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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:INPP5A-ACTN1 (FusionGDB2 ID:39797) |
Fusion Gene Summary for INPP5A-ACTN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: INPP5A-ACTN1 | Fusion gene ID: 39797 | Hgene | Tgene | Gene symbol | INPP5A | ACTN1 | Gene ID | 3632 | 87 |
| Gene name | inositol polyphosphate-5-phosphatase A | actinin alpha 1 | |
| Synonyms | 5PTASE | BDPLT15 | |
| Cytomap | 10q26.3 | 14q24.1|14q22-q24 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inositol polyphosphate-5-phosphatase A43 kDa inositol polyphosphate 5-phophatase43 kDa inositol polyphosphate 5-phosphataseCTCL tumor antigen HD-CL-02InsP3 5-phosphataseinositol polyphosphate-5-phosphatase, 40kDinositol polyphosphate-5-phosphatase, | alpha-actinin-1F-actin cross-linking proteinactinin 1 smooth musclealpha-actinin cytoskeletal isoformepididymis secretory sperm binding proteinnon-muscle alpha-actinin-1 | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | Q14642 | P12814 | |
| Ensembl transtripts involved in fusion gene | ENST00000368593, ENST00000368594, ENST00000487614, | ENST00000376839, ENST00000538545, ENST00000554508, ENST00000193403, ENST00000394419, ENST00000438964, | |
| Fusion gene scores | * DoF score | 21 X 9 X 11=2079 | 17 X 18 X 5=1530 |
| # samples | 21 | 20 | |
| ** MAII score | log2(21/2079*10)=-3.30742852519225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(20/1530*10)=-2.93545974780529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: INPP5A [Title/Abstract] AND ACTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | INPP5A(134464009)-ACTN1(69392389), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | INPP5A | GO:0046855 | inositol phosphate dephosphorylation | 8006039 |
| Fusion gene breakpoints across INPP5A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ACTN1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-BR-A4J9-01A | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
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Fusion Gene ORF analysis for INPP5A-ACTN1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000368593 | ENST00000376839 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| 5CDS-5UTR | ENST00000368593 | ENST00000538545 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| 5CDS-5UTR | ENST00000368594 | ENST00000376839 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| 5CDS-5UTR | ENST00000368594 | ENST00000538545 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| 5CDS-intron | ENST00000368593 | ENST00000554508 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| 5CDS-intron | ENST00000368594 | ENST00000554508 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368593 | ENST00000193403 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368593 | ENST00000394419 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368593 | ENST00000438964 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368594 | ENST00000193403 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368594 | ENST00000394419 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| In-frame | ENST00000368594 | ENST00000438964 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-3CDS | ENST00000487614 | ENST00000193403 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-3CDS | ENST00000487614 | ENST00000394419 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-3CDS | ENST00000487614 | ENST00000438964 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-5UTR | ENST00000487614 | ENST00000376839 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-5UTR | ENST00000487614 | ENST00000538545 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| intron-intron | ENST00000487614 | ENST00000554508 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368594 | INPP5A | chr10 | 134464009 | + | ENST00000193403 | ACTN1 | chr14 | 69392389 | - | 3873 | 583 | 277 | 3156 | 959 |
| ENST00000368594 | INPP5A | chr10 | 134464009 | + | ENST00000394419 | ACTN1 | chr14 | 69392389 | - | 3759 | 583 | 277 | 3222 | 981 |
| ENST00000368594 | INPP5A | chr10 | 134464009 | + | ENST00000438964 | ACTN1 | chr14 | 69392389 | - | 3315 | 583 | 277 | 3141 | 954 |
| ENST00000368593 | INPP5A | chr10 | 134464009 | + | ENST00000193403 | ACTN1 | chr14 | 69392389 | - | 3844 | 554 | 248 | 3127 | 959 |
| ENST00000368593 | INPP5A | chr10 | 134464009 | + | ENST00000394419 | ACTN1 | chr14 | 69392389 | - | 3730 | 554 | 248 | 3193 | 981 |
| ENST00000368593 | INPP5A | chr10 | 134464009 | + | ENST00000438964 | ACTN1 | chr14 | 69392389 | - | 3286 | 554 | 248 | 3112 | 954 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000368594 | ENST00000193403 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.003300753 | 0.9966993 |
| ENST00000368594 | ENST00000394419 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.003961928 | 0.9960381 |
| ENST00000368594 | ENST00000438964 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.007581681 | 0.9924183 |
| ENST00000368593 | ENST00000193403 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.003287252 | 0.9967128 |
| ENST00000368593 | ENST00000394419 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.003853357 | 0.9961467 |
| ENST00000368593 | ENST00000438964 | INPP5A | chr10 | 134464009 | + | ACTN1 | chr14 | 69392389 | - | 0.00755075 | 0.9924493 |
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Fusion Genomic Features for INPP5A-ACTN1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for INPP5A-ACTN1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:134464009/chr14:69392389) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| INPP5A | ACTN1 |
| FUNCTION: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8769125, PubMed:8626616). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q7TNC9, ECO:0000269|PubMed:8013665, ECO:0000269|PubMed:8626616, ECO:0000269|PubMed:8769125}. | FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 759_770 | 35 | 893.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 800_811 | 35 | 893.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 759_770 | 35 | 915.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 800_811 | 35 | 915.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 759_770 | 35 | 888.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 800_811 | 35 | 888.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 759_770 | 35 | 931.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 800_811 | 35 | 931.0 | Calcium binding | Ontology_term=ECO:0000255 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 144_250 | 35 | 893.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 746_781 | 35 | 893.0 | Domain | EF-hand 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 787_822 | 35 | 893.0 | Domain | EF-hand 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 144_250 | 35 | 915.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 746_781 | 35 | 915.0 | Domain | EF-hand 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 787_822 | 35 | 915.0 | Domain | EF-hand 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 144_250 | 35 | 888.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 746_781 | 35 | 888.0 | Domain | EF-hand 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 787_822 | 35 | 888.0 | Domain | EF-hand 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 144_250 | 35 | 931.0 | Domain | Calponin-homology (CH) 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 746_781 | 35 | 931.0 | Domain | EF-hand 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 787_822 | 35 | 931.0 | Domain | EF-hand 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 274_384 | 35 | 893.0 | Repeat | Note=Spectrin 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 394_499 | 35 | 893.0 | Repeat | Note=Spectrin 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 509_620 | 35 | 893.0 | Repeat | Note=Spectrin 3 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 630_733 | 35 | 893.0 | Repeat | Note=Spectrin 4 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 274_384 | 35 | 915.0 | Repeat | Note=Spectrin 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 394_499 | 35 | 915.0 | Repeat | Note=Spectrin 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 509_620 | 35 | 915.0 | Repeat | Note=Spectrin 3 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 630_733 | 35 | 915.0 | Repeat | Note=Spectrin 4 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 274_384 | 35 | 888.0 | Repeat | Note=Spectrin 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 394_499 | 35 | 888.0 | Repeat | Note=Spectrin 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 509_620 | 35 | 888.0 | Repeat | Note=Spectrin 3 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 630_733 | 35 | 888.0 | Repeat | Note=Spectrin 4 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 274_384 | 35 | 931.0 | Repeat | Note=Spectrin 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 394_499 | 35 | 931.0 | Repeat | Note=Spectrin 2 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 509_620 | 35 | 931.0 | Repeat | Note=Spectrin 3 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 630_733 | 35 | 931.0 | Repeat | Note=Spectrin 4 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 31_135 | 35 | 893.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 31_135 | 35 | 915.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 31_135 | 35 | 888.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 31_135 | 35 | 931.0 | Domain | Calponin-homology (CH) 1 | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 1_247 | 35 | 893.0 | Region | Note=Actin-binding | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 1_247 | 35 | 915.0 | Region | Note=Actin-binding | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 1_247 | 35 | 888.0 | Region | Note=Actin-binding | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 1_247 | 35 | 931.0 | Region | Note=Actin-binding |
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Fusion Gene Sequence for INPP5A-ACTN1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >39797_39797_1_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000193403_length(transcript)=3844nt_BP=554nt GCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCGAGCGAGCGAGCGCGAGGCCGGAGCCCCGG CCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTGACGCCCCGCGGCCCCGCGAAGACCCCGGC CGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCCGGGCACCATGGCGGGGAAGGCGGCCGCCC CGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAGAAGAACTGGCTTCGGGAATTTT ACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAACTACGAGGCCTCCATGTCCCACG TGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTACCTGGATGAAAACTACAAATCCC AGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGAACATCGAAGAGGACTTCCGGG ATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCAAGATGAGAGTGCACAAGATCT CCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAGAAATCGTGGATGGGAATGTGA AGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGTGGAAGAGACTTCAGCCAAGGAAGGGCTGC TCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACATAAGCTGGAAGGATGGCCTCGGCTTCTGTG CTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCCACTCACAAATCTGAATACGGCTTTTGACG TGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGCCCGACCGGATGAGAAAGCCATCATGACTT ACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCGCATCTGCAAGGTGTTGGCCGTCAACCAGG AGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCGCCGCACAATCCCGTGGCTGGAGAACCGGG TGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCGCCTGCACAAGCCGCCCAAGGTGCAGGAGA AGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCCTGCCTTCATGCCCTCTGAGGGCAGGATGG TCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTGGTTGCTGAATGAGATCCGGAGGCTGGAGC GACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGACGGCAAAGAGGCCATGCTGCGACAGAAGG ACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGAGAGTGACCTGGCTGCCCACCAGGACCGTG TGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAGTGTCAACGCCCGTTGCCAAAAGATCTGTG ACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGAGAAACTGCTGGAGACCATTGACCAGCTGT ACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGACCTGCAGGACACCTTCATTGTGCACACCA TTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGCCGACAAGGAGCGCCTGGCCATCCTGGGCA TCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCCCTACACAACCATCACGCCTCAGGAGATCA ATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGAGCATGCCCGACAGCAGCACAATGAGAGGC TACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGAGGATCTCCATTGAGATGC ATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTACAAGCCAAAGATTGATCAGCTGGAGGGCG ACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGAGCACATCCGTGTGGGCTGGGAGCAGCTGC TCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAAGGGCATCAGCCAGGAGCAGATGAATGAGT TCCGGGCCTCCTTCAACCACTTTGACCGGGATCACTCCGGCACACTGGGTCCCGAGGAGTTCAAAGCCTGCCTCATCAGCTTGGGTTATG ATATTGGCAACGACCCCCAGGGAGAAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCCCAACCGCCTGGGGGTAGTGACATTCCAGG CCTTCATTGACTTCATGTCCCGCGAGACAGCCGACACAGATACAGCAGACCAAGTCATGGCTTCCTTCAAGATCCTGGCTGGGGACAAGA ACTACATTACCATGGACGAGCTGCGCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCATCGCGCGGATGGCCCCCTACACCGGCCCCG ACTCCGTGCCAGGTGCTCTGGACTACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGACCTCTAATCCACCCCGCCCGGCCGCCCTC GTCTTGTGCGCCGTGCCCTGCCTTGCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGGTTTCAGCTCCCAGCCTCCACCCGGGTGAG CTGGGGCCCACGTGGCATCGATCCTCCCTGCCCGCGAAGTGACAGTTTACAAAATTATTTTCTGCAAAAAAGAAAAAAAAGTTACGTTAA AAACCAAAAAACTACATATTTTATTATAGAAAAAGTATTTTTTCTCCACCAGACAAATGGAAAAAAAGAGGAAAGATTAACTATTTGCAC CGAAATGTCTTGTTTTGTTGCGACATAGGAAAATAACCAAGCACAAAGTTATATTCCATCCTTTTTACTGATTTTTTTTTCTTCTATCTG TTCCATCTGCTGTATTCATTTCTCCAATCTCATGTCCATTTTGGTGTGGGAGTCGGGGTAGGGGGTACTCTTGTCAAAAGGCACATTGGT GCATGTGTGTTTGCTAGCTCACTTGTCCATGAAAATATTTTATGATATTAAAGAAAATCTTTTGAAATGGCTGTTTTTTAAGGAAGAGAA TTTATGTGGCTTCTCATTTTTAAATCCCCTCAGAGGTGTGACTAGTCTCTTTATCAGCACACACTTAAAAAATTTTTAATATTGTCTATT >39797_39797_1_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=959AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASF -------------------------------------------------------------- >39797_39797_2_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000394419_length(transcript)=3730nt_BP=554nt GCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCGAGCGAGCGAGCGCGAGGCCGGAGCCCCGG CCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTGACGCCCCGCGGCCCCGCGAAGACCCCGGC CGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCCGGGCACCATGGCGGGGAAGGCGGCCGCCC CGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAGAAGAACTGGCTTCGGGAATTTT ACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAACTACGAGGCCTCCATGTCCCACG TGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTACCTGGATGAAAACTACAAATCCC AGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGAACATCGAAGAGGACTTCCGGG ATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCAAGATGAGAGTGCACAAGATCT CCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAGAAATCGTGGATGGGAATGTGA AGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGTGGAAGAGACTTCAGCCAAGGAAGGGCTGC TCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACATAAGCTGGAAGGATGGCCTCGGCTTCTGTG CTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCCACTCACAAATCTGAATACGGCTTTTGACG TGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGCCCGACCGGATGAGAAAGCCATCATGACTT ACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCGCATCTGCAAGGTGTTGGCCGTCAACCAGG AGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCGCCGCACAATCCCGTGGCTGGAGAACCGGG TGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCGCCTGCACAAGCCGCCCAAGGTGCAGGAGA AGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCCTGCCTTCATGCCCTCTGAGGGCAGGATGG TCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTGGTTGCTGAATGAGATCCGGAGGCTGGAGC GACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGACGGCAAAGAGGCCATGCTGCGACAGAAGG ACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGAGAGTGACCTGGCTGCCCACCAGGACCGTG TGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAGTGTCAACGCCCGTTGCCAAAAGATCTGTG ACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGAGAAACTGCTGGAGACCATTGACCAGCTGT ACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGACCTGCAGGACACCTTCATTGTGCACACCA TTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGCCGACAAGGAGCGCCTGGCCATCCTGGGCA TCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCCCTACACAACCATCACGCCTCAGGAGATCA ATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGAGCATGCCCGACAGCAGCACAATGAGAGGC TACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGAGGATCTCCATTGAGATGC ATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTACAAGCCAAAGATTGATCAGCTGGAGGGCG ACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGAGCACATCCGTGTGGGCTGGGAGCAGCTGC TCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAAGGGCATCAGCCAGGAGCAGATGAATGAGT TCCGGGCCTCCTTCAACCACTTTGACCGGGATCACTCCGGCACACTGGGTCCCGAGGAGTTCAAAGCCTGCCTCATCAGCTTGGGTTATG ATATTGGCAACGACCCCCAGAAGAAGACAGGCATGATGGACACGGATGATTTCCGCGCCTGCCTGATCTCCATGGGTTACAACATGGGAG AAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCCCAACCGCCTGGGGGTAGTGACATTCCAGGCCTTCATTGACTTCATGTCCCGCG AGACAGCCGACACAGATACAGCAGACCAAGTCATGGCTTCCTTCAAGATCCTGGCTGGGGACAAGAACTACATTACCATGGACGAGCTGC GCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCATCGCGCGGATGGCCCCCTACACCGGCCCCGACTCCGTGCCAGGTGCTCTGGACT ACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGACCTCTAATCCACCCCGCCCGGCCGCCCTCGTCTTGTGCGCCGTGCCCTGCCTT GCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGGTTTCAGCTCCCAGCCTCCACCCGGGTGAGCTGGGGCCCACGTGGCATCGATCC TCCCTGCCCGCGAAGTGACAGTTTACAAAATTATTTTCTGCAAAAAAGAAAAAAAAGTTACGTTAAAAACCAAAAAACTACATATTTTAT TATAGAAAAAGTATTTTTTCTCCACCAGACAAATGGAAAAAAAGAGGAAAGATTAACTATTTGCACCGAAATGTCTTGTTTTGTTGCGAC ATAGGAAAATAACCAAGCACAAAGTTATATTCCATCCTTTTTACTGATTTTTTTTTCTTCTATCTGTTCCATCTGCTGTATTCATTTCTC CAATCTCATGTCCATTTTGGTGTGGGAGTCGGGGTAGGGGGTACTCTTGTCAAAAGGCACATTGGTGCATGTGTGTTTGCTAGCTCACTT >39797_39797_2_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=981AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQA -------------------------------------------------------------- >39797_39797_3_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000438964_length(transcript)=3286nt_BP=554nt GCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCGAGCGAGCGAGCGCGAGGCCGGAGCCCCGG CCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTGACGCCCCGCGGCCCCGCGAAGACCCCGGC CGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCCGGGCACCATGGCGGGGAAGGCGGCCGCCC CGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAACCTGCAGAAGAACTGGCTTCGGGAATTTT ACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGGGAAGAACTACGAGGCCTCCATGTCCCACG TGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCGAGTCTACCTGGATGAAAACTACAAATCCC AGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACAGATCGAGAACATCGAAGAGGACTTCCGGG ATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGAGCGAGGCAAGATGAGAGTGCACAAGATCT CCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGGAGCCGAAGAAATCGTGGATGGGAATGTGA AGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGTGGAAGAGACTTCAGCCAAGGAAGGGCTGC TCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACATAAGCTGGAAGGATGGCCTCGGCTTCTGTG CTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCCACTCACAAATCTGAATACGGCTTTTGACG TGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGCCCGACCGGATGAGAAAGCCATCATGACTT ACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCGCATCTGCAAGGTGTTGGCCGTCAACCAGG AGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCGCCGCACAATCCCGTGGCTGGAGAACCGGG TGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCGCCTGCACAAGCCGCCCAAGGTGCAGGAGA AGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCCTGCCTTCATGCCCTCTGAGGGCAGGATGG TCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTGGTTGCTGAATGAGATCCGGAGGCTGGAGC GACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGACGGCAAAGAGGCCATGCTGCGACAGAAGG ACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGAGAGTGACCTGGCTGCCCACCAGGACCGTG TGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAGTGTCAACGCCCGTTGCCAAAAGATCTGTG ACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGAGAAACTGCTGGAGACCATTGACCAGCTGT ACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGACCTGCAGGACACCTTCATTGTGCACACCA TTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGCCGACAAGGAGCGCCTGGCCATCCTGGGCA TCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCCCTACACAACCATCACGCCTCAGGAGATCA ATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGAGCATGCCCGACAGCAGCACAATGAGAGGC TACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGAGGAGATCGGGAGGATCTCCATTGAGATGC ATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTACAAGCCAAAGATTGATCAGCTGGAGGGCG ACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGAGCACATCCGTGTGGGCTGGGAGCAGCTGC TCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAAGGGCATCAGCCAGGAGCAGATGAATGAGT TCCGGGCCTCCTTCAACCACTTTGACCGGAAGAAGACAGGCATGATGGACACGGATGATTTCCGCGCCTGCCTGATCTCCATGGGTTACA ACATGGGAGAAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCCCAACCGCCTGGGGGTAGTGACATTCCAGGCCTTCATTGACTTCA TGTCCCGCGAGACAGCCGACACAGATACAGCAGACCAAGTCATGGCTTCCTTCAAGATCCTGGCTGGGGACAAGAACTACATTACCATGG ACGAGCTGCGCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCATCGCGCGGATGGCCCCCTACACCGGCCCCGACTCCGTGCCAGGTG CTCTGGACTACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGACCTCTAATCCACCCCGCCCGGCCGCCCTCGTCTTGTGCGCCGTG CCCTGCCTTGCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGGTTTCAGCTCCCAGCCTCCACCCGGGTGAGCTGGGGCCCACGTGG >39797_39797_3_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368593_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=954AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAG -------------------------------------------------------------- >39797_39797_4_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000193403_length(transcript)=3873nt_BP=583nt GGAACTTTCCCAGCGGATCTAATGGCTGCGCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCG AGCGAGCGAGCGCGAGGCCGGAGCCCCGGCCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTG ACGCCCCGCGGCCCCGCGAAGACCCCGGCCGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCC GGGCACCATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAA CCTGCAGAAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGG GAAGAACTACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCG AGTCTACCTGGATGAAAACTACAAATCCCAGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACA GATCGAGAACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGA GCGAGGCAAGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGG AGCCGAAGAAATCGTGGATGGGAATGTGAAGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGT GGAAGAGACTTCAGCCAAGGAAGGGCTGCTCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACAT AAGCTGGAAGGATGGCCTCGGCTTCTGTGCTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCC ACTCACAAATCTGAATACGGCTTTTGACGTGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGC CCGACCGGATGAGAAAGCCATCATGACTTACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCG CATCTGCAAGGTGTTGGCCGTCAACCAGGAGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCG CCGCACAATCCCGTGGCTGGAGAACCGGGTGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCG CCTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCC TGCCTTCATGCCCTCTGAGGGCAGGATGGTCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTG GTTGCTGAATGAGATCCGGAGGCTGGAGCGACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGA CGGCAAAGAGGCCATGCTGCGACAGAAGGACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGA GAGTGACCTGGCTGCCCACCAGGACCGTGTGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAG TGTCAACGCCCGTTGCCAAAAGATCTGTGACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGA GAAACTGCTGGAGACCATTGACCAGCTGTACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGA CCTGCAGGACACCTTCATTGTGCACACCATTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGC CGACAAGGAGCGCCTGGCCATCCTGGGCATCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCC CTACACAACCATCACGCCTCAGGAGATCAATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGA GCATGCCCGACAGCAGCACAATGAGAGGCTACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGA GGAGATCGGGAGGATCTCCATTGAGATGCATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTA CAAGCCAAAGATTGATCAGCTGGAGGGCGACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGA GCACATCCGTGTGGGCTGGGAGCAGCTGCTCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAA GGGCATCAGCCAGGAGCAGATGAATGAGTTCCGGGCCTCCTTCAACCACTTTGACCGGGATCACTCCGGCACACTGGGTCCCGAGGAGTT CAAAGCCTGCCTCATCAGCTTGGGTTATGATATTGGCAACGACCCCCAGGGAGAAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCC CAACCGCCTGGGGGTAGTGACATTCCAGGCCTTCATTGACTTCATGTCCCGCGAGACAGCCGACACAGATACAGCAGACCAAGTCATGGC TTCCTTCAAGATCCTGGCTGGGGACAAGAACTACATTACCATGGACGAGCTGCGCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCAT CGCGCGGATGGCCCCCTACACCGGCCCCGACTCCGTGCCAGGTGCTCTGGACTACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGA CCTCTAATCCACCCCGCCCGGCCGCCCTCGTCTTGTGCGCCGTGCCCTGCCTTGCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGG TTTCAGCTCCCAGCCTCCACCCGGGTGAGCTGGGGCCCACGTGGCATCGATCCTCCCTGCCCGCGAAGTGACAGTTTACAAAATTATTTT CTGCAAAAAAGAAAAAAAAGTTACGTTAAAAACCAAAAAACTACATATTTTATTATAGAAAAAGTATTTTTTCTCCACCAGACAAATGGA AAAAAAGAGGAAAGATTAACTATTTGCACCGAAATGTCTTGTTTTGTTGCGACATAGGAAAATAACCAAGCACAAAGTTATATTCCATCC TTTTTACTGATTTTTTTTTCTTCTATCTGTTCCATCTGCTGTATTCATTTCTCCAATCTCATGTCCATTTTGGTGTGGGAGTCGGGGTAG GGGGTACTCTTGTCAAAAGGCACATTGGTGCATGTGTGTTTGCTAGCTCACTTGTCCATGAAAATATTTTATGATATTAAAGAAAATCTT TTGAAATGGCTGTTTTTTAAGGAAGAGAATTTATGTGGCTTCTCATTTTTAAATCCCCTCAGAGGTGTGACTAGTCTCTTTATCAGCACA CACTTAAAAAATTTTTAATATTGTCTATTAAAAATAGGACAAACTTGGAGAGTATGGACAACTTTGATATTGCTTGGCACAGATGGTATT >39797_39797_4_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000193403_length(amino acids)=959AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASF -------------------------------------------------------------- >39797_39797_5_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000394419_length(transcript)=3759nt_BP=583nt GGAACTTTCCCAGCGGATCTAATGGCTGCGCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCG AGCGAGCGAGCGCGAGGCCGGAGCCCCGGCCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTG ACGCCCCGCGGCCCCGCGAAGACCCCGGCCGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCC GGGCACCATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAA CCTGCAGAAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGG GAAGAACTACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCG AGTCTACCTGGATGAAAACTACAAATCCCAGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACA GATCGAGAACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGA GCGAGGCAAGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGG AGCCGAAGAAATCGTGGATGGGAATGTGAAGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGT GGAAGAGACTTCAGCCAAGGAAGGGCTGCTCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACAT AAGCTGGAAGGATGGCCTCGGCTTCTGTGCTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCC ACTCACAAATCTGAATACGGCTTTTGACGTGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGC CCGACCGGATGAGAAAGCCATCATGACTTACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCG CATCTGCAAGGTGTTGGCCGTCAACCAGGAGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCG CCGCACAATCCCGTGGCTGGAGAACCGGGTGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCG CCTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCC TGCCTTCATGCCCTCTGAGGGCAGGATGGTCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTG GTTGCTGAATGAGATCCGGAGGCTGGAGCGACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGA CGGCAAAGAGGCCATGCTGCGACAGAAGGACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGA GAGTGACCTGGCTGCCCACCAGGACCGTGTGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAG TGTCAACGCCCGTTGCCAAAAGATCTGTGACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGA GAAACTGCTGGAGACCATTGACCAGCTGTACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGA CCTGCAGGACACCTTCATTGTGCACACCATTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGC CGACAAGGAGCGCCTGGCCATCCTGGGCATCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCC CTACACAACCATCACGCCTCAGGAGATCAATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGA GCATGCCCGACAGCAGCACAATGAGAGGCTACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGA GGAGATCGGGAGGATCTCCATTGAGATGCATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTA CAAGCCAAAGATTGATCAGCTGGAGGGCGACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGA GCACATCCGTGTGGGCTGGGAGCAGCTGCTCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAA GGGCATCAGCCAGGAGCAGATGAATGAGTTCCGGGCCTCCTTCAACCACTTTGACCGGGATCACTCCGGCACACTGGGTCCCGAGGAGTT CAAAGCCTGCCTCATCAGCTTGGGTTATGATATTGGCAACGACCCCCAGAAGAAGACAGGCATGATGGACACGGATGATTTCCGCGCCTG CCTGATCTCCATGGGTTACAACATGGGAGAAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCCCAACCGCCTGGGGGTAGTGACATT CCAGGCCTTCATTGACTTCATGTCCCGCGAGACAGCCGACACAGATACAGCAGACCAAGTCATGGCTTCCTTCAAGATCCTGGCTGGGGA CAAGAACTACATTACCATGGACGAGCTGCGCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCATCGCGCGGATGGCCCCCTACACCGG CCCCGACTCCGTGCCAGGTGCTCTGGACTACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGACCTCTAATCCACCCCGCCCGGCCG CCCTCGTCTTGTGCGCCGTGCCCTGCCTTGCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGGTTTCAGCTCCCAGCCTCCACCCGG GTGAGCTGGGGCCCACGTGGCATCGATCCTCCCTGCCCGCGAAGTGACAGTTTACAAAATTATTTTCTGCAAAAAAGAAAAAAAAGTTAC GTTAAAAACCAAAAAACTACATATTTTATTATAGAAAAAGTATTTTTTCTCCACCAGACAAATGGAAAAAAAGAGGAAAGATTAACTATT TGCACCGAAATGTCTTGTTTTGTTGCGACATAGGAAAATAACCAAGCACAAAGTTATATTCCATCCTTTTTACTGATTTTTTTTTCTTCT ATCTGTTCCATCTGCTGTATTCATTTCTCCAATCTCATGTCCATTTTGGTGTGGGAGTCGGGGTAGGGGGTACTCTTGTCAAAAGGCACA >39797_39797_5_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000394419_length(amino acids)=981AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQA -------------------------------------------------------------- >39797_39797_6_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000438964_length(transcript)=3315nt_BP=583nt GGAACTTTCCCAGCGGATCTAATGGCTGCGCGCGGGCCGCTGTGAGGCGCGGCGGCGAGCGACGGGCGCGGGGCCGCGGAGCAGCGAGCG AGCGAGCGAGCGCGAGGCCGGAGCCCCGGCCAGGCCCGGCCGACCCGCCGAGCCCGCGATGCGCCCCGGGGCCGCCCCCCGGCGCAGCTG ACGCCCCGCGGCCCCGCGAAGACCCCGGCCGGCCGGTCCCGGAGGAAGCGGCCGCCGCCGCCGCCGCCCAGCCCAGCGCCCGCGCCGCCC GGGCACCATGGCGGGGAAGGCGGCCGCCCCGGGCACCGCGGTGCTGCTGGTCACGGCCAACGTGGGCTCGCTCTTCGACGACCCAGAAAA CCTGCAGAAGAACTGGCTTCGGGAATTTTACCAGGTCGTGCACACACACAAGCCGCACTTCATGGCCTTGCACTGTCAGGAGTTTGGAGG GAAGAACTACGAGGCCTCCATGTCCCACGTGGACAAGTTCGTCAAAGAACTATTGTCGAGTGATGCGATGAAAGAATATAACAGGGCTCG AGTCTACCTGGATGAAAACTACAAATCCCAGGAGCACTTCACGACATTCACGGCATGGTGTAACTCCCACCTCCGGAAGGCGGGGACACA GATCGAGAACATCGAAGAGGACTTCCGGGATGGCCTGAAGCTCATGCTGCTGCTGGAGGTCATCTCAGGTGAACGCTTGGCCAAGCCAGA GCGAGGCAAGATGAGAGTGCACAAGATCTCCAACGTCAACAAGGCCCTGGATTTCATAGCCAGCAAAGGCGTCAAACTGGTGTCCATCGG AGCCGAAGAAATCGTGGATGGGAATGTGAAGATGACCCTGGGCATGATCTGGACCATCATCCTGCGCTTTGCCATCCAGGACATCTCCGT GGAAGAGACTTCAGCCAAGGAAGGGCTGCTCCTGTGGTGTCAGAGAAAGACAGCCCCTTACAAAAATGTCAACATCCAGAACTTCCACAT AAGCTGGAAGGATGGCCTCGGCTTCTGTGCTTTGATCCACCGACACCGGCCCGAGCTGATTGACTACGGGAAGCTGCGGAAGGATGATCC ACTCACAAATCTGAATACGGCTTTTGACGTGGCAGAGAAGTACCTGGACATCCCCAAGATGCTGGATGCCGAAGACATCGTTGGAACTGC CCGACCGGATGAGAAAGCCATCATGACTTACGTGTCTAGCTTCTACCACGCCTTCTCTGGAGCCCAGAAGGCGGAGACAGCAGCCAATCG CATCTGCAAGGTGTTGGCCGTCAACCAGGAGAACGAGCAGCTTATGGAAGACTACGAGAAGCTGGCCAGTGATCTGTTGGAGTGGATCCG CCGCACAATCCCGTGGCTGGAGAACCGGGTGCCCGAGAACACCATGCATGCCATGCAACAGAAGCTGGAGGACTTCCGGGACTACCGGCG CCTGCACAAGCCGCCCAAGGTGCAGGAGAAGTGCCAGCTGGAGATCAACTTCAACACGCTGCAGACCAAGCTGCGGCTCAGCAACCGGCC TGCCTTCATGCCCTCTGAGGGCAGGATGGTCTCGGACATCAACAATGCCTGGGGCTGCCTGGAGCAGGTGGAGAAGGGCTATGAGGAGTG GTTGCTGAATGAGATCCGGAGGCTGGAGCGACTGGACCACCTGGCAGAGAAGTTCCGGCAGAAGGCCTCCATCCACGAGGCCTGGACTGA CGGCAAAGAGGCCATGCTGCGACAGAAGGACTATGAGACCGCCACCCTCTCGGAGATCAAGGCCCTGCTCAAGAAGCATGAGGCCTTCGA GAGTGACCTGGCTGCCCACCAGGACCGTGTGGAGCAGATTGCCGCCATCGCACAGGAGCTCAATGAGCTGGACTATTATGACTCACCCAG TGTCAACGCCCGTTGCCAAAAGATCTGTGACCAGTGGGACAATCTGGGGGCCCTAACTCAGAAGCGAAGGGAAGCTCTGGAGCGGACCGA GAAACTGCTGGAGACCATTGACCAGCTGTACTTGGAGTATGCCAAGCGGGCTGCACCCTTCAACAACTGGATGGAGGGGGCCATGGAGGA CCTGCAGGACACCTTCATTGTGCACACCATTGAGGAGATCCAGGGACTGACCACAGCCCATGAGCAGTTCAAGGCCACCCTCCCTGATGC CGACAAGGAGCGCCTGGCCATCCTGGGCATCCACAATGAGGTGTCCAAGATTGTCCAGACCTACCACGTCAATATGGCGGGCACCAACCC CTACACAACCATCACGCCTCAGGAGATCAATGGCAAATGGGACCACGTGCGGCAGCTGGTGCCTCGGAGGGACCAAGCTCTGACGGAGGA GCATGCCCGACAGCAGCACAATGAGAGGCTACGCAAGCAGTTTGGAGCCCAGGCCAATGTCATCGGGCCCTGGATCCAGACCAAGATGGA GGAGATCGGGAGGATCTCCATTGAGATGCATGGGACCCTGGAGGACCAGCTCAGCCACCTGCGGCAGTATGAGAAGAGCATCGTCAACTA CAAGCCAAAGATTGATCAGCTGGAGGGCGACCACCAGCTCATCCAGGAGGCGCTCATCTTCGACAACAAGCACACCAACTACACCATGGA GCACATCCGTGTGGGCTGGGAGCAGCTGCTCACCACCATCGCCAGGACCATCAATGAGGTAGAGAACCAGATCCTGACCCGGGATGCCAA GGGCATCAGCCAGGAGCAGATGAATGAGTTCCGGGCCTCCTTCAACCACTTTGACCGGAAGAAGACAGGCATGATGGACACGGATGATTT CCGCGCCTGCCTGATCTCCATGGGTTACAACATGGGAGAAGCAGAATTTGCCCGCATCATGAGCATTGTGGACCCCAACCGCCTGGGGGT AGTGACATTCCAGGCCTTCATTGACTTCATGTCCCGCGAGACAGCCGACACAGATACAGCAGACCAAGTCATGGCTTCCTTCAAGATCCT GGCTGGGGACAAGAACTACATTACCATGGACGAGCTGCGCCGCGAGCTGCCACCCGACCAGGCTGAGTACTGCATCGCGCGGATGGCCCC CTACACCGGCCCCGACTCCGTGCCAGGTGCTCTGGACTACATGTCCTTCTCCACGGCGCTGTACGGCGAGAGTGACCTCTAATCCACCCC GCCCGGCCGCCCTCGTCTTGTGCGCCGTGCCCTGCCTTGCACCTCCGCCGTCGCCCATCTCCTGCCTGGGTTCGGTTTCAGCTCCCAGCC >39797_39797_6_INPP5A-ACTN1_INPP5A_chr10_134464009_ENST00000368594_ACTN1_chr14_69392389_ENST00000438964_length(amino acids)=954AA_BP=102 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVY LDENYKSQEHFTTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAE EIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGI SQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for INPP5A-ACTN1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000193403 | 0 | 21 | 274_733 | 35.0 | 893.0 | DDN | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000394419 | 0 | 22 | 274_733 | 35.0 | 915.0 | DDN | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000438964 | 0 | 21 | 274_733 | 35.0 | 888.0 | DDN | |
| Tgene | ACTN1 | chr10:134464009 | chr14:69392389 | ENST00000538545 | 0 | 21 | 274_733 | 35.0 | 931.0 | DDN |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for INPP5A-ACTN1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for INPP5A-ACTN1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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