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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:IMPAD1-TCF12 (FusionGDB2 ID:39694)

Fusion Gene Summary for IMPAD1-TCF12

Fusion gene summary

Fusion gene information	Fusion gene name: IMPAD1-TCF12
	Fusion gene ID: 39694
		Hgene	Tgene
	Gene symbol	IMPAD1	TCF12
	Gene ID	54928	6938
	Gene name	3'(2'), 5'-bisphosphate nucleotidase 2	transcription factor 12
	Synonyms	GPAPP\|IMP 3\|IMP-3\|IMPA3\|IMPAD1	CRS3\|HEB\|HTF4\|HsT17266\|TCF-12\|bHLHb20\|p64
	Cytomap	8q12.1	15q21.3
	Type of gene	protein-coding	protein-coding
	Description	Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphataseGolgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphataseIMPase 3golgi-resident PAP phosphatasegolgi-resident nucleotide phosphataseinositol monophosphatase domain containing 1inos	transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262644,	ENST00000333725, ENST00000343827, ENST00000452095, ENST00000537840, ENST00000543579, ENST00000557843, ENST00000559703, ENST00000559710, ENST00000560764, ENST00000267811, ENST00000438423,
Fusion gene scores	* DoF score	4 X 4 X 4=64	21 X 22 X 8=3696
	# samples	4	26
	** MAII score	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/3696*10)=-3.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: IMPAD1 [Title/Abstract] AND TCF12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	IMPAD1(57890608)-TCF12(57355947), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TCF12	GO:0045944	positive regulation of transcription by RNA polymerase II	11802795

Fusion gene breakpoints across IMPAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TCF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A43J	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+

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Fusion Gene ORF analysis for IMPAD1-TCF12

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262644	ENST00000333725	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000343827	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000452095	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000537840	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000543579	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000557843	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000559703	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000559710	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
5CDS-intron	ENST00000262644	ENST00000560764	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
In-frame	ENST00000262644	ENST00000267811	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+
In-frame	ENST00000262644	ENST00000438423	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000262644

IMPAD1

chr8

57890608

ENST00000438423

TCF12

chr15

57355947

5247

905

187

2877

896

ENST00000262644

IMPAD1

chr8

57890608

ENST00000267811

TCF12

chr15

57355947

6514

905

187

2805

872

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262644	ENST00000438423	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+	0.000691723	0.9993082
ENST00000262644	ENST00000267811	IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+	0.000463761	0.9995363

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Fusion Genomic Features for IMPAD1-TCF12

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+	3.32E-07	0.99999964
IMPAD1	chr8	57890608	-	TCF12	chr15	57355947	+	3.32E-07	0.99999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for IMPAD1-TCF12

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:57890608/chr15:57355947)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IMPAD1

chr8:57890608

chr15:57355947

ENST00000262644

53_56

215

360.0

Compositional bias

Note=Poly-Ala

Hgene

IMPAD1

chr8:57890608

chr15:57355947

ENST00000262644

1_12

215

360.0

Topological domain

Cytoplasmic

Hgene

IMPAD1

chr8:57890608

chr15:57355947

ENST00000262644

13_33

215

360.0

Transmembrane

Helical

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000267811

577_630

1821.3333333333333

Domain

bHLH

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000333725

577_630

1420.0

Domain

bHLH

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000343827

577_630

1254.6666666666667

Domain

bHLH

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000438423

577_630

1398.3333333333333

Domain

bHLH

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000557843

577_630

1301.0

Domain

bHLH

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000343827

19_27

1254.6666666666667

Motif

Note=9aaTAD

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000267811

119_140

1821.3333333333333

Region

Note=Leucine-zipper

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000267811

632_655

1821.3333333333333

Region

Note=Class A specific domain

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000333725

119_140

1420.0

Region

Note=Leucine-zipper

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000333725

632_655

1420.0

Region

Note=Class A specific domain

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000343827

119_140

1254.6666666666667

Region

Note=Leucine-zipper

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000343827

632_655

1254.6666666666667

Region

Note=Class A specific domain

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000438423

119_140

1398.3333333333333

Region

Note=Leucine-zipper

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000438423

632_655

1398.3333333333333

Region

Note=Class A specific domain

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000557843

119_140

1301.0

Region

Note=Leucine-zipper

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000557843

632_655

1301.0

Region

Note=Class A specific domain

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

IMPAD1

chr8:57890608

chr15:57355947

ENST00000262644

34_359

215

360.0

Topological domain

Lumenal

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000267811

19_27

1821.3333333333333

Motif

Note=9aaTAD

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000333725

19_27

1420.0

Motif

Note=9aaTAD

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000438423

19_27

1398.3333333333333

Motif

Note=9aaTAD

Tgene

TCF12

chr8:57890608

chr15:57355947

ENST00000557843

19_27

1301.0

Motif

Note=9aaTAD

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Fusion Gene Sequence for IMPAD1-TCF12

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>39694_39694_1_IMPAD1-TCF12_IMPAD1_chr8_57890608_ENST00000262644_TCF12_chr15_57355947_ENST00000267811_length(transcript)=6514nt_BP=905nt
GGAAGTCGGACCAGCCGGCCGGCGGAAGAACCTAGAGCGCGCTGCCTGGCGAGTCAGGCGCGCGGGGCGGCGTTGGTGGTCTTCGCGGCG
CAACTCGGCCTTTCCTGGGAGGGAGTGATGGGGCGCACCGGGGCCGGGGAGCGGGCGCCAGTGTAGCCCGCGCGGCGCCTGGCCCGGAGC
GCGGCGGCTGCGGCGGCGGCGGCGGCGGGCGCTGGAGGCCTGTGAGAGCCGCAGCCCGGAGCGCCCGGCTTCCCACGCCATGGCCCCCAT
GGGCATCCGCCTTTCCCCACTGGGGGTGGCAGTGTTTTGCCTGCTGGGGCTCGGCGTGCTCTACCACCTCTACTCGGGCTTCTTGGCCGG
CCGCTTCAGCCTCTTCGGCCTGGGCGGCGAGCCTGGCGGCGGCGCGGCGGGGCCCGCGGCCGCGGCCGATGGGGGCACCGTGGACTTGCG
CGAGATGCTGGCTGTGTCAGTGCTGGCCGCAGTCCGCGGCGGCGACGAGGTGAGGCGCGTCCGCGAGAGCAACGTCCTCCACGAGAAGTC
CAAGGGGAAGACGCGCGAGGGAGCCGAGGACAAGATGACCAGCGGCGACGTGCTGTCCAACCGCAAGATGTTCTACCTGCTCAAGACCGC
CTTCCCCAGCGTCCAGATTAATACTGAGGAACACGTGGATGCAGCTGATCAGGAGGTTATCTTGTGGGATCATAAGATTCCTGAGGATAT
CCTAAAGGAAGTAACTACTCCTAAAGAGGTACCAGCAGAAAGTGTTACTGTCTGGATTGACCCACTTGATGCTACACAGGAATATACAGA
GGATCTTCGAAAGTACGTCACTACTATGGTGTGTGTGGCTGTAAATGGTAAACCCATGCTAGGAGTTATACATAAGCCATTTTCCGAATA
TACAGGTATTGATGAAAGAGGAGGTACAACATCTTGGGGAACAAGTGGTCAACCAAGTCCTTCCTATGATTCATCTAGAGGTTTTACAGA
CAGCCCTCATTACAGTGATCACTTGAATGACAGTCGATTAGGAGCCCATGAAGGCTTGTCCCCAACACCTTTCATGAACTCAAATCTGAT
GGGAAAAACATCAGAGAGAGGCTCATTTTCCCTGTACAGCAGAGATACTGGATTACCAGGCTGTCAATCTAGTCTCCTGAGACAAGATCT
GGGGCTTGGGAGCCCAGCACAGCTATCTTCTTCAGGAAAACCTGGGACAGCATACTATTCATTCTCTGCTACAAGTTCCAGGAGGAGACC
ACTCCATGACTCTGCAGCGCTTGATCCCTTGCAAGCAAAAAAAGTCAGAAAGGTGCCTCCTGGTTTGCCTTCTTCTGTATATGCACCATC
CCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTTCGCTAGCACTTTCTTTATGCA
AGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGGAATTCTGGGGACCTCCACTTC
CCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTCAGTTTCACCAACAGACATAAA
CACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTCACACACTCCTCCCATCAATGG
ATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAAGGCTTTGGCATCTATTTATTC
TCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCACAGGTACCAGTCAGTGGCCAAG
ACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGCAGTCTCGAATGGAGGATCGTTTAGACAGACTGGA
TGATGCAATCCATGTGCTGCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGATATACATAGTTTATTGGGACC
ATCCCATAATGCACCAATTGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCGATCAGCTTCAATGGTTGGAAC
TCATCGGGAAGACTCTGTCAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAGCACAGACCTGAACCATAAAAC
ACAAGAAAATTATAGAGGTGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGAAAACAAAGAAAAGGATGAAAA
CCTTCATGAACCTCCTTCATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGTTTCATCTAGAGGCAGAACAAG
CAGTACTAATGAAGATGAGGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGCTAACAATGCCAGAGAACGCTT
ACGCGTGCGGGATATTAATGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGAAAAACCCCAAACAAAACTCCT
TATTCTTCATCAAGCCGTGGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCCCAAAGCAGCCTGCCTTAAGAG
AAGGGAAGAAGAAAAAGTTTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGGGCTTAGTGAAACTACCAACCC
TATGGGTCATATGTAAACATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCTCATAAGGACTTGGACAACTCA
GATTATCTGAAGACACAAACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAAATGTAATCCTACGATCAAAGC
AACTGGTCAACACTTCCATCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATGTTTGCAACAAATCTTTTGTTG
CAAGCAGTGTGTCGCTTCTGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTTGTGCCTAAACTGAATTGACAA
ATGCATTGTAACTACAAATTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTTAATGTGGAAAGCTGATCTACA
CTCAGCTGATGCCAGCATACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCCTTAGCATTCCCGGCATACCTA
TTAGTGTCTTAAAAAGGAAGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCGTTTTCCATGAAATAGGAAAAT
ATTACTTGGTATAGCATTTCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTATATTTGATCTCTAAATCTGAA
CAGTTTATGGTCACAGTCCAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGTAAGCAGAGACCATCTGTGACC
ATAGCCTAGCTAGCATTTTAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTTATTTCTAATAATAACCAAGAC
TTTTCAAGCTTCTAGATCTCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTACTTTTTAGAAATCGCTTTGTT
TTCCAAGCAGTAAGTACTACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTAAAATACAAAGACGATTTTTTC
AGGCTGTGATTATGGTGAACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACACACCACTCTGAGGCTAATTACC
TAATGGAATACAAGAGCAATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGATGGCTGGTCAATGGGGAAGAAT
TGAGTGGGTGATTTAATCAACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTAAACCAGTACTTGTCAGTCCAT
CTTAATACTGTTCATTAAGGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACTTTGAACTTCCATGAAACCTGT
CTTCCACCACAACAACCCTGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTATAGCCAATATCAACAGTGGCAA
TCAGCACACAGAGGAAAGGACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAAAACAAGACAGAACTTCTGGTA
CTCTAATCAGGATGATTCCTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATTTGCATATATTCTCCAGTTACA
TCGGACTCTATCTGTGGCCTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGATGTGTGAGTGAACATATGCCA
CTGCCTGGCCTTTTTTTCTTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGAAGCTTTCCTTCATAAAATAGA
AAGAAAAAAACATTTGGCTTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTTCTTGAATTCTAAATATTACTC
TTTCTAGATTTTTGAAATCAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAGTAAAAAATGTAGGGTTATTTA
CCATAACCTGTTCATTAATATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATACCGTGTAGTACCTATGGAGTAT
TGTAAGAGCTAATTGTTGGAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTGCAGATTTGTATCCTGTGTCAA
ATTCAAGGTATTATTGATAAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAACAGAAAACACAATATGTATAT
AACATTTATGTAGCAATAAATGTGCCATCTTTTTTTTAACACAGTAAAATAGTGAGTTTTTTACATTTCTCTTTCTCAAATAATAATGTA
TTTTGTTTTATTTTCTCCATCTCATTCGTCCCAGAAACACTCACACTGCTTTTCCTAACTGCATTACCGACATTATCTGGGAAACCCTTC
AGGACAGAATCAGGCTTGTGGAGCTAAGTTGGCAATCTGGTCTAGAGCTTCTCTAGCTTGTGCTTTTCTCCTCTTGCCCTCACTACTGAC
GGTGGCCTTTTAACCTTTTCCTAAAGATTGACCAAACAGCAACTAGTAGTTATAGAAAATCTACTCATTTGTAGATACAGAGAAAAATGA
AGAAGATGGAAAAAGACTCAAAAGAGGCTTTTTAAGTTATTCTTCAAAGCACTTTTCACATTTCCCCATACCCTTTCTCACAAAAAAAGT
GTCATAATTAAGTAATGGTATTGTTTACTGTTTAAAAGTTAAAAGATCAAAAATTTGCTTTTATCCCAGTTTTTAACCACAAAAAAAAGC
GTAGGGATTATCCATGAGGACTTCATGCCAAGCAAGAACCTCAAACAAACTAGACAAACTTTTTTTTTGACAGTGAATGACTTTTTGTAG
GACCTGTGCGTGCGAAACCCATGGCAATTGTCACATCCTCTTGGTATGCTGGCAGATTGCTTCTCTTGGTGAATTATGAAATCCACTGTT
CACATTGGGTGCCTAACAGAACATTTTGCTTCTTGTGGGATTTAGTGAAAACTATTAAACTTGTTAAGTTGATTTTATACAAAACGATAA
ATAAAAAGCTCTAAGAAGAAAATGTATAATCTTAGAGCTGAAATAAAATATAGAGACCATCTAGTAAATGACCTCATTAATATATCTGTG
AAAACTGAGACTCAGATTGTATGTCTCTAAGAACACATAATTAGTAACAGATCAAGACACTTAAAACTTTCCCTACAAAACCTCCCTGCC
TTGACTTTCTCTTTCTCTTTGCAGATTTCTAGGCCGCTTCTGCTCAGTGTCTTCATTTTCTTCCATATTTGTTTTATTTCATTTTTCTTT
TCTATAGTTCATGTTTTCTTTTTCCTTGGAAACTCAAAATTTAAACACACGTCGTGTGTGTGTGTGTGTGTGTGTCTGTGTGTGTGTGAC
TTAAAGAATCTTAAGCTTTGGCATTAAATAGTCCTCGATTCAAATCTAAGCTCAACATCTGATTAACTTCATTTTCCTATCTGAAAAATG
GAGATAACATTAGAATTGTGTAAGTATTGAATGAAACAATGTATGGAAAGCTCTTATGGTTCTTGTCACCTAAGAAGTACTTAATAAATG

>39694_39694_1_IMPAD1-TCF12_IMPAD1_chr8_57890608_ENST00000262644_TCF12_chr15_57355947_ENST00000267811_length(amino acids)=872AA_BP=239
MRRRRRRALEACESRSPERPASHAMAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGTVDLREM
LAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILK
EVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTGIDERGGTTSWGTSGQPSPSYDSSRGFTDSP
HYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLH
DSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHM
SQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPD
HTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPSH
NAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENLH
EPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLIL

--------------------------------------------------------------
>39694_39694_2_IMPAD1-TCF12_IMPAD1_chr8_57890608_ENST00000262644_TCF12_chr15_57355947_ENST00000438423_length(transcript)=5247nt_BP=905nt
GGAAGTCGGACCAGCCGGCCGGCGGAAGAACCTAGAGCGCGCTGCCTGGCGAGTCAGGCGCGCGGGGCGGCGTTGGTGGTCTTCGCGGCG
CAACTCGGCCTTTCCTGGGAGGGAGTGATGGGGCGCACCGGGGCCGGGGAGCGGGCGCCAGTGTAGCCCGCGCGGCGCCTGGCCCGGAGC
GCGGCGGCTGCGGCGGCGGCGGCGGCGGGCGCTGGAGGCCTGTGAGAGCCGCAGCCCGGAGCGCCCGGCTTCCCACGCCATGGCCCCCAT
GGGCATCCGCCTTTCCCCACTGGGGGTGGCAGTGTTTTGCCTGCTGGGGCTCGGCGTGCTCTACCACCTCTACTCGGGCTTCTTGGCCGG
CCGCTTCAGCCTCTTCGGCCTGGGCGGCGAGCCTGGCGGCGGCGCGGCGGGGCCCGCGGCCGCGGCCGATGGGGGCACCGTGGACTTGCG
CGAGATGCTGGCTGTGTCAGTGCTGGCCGCAGTCCGCGGCGGCGACGAGGTGAGGCGCGTCCGCGAGAGCAACGTCCTCCACGAGAAGTC
CAAGGGGAAGACGCGCGAGGGAGCCGAGGACAAGATGACCAGCGGCGACGTGCTGTCCAACCGCAAGATGTTCTACCTGCTCAAGACCGC
CTTCCCCAGCGTCCAGATTAATACTGAGGAACACGTGGATGCAGCTGATCAGGAGGTTATCTTGTGGGATCATAAGATTCCTGAGGATAT
CCTAAAGGAAGTAACTACTCCTAAAGAGGTACCAGCAGAAAGTGTTACTGTCTGGATTGACCCACTTGATGCTACACAGGAATATACAGA
GGATCTTCGAAAGTACGTCACTACTATGGTGTGTGTGGCTGTAAATGGTAAACCCATGCTAGGAGTTATACATAAGCCATTTTCCGAATA
TACAGGTATTGATGAAAGAGGAGGTACAACATCTTGGGGAACAAGTGGTCAACCAAGTCCTTCCTATGATTCATCTAGAGGTTTTACAGA
CAGCCCTCATTACAGTGATCACTTGAATGACAGTCGATTAGGAGCCCATGAAGGCTTGTCCCCAACACCTTTCATGAACTCAAATCTGAT
GGGAAAAACATCAGAGAGAGGCTCATTTTCCCTGTACAGCAGAGATACTGGATTACCAGGCTGTCAATCTAGTCTCCTGAGACAAGATCT
GGGGCTTGGGAGCCCAGCACAGCTATCTTCTTCAGGAAAACCTGGGACAGCATACTATTCATTCTCTGCTACAAGTTCCAGGAGGAGACC
ACTCCATGACTCTGCAGCGCTTGATCCCTTGCAAGCAAAAAAAGTCAGAAAGGTGCCTCCTGGTTTGCCTTCTTCTGTATATGCACCATC
CCCAAATTCAGATGATTTCAACCGTGAATCTCCTAGTTATCCATCTCCTAAGCCACCAACCAGTATGTTCGCTAGCACTTTCTTTATGCA
AGATGGGACCCACAATTCTTCTGACCTTTGGAGTTCATCAAATGGGATGAGCCAGCCTGGTTTTGGTGGAATTCTGGGGACCTCCACTTC
CCACATGTCTCAATCCAGTAGTTATGGCAACCTTCATTCACATGACCGCTTGAGTTATCCTCCACACTCAGTTTCACCAACAGACATAAA
CACGAGTCTTCCACCAATGTCCAGCTTTCATCGCGGCAGTACCAGCAGTTCACCTTACGTTGCTGCCTCACACACTCCTCCCATCAATGG
ATCAGACAGCATTCTAGGAACCAGAGGGAATGCTGCTGGAAGCTCACAGACAGGTGATGCACTTGGAAAGGCTTTGGCATCTATTTATTC
TCCTGACCATACCAGCAGTAGTTTTCCGTCAAATCCATCAACACCAGTTGGATCACCTTCACCTCTCACAGGTACCAGTCAGTGGCCAAG
ACCTGGAGGGCAAGCACCTTCATCCCCAAGCTATGAAAACTCACTCCACTCCCTGAAAAATCGAGTTGAGCAGCAACTTCACGAGCATTT
GCAAGATGCAATGTCCTTCTTAAAGGATGTCTGTGAGCAGTCTCGAATGGAGGATCGTTTAGACAGACTGGATGATGCAATCCATGTGCT
GCGGAACCATGCTGTGGGACCTTCCACCAGTTTGCCTGCTGGTCACAGTGATATACATAGTTTATTGGGACCATCCCATAATGCACCAAT
TGGAAGCCTCAATTCAAACTATGGAGGATCAAGCCTTGTTGCAAGCAGTCGATCAGCTTCAATGGTTGGAACTCATCGGGAAGACTCTGT
CAGTCTCAATGGCAATCATTCAGTCCTGTCTAGTACAGTCACTACTTCAAGCACAGACCTGAACCATAAAACACAAGAAAATTATAGAGG
TGGCTTGCAAAGTCAGTCTGGAACTGTTGTTACAACAGAAATCAAGACTGAAAACAAAGAAAAGGATGAAAACCTTCATGAACCTCCTTC
ATCAGATGACATGAAGTCAGATGATGAATCCTCCCAAAAAGATATCAAGGTTTCATCTAGAGGCAGAACAAGCAGTACTAATGAAGATGA
GGATTTGAACCCTGAACAGAAGATAGAAAGGGAGAAGGAGAGGCGGATGGCTAACAATGCCAGAGAACGCTTACGCGTGCGGGATATTAA
TGAAGCATTCAAAGAGCTTGGCCGAATGTGTCAGCTTCACTTGAAGAGTGAAAAACCCCAAACAAAACTCCTTATTCTTCATCAAGCCGT
GGCAGTCATCCTTAGTCTAGAACAGCAAGTCAGAGAGAGGAACCTTAACCCCAAAGCAGCCTGCCTTAAGAGAAGGGAAGAAGAAAAAGT
TTCTGCCGTATCGGCAGAGCCGCCAACCACACTGCCAGGAACCCATCCTGGGCTTAGTGAAACTACCAACCCTATGGGTCATATGTAAAC
ATCAGCCAGTTCCAGAGTTATCAGTAGGCTAGATAGAAGGTGACCTCTCCTCATAAGGACTTGGACAACTCAGATTATCTGAAGACACAA
ACCTGACAGGAGGGAGAAGAAAAAACAAAACACTTGAACCAAGAAACTCAAATGTAATCCTACGATCAAAGCAACTGGTCAACACTTCCA
TCAGAAGTGAAGATAGGAAGCTCATCAGATAGAACATCAGCCCATGAGATGTTTGCAACAAATCTTTTGTTGCAAGCAGTGTGTCGCTTC
TGCACAATCAGAGACTGTCTCGATCTCTCCACTCACCGTGGAAGTTGCCTTGTGCCTAAACTGAATTGACAAATGCATTGTAACTACAAA
TTTTATTTATTGTTATGAAACTGTAAGGTCTACATATAAAGGGAAAAAGTTAATGTGGAAAGCTGATCTACACTCAGCTGATGCCAGCAT
ACATTAAAGCGGTTCACGTGCAGAGAACAAAGCAGTGACAACCATTGGCCCTTAGCATTCCCGGCATACCTATTAGTGTCTTAAAAAGGA
AGGGAAAAGTCTTTTGTTGCCCTCTCCTATCCTCTTGCCATATGAATAGCGTTTTCCATGAAATAGGAAAATATTACTTGGTATAGCATT
TCTCTTGCTCTCATTTTTTGATTTATTTTTATTTTCTCTTTGTGGGTGTTATATTTGATCTCTAAATCTGAACAGTTTATGGTCACAGTC
CAGCCTCCTCCGTGCAGCCCTGTGTGCTTTGCACATTTACCTTACAGTGGTAAGCAGAGACCATCTGTGACCATAGCCTAGCTAGCATTT
TAAAAGGGGAAATTTTGTTCTCTAGGTTTTCCCCCAAATAAACATTGCTTTATTTCTAATAATAACCAAGACTTTTCAAGCTTCTAGATC
TCATAGGAAAGCTTGTAATAGCAAAATTGTAAATTACAAGGGAAGAATCTACTTTTTAGAAATCGCTTTGTTTTCCAAGCAGTAAGTACT
ACATACAGTACTTGTAAAGTGTTAGCTGTAAGTAAGCACAAAATACATTTAAAATACAAAGACGATTTTTTCAGGCTGTGATTATGGTGA
ACATAACAAAACCCAGTAGTCACCAAGGCAGGTAGTGTGATAAATGAACACACCACTCTGAGGCTAATTACCTAATGGAATACAAGAGCA
ATGGTCACCCGTATTTCCTTATCCTAGCCTTTATTTCTCTGTCATTTGGATGGCTGGTCAATGGGGAAGAATTGAGTGGGTGATTTAATC
AACTGCAAACCATCTGCCCCTGTCCCAAAATGATGAGCCAGATTAGCATTAAACCAGTACTTGTCAGTCCATCTTAATACTGTTCATTAA
GGCACTCTCTGTCTCTAATCCTTAGGAGTTGTTTTAAAAGACATAATCACTTTGAACTTCCATGAAACCTGTCTTCCACCACAACAACCC
TGGGAGAGAAAAACATGCTAAAGGAGGTATCTTGGCTTAATAATTCCTTATAGCCAATATCAACAGTGGCAATCAGCACACAGAGGAAAG
GACCCAAATCACTATGTAGCTTAAAGATTTCTGTTAATTTGAAAGAACAAAAACAAGACAGAACTTCTGGTACTCTAATCAGGATGATTC
CTAACAAGTCAGTCATTTGTGAACTTAGTGGACTTTTTGGTTACTTTAATTTGCATATATTCTCCAGTTACATCGGACTCTATCTGTGGC
CTTGTTCTTCATTTCAGTGTTAATCAGCTAAACAGAAGTTGTTGCTTATGATGTGTGAGTGAACATATGCCACTGCCTGGCCTTTTTTTC
TTCAGAGCTTGTTGTCTTTTTCGCTATATTAGACTTTGCAGTATGCCCAGAAGCTTTCCTTCATAAAATAGAAAGAAAAAAACATTTGGC
TTATTTTTCACTGTAGCTAGTCTTTTATACAATAATCTTGTAAGAAAATTTCTTGAATTCTAAATATTACTCTTTCTAGATTTTTGAAAT
CAAAAAGTTTTCAGTAAAAAGTTTCTTACTTTATTTTATTATATTAGGTAGTAAAAAATGTAGGGTTATTTACCATAACCTGTTCATTAA
TATCAGAAATTTACAATAGCATTTTAAGACCATAGTAGGATTCTAGCATACCGTGTAGTACCTATGGAGTATTGTAAGAGCTAATTGTTG
GAGATGAATTGCTTCTCATCTTGTTCTCCAGTTTCCATTGTTGGTTTATTGCAGATTTGTATCCTGTGTCAAATTCAAGGTATTATTGAT
AAACCTTTTCAACCAGCAGCAAGAAGTTCAAATTTTTTTCTGTCACTGTAACAGAAAACACAATATGTATATAACATTTATGTAGCAATA

>39694_39694_2_IMPAD1-TCF12_IMPAD1_chr8_57890608_ENST00000262644_TCF12_chr15_57355947_ENST00000438423_length(amino acids)=896AA_BP=239
MRRRRRRALEACESRSPERPASHAMAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAAAADGGTVDLREM
LAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGAEDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILK
EVTTPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTGIDERGGTTSWGTSGQPSPSYDSSRGFTDSP
HYSDHLNDSRLGAHEGLSPTPFMNSNLMGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPLH
DSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSHM
SQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPD
HTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRN
HAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGL
QSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IMPAD1-TCF12

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	TCF12	chr8:57890608	chr15:57355947	ENST00000267811		2	20	182_196	49.333333333333336	1821.3333333333333	RUNX1T1
Tgene	TCF12	chr8:57890608	chr15:57355947	ENST00000333725		2	21	182_196	49.333333333333336	1420.0	RUNX1T1
Tgene	TCF12	chr8:57890608	chr15:57355947	ENST00000343827		0	13	182_196	0	1254.6666666666667	RUNX1T1
Tgene	TCF12	chr8:57890608	chr15:57355947	ENST00000438423		2	21	182_196	49.333333333333336	1398.3333333333333	RUNX1T1
Tgene	TCF12	chr8:57890608	chr15:57355947	ENST00000557843		2	20	182_196	49.333333333333336	1301.0	RUNX1T1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for IMPAD1-TCF12

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for IMPAD1-TCF12

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source