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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IMMP2L-DOCK4 (FusionGDB2 ID:39665)

Fusion Gene Summary for IMMP2L-DOCK4

check button Fusion gene summary
Fusion gene informationFusion gene name: IMMP2L-DOCK4
Fusion gene ID: 39665
HgeneTgene
Gene symbol

IMMP2L

DOCK4

Gene ID

83943

9732

Gene nameinner mitochondrial membrane peptidase subunit 2dedicator of cytokinesis 4
SynonymsIMMP2L-IT1|IMP2|IMP2-LIKE-
Cytomap

7q31.1

7q31.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial inner membrane protease subunit 2IMP2 inner mitochondrial membrane peptidase-likeIMP2 inner mitochondrial membrane protease-likeinner mitochondrial membrane peptidase 2 likededicator of cytokinesis protein 4
Modification date2020031320200327
UniProtAcc.

Q8N1I0

Ensembl transtripts involved in fusion geneENST00000331762, ENST00000405709, 
ENST00000415362, ENST00000437687, 
ENST00000447215, ENST00000452895, 
ENST00000450877, ENST00000489381, 
ENST00000437633, ENST00000476846, 
ENST00000494651, ENST00000428084, 
Fusion gene scores* DoF score13 X 15 X 5=9757 X 8 X 7=392
# samples 1610
** MAII scorelog2(16/975*10)=-2.60733031374961
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IMMP2L [Title/Abstract] AND DOCK4 [Title/Abstract] AND fusion [Title/Abstract]

A novel KCNQ4 mutation and a private IMMP2L-DOCK4 duplication segregating with nonsyndromic hearing loss in a Brazilian family (pmid: 27081546)
Most frequent breakpointDOCK4(111846157)-IMMP2L(110603621), # samples:4
IMMP2L(111161368)-DOCK4(111409733), # samples:2
IMMP2L(111201907)-DOCK4(111644186), # samples:2
Anticipated loss of major functional domain due to fusion event.DOCK4-IMMP2L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
IMMP2L-DOCK4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IMMP2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A938-01AIMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
ChimerDB4PRADTCGA-YJ-A8SW-01AIMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
ChimerDB4PRADTCGA-YJ-A8SWIMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
ChimerDB4STADTCGA-D7-A4YU-01AIMMP2Lchr7

111201907

-DOCK4chr7

111644186

-


Top

Fusion Gene ORF analysis for IMMP2L-DOCK4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000331762ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000331762ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000331762ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000331762ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000331762ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000405709ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000405709ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000405709ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000405709ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000405709ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000415362ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000415362ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000415362ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000415362ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000415362ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000437687ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000437687ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000437687ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000437687ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000437687ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000447215ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000447215ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000447215ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000447215ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000447215ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000452895ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000452895ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5CDS-intronENST00000452895ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
5CDS-intronENST00000452895ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
5CDS-intronENST00000452895ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
5UTR-3CDSENST00000331762ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-3CDSENST00000405709ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-3CDSENST00000447215ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-3CDSENST00000452895ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-5UTRENST00000331762ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-5UTRENST00000405709ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-5UTRENST00000447215ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-5UTRENST00000452895ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000331762ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000331762ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000405709ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000405709ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000447215ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000447215ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000452895ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
5UTR-intronENST00000452895ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
Frame-shiftENST00000331762ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000331762ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000331762ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000331762ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000331762ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000331762ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000405709ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000415362ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000437687ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000447215ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
Frame-shiftENST00000452895ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
Frame-shiftENST00000452895ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
In-frameENST00000331762ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
In-frameENST00000405709ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
In-frameENST00000415362ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
In-frameENST00000437687ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
In-frameENST00000447215ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-3CDSENST00000415362ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-3CDSENST00000437687ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-3CDSENST00000450877ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-3CDSENST00000450877ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000450877ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-3CDSENST00000450877ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-3CDSENST00000450877ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000450877ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-3CDSENST00000450877ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000450877ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000428084IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-3CDSENST00000489381ENST00000428084IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000428084IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000428084IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-3CDSENST00000489381ENST00000437633IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000437633IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000494651IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-3CDSENST00000489381ENST00000494651IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-5UTRENST00000415362ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-5UTRENST00000437687ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-5UTRENST00000450877ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-5UTRENST00000489381ENST00000476846IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000415362ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000415362ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000437687ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000437687ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000450877ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000450877ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000450877ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000450877ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-intronENST00000450877ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-intronENST00000450877ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000450877ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000489381ENST00000437633IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000489381ENST00000437633IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-
intron-intronENST00000489381ENST00000476846IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000489381ENST00000476846IMMP2Lchr7

111161369

-DOCK4chr7

111409733

-
intron-intronENST00000489381ENST00000476846IMMP2Lchr7

111161368

-DOCK4chr7

111409733

-
intron-intronENST00000489381ENST00000494651IMMP2Lchr7

111127294

-DOCK4chr7

111452005

-
intron-intronENST00000489381ENST00000494651IMMP2Lchr7

111201907

-DOCK4chr7

111644186

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405709IMMP2Lchr7111127294-ENST00000428084DOCK4chr7111452005-547668244336791078
ENST00000331762IMMP2Lchr7111127294-ENST00000428084DOCK4chr7111452005-516236812933651078
ENST00000415362IMMP2Lchr7111127294-ENST00000428084DOCK4chr7111452005-5033239032361078
ENST00000447215IMMP2Lchr7111127294-ENST00000428084DOCK4chr7111452005-51093157633121078
ENST00000437687IMMP2Lchr7111127294-ENST00000428084DOCK4chr7111452005-5033239032361078

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405709ENST00000428084IMMP2Lchr7111127294-DOCK4chr7111452005-9.19E-050.9999081
ENST00000331762ENST00000428084IMMP2Lchr7111127294-DOCK4chr7111452005-6.15E-050.9999385
ENST00000415362ENST00000428084IMMP2Lchr7111127294-DOCK4chr7111452005-5.53E-050.9999447
ENST00000447215ENST00000428084IMMP2Lchr7111127294-DOCK4chr7111452005-5.68E-050.99994326
ENST00000437687ENST00000428084IMMP2Lchr7111127294-DOCK4chr7111452005-5.53E-050.9999447

Top

Fusion Genomic Features for IMMP2L-DOCK4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IMMP2L-DOCK4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:111846157/chr7:110603621)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK4

Q8N1I0

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens junction between cells (PubMed:12628187). Plays a role in cell migration (PubMed:20679435). {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:16464467, ECO:0000269|PubMed:20679435}.; FUNCTION: [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms. {ECO:0000269|PubMed:16464467}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000331762-4719_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000405709-3619_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000415362-2519_3779176.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000437687-2419_3779111.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000447215-3519_3779111.0TransmembraneHelical
HgeneIMMP2Lchr7:111127294chr7:111452005ENST00000452895-4719_3779176.0TransmembraneHelical
TgeneDOCK4chr7:111127294chr7:111452005ENST0000042808426531642_18639761976.0Compositional biasNote=Ser-rich
TgeneDOCK4chr7:111127294chr7:111452005ENST0000042808426531875_19609761976.0Compositional biasNote=Pro-rich
TgeneDOCK4chr7:111127294chr7:111452005ENST0000043763326521642_18639761967.0Compositional biasNote=Ser-rich
TgeneDOCK4chr7:111127294chr7:111452005ENST0000043763326521875_19609761967.0Compositional biasNote=Pro-rich
TgeneDOCK4chr7:111127294chr7:111452005ENST0000042808426531190_15969761976.0DomainDOCKER
TgeneDOCK4chr7:111127294chr7:111452005ENST0000043763326521190_15969761967.0DomainDOCKER
TgeneDOCK4chr7:111127294chr7:111452005ENST0000042808426531788_17949761976.0MotifSH3-binding
TgeneDOCK4chr7:111127294chr7:111452005ENST0000043763326521788_17949761967.0MotifSH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDOCK4chr7:111127294chr7:111452005ENST000004280842653401_5749761976.0DomainC2 DOCK-type
TgeneDOCK4chr7:111127294chr7:111452005ENST0000042808426536_679761976.0DomainSH3
TgeneDOCK4chr7:111127294chr7:111452005ENST000004376332652401_5749761967.0DomainC2 DOCK-type
TgeneDOCK4chr7:111127294chr7:111452005ENST0000043763326526_679761967.0DomainSH3


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Fusion Gene Sequence for IMMP2L-DOCK4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39665_39665_1_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000331762_DOCK4_chr7_111452005_ENST00000428084_length(transcript)=5162nt_BP=368nt
CGGCGGAGGGCGGGGTCTGCGCGGGGACTTCCCCCGGGCTGAGCTGCGCAGCGGGGTTTTGGCCAAATTGGGCGAGGGCACAAAATAACC
ACTTACCCCTTCTCACCGAGGAAGAGCGGGAGAAAGGGTATGGCACAGTCACAAGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAA
GGCTTCTTTGTGGCGGTGCCTGTGGCAGTGACTTTCTTGGATCGGGTCGCCTGTGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCT
TTGAATCCTGGGGGGAGCCAGTCATCTGATGTGGTGCTTTTGAACCACTGGAAAGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTA
TCATTGGTTGTTATTATTACAACAGTTCTATACCTCTCAGATGCACTTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGG
GATTCCTACTTTTACCTCGCAGTCATTTTTATAAACCAGTTGTGTCTGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTA
GAAAAGTATGGTGACATGCGGGTAACAATGGGTTGTGAAATTTTCAGCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCT
GCCCTGATTGGCCCCTTCCTAGAAGTGACCTTGATACCCCAGCCAGATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGAC
TGGGAGCAGAGGCGGAGTGGCAACTTTAAACAGGTGGAAGCCAAGCTAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGAC
GAAACATACCGCGAGCTCTTCAACAGTATAATTCCACTATTTGGTCCCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGG
GAAAGTGGCGTTTCATTAATTGCTACTGTAACTCGTCTAATGGAGAGGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGAT
GGCAAAAAGATTGGCTGCACAGTTAGCCTTCTGAACTTCTATAAGACTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAA
CTCTATGATCTGCATCTCAAAGCACAGAACTTTACAGAAGCTGCATATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGG
CCCCTCAGGGAGTTCCTGACCTACCCCATGCAAACAGAATGGCAGCGCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGA
GGCAAATGTTGGGAGAATGGCATTATCTTGTGCCGGAAGATTGCAGAGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATG
CGGATGATGGAAGCCTCTTTGTATGACAAAATTATGGACCAGCAACGTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAA
TTTCCATTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGAGGGCATGACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAG
TTCCCCCATGCCATCGCCATGCAGCACGCCAACCAGCCCGATGAGACCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTG
ACTCCCATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAGGGTGTTCCGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAA
TTCCGCTATGACCGACCATTTCACAAAGGCACAAAAGATAAAGAGAATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTG
GTGCAGAGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTGGAAAAGCGTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTG
CTAGAAAATAAGAATCAGCAGCTGAAGACTCTGATTAGTCAGTGTCAGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTG
AATGGAGTTATAGATGCTGCAGTTAATGGTGGCGTTTCCAGGTATCAAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAA
GATGGGGAGAAAATTGCACGATTAAGAGAGCTGATGCTTGAGCAGGCACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTA
CCTCAAGATATGAGACCCCTTCACAAAAAGCTGGTTGACCAATTCTTTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGT
ATGCAAGCCAGTCCTGTCCATTTTCCTAATGGAAGCCCTCGTGTGTGTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGG
GTAATTCCTAGACGCAGCCCGTTAAGTTACCCAGCTGTCAACCGATATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGC
AATATTACAGGGCAATCAGAAAGCTCTGATGAAGTCTTTAACATGCAGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCT
TCACCTAATGTGACAAGTTCTGCTCCATCGAGTGCCAGAGCTTCTCCTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGC
CTGTCACCAAGAGAGAGACCATGCAGTGCCATCTATCCAACACCTGTGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGG
GCCTTGCCACGCAGTGACCCAAATCTCTCTGCACCTGAAAAAGCTGTGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAA
GCCAAGAACATGTCGGATAGTGGGAAACTTATCTCTCCCCCTGTCCCTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACA
TCAGTATCCCCCTCGCCTGCCGGGCGATCTCCATTGAAGGGCTCTGTGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGA
CTCATCTCCAACTCCCCTGTCTTGTCGGGCAGCTACAGCAGTGGGATTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTT
GAAAATCAGGTGAATGAACAGTCGGCCCCCCTGCCGGTGCCAGTGCCGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAG
GAGAGCAAGACTCCGCCCCCGTACAGCGTCTACGAGCGGACTCTGCGGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACG
TCGGAGCCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCGCGATCCAGCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGG
CCCAGGCCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTCACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAG
TATGATGAGAAGACATTTAGTGTAGGCACTTTAATAACTTACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATG
TTGCACAATATTAAAAGTTGCTGATCTAAAACGCCAGATGTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTG
GTAAATAGTGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAAC
GATACAATGTGTGACAATGTTGTATCGTTTTTACTGAATACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTG
GTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGTGCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTA
TACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTTGAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCT
GTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCCTTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGG
TGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAAGCAAGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATA
GTTTCCTATATAAAATTTGTCATTGAACAAGAGCAAATGCTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAG
GAATCAATACAGACAGTATTAAATTAATAGCTTAAGTGAAGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGG
ACTTATAAAAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTT
AGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTCTCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGG
ATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTAGTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTA
TAACACTCAATTGACAATAGATATGAACTGTATTTTAAATCATACTGTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTA
ACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACTTTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGT
TGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTTCAAGTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTA
AAAAAAAGTAAAAATAAACGCAAACAGTTGTTGATGCAGTATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTT
GTACATATGTGCTTTTAACAATTCTGCCATATTGACTTTACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGT
GAAAGTGTTCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTGTATCTTGCAAGTTTTGCAGTCAGAAATTTTTTGAACTAGCTTTT

>39665_39665_1_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000331762_DOCK4_chr7_111452005_ENST00000428084_length(amino acids)=1078AA_BP=80
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVVIITTVLYLS
DALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIP
QPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRL
MERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTE
WQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCR
GHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD
KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVS
RYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSP
RVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSAR
ASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
PVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPV

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>39665_39665_2_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000405709_DOCK4_chr7_111452005_ENST00000428084_length(transcript)=5476nt_BP=682nt
CGGCCGCGAGTCCTGCGTGATCGCGAGCATGTGTGCGTGCGCGTGTTTATCTGAGGCGCGTGCGGCGGCCACCCCAGCCTAGTCCTCTTC
TTGGTGCCACTGGCTAACTAGGTTGAGAAACCGGCGCCACAGGCGGCACACCTGGCCCGGAGCTGGCCCGCTCCTCCCCGCCGAGCCGGC
GCCCCAACAACGCGCCCTCTCCCAGTCCTCACAAAGGGGCCTAGTCCGGCCCCCGGCTCTGGCCGTGAGGGAGCGCTGTGGGGGCGCGCT
GCCTTCTGCCTGGAAGTGTTGGGCAGGTGGTGGGAGAGCGTCAGGCTTGAACAACATGATTTTAAAGCACGTGTCTGTCTGTCGTTTTTT
ACTTTTAGGGTTTTGGCCAAATTGGGCGAGGGCACAAAATAACCACTTACCCCTTCTCACCGAGGAAGAGCGGGAGAAAGGGTATGGCAC
AGTCACAAGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAAGGCTTCTTTGTGGCGGTGCCTGTGGCAGTGACTTTCTTGGATCGGG
TCGCCTGTGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCTTTGAATCCTGGGGGGAGCCAGTCATCTGATGTGGTGCTTTTGAACC
ACTGGAAAGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTATCATTGGTTGTTATTATTACAACAGTTCTATACCTCTCAGATGCAC
TTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCCTACTTTTACCTCGCAGTCATTTTTATAAACCAGTTGTGTC
TGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAGTATGGTGACATGCGGGTAACAATGGGTTGTGAAATTTTCA
GCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTGATTGGCCCCTTCCTAGAAGTGACCTTGATACCCCAGCCAG
ATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAGCAGAGGCGGAGTGGCAACTTTAAACAGGTGGAAGCCAAGC
TAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACATACCGCGAGCTCTTCAACAGTATAATTCCACTATTTGGTC
CCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGTGGCGTTTCATTAATTGCTACTGTAACTCGTCTAATGGAGA
GGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAAAAGATTGGCTGCACAGTTAGCCTTCTGAACTTCTATAAGA
CTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTATGATCTGCATCTCAAAGCACAGAACTTTACAGAAGCTGCAT
ATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTCAGGGAGTTCCTGACCTACCCCATGCAAACAGAATGGCAGC
GCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAATGTTGGGAGAATGGCATTATCTTGTGCCGGAAGATTGCAG
AGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATGATGGAAGCCTCTTTGTATGACAAAATTATGGACCAGCAAC
GTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCATTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGAGGGCATG
ACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCCCATGCCATCGCCATGCAGCACGCCAACCAGCCCGATGAGA
CCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCCATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAGGGTGTTC
CGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGCTATGACCGACCATTTCACAAAGGCACAAAAGATAAAGAGA
ATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAGAGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTGGAAAAGC
GTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAAAATAAGAATCAGCAGCTGAAGACTCTGATTAGTCAGTGTC
AGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGAGTTATAGATGCTGCAGTTAATGGTGGCGTTTCCAGGTATC
AAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGGGAGAAAATTGCACGATTAAGAGAGCTGATGCTTGAGCAGG
CACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAAGATATGAGACCCCTTCACAAAAAGCTGGTTGACCAATTCT
TTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAAGCCAGTCCTGTCCATTTTCCTAATGGAAGCCCTCGTGTGT
GTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATTCCTAGACGCAGCCCGTTAAGTTACCCAGCTGTCAACCGAT
ATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATTACAGGGCAATCAGAAAGCTCTGATGAAGTCTTTAACATGC
AGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCTAATGTGACAAGTTCTGCTCCATCGAGTGCCAGAGCTTCTC
CTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCACCAAGAGAGAGACCATGCAGTGCCATCTATCCAACACCTG
TGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTGCCACGCAGTGACCCAAATCTCTCTGCACCTGAAAAAGCTG
TGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAGAACATGTCGGATAGTGGGAAACTTATCTCTCCCCCTGTCC
CTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTATCCCCCTCGCCTGCCGGGCGATCTCCATTGAAGGGCTCTG
TGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATCTCCAACTCCCCTGTCTTGTCGGGCAGCTACAGCAGTGGGA
TTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAATCAGGTGAATGAACAGTCGGCCCCCCTGCCGGTGCCAGTGC
CGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGCAAGACTCCGCCCCCGTACAGCGTCTACGAGCGGACTCTGC
GGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAGCCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCGCGATCCA
GCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGGCCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTCACTTTTC
TATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGAGAAGACATTTAGTGTAGGCACTTTAATAACTTACTCAG
CTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAATATTAAAAGTTGCTGATCTAAAACGCCAGATGTTAAAT
GAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAATAGTGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTT
TTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACAATGTGTGACAATGTTGTATCGTTTTTACTGAATACTTGAT
ACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGT
GCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTT
GAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCC
TTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAAGCAAGAGGCT
CCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTATATAAAATTTGTCATTGAACAAGAGCAAATGCTGAAGT
ATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAATACAGACAGTATTAAATTAATAGCTTAAGTGAAGAAAAA
AAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTATAAAAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAA
AAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTC
TCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTA
GTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACACTCAATTGACAATAGATATGAACTGTATTTTAAATCATACT
GTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACT
TTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTTCAAGTATTTT
TGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAGTAAAAATAAACGCAAACAGTTGTTGATGCAGTATGATT
GTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATATGTGCTTTTAACAATTCTGCCATATTGACTTTACAATTT
TGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGTGTTCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTG

>39665_39665_2_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000405709_DOCK4_chr7_111452005_ENST00000428084_length(amino acids)=1078AA_BP=80
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVVIITTVLYLS
DALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIP
QPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRL
MERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTE
WQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCR
GHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD
KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVS
RYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSP
RVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSAR
ASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
PVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPV

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>39665_39665_3_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000415362_DOCK4_chr7_111452005_ENST00000428084_length(transcript)=5033nt_BP=239nt
ATGGCACAGTCACAAGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAAGGCTTCTTTGTGGCGGTGCCTGTGGCAGTGACTTTCTTG
GATCGGGTCGCCTGTGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCTTTGAATCCTGGGGGGAGCCAGTCATCTGATGTGGTGCTT
TTGAACCACTGGAAAGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTATCATTGGTTGTTATTATTACAACAGTTCTATACCTCTCA
GATGCACTTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCCTACTTTTACCTCGCAGTCATTTTTATAAACCAG
TTGTGTCTGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAGTATGGTGACATGCGGGTAACAATGGGTTGTGAA
ATTTTCAGCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTGATTGGCCCCTTCCTAGAAGTGACCTTGATACCC
CAGCCAGATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAGCAGAGGCGGAGTGGCAACTTTAAACAGGTGGAA
GCCAAGCTAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACATACCGCGAGCTCTTCAACAGTATAATTCCACTA
TTTGGTCCCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGTGGCGTTTCATTAATTGCTACTGTAACTCGTCTA
ATGGAGAGGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAAAAGATTGGCTGCACAGTTAGCCTTCTGAACTTC
TATAAGACTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTATGATCTGCATCTCAAAGCACAGAACTTTACAGAA
GCTGCATATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTCAGGGAGTTCCTGACCTACCCCATGCAAACAGAA
TGGCAGCGCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAATGTTGGGAGAATGGCATTATCTTGTGCCGGAAG
ATTGCAGAGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATGATGGAAGCCTCTTTGTATGACAAAATTATGGAC
CAGCAACGTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCATTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGA
GGGCATGACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCCCATGCCATCGCCATGCAGCACGCCAACCAGCCC
GATGAGACCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCCATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAG
GGTGTTCCGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGCTATGACCGACCATTTCACAAAGGCACAAAAGAT
AAAGAGAATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAGAGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTG
GAAAAGCGTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAAAATAAGAATCAGCAGCTGAAGACTCTGATTAGT
CAGTGTCAGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGAGTTATAGATGCTGCAGTTAATGGTGGCGTTTCC
AGGTATCAAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGGGAGAAAATTGCACGATTAAGAGAGCTGATGCTT
GAGCAGGCACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAAGATATGAGACCCCTTCACAAAAAGCTGGTTGAC
CAATTCTTTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAAGCCAGTCCTGTCCATTTTCCTAATGGAAGCCCT
CGTGTGTGTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATTCCTAGACGCAGCCCGTTAAGTTACCCAGCTGTC
AACCGATATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATTACAGGGCAATCAGAAAGCTCTGATGAAGTCTTT
AACATGCAGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCTAATGTGACAAGTTCTGCTCCATCGAGTGCCAGA
GCTTCTCCTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCACCAAGAGAGAGACCATGCAGTGCCATCTATCCA
ACACCTGTGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTGCCACGCAGTGACCCAAATCTCTCTGCACCTGAA
AAAGCTGTGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAGAACATGTCGGATAGTGGGAAACTTATCTCTCCC
CCTGTCCCTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTATCCCCCTCGCCTGCCGGGCGATCTCCATTGAAG
GGCTCTGTGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATCTCCAACTCCCCTGTCTTGTCGGGCAGCTACAGC
AGTGGGATTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAATCAGGTGAATGAACAGTCGGCCCCCCTGCCGGTG
CCAGTGCCGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGCAAGACTCCGCCCCCGTACAGCGTCTACGAGCGG
ACTCTGCGGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAGCCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCG
CGATCCAGCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGGCCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTC
ACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGAGAAGACATTTAGTGTAGGCACTTTAATAACT
TACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAATATTAAAAGTTGCTGATCTAAAACGCCAGAT
GTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAATAGTGATAAAGACTCCTTTTGTACCTTTTTATGT
TCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACAATGTGTGACAATGTTGTATCGTTTTTACTGAAT
ACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTT
TATCAGTGCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTT
TGTTCTTGAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCT
AAATCCCTTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAAGCA
AGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTATATAAAATTTGTCATTGAACAAGAGCAAATG
CTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAATACAGACAGTATTAAATTAATAGCTTAAGTGA
AGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTATAAAAGGCAAGGGCATTAACTTTCAGTCCTGCAC
AAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGT
AGACTTCTCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTT
GTATGTAGTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACACTCAATTGACAATAGATATGAACTGTATTTTAAA
TCATACTGTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGT
GACCACTTTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTTCAA
GTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAGTAAAAATAAACGCAAACAGTTGTTGATGCAG
TATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATATGTGCTTTTAACAATTCTGCCATATTGACTTT
ACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGTGTTCATAATTGAGAAAAGGAACATATGCATTTT

>39665_39665_3_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000415362_DOCK4_chr7_111452005_ENST00000428084_length(amino acids)=1078AA_BP=80
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVVIITTVLYLS
DALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIP
QPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRL
MERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTE
WQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCR
GHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD
KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVS
RYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSP
RVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSAR
ASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
PVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPV

--------------------------------------------------------------
>39665_39665_4_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000437687_DOCK4_chr7_111452005_ENST00000428084_length(transcript)=5033nt_BP=239nt
ATGGCACAGTCACAAGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAAGGCTTCTTTGTGGCGGTGCCTGTGGCAGTGACTTTCTTG
GATCGGGTCGCCTGTGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCTTTGAATCCTGGGGGGAGCCAGTCATCTGATGTGGTGCTT
TTGAACCACTGGAAAGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTATCATTGGTTGTTATTATTACAACAGTTCTATACCTCTCA
GATGCACTTCGTAAGAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCCTACTTTTACCTCGCAGTCATTTTTATAAACCAG
TTGTGTCTGCAGTTGGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAGTATGGTGACATGCGGGTAACAATGGGTTGTGAA
ATTTTCAGCATGTGGCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTGATTGGCCCCTTCCTAGAAGTGACCTTGATACCC
CAGCCAGATCTTCGGAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAGCAGAGGCGGAGTGGCAACTTTAAACAGGTGGAA
GCCAAGCTAATTGACAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACATACCGCGAGCTCTTCAACAGTATAATTCCACTA
TTTGGTCCCTATCCTAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGTGGCGTTTCATTAATTGCTACTGTAACTCGTCTA
ATGGAGAGGTTGTTAGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAAAAGATTGGCTGCACAGTTAGCCTTCTGAACTTC
TATAAGACTGAACTGAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTATGATCTGCATCTCAAAGCACAGAACTTTACAGAA
GCTGCATATACCCTCCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTCAGGGAGTTCCTGACCTACCCCATGCAAACAGAA
TGGCAGCGCAAAGAGCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAATGTTGGGAGAATGGCATTATCTTGTGCCGGAAG
ATTGCAGAGCAGTATGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATGATGGAAGCCTCTTTGTATGACAAAATTATGGAC
CAGCAACGTCTTGAACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCATTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGA
GGGCATGACTACGAGAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCCCATGCCATCGCCATGCAGCACGCCAACCAGCCC
GATGAGACCATCTTCCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCCATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAG
GGTGTTCCGGACAACATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGCTATGACCGACCATTTCACAAAGGCACAAAAGAT
AAAGAGAATGAATTCAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAGAGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTG
GAAAAGCGTGAAGTGGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAAAATAAGAATCAGCAGCTGAAGACTCTGATTAGT
CAGTGTCAGACAAGACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGAGTTATAGATGCTGCAGTTAATGGTGGCGTTTCC
AGGTATCAAGAGGCATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGGGAGAAAATTGCACGATTAAGAGAGCTGATGCTT
GAGCAGGCACAGATTCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAAGATATGAGACCCCTTCACAAAAAGCTGGTTGAC
CAATTCTTTGTGATGAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAAGCCAGTCCTGTCCATTTTCCTAATGGAAGCCCT
CGTGTGTGTAGAAACTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATTCCTAGACGCAGCCCGTTAAGTTACCCAGCTGTC
AACCGATATTCTTCCTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATTACAGGGCAATCAGAAAGCTCTGATGAAGTCTTT
AACATGCAGCCAAGTCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCTAATGTGACAAGTTCTGCTCCATCGAGTGCCAGA
GCTTCTCCTTTGTTGTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCACCAAGAGAGAGACCATGCAGTGCCATCTATCCA
ACACCTGTGGAGCCTTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTGCCACGCAGTGACCCAAATCTCTCTGCACCTGAA
AAAGCTGTGAACCCCACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAGAACATGTCGGATAGTGGGAAACTTATCTCTCCC
CCTGTCCCTCCAAGACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTATCCCCCTCGCCTGCCGGGCGATCTCCATTGAAG
GGCTCTGTGCAGTCTTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATCTCCAACTCCCCTGTCTTGTCGGGCAGCTACAGC
AGTGGGATTTCTTCTCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAATCAGGTGAATGAACAGTCGGCCCCCCTGCCGGTG
CCAGTGCCGGTGCCCGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGCAAGACTCCGCCCCCGTACAGCGTCTACGAGCGG
ACTCTGCGGCGCCCCGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAGCCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCG
CGATCCAGCCACCTGGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGGCCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTC
ACTTTTCTATGTACCTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGAGAAGACATTTAGTGTAGGCACTTTAATAACT
TACTCAGCTCCTTCGATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAATATTAAAAGTTGCTGATCTAAAACGCCAGAT
GTTAAATGAAGTATGGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAATAGTGATAAAGACTCCTTTTGTACCTTTTTATGT
TCACTTTTTTTTATATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACAATGTGTGACAATGTTGTATCGTTTTTACTGAAT
ACTTGATACTTGGAGAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTT
TATCAGTGCAGATCATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTT
TGTTCTTGAAACAAAATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCT
AAATCCCTTACTACCCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAAGCA
AGAGGCTCCAGAAGAAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTATATAAAATTTGTCATTGAACAAGAGCAAATG
CTGAAGTATTAATGAGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAATACAGACAGTATTAAATTAATAGCTTAAGTGA
AGAAAAAAAAAACTTAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTATAAAAGGCAAGGGCATTAACTTTCAGTCCTGCAC
AAAATAAAAAATTCCTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGT
AGACTTCTCTAGCTTGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTT
GTATGTAGTAATGTATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACACTCAATTGACAATAGATATGAACTGTATTTTAAA
TCATACTGTTAAATATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGT
GACCACTTTTTTATATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTTCAA
GTATTTTTGTATATAACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAGTAAAAATAAACGCAAACAGTTGTTGATGCAG
TATGATTGTTATAATTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATATGTGCTTTTAACAATTCTGCCATATTGACTTT
ACAATTTTGAATGTCGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGTGTTCATAATTGAGAAAAGGAACATATGCATTTT

>39665_39665_4_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000437687_DOCK4_chr7_111452005_ENST00000428084_length(amino acids)=1078AA_BP=80
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVVIITTVLYLS
DALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIP
QPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRL
MERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTE
WQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCR
GHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD
KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVS
RYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSP
RVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSAR
ASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
PVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPV

--------------------------------------------------------------
>39665_39665_5_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000447215_DOCK4_chr7_111452005_ENST00000428084_length(transcript)=5109nt_BP=315nt
GGGTTTTGGCCAAATTGGGCGAGGGCACAAAATAACCACTTACCCCTTCTCACCGAGGAAGAGCGGGAGAAAGGGTATGGCACAGTCACA
AGGGTGGGTGAAAAGATACATCAAGGCCTTTTGTAAAGGCTTCTTTGTGGCGGTGCCTGTGGCAGTGACTTTCTTGGATCGGGTCGCCTG
TGTGGCAAGAGTAGAAGGAGCATCGATGCAGCCTTCTTTGAATCCTGGGGGGAGCCAGTCATCTGATGTGGTGCTTTTGAACCACTGGAA
AGTGAGGAATTTTGAAGTACACCGTGGTGACATTGTATCATTGGTTGTTATTATTACAACAGTTCTATACCTCTCAGATGCACTTCGTAA
GAACTTCTTAAATGAAAACTTTGATTATAAGATCTGGGATTCCTACTTTTACCTCGCAGTCATTTTTATAAACCAGTTGTGTCTGCAGTT
GGAGATGTTCACACCTTCCAAGAAGAAAAAGGTGTTAGAAAAGTATGGTGACATGCGGGTAACAATGGGTTGTGAAATTTTCAGCATGTG
GCAAAACCTAGGAGAGCACAAGCTTCATTTTATCCCTGCCCTGATTGGCCCCTTCCTAGAAGTGACCTTGATACCCCAGCCAGATCTTCG
GAATGTCATGATTCCAATTTTTCATGATATGATGGACTGGGAGCAGAGGCGGAGTGGCAACTTTAAACAGGTGGAAGCCAAGCTAATTGA
CAAACTGGATAGCCTGATGTCAGAAGGCAAAGGTGACGAAACATACCGCGAGCTCTTCAACAGTATAATTCCACTATTTGGTCCCTATCC
TAGTCTACTAAAGAAAATTGAGCGGGAAACATGGCGGGAAAGTGGCGTTTCATTAATTGCTACTGTAACTCGTCTAATGGAGAGGTTGTT
AGATTACAGGGACTGCATGAAAATGGGAGAGGTAGATGGCAAAAAGATTGGCTGCACAGTTAGCCTTCTGAACTTCTATAAGACTGAACT
GAACAAGGAGGAGATGTATATACGCTACATTCACAAACTCTATGATCTGCATCTCAAAGCACAGAACTTTACAGAAGCTGCATATACCCT
CCTCTTATATGACGAGCTACTGGAATGGTCTGATCGGCCCCTCAGGGAGTTCCTGACCTACCCCATGCAAACAGAATGGCAGCGCAAAGA
GCACCTGCACCTCACCATCATCCAGAACTTTGACAGAGGCAAATGTTGGGAGAATGGCATTATCTTGTGCCGGAAGATTGCAGAGCAGTA
TGAGAGTTATTATGACTACAGAAACCTGAGCAAGATGCGGATGATGGAAGCCTCTTTGTATGACAAAATTATGGACCAGCAACGTCTTGA
ACCAGAGTTCTTCAGAGTTGGATTTTATGGAAAAAAATTTCCATTTTTCTTAAGAAATAAGGAGTTTGTGTGTCGAGGGCATGACTACGA
GAGGCTGGAAGCCTTCCAACAGAGAATGCTGAACGAGTTCCCCCATGCCATCGCCATGCAGCACGCCAACCAGCCCGATGAGACCATCTT
CCAGGCAGAAGCTCAGTATTTGCAGATATATGCTGTGACTCCCATTCCAGAGAGCCAGGAGGTCCTGCAGAGAGAGGGTGTTCCGGACAA
CATCAAAAGCTTCTATAAAGTGAATCACATCTGGAAATTCCGCTATGACCGACCATTTCACAAAGGCACAAAAGATAAAGAGAATGAATT
CAAGAGTCTCTGGGTGGAGAGAACGTCATTATACTTGGTGCAGAGTTTGCCTGGCATCTCTCGCTGGTTTGAAGTGGAAAAGCGTGAAGT
GGTAGAAATGAGTCCTCTGGAAAATGCAATTGAAGTGCTAGAAAATAAGAATCAGCAGCTGAAGACTCTGATTAGTCAGTGTCAGACAAG
ACAGATGCAGAATATTAATCCCCTGACTATGTGCCTGAATGGAGTTATAGATGCTGCAGTTAATGGTGGCGTTTCCAGGTATCAAGAGGC
ATTCTTTGTCAAAGAATATATCTTAAGTCACCCTGAAGATGGGGAGAAAATTGCACGATTAAGAGAGCTGATGCTTGAGCAGGCACAGAT
TCTGGAATTTGGTTTGGCCGTGCATGAGAAGTTTGTACCTCAAGATATGAGACCCCTTCACAAAAAGCTGGTTGACCAATTCTTTGTGAT
GAAGTCGAGCTTAGGGATACAGGAGTTCTCTGCTTGTATGCAAGCCAGTCCTGTCCATTTTCCTAATGGAAGCCCTCGTGTGTGTAGAAA
CTCAGCACCTGCTTCTGTGAGCCCAGATGGTACCAGGGTAATTCCTAGACGCAGCCCGTTAAGTTACCCAGCTGTCAACCGATATTCTTC
CTCCTCACTGTCCTCACAAGCTTCTGCTGAAGTAAGCAATATTACAGGGCAATCAGAAAGCTCTGATGAAGTCTTTAACATGCAGCCAAG
TCCATCTACCTCAAGCTTGAGTTCTACTCACTCGGCTTCACCTAATGTGACAAGTTCTGCTCCATCGAGTGCCAGAGCTTCTCCTTTGTT
GTCTGACAAACACAAACATTCCCGAGAAAACTCTTGCCTGTCACCAAGAGAGAGACCATGCAGTGCCATCTATCCAACACCTGTGGAGCC
TTCGCAGAGGATGCTGTTTAATCATATTGGAGACGGGGCCTTGCCACGCAGTGACCCAAATCTCTCTGCACCTGAAAAAGCTGTGAACCC
CACCCCTAGCAGCTGGAGCCTGGACAGTGGGAAGGAAGCCAAGAACATGTCGGATAGTGGGAAACTTATCTCTCCCCCTGTCCCTCCAAG
ACCCACACAGACTGCTTCACCAGCAAGACACACGACATCAGTATCCCCCTCGCCTGCCGGGCGATCTCCATTGAAGGGCTCTGTGCAGTC
TTTCACCCCCTCTCCAGTGGAGTACCACTCGCCAGGACTCATCTCCAACTCCCCTGTCTTGTCGGGCAGCTACAGCAGTGGGATTTCTTC
TCTCAGCCGGTGCAGCACGTCGGAAACCTCAGGCTTTGAAAATCAGGTGAATGAACAGTCGGCCCCCCTGCCGGTGCCAGTGCCGGTGCC
CGTGCCGAGCTACGGCGGGGAGGAGCCAGTGCGCAAGGAGAGCAAGACTCCGCCCCCGTACAGCGTCTACGAGCGGACTCTGCGGCGCCC
CGTCCCGCTACCTCACAGCCTCTCCATCCCCGTCACGTCGGAGCCGCCCGCGCTGCCCCCCAAGCCTCTGGCAGCGCGATCCAGCCACCT
GGAGAATGGGGCCCGGAGGACTGACCCCGGCCCGCGGCCCAGGCCCCTGCCCCGCAAGGTCTCTCAGTTATAAGTCACTTTTCTATGTAC
CTGCGATGCATTCTTTGCCCGTTTACAAAATAAGAAGTATGATGAGAAGACATTTAGTGTAGGCACTTTAATAACTTACTCAGCTCCTTC
GATGAATGGAATTAAAACTTGCTTATTAAATATCATGTTGCACAATATTAAAAGTTGCTGATCTAAAACGCCAGATGTTAAATGAAGTAT
GGCTGAATTTCATTAAAACGTTTCTCATTTGGAAGTGGTAAATAGTGATAAAGACTCCTTTTGTACCTTTTTATGTTCACTTTTTTTTAT
ATAGTTTAATCTTAAAACCAATACGATATTGTCAAACGATACAATGTGTGACAATGTTGTATCGTTTTTACTGAATACTTGATACTTGGA
GAAAGCTTATTAAGTCAGTGCACATCCTAACACAGTGGTCCTTATTTTAGAAGACTTCTGTAAATAAGGCAAGGTTTATCAGTGCAGATC
ATCAGAATTAAAGTTCAAGCAGGCGAGCAAGACAGTATACTTAAGGGGTTGCAAAGCTTGGGACTGGAAATTGTTTTGTTCTTGAAACAA
AATACTTCTTTAAGGTTGCTTTTGCTGTTTGACTGCTGTCTACATTCGTAAAATTCTATTTTGTGAATTGGTAGCTAAATCCCTTACTAC
CCTGACACCGTGGTATCTACTGTATTTCTTTTCAAGGTGCAATTTGCTTCAGAGTTCCAATCAGCTAGATTAAGCAAGAGGCTCCAGAAG
AAATGTTTACTTGAATTTTGCGCTTCCTTTCTTGATAGTTTCCTATATAAAATTTGTCATTGAACAAGAGCAAATGCTGAAGTATTAATG
AGGCACAAATGACTGTGCCCCATTAGCAAGAATTCAGGAATCAATACAGACAGTATTAAATTAATAGCTTAAGTGAAGAAAAAAAAAACT
TAGTGAAAATGTATTAGCACGATTAAATGGCAAAAGGACTTATAAAAGGCAAGGGCATTAACTTTCAGTCCTGCACAAAATAAAAAATTC
CTCACGACTCTCCACTTTTACCAGTGGAGTTTGTCTTAGCTGACCTGTCGTCTTTCTCTTGAAGGAGGATTGCTGTAGACTTCTCTAGCT
TGAATATTGCAACATAGCATCTTAGGTCTAGATAGGGATGCTAATGCCAGTTGTAGAAGTGTGAAAAAAGCACCTTGTATGTAGTAATGT
ATTTTATATCTTTGTTTTTTCTTTTACTGACTGTTTATAACACTCAATTGACAATAGATATGAACTGTATTTTAAATCATACTGTTAAAT
ATTTTCCCTCTTTTGTTGGGAAGCTCATTTTAGTTTAACCATGTTTGTTTTGTTGGTAGCTTACCTGGAAGGCAGTGACCACTTTTTTAT
ATTCTCTTAATGAAACCATTCAGCAGGTATATGCTGTTGAGGCTGGTTATAGAGGTTTTCTATAATAAATGTTCAAGTATTTTTGTATAT
AACTGGTTAATTTTAATAAGAGATACCATTATGTGTAAAAAAAAGTAAAAATAAACGCAAACAGTTGTTGATGCAGTATGATTGTTATAA
TTATGCCAAATACTTTACGTATGGAAAAAGAATATTTGTACATATGTGCTTTTAACAATTCTGCCATATTGACTTTACAATTTTGAATGT
CGGAAAAATTAATATATGTTAAATATTTATGTTTAGTGAAAGTGTTCATAATTGAGAAAAGGAACATATGCATTTTAGCTTTGTATCTTG

>39665_39665_5_IMMP2L-DOCK4_IMMP2L_chr7_111127294_ENST00000447215_DOCK4_chr7_111452005_ENST00000428084_length(amino acids)=1078AA_BP=80
MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVVIITTVLYLS
DALRKNFLNENFDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIP
QPDLRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATVTRL
MERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTE
WQRKEHLHLTIIQNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEFVCR
GHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKD
KENEFKSLWVERTSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNGGVS
RYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSP
RVCRNSAPASVSPDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPSSAR
ASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
PVPPRPTQTASPARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAPLPV

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Fusion Gene PPI Analysis for IMMP2L-DOCK4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IMMP2L-DOCK4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IMMP2L-DOCK4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource