00000263383-121613_33490633.0TransmembraneHelical
TgeneTECRchr19:15226661chr19:14673337ENST00000215567013194_2145309.0TransmembraneHelical
TgeneTECRchr19:15226661chr19:14673337ENST00000215567013255_2755309.0TransmembraneHelical
TgeneTECRchr19:15226661chr19:14673337ENST0000021556701387_1075309.0TransmembraneHelical
TgeneTECRchr19:15226962chr19:14673336ENST00000215567013194_2145309.0TransmembraneHelical
TgeneTECRchr19:15226962chr19:14673336ENST00000215567013255_2755309.0TransmembraneHelical
TgeneTECRchr19:15226962chr19:14673336ENST0000021556701387_1075309.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneILVBLchr19:15226661chr19:14673337ENST00000263383-1416470_550538633.0RegionThiamine pyrophosphate binding
HgeneILVBLchr19:15226962chr19:14673336ENST00000263383-1216470_550490633.0RegionThiamine pyrophosphate binding


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Fusion Gene Sequence for ILVBL-TECR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39652_39652_1_ILVBL-TECR_ILVBL_chr19_15226661_ENST00000534378_TECR_chr19_14673337_ENST00000215567_length(transcript)=2565nt_BP=1546nt
TCCCGGGTCACGTGACACGGAGGGGGCCGAATTCTGCTGGAGGCAGCGCCATATCCTGGAGGTGAAGGTGGACAAGGCAAGCGTCCGGCA
TGGCGGAGAGAACGTGGCCGCTGTGCTGAGGGCCCATGGTGTGCGGTTCATCTTCACGCTGGTCGGTGGGCACATTTCCCCGCTGCTGGT
GGCCTGTGAGAAACTGGGCATCCGTGTGGTGGACACACGCCATGAGGTCACGGCCGTCTTTGCTGCTGATGCTATGGCCCGCCTGTCCGG
GACGGTGGGCGTGGCGGCAGTGACAGCAGGCCCTGGCCTCACCAACACGGTGACTGCGGTGAAGAATGCTCAGATGGCTCAGTCCCCAAT
CCTGCTTCTGGGTGGGGCTGCCAGCACTCTGCTGCAGAACCGGGGTGCGCTCCAGGCTGTTGATCAGCTGTCCCTTTTCCGGCCACTCTG
TAAGTTTTGTGTGTCTGTGCGGAGGGTGCGGGACATTGTGCCCACCCTGAGGGCCGCGATGGCTGCCGCCCAGTCGGGCACCCCAGGTCC
GGTGTTTGTGGAGCTGCCCGTTGACGTGCTGTACCCCTACTTCATGGTCCAGAAGGAGATGGTGCCAGCCAAGCCACCCAAGGGCCTCGT
GGGCCGAGTGGTCTCCTGGTATTTAGAGAATTACCTGGCCAACCTCTTTGCAGGAGCCTGGGAGCCTCAGCCCGAGGGACCGCTGCCCCT
GGACATCCCCCAGGCTTCCCCGCAGCAGGTTCAGCGCTGTGTGGAGATCCTGAGCCGGGCCAAGAGGCCTCTGATGGTGCTGGGGAGTCA
GGCCCTGCTCACCCCAACGTCTGCCGACAAGCTTCGGGCTGCCGTGGAGACCTTGGGTGTTCCCTGCTTCCTTGGAGGGATGGCACGGGG
GCTGTTAGGCCGCAACCACCCCCTCCACATCCGGGAGAACCGCAGTGCGGCCCTGAAGAAGGCGGATGTCATTGTCCTAGCAGGAACTGT
GTGTGACTTCCGCCTATCCTATGGCCGTGTCCTCAGCCACAGCAGCAAGATCATCATCGTCAATCGTAATCGGGAAGAGATGTTGCTCAA
CTCAGACATCTTCTGGAAGCCCCAGGAGGCTGTGCAGGGAGATGTGGGTTCCTTCGTGCTGAAGTTAGTGGAGGGCCTTCAGGGCCAGAC
CTGGGCCCCAGACTGGGTGGAGGAGCTGCGGGAAGCCGACCGGCAGAAGGAGCAGACCTTTCGGGAGAAGGCAGCGATGCCTGTGGCCCA
GCACCTGAACCCAGTGCAGGTGCTGCAGCTGGTGGAGGAAACGCTACCTGACAACTCAATTCTGGTGGTGGATGGCGGGGACTTCGTGGG
CACTGCTGCCCATCTGGTACAGCCCCGCGGCCCCCTGCGCTGGCTCGATCCTGGGGCCTTTGGGACTCTGGGAGTTGGTGCAGGATTTGC
ACTTGGGGCCAAGCTGTGCCGGCCAGATGCTGAGGTCTGGTGCCTGTTTGGGGACGGAGCTTTTGGCTACAGCCTCATCGAATTTGATAC
ATTCGTCAGACACAAGGTGGAGATTCTGGACGCAAAGACAAGGGAGAAGCTGTGTTTCTTGGACAAGGTGGAGCCCCACGCCACCATTGC
GGAGATCAAGAACCTCTTCACTAAGACCCATCCGCAGTGGTACCCCGCCCGCCAGTCCCTCCGCCTGGACCCCAAGGGCAAGTCCCTGAA
GGATGAGGATGTTCTGCAGAAGCTGCCCGTGGGCACCACGGCCACACTGTACTTCCGGGACCTGGGGGCCCAGATCAGCTGGGTGACGGT
CTTCCTAACAGAGTACGCGGGGCCCCTTTTCATCTACCTGCTCTTCTACTTCCGAGTGCCCTTCATCTATGGCCACAAATATGACTTTAC
GTCCAGTCGGCATACAGTGGTGCACCTCGCCTGCATCTGTCACTCATTCCACTACATCAAGCGCCTGCTGGAGACGCTCTTCGTGCACCG
CTTCTCCCATGGCACTATGCCTTTGCGCAACATCTTCAAGAACTGCACCTACTACTGGGGCTTCGCCGCGTGGATGGCCTATTACATCAA
TCACCCTCTCTACACTCCCCCTACCTACGGAGCTCAGCAGGTGAAACTGGCGCTCGCCATCTTTGTGATCTGCCAGCTCGGCAACTTCTC
CATCCACATGGCCCTGCGGGACCTGCGGCCCGCTGGGTCCAAGACGCGGAAGATCCCATACCCCACCAAGAACCCCTTCACGTGGCTCTT
CCTGCTGGTGTCCTGCCCCAACTACACCTACGAGGTGGGGTCCTGGATCGGTTTCGCCATCATGACGCAGTGTCTCCCAGTGGCCCTGTT
CTCCCTGGTGGGCTTCACCCAGATGACCATCTGGGCCAAGGGCAAGCACCGCAGCTACCTGAAGGAGTTCCGGGACTACCCGCCCCTGCG
CATGCCCATCATCCCCTTCCTGCTCTGAGCGCTCACCCCTGCTGAGGCTCAGCCCCTCAACCCGGTGGCATTCTGGGGGAGGAGTGGGGC

>39652_39652_1_ILVBL-TECR_ILVBL_chr19_15226661_ENST00000534378_TECR_chr19_14673337_ENST00000215567_length(amino acids)=800AA_BP=497
MEVKVDKASVRHGGENVAAVLRAHGVRFIFTLVGGHISPLLVACEKLGIRVVDTRHEVTAVFAADAMARLSGTVGVAAVTAGPGLTNTVT
AVKNAQMAQSPILLLGGAASTLLQNRGALQAVDQLSLFRPLCKFCVSVRRVRDIVPTLRAAMAAAQSGTPGPVFVELPVDVLYPYFMVQK
EMVPAKPPKGLVGRVVSWYLENYLANLFAGAWEPQPEGPLPLDIPQASPQQVQRCVEILSRAKRPLMVLGSQALLTPTSADKLRAAVETL
GVPCFLGGMARGLLGRNHPLHIRENRSAALKKADVIVLAGTVCDFRLSYGRVLSHSSKIIIVNRNREEMLLNSDIFWKPQEAVQGDVGSF
VLKLVEGLQGQTWAPDWVEELREADRQKEQTFREKAAMPVAQHLNPVQVLQLVEETLPDNSILVVDGGDFVGTAAHLVQPRGPLRWLDPG
AFGTLGVGAGFALGAKLCRPDAEVWCLFGDGAFGYSLIEFDTFVRHKVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQ
SLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHY
IKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKI

--------------------------------------------------------------
>39652_39652_2_ILVBL-TECR_ILVBL_chr19_15226962_ENST00000263383_TECR_chr19_14673336_ENST00000215567_length(transcript)=2630nt_BP=1611nt
TGCGCATCGGGCCGGACTACGGGGCGCCGCTGAGCCAAGTGGGCCACCCGGGCACGGCCACGCTCCCGGGTCACGTGACACGGAGGGGGC
CGAATTCTGCTGGAGGCAGCGCCATATCCTGGAGGTGAAGGTACCACCTCATGGAGACCCCCGCGGCCGCCGCCCCCGCTGGGAGCTTAT
TCCCCTCCTTCCTGCTCCTGGCCTGCGGGACGCTGGTGGCCGCCTTGCTGGGCGCCGCTCACCGCCTGGGGCTCTTCTATCAGCTGCTGC
ACAAGGTGGACAAGGCAAGCGTCCGGCATGGCGGAGAGAACGTGGCCGCTGTGCTGAGGGCCCATGGTGTGCGGTTCATCTTCACGCTGG
TCGGTGGGCACATTTCCCCGCTGCTGGTGGCCTGTGAGAAACTGGGCATCCGTGTGGTGGACACACGCCATGAGGTCACGGCCGTCTTTG
CTGCTGATGCTATGGCCCGCCTGTCCGGGACGGTGGGCGTGGCGGCAGTGACAGCAGGCCCTGGCCTCACCAACACGGTGACTGCGGTGA
AGAATGCTCAGATGGCTCAGTCCCCAATCCTGCTTCTGGGTGGGGCTGCCAGCACTCTGCTGCAGAACCGGGGTGCGCTCCAGGCTGTTG
ATCAGCTGTCCCTTTTCCGGCCACTCTGTAAGTTTTGTGTGTCTGTGCGGAGGGTGCGGGACATTGTGCCCACCCTGAGGGCCGCGATGG
CTGCCGCCCAGTCGGGCACCCCAGGTCCGGTGTTTGTGGAGCTGCCCGTTGACGTGCTGTACCCCTACTTCATGGTCCAGAAGGAGATGG
TGCCAGCCAAGCCACCCAAGGGCCTCGTGGGCCGAGTGGTCTCCTGGTATTTAGAGAATTACCTGGCCAACCTCTTTGCAGGAGCCTGGG
AGCCTCAGCCCGAGGGACCGCTGCCCCTGGACATCCCCCAGGCTTCCCCGCAGCAGGTTCAGCGCTGTGTGGAGATCCTGAGCCGGGCCA
AGAGGCCTCTGATGGTGCTGGGGAGTCAGGCCCTGCTCACCCCAACGTCTGCCGACAAGCTTCGGGCTGCCGTGGAGACCTTGGGTGTTC
CCTGCTTCCTTGGAGGGATGGCACGGGGGCTGTTAGGCCGCAACCACCCCCTCCACATCCGGGAGAACCGCAGTGCGGCCCTGAAGAAGG
CGGATGTCATTGTCCTAGCAGGAACTGTGTGTGACTTCCGCCTATCCTATGGCCGTGTCCTCAGCCACAGCAGCAAGATCATCATCGTCA
ATCGTAATCGGGAAGAGATGTTGCTCAACTCAGACATCTTCTGGAAGCCCCAGGAGGCTGTGCAGGGAGATGTGGGTTCCTTCGTGCTGA
AGTTAGTGGAGGGCCTTCAGGGCCAGACCTGGGCCCCAGACTGGGTGGAGGAGCTGCGGGAAGCCGACCGGCAGAAGGAGCAGACCTTTC
GGGAGAAGGCAGCGATGCCTGTGGCCCAGCACCTGAACCCAGTGCAGGTGCTGCAGCTGGTGGAGGAAACGCTACCTGACAACTCAATTC
TGGTGGTGGATGGCGGGGACTTCGTGGGCACTGCTGCCCATCTGGTACAGCCCCGCGGCCCCCTGCGCTGGCTCGATCCTGGTGGAGATT
CTGGACGCAAAGACAAGGGAGAAGCTGTGTTTCTTGGACAAGGTGGAGCCCCACGCCACCATTGCGGAGATCAAGAACCTCTTCACTAAG
ACCCATCCGCAGTGGTACCCCGCCCGCCAGTCCCTCCGCCTGGACCCCAAGGGCAAGTCCCTGAAGGATGAGGATGTTCTGCAGAAGCTG
CCCGTGGGCACCACGGCCACACTGTACTTCCGGGACCTGGGGGCCCAGATCAGCTGGGTGACGGTCTTCCTAACAGAGTACGCGGGGCCC
CTTTTCATCTACCTGCTCTTCTACTTCCGAGTGCCCTTCATCTATGGCCACAAATATGACTTTACGTCCAGTCGGCATACAGTGGTGCAC
CTCGCCTGCATCTGTCACTCATTCCACTACATCAAGCGCCTGCTGGAGACGCTCTTCGTGCACCGCTTCTCCCATGGCACTATGCCTTTG
CGCAACATCTTCAAGAACTGCACCTACTACTGGGGCTTCGCCGCGTGGATGGCCTATTACATCAATCACCCTCTCTACACTCCCCCTACC
TACGGAGCTCAGCAGGTGAAACTGGCGCTCGCCATCTTTGTGATCTGCCAGCTCGGCAACTTCTCCATCCACATGGCCCTGCGGGACCTG
CGGCCCGCTGGGTCCAAGACGCGGAAGATCCCATACCCCACCAAGAACCCCTTCACGTGGCTCTTCCTGCTGGTGTCCTGCCCCAACTAC
ACCTACGAGGTGGGGTCCTGGATCGGTTTCGCCATCATGACGCAGTGTCTCCCAGTGGCCCTGTTCTCCCTGGTGGGCTTCACCCAGATG
ACCATCTGGGCCAAGGGCAAGCACCGCAGCTACCTGAAGGAGTTCCGGGACTACCCGCCCCTGCGCATGCCCATCATCCCCTTCCTGCTC
TGAGCGCTCACCCCTGCTGAGGCTCAGCCCCTCAACCCGGTGGCATTCTGGGGGAGGAGTGGGGCCCACAGCTCTCCAGCACCCGGAATA

>39652_39652_2_ILVBL-TECR_ILVBL_chr19_15226962_ENST00000263383_TECR_chr19_14673336_ENST00000215567_length(amino acids)=522AA_BP=490
METPAAAAPAGSLFPSFLLLACGTLVAALLGAAHRLGLFYQLLHKVDKASVRHGGENVAAVLRAHGVRFIFTLVGGHISPLLVACEKLGI
RVVDTRHEVTAVFAADAMARLSGTVGVAAVTAGPGLTNTVTAVKNAQMAQSPILLLGGAASTLLQNRGALQAVDQLSLFRPLCKFCVSVR
RVRDIVPTLRAAMAAAQSGTPGPVFVELPVDVLYPYFMVQKEMVPAKPPKGLVGRVVSWYLENYLANLFAGAWEPQPEGPLPLDIPQASP
QQVQRCVEILSRAKRPLMVLGSQALLTPTSADKLRAAVETLGVPCFLGGMARGLLGRNHPLHIRENRSAALKKADVIVLAGTVCDFRLSY
GRVLSHSSKIIIVNRNREEMLLNSDIFWKPQEAVQGDVGSFVLKLVEGLQGQTWAPDWVEELREADRQKEQTFREKAAMPVAQHLNPVQV

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Fusion Gene PPI Analysis for ILVBL-TECR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ILVBL-TECR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ILVBL-TECR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource