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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IMMP2L-ATXN7L1 (FusionGDB2 ID:39662)

Fusion Gene Summary for IMMP2L-ATXN7L1

check button Fusion gene summary
Fusion gene informationFusion gene name: IMMP2L-ATXN7L1
Fusion gene ID: 39662
HgeneTgene
Gene symbol

IMMP2L

ATXN7L1

Gene ID

83943

222255

Gene nameinner mitochondrial membrane peptidase subunit 2ataxin 7 like 1
SynonymsIMMP2L-IT1|IMP2|IMP2-LIKEATXN7L4
Cytomap

7q31.1

7q22.3

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial inner membrane protease subunit 2IMP2 inner mitochondrial membrane peptidase-likeIMP2 inner mitochondrial membrane protease-likeinner mitochondrial membrane peptidase 2 likeataxin-7-like protein 1ataxin 7-like 4ataxin-7-like protein 4
Modification date2020031320200313
UniProtAcc.

Q9ULK2

Ensembl transtripts involved in fusion geneENST00000331762, ENST00000405709, 
ENST00000415362, ENST00000437687, 
ENST00000447215, ENST00000452895, 
ENST00000450877, ENST00000489381, 
ENST00000472910, ENST00000477775, 
ENST00000318724, ENST00000388807, 
ENST00000478915, ENST00000419735, 
Fusion gene scores* DoF score13 X 15 X 5=97512 X 8 X 5=480
# samples 1612
** MAII scorelog2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IMMP2L [Title/Abstract] AND ATXN7L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIMMP2L(111127294)-ATXN7L1(105305735), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IMMP2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATXN7L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6822-01AIMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-


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Fusion Gene ORF analysis for IMMP2L-ATXN7L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000331762ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000331762ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000405709ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000405709ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000415362ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000415362ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000437687ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000437687ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000447215ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000447215ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000452895ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-5UTRENST00000452895ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000331762ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000331762ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000331762ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000405709ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000405709ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000405709ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000415362ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000415362ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000415362ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000437687ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000437687ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000437687ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000447215ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000447215ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000447215ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000452895ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000452895ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
5CDS-intronENST00000452895ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
Frame-shiftENST00000331762ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
Frame-shiftENST00000405709ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
Frame-shiftENST00000415362ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
Frame-shiftENST00000437687ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
Frame-shiftENST00000447215ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
In-frameENST00000452895ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-3CDSENST00000450877ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-3CDSENST00000489381ENST00000419735IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-5UTRENST00000450877ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-5UTRENST00000450877ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-5UTRENST00000489381ENST00000472910IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-5UTRENST00000489381ENST00000477775IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000450877ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000450877ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000450877ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000489381ENST00000318724IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000489381ENST00000388807IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-
intron-intronENST00000489381ENST00000478915IMMP2Lchr7

111127294

-ATXN7L1chr7

105305735

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452895IMMP2Lchr7111127294-ENST00000419735ATXN7L1chr7105305735-53743583752588737

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452895ENST00000419735IMMP2Lchr7111127294-ATXN7L1chr7105305735-0.0028012280.9971988

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Fusion Genomic Features for IMMP2L-ATXN7L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IMMP2L-ATXN7L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:111127294/chr7:105305735)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATXN7L1

Q9ULK2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000331762-4719_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000405709-3619_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000415362-2519_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000437687-2419_3779111.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000447215-3519_3779111.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:105305735ENST00000452895-4719_3779176.0TransmembraneHelical
TgeneATXN7L1chr7:111127294chr7:105305735ENST0000031872404364_4170147.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST0000031872404536_8470147.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000419735212364_417118862.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000419735212536_847118862.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000477775010364_4170739.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000477775010536_8470739.0Compositional biasNote=Ser-rich
TgeneATXN7L1chr7:111127294chr7:105305735ENST0000031872404284_3510147.0DomainSCA7
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000419735212284_351118862.0DomainSCA7
TgeneATXN7L1chr7:111127294chr7:105305735ENST00000477775010284_3510739.0DomainSCA7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for IMMP2L-ATXN7L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39662_39662_1_IMMP2L-ATXN7L1_IMMP2L_chr7_111127294_ENST00000452895_ATXN7L1_chr7_105305735_ENST00000419735_length(transcript)=5374nt_BP=358nt
CCCCCGGGCTGAGCTGCGCAGCGGGTGCGGAGGGCGGGCGCCCGGGTTTTGGCCAAATTGGGCGAGGGCACAAAATAACCACTTACCCCT
TCTCACCGAGGAAGAGCGGGAGAAAGGGTATGGCACAGTCACAAGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAAGGCTTCTTTG
TGGCGGTGCCTGTGGCAGTGACTTTCTTGGATCGGGTCGCCTGTGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCTTTGAATCCTG
GGGGGAGCCAGTCATCTGATGTGGTGCTTTTGAACCACTGGAAAGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTATCATTGGTAG
AGAAGACACGGTTCAATGTGTAGACCTTCTCCCTCTCCAGTGTCTCCAGCCTCCAATCCCAGGACATCACTAGTACAGGTGAAAACAAAA
GCCTGTCTCAGCGGCCATCACTCTGCCAGCAGCACCTCAAAGCCATTCAAAACGCCCAAAGACAATCTACTTACCTCCAGCAGCAAACAG
CACACAGTCTTTCCTGCGAAAGGATCAAGGGATAAACCATGTGTTCCAGTTCCTGTAGTCAGTTTAGAGAAAATTCCTAACCTAGTGAAG
GCAGATGGTGCCAATGTCAAAATGAACTCCACAACCACTACTGCAGTTTCTGCCTCCTCCACCTCGTCCTCTGCCGTCTCCACCCCTCCT
TTAATTAAGCCTGTCCTGATGTCCAAGTCAGTGCCACCTTCACCAGAGAAGATCTTAAATGGCAAAGGAATTCTGCCAACCACCATAGAC
AAGAAACACCAAAATGGCACCAAAAACAGCAACAAGCCTTACAGGAGACTTTCAGAGAGAGAATTTGACCCAAATAAACACTGTGGAGTA
TTGGATCCCGAGACAAAGAAACCTTGCACAAGATCCCTCACCTGCAAGACACATTCGCTAAGCCATCGGAGGGCAGTCCCAGGCCGGAAA
AAGCAATTTGACCTCCTCCTGGCAGAACACAAAGCAAAGTCCCGGGAAAAAGAAGTTAAAGATAAAGAGCATCTCCTGACTTCCACGAGG
GAAATACTTCCAAGCCAATCCGGGCCGGCACAGGATTCTCTGCTAGGGTCTTCAGGGAGCTCTGGGCCAGAACCAAAAGTTGCATCCCCT
GCAAAATCCAGACCACCCAACTCTGTACTTCCTAGACCATCATCTGCAAATAGCATAAGCAGCAGCACATCTTCAAATCATAGCGGCCAC
ACTCCAGAGCCCCCACTCCCACCGGTTGGAGGTGACCTCGCCAGCCGACTGTCCAGTGATGAAGGGGAGATGGACGGAGCCGACGAATCC
GAGAAGCTAGACTGTCAGTTCTCCACGCACCACCCCAGACCTCTGGCGTTTTGCTCATTTGGGAGTCGCCTCATGGGACGAGGGTACTAT
GTGTTTGATAGAAGATGGGATCGTTTTCGATTCGCACTAAACTCCATGGTAGAAAAACACCTGAATTCACAGATGTGGAAGAAGATCCCT
CCTGCGGCAGATAGCCCCCTGCCCTCGCCAGCAGCCCACATCACCACCCCCGTTCCAGCATCCGTTTTGCAGCCTTTCAGCAACCCCAGT
GCTGTGTATCTTCCTTCAGCTCCCATCAGCTCGAGGCTCACCTCTTCTTACATAATGACATCAGCCATGCTCTCAAACGCAGCTTTCGTG
ACATCGCCGGACCCGAGCGCCCTCATGTCCCACACCACAGCTTTCCCTCATGTGGCCGCAACCCTCAGCATCATGGACTCAACCTTCAAG
GCCCCATCCGCCGTGTCCCCGATACCAGCCGTCATCCCTTCCCCATCCCACAAGCCATCCAAAACCAAAACCAGCAAATCCTCAAAAGTC
AAAGACCTGTCCACCCGTAGCGACGAGTCTCCAAGTAACAAAAAAAGGAAGCCACAGTCTTCGACTTCCTCCTCCTCCTCCTCCTCCTCC
TCTTCCTTGCAGACATCCCTCTCGTCTCCACTGTCAGGGCCTCACAAAAAGAACTGTGTTTTGAATGCCAGTTCTGCTTTGAACTCCTAT
CAGGCGGCCCCTCCCTATAACAGCCTGTCTGTGCACAACTCAAACAATGGGGTGAGCCCACTCAGTGCCAAACTGGAGCCCTCAGGACGG
ACCTCGCTGCCCGGCGGCCCCGCGGACATAGTGAGACAGGTGGGCGCGGTGGGAGGCAGCAGTGACTCCTGTCCCCTCTCTGTGCCCTCC
CTTGCGCTCCACGCAGGGGACCTCTCTCTGGCCTCACACAATGCTGTGTCTTCTCTGCCCCTCTCTTTTGACAAATCAGAAGGAAAAAAG
CGTAAGAACTCGAGTTCTAGTAGCAAAGCCTGTAAAATCACTAAAATGCCTGGTATGAATAGCGTTCACAAAAAGAACCCGCCCAGCCTT
CTCGCACCGGTGCCCGATCCCGTTAACAGCACCTCCTCTCGGCAGGTTGGGAAAAATAGCAGCCTAGCTTTGTCACAATCCAGTCCTTCA
AGTATATCCAGCCCAGGACACAGCCGACAGAACACAAACAGAACGGGCAGGATAAGGACTCTTCCATAACAAGACTATGAAGCCACTTCC
ACATCAATTCCAGGCCACCTAATCCCATCCGAGGAGGCCATGGGGAGGAGGAGGGAGGGGAGTGGGCTGGGGGGAGAGTCTGTTTTCTGT
GCACTCCCTGTGACTCTGGCCTTTCTTCTTCTTTTTTTAATTGACCAATTTTTAGTTAAAAAGGCAAAAGAAGGTGAATTTGAGATTTAC
AGAAAACAGTTCCAGTGTTTGGTTTCCGCTGTCTTTCCTTTCATTTGCCATGTTTTTACATTCTTCCAAATTTGGGGTCACTCCCCTAGC
TCCTGATGCTGCTACTGTACCATCCTTTTGCTCCAGCCATGAGAGCAGACATTGCAGAATGTTGGTTCCAGGTTGGCATGCTCTGAAGCT
CTTGAACTGTAGCACAGGCAGAGCCCTTTTTCTTCCTGTCATCTCCACCCGATTCCTTCCATCCCTACGTCTACCACTCTCTGGGTCCTC
ACTGGTCTTCAAAGGACCTGGCTCTCATAGGATCCCCTCAGGATTGTGTGCAGGGAGAGGGGGCTTTGCTGGGGAGGAGCTGGGAGTGGA
GAGTTGGAGGGTGGGTGGGGTTCCCTCATCCAGTTTCCACAGCCCACCATGGCTGGAGCCAAATGCTAGAAGCGAGATTGAGAACAGTGG
CCGTTTAGTGATGTGGTTTACCTAATACCACTGTCCAGCTGTGCAGCTCAGAAAGGATAAACCAGTCAGGGACAGGGGCCAGAACAGGTT
TGGGAAGGTGGCAGCAAGCAGAGCATGGTGGGTAGGAGATGATCCCTAAAAAAACTGGAGACTGTGGTGGTCTGAGCTGGTCAGGAATCT
GCAGAATCCCTTCCAGGAATCAGTGTGCCAGTGCCCACAGCAGGGTGAGCTAGGAGGGAGAAATCCCAGGAAAAAGGTCGTGAGAACCCA
GAAAGCCACTCCATGAGGAGGCACGGTGACCACAGCTGCTAAAGGTTCTTAGGCTGCCTTCCTGGGCTAGGAAGAGCCCCCCAGGGAGAG
CTTCCACAAAAGGGTATGTGTCAAACCTTTTGTCAGAATAAATAATAGCATTTCCCACCCACCCCCATGCCCTGGGCCACAGGGACTTGG
TGGGATCAGCACACCCATGGATCAGCTTTTGCTGTCTTAGAGACAGCCATCCCCATGAAGGAATGGTAAGGACAGCCACTGCTCAGTGAA
GAACAGCCATTTGGAAGAGCCACGCTGGAGCCCTGCAGCCATAGAACTATTCACACTGGAGTTTTAAAAGAAACAGCAATACCATAAGCT
CTAGTAGGGAATCATAATCAGGAAAGGAATTCACAACATAAAATAGGTGTTCTGTGCTATTAATCATGTAACTTTGTATATGATGTATAG
CAAAGATACTGGGAGGTTTTGTTTCATCCTTAAATCAGAAATGAATGCTAGTTTCATAGCTGGGCAGAACCCTCATCCCCACCCCAAAGT
TTTCCTTTTCTTTCCCGTTCCCCCAACCCAAAGATCAGACTACTGTTAAGTTTCACCACACAATTGGAATTGCAAAGACGGGAGGCAAAT
GGAGTGATTTTCATCAATGGAATTGCACTGACAGTGAGTGTTTCTTATAGGATTACTAAATTTTTTAATATAAAATGATTTGTTTAAAAA
TCAGGAGTTGATATTAAGTACCAGGACATTAGTTCGGATGATTTCATTTTTATTTCTACAGTGTTAAAAGTGCACTTATATGCTGGTTTA
TTTACGTCTTGGGAAAAGAGACTGCAAATTGAAGGGATGATTGTTACTTTTTCTTTTTTTAAAAAAAAAAGGTTAAGGAGATTTTAAGAC
TTATAAATGTTTAAGAAATTATAAACAAGGTTAGACCCTTTGAAAAAAAGTTTAGAAGATATTCTTAAAGTAAATTTTTATAGTGTTAAT
TTTGTAATAATTTATGTTTTACTATATTACAGAGCTAACTGACCAGAATAGTTTCAGAAACAATATGAAACTTAGGAAAGTTTAAGCAAT
GTTTATATTTTTAAAATGTTCTTTGAATTATGTTTTTATTGTACATTTCTTCAGACTGAAAAGTATGTACATATCTTTGTTATTTTTGCA
CAATTTTGTCTTGTTCGGTTTCAGAGGTCTGTTGTTTTTTATAATTTATTTTGAGTTGTAAAACTTGCAGGAGTAAAAACAAAAAACAAA
ATCTCCACAACAAAATAACCCTCTGATTTATAAACTCTTATAGTCAAAGAGGGAAAACAAAGGTTGAGAGATTAAGTGGCTGCTTCTGAG
AAATAATGTCTCAAGGACTAAAGGAGCAATTCAATAGGTTTAGACATTGTAGCTCTCTACATCTTGAATTGGAAGCTGGAATAAAGAGCC
CCCACCCCCCCCCCCACCCTCATCGAATGCTGCTTACTTTGTCAAAAGACTGGCTATGACCAAGGTGAGGATATTTCTGGAAAACTGGGC
AAAAAGGGAAAGCCCACAGTATTCTTCCTTGGCAGTCAACCACAGGTTTACTTTACAATGATGTATTAAAAACTTGCAGCTTGAAAAATG
GAATGCAAATAAAAGGTTCTCTTTGGGTTTGTCTTAATGGAGTTAAACTGGAGCAGCCTATAAAACATTTTTAGGGTGATGTCCTCTGGG
TCCTTCTGTTCTGCACACCCACTCAGTCTTCTCTCCCAGCCCCTTGACTGCACACACCCCTCTTTGCCTGAAGATCTCCTGACTTGTCGC

