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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ING4-A2ML1 (FusionGDB2 ID:39745)

Fusion Gene Summary for ING4-A2ML1

check button Fusion gene summary
Fusion gene informationFusion gene name: ING4-A2ML1
Fusion gene ID: 39745
HgeneTgene
Gene symbol

ING4

A2ML1

Gene ID

51147

144568

Gene nameinhibitor of growth family member 4alpha-2-macroglobulin like 1
Synonymsmy036|p29ING4CPAMD9|OMS|p170
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
Descriptioninhibitor of growth protein 4brain my036 proteincandidate tumor suppressor p33 ING1 homologalpha-2-macroglobulin-like protein 1C3 and PZP-like, alpha-2-macroglobulin domain containing 9
Modification date2020032220200313
UniProtAcc

Q9UNL4

A8K2U0

Ensembl transtripts involved in fusion geneENST00000341550, ENST00000396807, 
ENST00000412586, ENST00000423703, 
ENST00000444704, ENST00000446105, 
ENST00000486287, 		ENST00000540049, 
ENST00000299698, ENST00000539547, 
Fusion gene scores* DoF score3 X 3 X 3=277 X 6 X 4=168
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ING4 [Title/Abstract] AND A2ML1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointING4(6772231)-A2ML1(9027021), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneING4

GO:0006260

DNA replication

16387653

HgeneING4

GO:0006473

protein acetylation

12750254

HgeneING4

GO:0006915

apoptotic process

15251430

HgeneING4

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

16387653

HgeneING4

GO:0007050

cell cycle arrest

15251430

HgeneING4

GO:0008285

negative regulation of cell proliferation

12750254|15251430

HgeneING4

GO:0043065

positive regulation of apoptotic process

16387653

HgeneING4

GO:0043966

histone H3 acetylation

16387653

HgeneING4

GO:0043981

histone H4-K5 acetylation

16387653

HgeneING4

GO:0043982

histone H4-K8 acetylation

16387653

HgeneING4

GO:0043983

histone H4-K12 acetylation

16387653

HgeneING4

GO:0043984

histone H4-K16 acetylation

16387653

HgeneING4

GO:0045892

negative regulation of transcription, DNA-templated

15029197

HgeneING4

GO:0045926

negative regulation of growth

12750254

TgeneA2ML1

GO:0052548

regulation of endopeptidase activity

16298998


check buttonFusion gene breakpoints across ING4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across A2ML1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3CC-06AING4chr12

6772231

-A2ML1chr12

9027021

+


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Fusion Gene ORF analysis for ING4-A2ML1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000341550ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
5CDS-intronENST00000396807ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
5CDS-intronENST00000412586ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
5CDS-intronENST00000423703ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
5CDS-intronENST00000444704ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
5CDS-intronENST00000446105ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000341550ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000341550ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000396807ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000396807ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000412586ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000412586ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000423703ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000423703ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000444704ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000444704ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000446105ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
In-frameENST00000446105ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
intron-3CDSENST00000486287ENST00000299698ING4chr12

6772231

-A2ML1chr12

9027021

+
intron-3CDSENST00000486287ENST00000539547ING4chr12

6772231

-A2ML1chr12

9027021

+
intron-intronENST00000486287ENST00000540049ING4chr12

6772231

-A2ML1chr12

9027021

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341550ING4chr126772231-ENST00000299698A2ML1chr129027021+9578478649696
ENST00000341550ING4chr126772231-ENST00000539547A2ML1chr129027021+628842722766
ENST00000396807ING4chr126772231-ENST00000299698A2ML1chr129027021+9497677848896
ENST00000396807ING4chr126772231-ENST00000539547A2ML1chr129027021+620761921966
ENST00000446105ING4chr126772231-ENST00000299698A2ML1chr129027021+9517878049096
ENST00000446105ING4chr126772231-ENST00000539547A2ML1chr129027021+622782122166
ENST00000444704ING4chr126772231-ENST00000299698A2ML1chr129027021+9103773944996
ENST00000444704ING4chr126772231-ENST00000539547A2ML1chr129027021+58137418058
ENST00000423703ING4chr126772231-ENST00000299698A2ML1chr129027021+9103773944996
ENST00000423703ING4chr126772231-ENST00000539547A2ML1chr129027021+58137418058
ENST00000412586ING4chr126772231-ENST00000299698A2ML1chr129027021+9103773944996
ENST00000412586ING4chr126772231-ENST00000539547A2ML1chr129027021+58137418058

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341550ENST00000299698ING4chr126772231-A2ML1chr129027021+0.925113860.07488609
ENST00000341550ENST00000539547ING4chr126772231-A2ML1chr129027021+0.326354440.67364556
ENST00000396807ENST00000299698ING4chr126772231-A2ML1chr129027021+0.891014930.108985096
ENST00000396807ENST00000539547ING4chr126772231-A2ML1chr129027021+0.218175140.7818249
ENST00000446105ENST00000299698ING4chr126772231-A2ML1chr129027021+0.90723650.09276349
ENST00000446105ENST00000539547ING4chr126772231-A2ML1chr129027021+0.242142470.7578575
ENST00000444704ENST00000299698ING4chr126772231-A2ML1chr129027021+0.850879970.14912003
ENST00000444704ENST00000539547ING4chr126772231-A2ML1chr129027021+0.136172560.8638274
ENST00000423703ENST00000299698ING4chr126772231-A2ML1chr129027021+0.850879970.14912003
ENST00000423703ENST00000539547ING4chr126772231-A2ML1chr129027021+0.136172560.8638274
ENST00000412586ENST00000299698ING4chr126772231-A2ML1chr129027021+0.850879970.14912003
ENST00000412586ENST00000539547ING4chr126772231-A2ML1chr129027021+0.136172560.8638274

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Fusion Genomic Features for ING4-A2ML1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ING4chr126772230-A2ML1chr129027020+3.80E-070.99999964
ING4chr126772230-A2ML1chr129027020+3.80E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ING4-A2ML1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:6772231/chr12:9027021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ING4

Q9UNL4

A2ML1

A8K2U0

FUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:16387653). May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276). Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197). May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197). Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). {ECO:0000250|UniProtKB:Q8C0D7, ECO:0000269|PubMed:15029197, ECO:0000269|PubMed:15251430, ECO:0000269|PubMed:15528276, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:16387653}.FUNCTION: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. {ECO:0000250|UniProtKB:P01023, ECO:0000269|PubMed:16298998}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneING4chr12:6772231chr12:9027021ENST00000341550-1825_11812249.0Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000396807-1825_11812250.0Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000412586-1825_11812247.0Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000423703-1725_11812177.66666666666666Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000444704-1725_11812226.0Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000446105-1825_11812246.0Coiled coilOntology_term=ECO:0000269
HgeneING4chr12:6772231chr12:9027021ENST00000341550-18127_14812249.0MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000396807-18127_14812250.0MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000412586-18127_14812247.0MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000423703-17127_14812177.66666666666666MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000444704-17127_14812226.0MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000446105-18127_14812246.0MotifNote=Bipartite nuclear localization signal
HgeneING4chr12:6772231chr12:9027021ENST00000341550-18196_24512249.0Zinc fingerPHD-type
HgeneING4chr12:6772231chr12:9027021ENST00000396807-18196_24512250.0Zinc fingerPHD-type
HgeneING4chr12:6772231chr12:9027021ENST00000412586-18196_24512247.0Zinc fingerPHD-type
HgeneING4chr12:6772231chr12:9027021ENST00000423703-17196_24512177.66666666666666Zinc fingerPHD-type
HgeneING4chr12:6772231chr12:9027021ENST00000444704-17196_24512226.0Zinc fingerPHD-type
HgeneING4chr12:6772231chr12:9027021ENST00000446105-18196_24512246.0Zinc fingerPHD-type
TgeneA2ML1chr12:6772231chr12:9027021ENST000002996983236695_72614071617.0RegionBait region


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Fusion Gene Sequence for ING4-A2ML1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>39745_39745_1_ING4-A2ML1_ING4_chr12_6772231_ENST00000341550_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=957nt_BP=84nt
ACAGTCACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATT
AAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTAC
CTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTAC
TGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGA
ATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCA
GGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTA
GAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTG
AGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCC
TGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCA
CTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGA

>39745_39745_1_ING4-A2ML1_ING4_chr12_6772231_ENST00000341550_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_2_ING4-A2ML1_ING4_chr12_6772231_ENST00000341550_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=628nt_BP=84nt
ACAGTCACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATT
AAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTAC
CTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTAC
TGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGA
ATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCA
GGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTA

>39745_39745_2_ING4-A2ML1_ING4_chr12_6772231_ENST00000341550_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=66AA_BP=19

--------------------------------------------------------------
>39745_39745_3_ING4-A2ML1_ING4_chr12_6772231_ENST00000396807_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=949nt_BP=76nt
TTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACAC
TCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGA
TGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGT
GGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCT
GAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATA
GGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGAT
AAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGG
AGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCG
CAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCC
TGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGA

>39745_39745_3_ING4-A2ML1_ING4_chr12_6772231_ENST00000396807_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_4_ING4-A2ML1_ING4_chr12_6772231_ENST00000396807_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=620nt_BP=76nt
TTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACAC
TCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGA
TGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGT
GGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCT
GAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATA
GGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGAT

>39745_39745_4_ING4-A2ML1_ING4_chr12_6772231_ENST00000396807_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=66AA_BP=19

--------------------------------------------------------------
>39745_39745_5_ING4-A2ML1_ING4_chr12_6772231_ENST00000412586_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=910nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT
CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC
ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA
TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA

>39745_39745_5_ING4-A2ML1_ING4_chr12_6772231_ENST00000412586_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_6_ING4-A2ML1_ING4_chr12_6772231_ENST00000412586_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=581nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT

>39745_39745_6_ING4-A2ML1_ING4_chr12_6772231_ENST00000412586_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=58AA_BP=11

--------------------------------------------------------------
>39745_39745_7_ING4-A2ML1_ING4_chr12_6772231_ENST00000423703_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=910nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT
CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC
ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA
TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA

>39745_39745_7_ING4-A2ML1_ING4_chr12_6772231_ENST00000423703_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_8_ING4-A2ML1_ING4_chr12_6772231_ENST00000423703_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=581nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT

>39745_39745_8_ING4-A2ML1_ING4_chr12_6772231_ENST00000423703_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=58AA_BP=11

--------------------------------------------------------------
>39745_39745_9_ING4-A2ML1_ING4_chr12_6772231_ENST00000444704_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=910nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT
GTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCT
CTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAATCGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAAC
ACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAA
TAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGTGATTTAGGGCTTTGGAAATTGGCTAAAAAAATAAAAATGGA

>39745_39745_9_ING4-A2ML1_ING4_chr12_6772231_ENST00000444704_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_10_ING4-A2ML1_ING4_chr12_6772231_ENST00000444704_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=581nt_BP=37nt
ATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAACACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGT
CACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCAGATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATG
AGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGGGTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAAT
CAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGTCTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGA
GATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCATAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATT
CAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAGATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCT

>39745_39745_10_ING4-A2ML1_ING4_chr12_6772231_ENST00000444704_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=58AA_BP=11

--------------------------------------------------------------
>39745_39745_11_ING4-A2ML1_ING4_chr12_6772231_ENST00000446105_A2ML1_chr12_9027021_ENST00000299698_length(transcript)=951nt_BP=78nt
ACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAAC
ACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCA
GATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGG
GTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGT
CTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCA
TAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAG
ATAAGAATGTCTTCCTAGGCCGGATGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGATTGCGAGGTGGGCGGATCACTTGAGGTCA
GGAGTTCAAGACCAGCCTGGCCAACATGGTAAAACCCGTCTCTACTAACAATACAAAGATTAGCCTGGTGTGGTGGCACGGGCCTGTAAT
CGCAGCCCCTTGGAAGGCCAAGGCAGGAGAATCGCCTCAACACTGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAG
CCTGGGCAATGAGGCAAGACCCTGTCTCAAAAAATAATAAATAATAATAATAATAATGTTTTTCTAGAGTTTCAGTCTAAGGGAAAATGT

>39745_39745_11_ING4-A2ML1_ING4_chr12_6772231_ENST00000446105_A2ML1_chr12_9027021_ENST00000299698_length(amino acids)=96AA_BP=
MQPPPPVLRRFSCLGLPRGCDYRPVPPHQANLCIVSRDGFYHVGQAGLELLTSSDPPTSQSQSAGITGVSHRIRPRKTFLSSLVHPLPPS

--------------------------------------------------------------
>39745_39745_12_ING4-A2ML1_ING4_chr12_6772231_ENST00000446105_A2ML1_chr12_9027021_ENST00000539547_length(transcript)=622nt_BP=78nt
ACTTCCGGGGCGGATCGGAAGTTGCTTTGTTTTGCTTCGAGATGGCTGCGGGGATGTATTTGGAACATTATCTGGACACTCATTAAGAAC
ACTCAGACTTACACCTTCACCATCAGCCAAAGTGTGCTGGTCACCAACTTGAAACCAGCAACCATCAAGGTCTATGACTACTACCTACCA
GATGAACAGGCAACAATTCAGTATTCTGATCCCTGTGAATGAGGATAGGAGCTGGAAACTCAATTAGTCCTCTGTGACATTTACTGGAGG
GTGGAACATTCTTCTGTCGCTTGAAGCAGAACTCATTCAATCAAATAATTTAATTTCTCTGACTAGTATATGGGTAACAAATGAATATGT
CTGAACCTCAGCTATAATACTTTCTACTACCTTTGCAAGGAGATGGGATAGGAACAATCACTCAGAGGAGGCGTTGCATGGGCAGGGTCA
TAGGGGGAAGAAAGGTGGTTTAGCTGTTTTATTTAGCCATTCAGGGGGCTCTCCAGAGAGGAGACGGTGGTAGAGGGTGAACTAGAGAAG

>39745_39745_12_ING4-A2ML1_ING4_chr12_6772231_ENST00000446105_A2ML1_chr12_9027021_ENST00000539547_length(amino acids)=66AA_BP=19

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ING4-A2ML1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ING4-A2ML1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ING4-A2ML1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource