FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:IMPDH1-GRM8 (FusionGDB2 ID:39697)

Fusion Gene Summary for IMPDH1-GRM8

check button Fusion gene summary
Fusion gene informationFusion gene name: IMPDH1-GRM8
Fusion gene ID: 39697
HgeneTgene
Gene symbol

IMPDH1

GRM8

Gene ID

3614

2918

Gene nameinosine monophosphate dehydrogenase 1glutamate metabotropic receptor 8
SynonymsIMPD|IMPD1|IMPDH-I|LCA11|RP10|sWSS2608GLUR8|GPRC1H|MGLUR8|mGlu8
Cytomap

7q32.1

7q31.33

Type of geneprotein-codingprotein-coding
Descriptioninosine-5'-monophosphate dehydrogenase 1IMP (inosine 5'-monophosphate) dehydrogenase 1IMP (inosine monophosphate) dehydrogenase 1IMPD 1IMPDH 1metabotropic glutamate receptor 8glutamate receptor, metabotropic 8
Modification date2020032820200313
UniProtAcc

P20839

O00222

Ensembl transtripts involved in fusion geneENST00000338791, ENST00000343214, 
ENST00000348127, ENST00000354269, 
ENST00000378717, ENST00000419067, 
ENST00000470772, ENST00000480861, 
ENST00000496200, 		ENST00000480995, 
ENST00000339582, ENST00000358373, 
ENST00000405249, ENST00000444921, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 7 X 7=441
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IMPDH1 [Title/Abstract] AND GRM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIMPDH1(128043760)-GRM8(126544737), # samples:1
Anticipated loss of major functional domain due to fusion event.IMPDH1-GRM8 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
IMPDH1-GRM8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
IMPDH1-GRM8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
IMPDH1-GRM8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGRM8

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

11166323


check buttonFusion gene breakpoints across IMPDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-ZN-A9VO-01AIMPDH1chr7

128043760

-GRM8chr7

126544737

-


Top

Fusion Gene ORF analysis for IMPDH1-GRM8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000338791ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000343214ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000348127ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000354269ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000378717ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000419067ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000470772ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000480861ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
5CDS-5UTRENST00000496200ENST00000480995IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000338791ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000338791ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000338791ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000338791ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000348127ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000348127ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000348127ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000348127ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000354269ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000354269ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000354269ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000354269ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000378717ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000378717ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000378717ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000378717ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000419067ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000419067ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000419067ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000419067ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000470772ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000470772ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000470772ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000470772ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000480861ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000480861ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000480861ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000480861ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000496200ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000496200ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000496200ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
Frame-shiftENST00000496200ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-
In-frameENST00000343214ENST00000339582IMPDH1chr7

128043760

-GRM8chr7

126544737

-
In-frameENST00000343214ENST00000358373IMPDH1chr7

128043760

-GRM8chr7

126544737

-
In-frameENST00000343214ENST00000405249IMPDH1chr7

128043760

-GRM8chr7

126544737

-
In-frameENST00000343214ENST00000444921IMPDH1chr7

128043760

-GRM8chr7

126544737

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343214IMPDH1chr7128043760-ENST00000444921GRM8chr7126544737-28873664432365640
ENST00000343214IMPDH1chr7128043760-ENST00000339582GRM8chr7126544737-28873664432365640
ENST00000343214IMPDH1chr7128043760-ENST00000358373GRM8chr7126544737-29253664432365640
ENST00000343214IMPDH1chr7128043760-ENST00000405249GRM8chr7126544737-11453664431144234

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343214ENST00000444921IMPDH1chr7128043760-GRM8chr7126544737-0.0018423950.99815756
ENST00000343214ENST00000339582IMPDH1chr7128043760-GRM8chr7126544737-0.0018423950.99815756
ENST00000343214ENST00000358373IMPDH1chr7128043760-GRM8chr7126544737-0.0017497590.9982502
ENST00000343214ENST00000405249IMPDH1chr7128043760-GRM8chr7126544737-0.0112099830.98879004

Top

Fusion Genomic Features for IMPDH1-GRM8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for IMPDH1-GRM8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:128043760/chr7:126544737)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IMPDH1

P20839

GRM8

O00222

FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211609_620242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211642_647242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211669_695242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211717_746242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211769_781242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211804_818242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211844_908242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211609_620242836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211642_647242836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211669_695242836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211717_746242836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211769_781242836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211804_818242836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211844_908242836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918609_620242502.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918642_647242502.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918669_695242502.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918717_746242502.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918769_781242502.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918804_818242502.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918844_908242502.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110609_620242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110642_647242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110669_695242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110717_746242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110769_781242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110804_818242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110844_908242909.0Topological domainCytoplasmic
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211584_608242909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211621_641242909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211648_668242909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211696_716242909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211747_768242909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211782_803242909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211819_843242909.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211584_608242836.3333333333334TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211621_641242836.3333333333334TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211648_668242836.3333333333334TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211696_716242836.3333333333334TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211747_768242836.3333333333334TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211782_803242836.3333333333334TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211819_843242836.3333333333334TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918584_608242502.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918621_641242502.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918648_668242502.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918696_716242502.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918747_768242502.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918782_803242502.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918819_843242502.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110584_608242909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110621_641242909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110648_668242909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110696_716242909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110747_768242909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110782_803242909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110819_843242909.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517114_173134600.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517179_237134600.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314114_17349490.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314179_23749490.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315114_17398564.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315179_23798564.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416114_173124590.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416179_237124590.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416114_173101567.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416179_237101567.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214114_17349510.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214179_23749510.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213114_17349490.0DomainCBS 1
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213179_23749490.0DomainCBS 2
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517274_276134600.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517324_326134600.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314274_27649490.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314324_32649490.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315274_27698564.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315324_32698564.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416274_276124590.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416324_326124590.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416274_276101567.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416324_326101567.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214274_27649510.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214324_32649510.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213274_27649490.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213324_32649490.0Nucleotide bindingNAD
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517364_366134600.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517387_388134600.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000338791-517411_415134600.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314364_36649490.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314387_38849490.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000343214-314411_41549490.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315364_36698564.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315387_38898564.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000348127-315411_41598564.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416364_366124590.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416387_388124590.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000354269-416411_415124590.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416364_366101567.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416387_388101567.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000419067-416411_415101567.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214364_36649510.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214387_38849510.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000480861-214411_41549510.0RegionIMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213364_36649490.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213387_38849490.0RegionNote=IMP binding
HgeneIMPDH1chr7:128043760chr7:126544737ENST00000496200-213411_41549490.0RegionIMP binding
TgeneGRM8chr7:128043760chr7:126544737ENST00000339582211177_179242909.0RegionGlutamate binding
TgeneGRM8chr7:128043760chr7:126544737ENST00000358373211177_179242836.3333333333334RegionGlutamate binding
TgeneGRM8chr7:128043760chr7:126544737ENST0000040524918177_179242502.0RegionGlutamate binding
TgeneGRM8chr7:128043760chr7:126544737ENST00000444921110177_179242909.0RegionGlutamate binding
TgeneGRM8chr7:128043760chr7:126544737ENST0000033958221134_583242909.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST0000035837321134_583242836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST000004052491834_583242502.0Topological domainExtracellular
TgeneGRM8chr7:128043760chr7:126544737ENST0000044492111034_583242909.0Topological domainExtracellular


Top

Fusion Gene Sequence for IMPDH1-GRM8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39697_39697_1_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000339582_length(transcript)=2887nt_BP=366nt
GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT
CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC
AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG
CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT
GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG
AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG
GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA
TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG
AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG
CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA
AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT
TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA
AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC
ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT
GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC
TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG
TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC
TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT
TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA
GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA
TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT
GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA
AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA
TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA
TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC
AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACACTTCCTCTACCAAGACAACATATA
TCAGTTACAGCAATCATTCAATCTGAAACAGGGAAATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCG
CAAAAATTCACTCCTGGAGATCTCCGTAGACTACAATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAA
AGTATCAATAAACGGGGAGTGAAGAAACCCGTTTTATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTA
AAACAAATCACAAAAGGAAAACTAATGTTAGCTCGTGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCT
GTGATTGTGAGAACTCCCGTTCCTGTCCCACATTGTTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAG
CCCTGGGTTGTGCTAAAAATAAATGCAATGATTGATGCATGCAATTTTTTATACAAATAATTTATTTCTAATAATAAAGGAATGTTTTGC

>39697_39697_1_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000339582_length(amino acids)=640AA_BP=
MLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW
FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRA
VNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHC
ERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG
IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDP
PHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA
EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKT

--------------------------------------------------------------
>39697_39697_2_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000358373_length(transcript)=2925nt_BP=366nt
GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT
CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC
AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG
CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT
GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG
AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG
GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA
TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG
AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG
CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA
AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT
TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA
AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC
ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT
GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC
TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG
TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC
TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT
TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA
GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA
TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT
GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA
AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA
TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA
TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC
AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACAGTAAGTCATCTGTAGAGTTTCCGA
TGGTCAAGAGCGGGAGCACTTCCTAATAGATCTTCCTCTACCAAGACAACATATATCAGTTACAGCAATCATTCAATCTGAAACAGGGAA
ATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCGCAAAAATTCACTCCTGGAGATCTCCGTAGACTACA
ATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAAAGTATCAATAAACGGGGAGTGAAGAAACCCGTTTT
ATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTAAAACAAATCACAAAAGGAAAACTAATGTTAGCTCG
TGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCTGTGATTGTGAGAACTCCCGTTCCTGTCCCACATTG
TTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAGCCCTGGGTTGTGCTAAAAATAAATGCAATGATTGA

>39697_39697_2_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000358373_length(amino acids)=640AA_BP=
MLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW
FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRA
VNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHC
ERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG
IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDP
PHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA
EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVE

--------------------------------------------------------------
>39697_39697_3_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000405249_length(transcript)=1145nt_BP=366nt
GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT
CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC
AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG
CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT
GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG
AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG
GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA
TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG
AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG
CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA
AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT
TTAATGGTTGCCGAAGAGGGATCCAGATGTCTCTACCCTGGCCAACTCTTTTTACTCCTTCATTTTCCAGTAGTTGGGCAGTGCTGGCAC

>39697_39697_3_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000405249_length(amino acids)=234AA_BP=
MLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW
FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRA

--------------------------------------------------------------
>39697_39697_4_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000444921_length(transcript)=2887nt_BP=366nt
GGCTGCGCTCACTGCCCAGCCGGGGCCCCGGGAGCCTCCAGGCTCCCGCCCGCCCTGAGCTGCGGCCTCCGCATGGAGGGGCCACTCACT
CCACCACCGCTGCAGGGAGGCGGAGCCGCCGCTGTTCCGGAGCCCGGAGCCCGGCAACACCCGGGACACGAGACGGCGGCGCAGCGGTAC
AGCGCCCGACTGCTGCAGGCCGGCTACGAGCCCGAGAGCATGGCGGACTACCTGATCAGCGGCGGCACCGGCTACGTGCCCGAGGATGGG
CTCACCGCGCAGCAGCTCTTCGCCAGCGCCGACGGCCTCACCTACAACGACTTCCTGATTCTCCCAGGATTCATAGACTTCATAGCTGAT
GAGGTGGTGGTGTTTGCATTGCTCAGTCACAGAAAATCCCACGTGAACCAAGACCTGGAGAATTTGAAAAAATTATCAAACGCCTGCTAG
AAACACCTAATGCTCGAGCAGTGATTATGTTTGCCAATGAGGATGACATCAGGAGGATATTGGAAGCAGCAAAAAAACTAAACCAAAGTG
GGCATTTTCTCTGGATTGGCTCAGATAGTTGGGGATCCAAAATAGCACCTGTCTATCAGCAAGAGGAGATTGCAGAAGGGGCTGTGACAA
TTTTGCCCAAACGAGCATCAATTGATGGATTTGATCGATACTTTAGAAGCCGAACTCTTGCCAATAATCGAAGAAATGTGTGGTTTGCAG
AATTCTGGGAGGAGAATTTTGGCTGCAAGTTAGGATCACATGGGAAAAGGAACAGTCATATAAAGAAATGCACAGGGCTGGAGCGAATTG
CTCGGGATTCATCTTATGAACAGGAAGGAAAGGTCCAATTTGTAATTGATGCTGTATATTCCATGGCTTACGCCCTGCACAATATGCACA
AAGATCTCTGCCCTGGATACATTGGCCTTTGTCCACGAATGAGTACCATTGATGGGAAAGAGCTACTTGGTTATATTCGGGCTGTAAATT
TTAATGGCAGTGCTGGCACTCCTGTCACTTTTAATGAAAACGGAGATGCTCCTGGACGTTATGATATCTTCCAGTATCAAATAACCAACA
AAAGCACAGAGTACAAAGTCATCGGCCACTGGACCAATCAGCTTCATCTAAAAGTGGAAGACATGCAGTGGGCTCATAGAGAACATACTC
ACCCGGCGTCTGTCTGCAGCCTGCCGTGTAAGCCAGGGGAGAGGAAGAAAACGGTGAAAGGGGTCCCTTGCTGCTGGCACTGTGAACGCT
GTGAAGGTTACAACTACCAGGTGGATGAGCTGTCCTGTGAACTTTGCCCTCTGGATCAGAGACCCAACATGAACCGCACAGGCTGCCAGC
TTATCCCCATCATCAAATTGGAGTGGCATTCTCCCTGGGCTGTGGTGCCTGTGTTTGTTGCAATATTGGGAATCATCGCCACCACCTTTG
TGATCGTGACCTTTGTCCGCTATAATGACACACCTATCGTGAGGGCTTCAGGACGCGAACTTAGTTACGTGCTCCTAACGGGGATTTTTC
TCTGTTATTCAATCACGTTTTTAATGATTGCAGCACCAGATACAATCATATGCTCCTTCCGACGGGTCTTCCTAGGACTTGGCATGTGTT
TCAGCTATGCAGCCCTTCTGACCAAAACAAACCGTATCCACCGAATATTTGAGCAGGGGAAGAAATCTGTCACAGCGCCCAAGTTCATTA
GTCCAGCATCTCAGCTGGTGATCACCTTCAGCCTCATCTCCGTCCAGCTCCTTGGAGTGTTTGTCTGGTTTGTTGTGGATCCCCCCCACA
TCATCATTGACTATGGAGAGCAGCGGACACTAGATCCAGAGAAGGCCAGGGGAGTGCTCAAGTGTGACATTTCTGATCTCTCACTCATTT
GTTCACTTGGATACAGTATCCTCTTGATGGTCACTTGTACTGTTTATGCCATTAAAACGAGAGGTGTCCCAGAGACTTTCAATGAAGCCA
AACCTATTGGATTTACCATGTATACCACCTGCATCATTTGGTTAGCTTTCATCCCCATCTTTTTTGGTACAGCCCAGTCAGCAGAAAAGA
TGTACATCCAGACAACAACACTTACTGTCTCCATGAGTTTAAGTGCTTCAGTATCTCTGGGCATGCTCTATATGCCCAAGGTTTATATTA
TAATTTTTCATCCAGAACAGAATGTTCAAAAACGCAAGAGGAGCTTCAAGGCTGTGGTGACAGCTGCCACCATGCAAAGCAAACTGATCC
AAAAAGGAAATGACAGACCAAATGGCGAGGTGAAAAGTGAACTCTGTGAGAGTCTTGAAACCAACACTTCCTCTACCAAGACAACATATA
TCAGTTACAGCAATCATTCAATCTGAAACAGGGAAATGGCACAATCTGAAGAGATGTGGTATATGATCTTAAATGATGAACATGAGACCG
CAAAAATTCACTCCTGGAGATCTCCGTAGACTACAATCAATCAAATCAATAGTCAGTCTTGTAAGGAACAAAAATTAGCCATGAGCCAAA
AGTATCAATAAACGGGGAGTGAAGAAACCCGTTTTATACAATAAAACCAATGAGTGTCAAGCTAAAGTATTGCTTATTCATGAGCAGTTA
AAACAAATCACAAAAGGAAAACTAATGTTAGCTCGTGAAAAAAAATGCTGTTGAAATAAATAATGTCTGATGTTATTCTTGTATTTTTCT
GTGATTGTGAGAACTCCCGTTCCTGTCCCACATTGTTTAACTTGTATAAGACAATGAGTCTGTTTCTTGTAATGGCTGACCAGATTGAAG
CCCTGGGTTGTGCTAAAAATAAATGCAATGATTGATGCATGCAATTTTTTATACAAATAATTTATTTCTAATAATAAAGGAATGTTTTGC

>39697_39697_4_IMPDH1-GRM8_IMPDH1_chr7_128043760_ENST00000343214_GRM8_chr7_126544737_ENST00000444921_length(amino acids)=640AA_BP=
MLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVW
FAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRA
VNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHC
ERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG
IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDP
PHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA
EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for IMPDH1-GRM8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for IMPDH1-GRM8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for IMPDH1-GRM8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource