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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:INADL-APITD1-CORT (FusionGDB2 ID:39707)

Fusion Gene Summary for INADL-APITD1-CORT

Fusion gene summary

Fusion gene information	Fusion gene name: INADL-APITD1-CORT
	Fusion gene ID: 39707
		Hgene	Tgene
	Gene symbol	INADL	APITD1-CORT
	Gene ID	10207	100526739
	Gene name	PATJ crumbs cell polarity complex component	CENPS-CORT readthrough
	Synonyms	Cipp\|INADL\|InaD-like\|hINADL	APITD1\|APITD1-CORT\|CENP-S\|CENPS\|FAAP16\|MHF1
	Cytomap	1p31.3	1p36.22
	Type of gene	protein-coding	protein-coding
	Description	inaD-like proteinPALS1-associated tight junction proteinPDZ domain proteinchannel-interacting PDZ domain proteinchannel-interacting PDZ domain-containing proteininactivation no after-potential D-like proteininactivation-no-afterpotential D-likeprot	APITD1-CORT proteinAPITD1-CORT readthroughApoptosis-inducing TAF9-like domain-containing protein 1Centromere protein SFANCM-associated histone fold protein 1FANCM-interacting histone fold protein 1Fanconi anemia-associated polypeptide of 16 kDa
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000316485, ENST00000371158, ENST00000472512, ENST00000543708, ENST00000545929,	ENST00000465026, ENST00000400900, ENST00000470413,
Fusion gene scores	* DoF score	15 X 12 X 10=1800	1 X 1 X 1=1
	# samples	18	1
	** MAII score	log2(18/1800*10)=-3.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: INADL [Title/Abstract] AND APITD1-CORT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	INADL(62293255)-APITD1-CORT(10493899), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across INADL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across APITD1-CORT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-C5-A8YQ-01A	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+

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Fusion Gene ORF analysis for INADL-APITD1-CORT

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000316485	ENST00000465026	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
5CDS-intron	ENST00000371158	ENST00000465026	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
In-frame	ENST00000316485	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
In-frame	ENST00000316485	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
In-frame	ENST00000371158	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
In-frame	ENST00000371158	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000472512	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000472512	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000543708	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000543708	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000545929	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-3CDS	ENST00000545929	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-intron	ENST00000472512	ENST00000465026	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-intron	ENST00000543708	ENST00000465026	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+
intron-intron	ENST00000545929	ENST00000465026	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000316485	INADL	chr1	62293255	-	ENST00000400900	APITD1-CORT	chr1	10493899	+	3096	2094	114	2537	807
ENST00000316485	INADL	chr1	62293255	-	ENST00000470413	APITD1-CORT	chr1	10493899	+	2535	2094	114	2276	720
ENST00000371158	INADL	chr1	62293255	-	ENST00000400900	APITD1-CORT	chr1	10493899	+	3096	2094	114	2537	807
ENST00000371158	INADL	chr1	62293255	-	ENST00000470413	APITD1-CORT	chr1	10493899	+	2535	2094	114	2276	720

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316485	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+	0.001032753	0.9989673
ENST00000316485	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+	0.003404212	0.9965958
ENST00000371158	ENST00000400900	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+	0.001032753	0.9989673
ENST00000371158	ENST00000470413	INADL	chr1	62293255	-	APITD1-CORT	chr1	10493899	+	0.003404212	0.9965958

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Fusion Genomic Features for INADL-APITD1-CORT

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for INADL-APITD1-CORT

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:62293255/chr1:10493899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

134_221

660

1583.0

Domain

PDZ 1

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1_65

660

1583.0

Domain

L27

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

248_328

660

1583.0

Domain

PDZ 2

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

365_453

660

1583.0

Domain

PDZ 3

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

553_639

660

1583.0

Domain

PDZ 4

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

134_221

660

1802.0

Domain

PDZ 1

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1_65

660

1802.0

Domain

L27

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

248_328

660

1802.0

Domain

PDZ 2

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

365_453

660

1802.0

Domain

PDZ 3

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

553_639

660

1802.0

Domain

PDZ 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1068_1160

660

1583.0

Domain

PDZ 6

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1239_1322

660

1583.0

Domain

PDZ 7

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1437_1520

660

1583.0

Domain

PDZ 8

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1533_1615

660

1583.0

Domain

PDZ 9

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

1676_1762

660

1583.0

Domain

PDZ 10

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000316485

686_772

660

1583.0

Domain

PDZ 5

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1068_1160

660

1802.0

Domain

PDZ 6

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1239_1322

660

1802.0

Domain

PDZ 7

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1437_1520

660

1802.0

Domain

PDZ 8

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1533_1615

660

1802.0

Domain

PDZ 9

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

1676_1762

660

1802.0

Domain

PDZ 10

Hgene

INADL

chr1:62293255

chr1:10493899

ENST00000371158

686_772

660

1802.0

Domain

PDZ 5

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Fusion Gene Sequence for INADL-APITD1-CORT

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>39707_39707_1_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000316485_APITD1-CORT_chr1_10493899_ENST00000400900_length(transcript)=3096nt_BP=2094nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGCTG
CTGCCTATTCACACTCTGAGGCTTGGTGTGGAAGTGGATTCCTTTGATGGGCACCATTATATTTCTTCAATTGTTTCTGGTGGTCCTGTT
GATACATTGGGTCTCCTACAGCCAGAAGATGAGCTGCTTGAGGTCAATGGCATGCAGCTTTATGGAAAATCTCGCCGAGAAGCAGTCTCC
TTTCTTAAAGAAGTGCCACCCCCTTTTACTTTGGTTTGCTGTCGGAGGTTGTTTGATGATGAAGCTTCTGTAGATGAACCAAGGCGCACT
GAAACCTCTCTTCCTGAGACAGAGAGGCTAAAGGCAGCAGTTCACTATACTGTGGGTTGTCTTTGCGAGGAAGTTGCATTGGACAAAGAG
ATGCAGTTCAGCAAACAGACCATTGCGGCCATTTCGGAGCTGACTTTCCGACAGTGTGAAAATTTTGCCAAAGACCTTGAAATGTTTGCA
AGACATGCGAAAAGAACCACAATTAACACTGAAGATGTGAAGCTCTTAGCCAGGAGGAGTAATTCACTGCATATGCAGGAAGCGGCAGGA
ATAAGGAAAAGCAGCCTCCTGACTTTCCTCGCTTGGTGGTTTGAGTGGACCTCCCAGGCCAGTGCCGGGCCCCTCATAGGAGAGGAAGCC
CGGGAGGTGGCCAGGCGGCAGGAAGGCGCACCCCCCCAGCAATCTGCGCGCCGGGACAGAATGCCCTGCAGGAACTTCTTCTGGAAGACC
TTCTCCTCCTGCAAATAAAACCTCACCCATGAATGCTCACGCAAGTGTAATGACAGACCTGAATAAAATGTATTAAGCAGCAGTGATCTT
TCCTCTCCTCCTTCCCAAGTCATTTGAAAAGTGTTTGTTATTTAAATTCCAATAATGCCCAATACTGACGTGTCTTGAGTAATTTGGAAC
CCAAAGTGAAGATCTTTGATAAAGATTTTTTTGTGGTTCGACTGGACTGTGCTGAGTGCGGGCACTGGGCTTTTCTTCTGATGTTCATTA
TGGTGCTGGGAAGCTCTGTCTTTGATTTAAAATAAAATAGCTAAAGGCTACACAATTAAGAGTTCAGAATAACATCTTATTTCAGTTTAT
GAATTGATATGAATTGTCTAATTTAAAAAATATTTCCCTCACATTAAAAGCAAATTTTTAATATCAGGCTCGAAGAGCAAAATGATTATT
CCTCATGTTTTAGCTGAAATTAATTTTAAAACATATTAAACAGAAAACCTGCTGACATGCCTGTGAAACTGATACTCGAACTTGCTGTTA

>39707_39707_1_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000316485_APITD1-CORT_chr1_10493899_ENST00000400900_length(amino acids)=807AA_BP=660
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP
FTLVCCRRLFDDEASVDEPRRTETSLPETERLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTI

--------------------------------------------------------------
>39707_39707_2_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000316485_APITD1-CORT_chr1_10493899_ENST00000470413_length(transcript)=2535nt_BP=2094nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGCTG
CTGCCTATTCACACTCTGAGGCTTGGTGTGGAAGTGGATTCCTTTGATGGGCACCATTATATTTCTTCAATTGTTTCTGGTGGTCCTGTT
GATACATTGGGTCTCCTACAGCCAGAAGATGAGCTGCTTGAGGTCAATGGCATGCAGCTTTATGGAAAATCTCGCCGAGAAGCAGTCTCC
TTTCTTAAAGAAGTGCCACCCCCTTTTACTTTGGTTTGCTGTCGGAGGTTGTTTGATGATGAAGCTTCTGTAGATGAACCAAGGCGCACT
GAAACCTCTCTTCCTGAGACAGAGAGGCTAAAGGCAGCAGTTCACTATACTGTGGGTTGTCTTTGCGAGGAAGTTGCATTGGACAAAGAG
ATGCAGTTCAGCAAACAGACCATTGCGGCCATTTCGGAGCTGACTTTCCGACAGTGTGAAAATTTTGCCAAAGACCTTGAAATGTTTGCA
AGCATATGCAGGAAGCGGCAGGAATAAGGAAAAGCAGCCTCCTGACTTTCCTCGCTTGGTGGTTTGAGTGGACCTCCCAGGCCAGTGCCG
GGCCCCTCATAGGAGAGGAAGCCCGGGAGGTGGCCAGGCGGCAGGAAGGCGCACCCCCCCAGCAATCTGCGCGCCGGGACAGAATGCCCT
GCAGGAACTTCTTCTGGAAGACCTTCTCCTCCTGCAAATAAAACCTCACCCATGAATGCTCACGCAAGTGTAATGACAGACCTGAATAAA

>39707_39707_2_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000316485_APITD1-CORT_chr1_10493899_ENST00000470413_length(amino acids)=720AA_BP=660
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP
FTLVCCRRLFDDEASVDEPRRTETSLPETERLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFASICRKRQE

--------------------------------------------------------------
>39707_39707_3_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000371158_APITD1-CORT_chr1_10493899_ENST00000400900_length(transcript)=3096nt_BP=2094nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGCTG
CTGCCTATTCACACTCTGAGGCTTGGTGTGGAAGTGGATTCCTTTGATGGGCACCATTATATTTCTTCAATTGTTTCTGGTGGTCCTGTT
GATACATTGGGTCTCCTACAGCCAGAAGATGAGCTGCTTGAGGTCAATGGCATGCAGCTTTATGGAAAATCTCGCCGAGAAGCAGTCTCC
TTTCTTAAAGAAGTGCCACCCCCTTTTACTTTGGTTTGCTGTCGGAGGTTGTTTGATGATGAAGCTTCTGTAGATGAACCAAGGCGCACT
GAAACCTCTCTTCCTGAGACAGAGAGGCTAAAGGCAGCAGTTCACTATACTGTGGGTTGTCTTTGCGAGGAAGTTGCATTGGACAAAGAG
ATGCAGTTCAGCAAACAGACCATTGCGGCCATTTCGGAGCTGACTTTCCGACAGTGTGAAAATTTTGCCAAAGACCTTGAAATGTTTGCA
AGACATGCGAAAAGAACCACAATTAACACTGAAGATGTGAAGCTCTTAGCCAGGAGGAGTAATTCACTGCATATGCAGGAAGCGGCAGGA
ATAAGGAAAAGCAGCCTCCTGACTTTCCTCGCTTGGTGGTTTGAGTGGACCTCCCAGGCCAGTGCCGGGCCCCTCATAGGAGAGGAAGCC
CGGGAGGTGGCCAGGCGGCAGGAAGGCGCACCCCCCCAGCAATCTGCGCGCCGGGACAGAATGCCCTGCAGGAACTTCTTCTGGAAGACC
TTCTCCTCCTGCAAATAAAACCTCACCCATGAATGCTCACGCAAGTGTAATGACAGACCTGAATAAAATGTATTAAGCAGCAGTGATCTT
TCCTCTCCTCCTTCCCAAGTCATTTGAAAAGTGTTTGTTATTTAAATTCCAATAATGCCCAATACTGACGTGTCTTGAGTAATTTGGAAC
CCAAAGTGAAGATCTTTGATAAAGATTTTTTTGTGGTTCGACTGGACTGTGCTGAGTGCGGGCACTGGGCTTTTCTTCTGATGTTCATTA
TGGTGCTGGGAAGCTCTGTCTTTGATTTAAAATAAAATAGCTAAAGGCTACACAATTAAGAGTTCAGAATAACATCTTATTTCAGTTTAT
GAATTGATATGAATTGTCTAATTTAAAAAATATTTCCCTCACATTAAAAGCAAATTTTTAATATCAGGCTCGAAGAGCAAAATGATTATT
CCTCATGTTTTAGCTGAAATTAATTTTAAAACATATTAAACAGAAAACCTGCTGACATGCCTGTGAAACTGATACTCGAACTTGCTGTTA

>39707_39707_3_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000371158_APITD1-CORT_chr1_10493899_ENST00000400900_length(amino acids)=807AA_BP=660
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP
FTLVCCRRLFDDEASVDEPRRTETSLPETERLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTI

--------------------------------------------------------------
>39707_39707_4_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000371158_APITD1-CORT_chr1_10493899_ENST00000470413_length(transcript)=2535nt_BP=2094nt
CTCACTTCCGCCCAGGTGAGGCAGGGCCGACACCGAGCCCGCCCGACCCGGGCTCCCACCTGCTCCTCCAGCGCACCAGGTGTCTTTAAG
AGTGATTGAAGAGAATAATTCAAAATGCCTGAAAATCCTGCTACAGATAAACTGCAGGTGCTGCAGGTACTTGATCGCCTGAAAATGAAA
TTGCAGGAGAAGGGTGACACGTCGCAGAATGAGAAGTTATCTATGTTTTATGAGACACTAAAGAGTCCTCTCTTCAACCAGATACTCACA
CTTCAGCAGTCCATCAAGCAACTGAAGGGTCAACTCAACCATATACCCTCAGATTGTTCAGCCAACTTTGATTTTTCTAGGAAAGGTTTG
TTAGTGTTCACAGATGGTTCCATCACTAATGGAAATGTCCACAGGCCCTCTAATAACTCGACTGTATCTGGGTTATTTCCGTGGACCCCG
AAGTTGGGAAATGAAGACTTTAACTCAGTCATTCAACAGATGGCTCAGGGCCGGCAAATTGAATATATAGATATAGAACGGCCTTCAACT
GGAGGCCTTGGATTCAGTGTGGTGGCCCTCAGAAGTCAAAATCTCGGAAAAGTTGATATCTTCGTGAAGGATGTCCAGCCAGGGAGTGTA
GCAGACAGGGATCAAAGATTAAAGGAAAATGATCAAATATTGGCCATTAATCACACGCCATTGGATCAGAACATTTCCCATCAGCAAGCA
ATTGCATTATTACAACAAACCACTGGATCTTTGAGACTGATTGTGGCCAGGGAACCAGTCCACACAAAAAGCAGTACTTCTAGCAGCCTA
AATGATACAACTCTGCCTGAAACAGTTTGTTGGGGCCATGTTGAAGAGGTTGAGCTCATTAATGATGGCTCTGGACTAGGTTTTGGAATA
GTTGGAGGAAAAACAAGTGGCGTGGTTGTGAGGACTATAGTTCCTGGAGGATTAGCAGATCGAGATGGAAGACTCCAGACAGGGGACCAC
ATCTTGAAGATTGGTGGCACAAACGTGCAGGGAATGACCAGTGAGCAAGTTGCACAAGTTCTAAGGAACTGTGGGAATTCAGTCAGGATG
CTCGTTGCTAGAGATCCAGCTGGTGACATTTCAGTCACCCCCCCTGCCCCTGCAGCCTTACCTGTTGCCCTGCCTACTGTAGCCAGCAAG
GGCCCTGGTTCTGACAGTTCTCTTTTTGAAACTTATAATGTTGAGCTTGTGAGAAAAGATGGGCAGAGTCTTGGAATTAGAATTGTTGGC
TATGTTGGAACATCTCATACAGGGGAAGCTTCAGGGATTTATGTGAAAAGTATAATACCTGGCAGTGCTGCGTACCACAATGGCCACATT
CAAGTGAATGACAAAATAGTTGCTGTCGATGGCGTGAACATTCAGGGTTTTGCCAACCATGATGTTGTTGAAGTATTACGAAATGCAGGG
CAGGTGGTACACCTAACCCTAGTTCGAAGGAAGACATCCTCATCTACTTCTCCACTTGAACCACCTTCAGACAGAGGAACTGTTGTAGAA
CCACTGAAACCACCAGCTCTCTTTCTAACTGGAGCAGTGGAAACTGAAACTAATGTGGATGGTGAAGATGAGGAAATTAAAGAAAGAATT
GATACTTTAAAAAATGACAACATACAAGCCTTAGAAAAATTGGAAAAAGTCCCAGACTCTCCAGAAAATGAGCTGAAATCCAGATGGGAA
AACCTGTTGGGTCCTGATTATGAAGTAATGGTTGCTACTTTGGACACACAGATTGCAGATGATGCTGAGTTACAGAAATATTCAAAGCTG
CTGCCTATTCACACTCTGAGGCTTGGTGTGGAAGTGGATTCCTTTGATGGGCACCATTATATTTCTTCAATTGTTTCTGGTGGTCCTGTT
GATACATTGGGTCTCCTACAGCCAGAAGATGAGCTGCTTGAGGTCAATGGCATGCAGCTTTATGGAAAATCTCGCCGAGAAGCAGTCTCC
TTTCTTAAAGAAGTGCCACCCCCTTTTACTTTGGTTTGCTGTCGGAGGTTGTTTGATGATGAAGCTTCTGTAGATGAACCAAGGCGCACT
GAAACCTCTCTTCCTGAGACAGAGAGGCTAAAGGCAGCAGTTCACTATACTGTGGGTTGTCTTTGCGAGGAAGTTGCATTGGACAAAGAG
ATGCAGTTCAGCAAACAGACCATTGCGGCCATTTCGGAGCTGACTTTCCGACAGTGTGAAAATTTTGCCAAAGACCTTGAAATGTTTGCA
AGCATATGCAGGAAGCGGCAGGAATAAGGAAAAGCAGCCTCCTGACTTTCCTCGCTTGGTGGTTTGAGTGGACCTCCCAGGCCAGTGCCG
GGCCCCTCATAGGAGAGGAAGCCCGGGAGGTGGCCAGGCGGCAGGAAGGCGCACCCCCCCAGCAATCTGCGCGCCGGGACAGAATGCCCT
GCAGGAACTTCTTCTGGAAGACCTTCTCCTCCTGCAAATAAAACCTCACCCATGAATGCTCACGCAAGTGTAATGACAGACCTGAATAAA

>39707_39707_4_INADL-APITD1-CORT_INADL_chr1_62293255_ENST00000371158_APITD1-CORT_chr1_10493899_ENST00000470413_length(amino acids)=720AA_BP=660
MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSI
TNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK
ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGV
VVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSL
FETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE
VMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP
FTLVCCRRLFDDEASVDEPRRTETSLPETERLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFASICRKRQE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for INADL-APITD1-CORT

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for INADL-APITD1-CORT

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for INADL-APITD1-CORT

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source