>39662_39662_1_IMMP2L-ATXN7L1_IMMP2L_chr7_111127294_ENST00000452895_ATXN7L1_chr7_105305735_ENST00000419735_length(amino acids)=737AA_BP=
MCRPSPSPVSPASNPRTSLVQVKTKACLSGHHSASSTSKPFKTPKDNLLTSSSKQHTVFPAKGSRDKPCVPVPVVSLEKIPNLVKADGAN
VKMNSTTTTAVSASSTSSSAVSTPPLIKPVLMSKSVPPSPEKILNGKGILPTTIDKKHQNGTKNSNKPYRRLSEREFDPNKHCGVLDPET
KKPCTRSLTCKTHSLSHRRAVPGRKKQFDLLLAEHKAKSREKEVKDKEHLLTSTREILPSQSGPAQDSLLGSSGSSGPEPKVASPAKSRP
PNSVLPRPSSANSISSSTSSNHSGHTPEPPLPPVGGDLASRLSSDEGEMDGADESEKLDCQFSTHHPRPLAFCSFGSRLMGRGYYVFDRR
WDRFRFALNSMVEKHLNSQMWKKIPPAADSPLPSPAAHITTPVPASVLQPFSNPSAVYLPSAPISSRLTSSYIMTSAMLSNAAFVTSPDP
SALMSHTTAFPHVAATLSIMDSTFKAPSAVSPIPAVIPSPSHKPSKTKTSKSSKVKDLSTRSDESPSNKKRKPQSSTSSSSSSSSSSLQT
SLSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSNNGVSPLSAKLEPSGRTSLPGGPADIVRQVGAVGGSSDSCPLSVPSLALHA
GDLSLASHNAVSSLPLSFDKSEGKKRKNSSSSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNSTSSRQVGKNSSLALSQSSPSSISSP

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Fusion Gene PPI Analysis for IMMP2L-ATXN7L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IMMP2L-ATXN7L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IMMP2L-ATXN7L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource