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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ING3-IVNS1ABP (FusionGDB2 ID:39742)

Fusion Gene Summary for ING3-IVNS1ABP

check button Fusion gene summary
Fusion gene informationFusion gene name: ING3-IVNS1ABP
Fusion gene ID: 39742
HgeneTgene
Gene symbol

ING3

IVNS1ABP

Gene ID

54556

10625

Gene nameinhibitor of growth family member 3influenza virus NS1A binding protein
SynonymsEaf4|ING2|MEAF4|p47ING3ARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP
Cytomap

7q31.31

1q25.3

Type of geneprotein-codingprotein-coding
Descriptioninhibitor of growth protein 3influenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39kelch-like protein 39
Modification date2020031320200320
UniProtAcc

Q9NXR8

Q9Y6Y0

Ensembl transtripts involved in fusion geneENST00000315870, ENST00000339121, 
ENST00000431467, ENST00000445699, 
ENST00000392007, ENST00000459929, 
ENST00000367497, ENST00000367498, 
Fusion gene scores* DoF score6 X 1 X 3=1817 X 9 X 9=1377
# samples 618
** MAII scorelog2(6/18*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/1377*10)=-2.93545974780529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ING3 [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointING3(120595678)-IVNS1ABP(185274775), # samples:1
Anticipated loss of major functional domain due to fusion event.ING3-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ING3-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ING3-IVNS1ABP seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ING3-IVNS1ABP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneING3

GO:0043065

positive regulation of apoptotic process

16387653

HgeneING3

GO:0043967

histone H4 acetylation

14966270|16387653

HgeneING3

GO:0043968

histone H2A acetylation

14966270|16387653


check buttonFusion gene breakpoints across ING3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IVNS1ABP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-5489ING3chr7

120595678

+IVNS1ABPchr1

185274775

-


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Fusion Gene ORF analysis for ING3-IVNS1ABP

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000315870ENST00000392007ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000315870ENST00000459929ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000339121ENST00000392007ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000339121ENST00000459929ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000431467ENST00000392007ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000431467ENST00000459929ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000445699ENST00000392007ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-5UTRENST00000445699ENST00000459929ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000315870ENST00000367497ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000339121ENST00000367497ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000431467ENST00000367497ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
5CDS-intronENST00000445699ENST00000367497ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
Frame-shiftENST00000445699ENST00000367498ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
In-frameENST00000315870ENST00000367498ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
In-frameENST00000339121ENST00000367498ING3chr7

120595678

+IVNS1ABPchr1

185274775

-
In-frameENST00000431467ENST00000367498ING3chr7

120595678

+IVNS1ABPchr1

185274775

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000315870ING3chr7120595678+ENST00000367498IVNS1ABPchr1185274775-33344151121686524
ENST00000339121ING3chr7120595678+ENST00000367498IVNS1ABPchr1185274775-3320401981672524
ENST00000431467ING3chr7120595678+ENST00000367498IVNS1ABPchr1185274775-3206287411558505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000315870ENST00000367498ING3chr7120595678+IVNS1ABPchr1185274775-0.0001459460.9998541
ENST00000339121ENST00000367498ING3chr7120595678+IVNS1ABPchr1185274775-0.0001473170.99985266
ENST00000431467ENST00000367498ING3chr7120595678+IVNS1ABPchr1185274775-0.0002040350.999796

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Fusion Genomic Features for ING3-IVNS1ABP


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ING3-IVNS1ABP


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:120595678/chr1:185274775)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ING3

Q9NXR8

IVNS1ABP

Q9Y6Y0

FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269|PubMed:12545155, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). {ECO:0000250|UniProtKB:Q920Q8, ECO:0000269|PubMed:16582008, ECO:0000269|PubMed:25619834, ECO:0000269|PubMed:9696811}.; FUNCTION: (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. {ECO:0000269|PubMed:23825951, ECO:0000269|PubMed:9696811}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615369_415219643.0RepeatNote=Kelch 1
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615416_463219643.0RepeatNote=Kelch 2
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615465_512219643.0RepeatNote=Kelch 3
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615513_559219643.0RepeatNote=Kelch 4
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615560_606219643.0RepeatNote=Kelch 5
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615608_642219643.0RepeatNote=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneING3chr7:120595678chr1:185274775ENST00000315870+412313_32989419.0Compositional biasNote=Poly-Ser
HgeneING3chr7:120595678chr1:185274775ENST00000339121+45313_3298993.0Compositional biasNote=Poly-Ser
HgeneING3chr7:120595678chr1:185274775ENST00000445699+14313_3290100.0Compositional biasNote=Poly-Ser
HgeneING3chr7:120595678chr1:185274775ENST00000315870+412360_40989419.0Zinc fingerPHD-type
HgeneING3chr7:120595678chr1:185274775ENST00000339121+45360_4098993.0Zinc fingerPHD-type
HgeneING3chr7:120595678chr1:185274775ENST00000445699+14360_4090100.0Zinc fingerPHD-type
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST00000367498615134_233219643.0DomainNote=BACK
TgeneIVNS1ABPchr7:120595678chr1:185274775ENST0000036749861532_99219643.0DomainBTB


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Fusion Gene Sequence for ING3-IVNS1ABP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39742_39742_1_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000315870_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3334nt_BP=415nt
TTTTTTTTTTTTTCTTTTTTTTTTTTTGCCGGAGTCGAGCGGGTGCTGCTAGCGGAGGCGCCATATTGGAGGGGACAAAACTCCGGCGAC
AGCGAGTGACACAAATAAACCCCTGGACCCCCTTGTTCCCTCAGCTCTAAGGGCCGCGATGTTGTACCTAGAAGACTATCTGGAAATGAT
TGAGCAGCTTCCTATGGATCTGCGGGACCGCTTCACGGAAATGCGCGAGATGGACCTGCAGGTGCAGAATGCAATGGATCAACTAGAACA
AAGAGTCAGTGAATTCTTTATGAATGCAAAGAAAAATAAACCTGAGTGGAGGGAAGAGCAAATGGCATCCATCAAAAAAGACTACTATAA
AGCTTTGGAAGATGCAGATGAGAAGGTTCAGTTGGCAAACCAGATATATGACTTGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCT
GCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGA
GAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAAT
CGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAA
CAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCAT
GTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATG
TCTTCGAACAGTCGAATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGC
TGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGA
TGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTC
TGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCG
GAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACG
ATACAATCCTGAAAATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACT
GTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAA
TATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAA
TACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACT
AACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAA
AGCTTTTGCATATTGCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTG
TACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCC
ACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAG
TTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTT
TTATTAAAAGGAAGCTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTAC
CAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGA
GTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGT
AACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAG
CAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAA
TTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGT
TGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACA
CATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGA
AATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTT
TTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACT
TGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCA
CCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAA
TTTGCCTAATATGATGACTGTTTTTAATATGGATCTGTATGTGTTCTATTCAGCACAAGGAAATAAAATTTTAGTTGAGGATTCAGCACT

>39742_39742_1_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000315870_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=524AA_BP=101
MDPLVPSALRAAMLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADE
KVQLANQIYDLVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTS
NNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECY
NPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKG
LKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD

--------------------------------------------------------------
>39742_39742_2_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000339121_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3320nt_BP=401nt
TTTTTTTTTTTTTGCCGGAGTCGAGCGGGTGCTGCTAGCGGAGGCGCCATATTGGAGGGGACAAAACTCCGGCGACAGCGAGTGACACAA
ATAAACCCCTGGACCCCCTTGTTCCCTCAGCTCTAAGGGCCGCGATGTTGTACCTAGAAGACTATCTGGAAATGATTGAGCAGCTTCCTA
TGGATCTGCGGGACCGCTTCACGGAAATGCGCGAGATGGACCTGCAGGTGCAGAATGCAATGGATCAACTAGAACAAAGAGTCAGTGAAT
TCTTTATGAATGCAAAGAAAAATAAACCTGAGTGGAGGGAAGAGCAAATGGCATCCATCAAAAAAGACTACTATAAAGCTTTGGAAGATG
CAGATGAGAAGGTTCAGTTGGCAAACCAGATATATGACTTGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACC
TACTAGATGGACAGGCTGAGGTGTTTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGC
AGATAAGTAGCAGTTCAACTGGATGTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAA
AGACTTCAAATAACACTTACTTGTGCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCT
CACCAACAAGTACTCCAAAACTAAGTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGT
ACGCACGATCTGGTCTGGGAACAGCAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCG
AATGCTATAATCCACATACAGATCACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCC
AGCTCTATGTGGTAGGTGGATCAAATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTG
TTCCAGAATTGAGAACTAACCGTTGTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTC
AAAAAGGACTGAAAAATTGTGATGTATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTG
CAGTCTGTGAGCTTGGTGGTTATTTGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAA
ATAATACCTGGACTTTAATTGCACCCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTG
GCTTTGATGGTTCTCATGCCATCAGTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAA
GGAGCAATGCTGGGATTGCAACTGTAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCT
ATAACCTTGAGTCAAATGAATGGAGCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGA
TGTAATTATGGTTAGTAGAGGTACACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATT
GCATACTATTAAACATGCTGTACATACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTT
TGGTTATTTTACTTTTTGGAAAAGAATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCC
AATTTGCACATTAAATGACTCTTCCCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAG
GGCCCTTTTTCAATAACTGGAACACTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAG
CTTACATGCCTACCAATATTTAATCTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAA
TGTGGCAGGCTGGAGTTATTGAAGCAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGA
GTTCTTGCCTTGGCTGCAGTTTTTTTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGAT
TTTTGGTATTTGAAACACTGGTTTTAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGT
GTTTTATCTTCTATATAATTCCTGTTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTA
CATTAGGTTGTGAATGCAGGTTTTATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGT
GTCTAATGTGTAGTGCTACACACCTAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTT
TGCAGGAAATCCTTGCACCATGGGATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCA
GTAATGAGCTTAAGAAATTTGTGGAAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGA
AGATGAAGCACACAGGAACCTAATGGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAA
AATAATTAGGTATTTTCTCCAAATGTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAAT
CAGTTTGGTTGGTAACTCTGTAATTCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGA

>39742_39742_2_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000339121_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=524AA_BP=101
MDPLVPSALRAAMLYLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADE
KVQLANQIYDLVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTS
NNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECY
NPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKG
LKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD

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>39742_39742_3_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000431467_IVNS1ABP_chr1_185274775_ENST00000367498_length(transcript)=3206nt_BP=287nt
GTATTTCGCCGTTGGCCCCGCCCCTCTGACGGACTCTCCCTTTGACAGTGATTGAGCAGCTTCCTATGGATCTGCGGGACCGCTTCACGG
AAATGCGCGAGATGGACCTGCAGGTGCAGAATGCAATGGATCAACTAGAACAAAGAGTCAGTGAATTCTTTATGAATGCAAAGAAAAATA
AACCTGAGTGGAGGGAAGAGCAAATGGCATCCATCAAAAAAGACTACTATAAAGCTTTGGAAGATGCAGATGAGAAGGTTCAGTTGGCAA
ACCAGATATATGACTTGGTTCAAACCTTGTACTACTCAGCTGATCACAAGCTGCTTGATGGGAACCTACTAGATGGACAGGCTGAGGTGT
TTGGCAGTGATGATGACCACATTCAGTTTGTGCAGAAAAAGCCACCACGTGAGAATGGCCATAAGCAGATAAGTAGCAGTTCAACTGGAT
GTCTCTCTTCTCCAAATGCTACAGTACAAAGCCCTAAGCATGAGTGGAAAATCGTTGCTTCAGAAAAGACTTCAAATAACACTTACTTGT
GCCTGGCTGTGCTGGATGGTATATTCTGTGTCATTTTTCTTCATGGGAGAAACAGCCCACAGAGCTCACCAACAAGTACTCCAAAACTAA
GTAAGAGTTTAAGCTTTGAGATGCAACAAGATGAGCTAATCGAAAAGCCCATGTCTCCTATGCAGTACGCACGATCTGGTCTGGGAACAG
CAGAGATGAATGGCAAACTCATAGCTGCAGGTGGCTATAACAGAGAGGAATGTCTTCGAACAGTCGAATGCTATAATCCACATACAGATC
ACTGGTCCTTTCTTGCTCCCATGAGAACACCAAGAGCCCGATTTCAAATGGCTGTACTCATGGGCCAGCTCTATGTGGTAGGTGGATCAA
ATGGCCACTCAGATGACCTGAGTTGTGGAGAGATGTATGATTCAAACATAGATGACTGGATTCCTGTTCCAGAATTGAGAACTAACCGTT
GTAATGCAGGAGTGTGTGCTCTGAATGGAAAGTTATACATCGTTGGTGGCTCTGATCCATATGGTCAAAAAGGACTGAAAAATTGTGATG
TATTTGATCCTGTAACAAAGTTGTGGACAAGCTGTGCCCCTCTTAACATTCGGAGACACCAGTCTGCAGTCTGTGAGCTTGGTGGTTATT
TGTACATAATCGGAGGTGCAGAATCTTGGAATTGTCTGAACACAGTAGAACGATACAATCCTGAAAATAATACCTGGACTTTAATTGCAC
CCATGAATGTGGCTAGGCGAGGAGCTGGAGTGGCTGTTCTTAATGGAAAACTGTTTGTATGTGGTGGCTTTGATGGTTCTCATGCCATCA
GTTGTGTGGAAATGTATGATCCAACTAGAAATGAATGGAAGATGATGGGAAATATGACTTCACCAAGGAGCAATGCTGGGATTGCAACTG
TAGGGAACACCATTTATGCAGTGGGAGGATTCGATGGCAATGAATTTCTGAATACGGTGGAAGTCTATAACCTTGAGTCAAATGAATGGA
GCCCCTATACAAAGATTTTCCAGTTTTAACAAATTTAAGACCCTCTCAAACTAACAGGCTTAGTGATGTAATTATGGTTAGTAGAGGTAC
ACTTGTGAATAAAGAGGGTGGGTGGGTATAGATGTTGCTAACAGCAACACAAAGCTTTTGCATATTGCATACTATTAAACATGCTGTACA
TACTTTTTGGGTTTATTTGGAAAGGAATGCAAAGATGAAGGTCTGTTTTGTGTACTTTTAAGACTTTGGTTATTTTACTTTTTGGAAAAG
AATAAACCAAGAATTGATTGGGCACATCATTTCAAGAAGTCCCCTCTCCTCCACATTTGTTTTGCCAATTTGCACATTAAATGACTCTTC
CCTCAAATGTGTACTATGGGGTAAAAGGGGTAGGGTTTAAAGATGTAGACAGTTGGGTTTTTTAAGGGCCCTTTTTCAATAACTGGAACA
CTCTATAACAAAGGATACTTATTTAAATAGATGACATTGACTATTTTTGTTTTTATTAAAAGGAAGCTTACATGCCTACCAATATTTAAT
CTTTTATGATTGCCTTTTTATAACTTTTTATATTCTCAGCAGAGTGCTTTACCAATTGAAGTAAAATGTGGCAGGCTGGAGTTATTGAAG
CAGAGTGGCAGTCTTCAGTTTGCAGAGTAGGGGTCTGTCTTTTAAACTCTGAGTGCAAACTTCAGAGTTCTTGCCTTGGCTGCAGTTTTT
TTCCTTCAAGAATGCAGTACTAACATTTATTTGAGTGGAGTTACTGAACAGTAACATAGCTGTGATTTTTGGTATTTGAAACACTGGTTT
TAAATATTTTGACTTGTTGAGGGTATGTTTTATATAGCAAGACATTATATAGCAGTAAAAAATGGTGTTTTATCTTCTATATAATTCCTG
TTTTTATTATTAACAAAACAGTCCTAAATAGCAGCCCTCAATTGTGAAAAAATTTACTTTAAACTACATTAGGTTGTGAATGCAGGTTTT
ATCAGAACTATGTTTTTGTTCAGTTTATCTGTTCATATGGATAAATATTGGTTGGGATGACTTGGTGTCTAATGTGTAGTGCTACACACC
TAACTTATGGGGCCAAAATAGCATGTCCTAATGCTTGCTGCTGATTTAAACACATTAAAGGTACTTTGCAGGAAATCCTTGCACCATGGG
ATTAATATCCAATTGCTGCTTGTACACTCATTCATTACTAAAAGTTTTGAGAAATTTTTTTTTCCAGTAATGAGCTTAAGAAATTTGTGG
AAAATAACTCACCTGGCATCTTACATCTGAAATAAGGAATGATATAAGGTTTTTTTTTCTCACAGAAGATGAAGCACACAGGAACCTAAT
GGGCCAACTGGGATGAGGTGACTATTCTGAGATGACTATTCAGTGGCTAACTTGGGTTAGGAAGAAAATAATTAGGTATTTTCTCCAAAT
GTTCACTGGTACTCTGCCACTTTATTTCTCTCATCTGTTACACAAAGAACCACCAGGAAAGCAAATCAGTTTGGTTGGTAACTCTGTAAT
TCCTAACTATCACTGGTTTGGTTCTGGACTAAAACTACATTGACAGATTGAATTTGCCTAATATGATGACTGTTTTTAATATGGATCTGT

>39742_39742_3_ING3-IVNS1ABP_ING3_chr7_120595678_ENST00000431467_IVNS1ABP_chr1_185274775_ENST00000367498_length(amino acids)=505AA_BP=82
MTVIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKKDYYKALEDADEKVQLANQIYDLVQTLYYSA
DHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFL
HGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRAR
FQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAP
LNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWK

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Fusion Gene PPI Analysis for ING3-IVNS1ABP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ING3-IVNS1ABP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ING3-IVNS1ABP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource