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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
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Fusion gene:INSR-ERCC1 (FusionGDB2 ID:39897)

Fusion Gene Summary for INSR-ERCC1

Fusion gene summary

Fusion gene information	Fusion gene name: INSR-ERCC1
	Fusion gene ID: 39897
		Hgene	Tgene
	Gene symbol	INSR	ERCC1
	Gene ID	3643	2067
	Gene name	insulin receptor	ERCC excision repair 1, endonuclease non-catalytic subunit
	Synonyms	CD220\|HHF5	COFS4\|RAD10\|UV20
	Cytomap	19p13.2	19q13.32
	Type of gene	protein-coding	protein-coding
	Description	insulin receptorIR	DNA excision repair protein ERCC-1excision repair cross-complementation group 1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
	Modification date	20200313	20200329
	UniProtAcc	.	P07992
	Ensembl transtripts involved in fusion gene	ENST00000302850, ENST00000341500,	ENST00000013807, ENST00000300853, ENST00000340192, ENST00000423698, ENST00000589165, ENST00000591636, ENST00000588738,
Fusion gene scores	* DoF score	11 X 11 X 6=726	10 X 8 X 5=400
	# samples	15	11
	** MAII score	log2(15/726*10)=-2.27500704749987 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/400*10)=-1.86249647625006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: INSR [Title/Abstract] AND ERCC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	INSR(7293803)-ERCC1(45926639), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	INSR	GO:0001934	positive regulation of protein phosphorylation	7556070
Hgene	INSR	GO:0002092	positive regulation of receptor internalization	25401701
Hgene	INSR	GO:0007186	G protein-coupled receptor signaling pathway	9092559
Hgene	INSR	GO:0008284	positive regulation of cell proliferation	17925406
Hgene	INSR	GO:0008286	insulin receptor signaling pathway	6849137\|8440175\|20455999
Hgene	INSR	GO:0018108	peptidyl-tyrosine phosphorylation	8496180
Hgene	INSR	GO:0032148	activation of protein kinase B activity	7556070
Hgene	INSR	GO:0032869	cellular response to insulin stimulus	8440175
Hgene	INSR	GO:0043410	positive regulation of MAPK cascade	20455999
Hgene	INSR	GO:0045725	positive regulation of glycogen biosynthetic process	17925406
Hgene	INSR	GO:0046326	positive regulation of glucose import	3518947
Hgene	INSR	GO:0046777	protein autophosphorylation	6849137\|8496180
Hgene	INSR	GO:0060267	positive regulation of respiratory burst	9092559
Tgene	ERCC1	GO:0006289	nucleotide-excision repair	3290851

Fusion gene breakpoints across INSR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ERCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-2027-01A	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
ChimerDB4	OV	TCGA-24-2027-01A	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
ChimerDB4	OV	TCGA-24-2027	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-

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Fusion Gene ORF analysis for INSR-ERCC1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000302850	ENST00000013807	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000013807	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000300853	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000340192	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000340192	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000423698	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000423698	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000589165	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000589165	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000591636	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000302850	ENST00000591636	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000013807	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000013807	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000300853	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000340192	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000340192	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000423698	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000423698	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000589165	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000589165	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000591636	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-5UTR	ENST00000341500	ENST00000591636	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-intron	ENST00000302850	ENST00000013807	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000302850	ENST00000340192	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000302850	ENST00000423698	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000302850	ENST00000588738	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000302850	ENST00000588738	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-intron	ENST00000302850	ENST00000588738	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-intron	ENST00000302850	ENST00000589165	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000302850	ENST00000591636	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000013807	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000340192	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000423698	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000588738	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000588738	INSR	chr19	7293803	-	ERCC1	chr19	45926639	-
5CDS-intron	ENST00000341500	ENST00000588738	INSR	chr19	7293802	-	ERCC1	chr19	45926639	-
5CDS-intron	ENST00000341500	ENST00000589165	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
5CDS-intron	ENST00000341500	ENST00000591636	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
In-frame	ENST00000302850	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-
In-frame	ENST00000341500	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341500	INSR	chr19	7293803	-	ENST00000300853	ERCC1	chr19	45924651	-	3271	140	2418	1102	438
ENST00000302850	INSR	chr19	7293803	-	ENST00000300853	ERCC1	chr19	45924651	-	3374	243	2521	1205	438

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341500	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-	0.79874873	0.2012513
ENST00000302850	ENST00000300853	INSR	chr19	7293803	-	ERCC1	chr19	45924651	-	0.78548986	0.21451019

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Fusion Genomic Features for INSR-ERCC1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for INSR-ERCC1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:7293803/chr19:45926639)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ERCC1 P07992
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. {ECO:0000269\|PubMed:17273966, ECO:0000269\|PubMed:23623389, ECO:0000269\|PubMed:24036546}.; FUNCTION: [Isoform 2]: Not functional in the nucleotide excision repair pathway. {ECO:0000305\|PubMed:24036546}.; FUNCTION: [Isoform 3]: Not functional in the nucleotide excision repair pathway. {ECO:0000305\|PubMed:24036546}.; FUNCTION: [Isoform 4]: Not functional in the nucleotide excision repair pathway. {ECO:0000305\|PubMed:24036546}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000013807

134_156

324.0

DNA binding

Ontology_term=ECO:0000255

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000300853

134_156

298.0

DNA binding

Ontology_term=ECO:0000255

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000340192

134_156

274.0

DNA binding

Ontology_term=ECO:0000255

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000423698

134_156

226.0

DNA binding

Ontology_term=ECO:0000255

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000589165

134_156

298.0

DNA binding

Ontology_term=ECO:0000255

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000423698

17_23

226.0

Motif

Nuclear localization signal

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000013807

220_297

324.0

Region

HhH2%2C dimerization with ERCC4/XPF

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000300853

220_297

298.0

Region

HhH2%2C dimerization with ERCC4/XPF

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000340192

220_297

274.0

Region

HhH2%2C dimerization with ERCC4/XPF

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000423698

220_297

226.0

Region

HhH2%2C dimerization with ERCC4/XPF

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000589165

220_297

298.0

Region

HhH2%2C dimerization with ERCC4/XPF

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

182_339

1383.0

Compositional bias

Note=Cys-rich

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

28_174

1383.0

Compositional bias

Note=Leu-rich

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

182_339

1371.0

Compositional bias

Note=Cys-rich

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

28_174

1371.0

Compositional bias

Note=Leu-rich

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

1023_1298

1383.0

Domain

Protein kinase

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

624_726

1383.0

Domain

Fibronectin type-III 1

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

757_842

1383.0

Domain

Fibronectin type-III 2

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

853_947

1383.0

Domain

Fibronectin type-III 3

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

1023_1298

1371.0

Domain

Protein kinase

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

624_726

1371.0

Domain

Fibronectin type-III 1

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

757_842

1371.0

Domain

Fibronectin type-III 2

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

853_947

1371.0

Domain

Fibronectin type-III 3

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

1104_1110

1383.0

Nucleotide binding

ATP

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

1163_1164

1383.0

Nucleotide binding

ATP

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

1104_1110

1371.0

Nucleotide binding

ATP

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

1163_1164

1371.0

Nucleotide binding

ATP

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

1361_1364

1383.0

Region

Note=PIK3R1-binding

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

733_741

1383.0

Region

Note=Insulin-binding

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

1361_1364

1371.0

Region

Note=PIK3R1-binding

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

733_741

1371.0

Region

Note=Insulin-binding

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

28_758

1383.0

Topological domain

Extracellular

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

763_956

1383.0

Topological domain

Extracellular

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

980_1382

1383.0

Topological domain

Cytoplasmic

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

28_758

1371.0

Topological domain

Extracellular

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

763_956

1371.0

Topological domain

Extracellular

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

980_1382

1371.0

Topological domain

Cytoplasmic

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000302850

957_979

1383.0

Transmembrane

Helical

Hgene

INSR

chr19:7293803

chr19:45924651

ENST00000341500

957_979

1371.0

Transmembrane

Helical

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000013807

17_23

324.0

Motif

Nuclear localization signal

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000300853

17_23

298.0

Motif

Nuclear localization signal

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000340192

17_23

274.0

Motif

Nuclear localization signal

Tgene

ERCC1

chr19:7293803

chr19:45924651

ENST00000589165

17_23

298.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for INSR-ERCC1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>39897_39897_1_INSR-ERCC1_INSR_chr19_7293803_ENST00000302850_ERCC1_chr19_45924651_ENST00000300853_length(transcript)=3374nt_BP=243nt
GGGGGGCTGCGGCCCGCGGGTCGCGGGCGTGGAAGAGAAGGACGCGCGGCCCCCAGCGCCTCTTGGGTGGCCGCCTCGGAGCATGACCCC
CGCGGGCCAGCGCCGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGC
CGCTGCTGGTGGCGGTGGCCGCGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGGCCAAGCCCTTATTCCGATCTACACAG
AGCCTTCCCACTGTGGACACCTCGGCCCAGGCGGCCCCTCAGACCTACGCCGAATATGCCATCTCACAGCCTCTGGAAGGGGCTGGGGCC
ACGTGCCCCACAGGGTCAGAGCCCCTGGCAGGAGAGACGCCCAACCAGGCCCTGAAACCCGGGGCAAAATCCAACAGCATCATTGTGAGC
CCTCGGCAGAGGGGCAATCCCGTACTGAAGTTCGTGCGCAATGTGCCCTGGGAATTTGGCGACGTAATTCCCGACTATGTGCTGGGCCAG
AGCACCTGTGCCCTGTTCCTCAGCCTCCGCTACCACAACCTGCACCCAGACTACATCCATGGGCGGCTGCAGAGCCTGGGGAAGAACTTC
GCCTTGCGGGTCCTGCTTGTCCAGGTGGATGTGAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGC
ACATTGATCCTCGCCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATG
GAGAAGCTAGAGCAGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTG
ACCACATTTGGATCTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGG
CTGTTTGATGTCCTGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTC
CCAGGCCAGGCTCCTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTC
AGCTTTCTTTAGTTCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCC
TCCTCCCCAGACTCTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTC
CTCTTCTTGGTGGATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACT
GTGTGACCTCTCTCTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACC
ACCTCTGTCTCTGGCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGC
TTCGCTCCTTCTGGCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTC
CCTGGCTCCATCATTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTC
ACCTGTGGCTGAGACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGG
ACTGTGTCTTCTAGAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTC
CTCTTCTTGGTGGTGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGT
TCTTTCAGCTGCTGATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGC
CCATTCACTGCCTCCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCT
GACCTAGGCCCTGTGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGG
ATGGGCTGCAGAGGGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCA
CCTCCTGCCTCCGTTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCC
AATTTGCCCTTGACGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTG
GAACAGGAGAGGGAAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGA
TCTCGGCTCACTGCAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACC
ACGCCCAGCCAATTTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTC
GCCTCGGCCTCCCAAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTC
CATCTTAAAGTGAGTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTAC
AGAATATTTATGGCCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAA
CATAAATGAGCAAGCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAG
TTTAACTATAGTTCCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACT

>39897_39897_1_INSR-ERCC1_INSR_chr19_7293803_ENST00000302850_ERCC1_chr19_45924651_ENST00000300853_length(amino acids)=438AA_BP=
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------
>39897_39897_2_INSR-ERCC1_INSR_chr19_7293803_ENST00000341500_ERCC1_chr19_45924651_ENST00000300853_length(transcript)=3271nt_BP=140nt
CGCGCGCTCTGATCCGAGGAGACCCCGCGCTCCCGCAGCCATGGCCACCGGGGGCCGGCGGGGGGCGGCGGCCGCGCCGCTGCTGGTGGC
GGTGGCCGCGCTGCTACTGGGCGCCGCGGGCCACCTGTACCCCGGAGAGGGCCAAGCCCTTATTCCGATCTACACAGAGCCTTCCCACTG
TGGACACCTCGGCCCAGGCGGCCCCTCAGACCTACGCCGAATATGCCATCTCACAGCCTCTGGAAGGGGCTGGGGCCACGTGCCCCACAG
GGTCAGAGCCCCTGGCAGGAGAGACGCCCAACCAGGCCCTGAAACCCGGGGCAAAATCCAACAGCATCATTGTGAGCCCTCGGCAGAGGG
GCAATCCCGTACTGAAGTTCGTGCGCAATGTGCCCTGGGAATTTGGCGACGTAATTCCCGACTATGTGCTGGGCCAGAGCACCTGTGCCC
TGTTCCTCAGCCTCCGCTACCACAACCTGCACCCAGACTACATCCATGGGCGGCTGCAGAGCCTGGGGAAGAACTTCGCCTTGCGGGTCC
TGCTTGTCCAGGTGGATGTGAAAGATCCCCAGCAGGCCCTCAAGGAGCTGGCTAAGATGTGTATCCTGGCCGACTGCACATTGATCCTCG
CCTGGAGCCCCGAGGAAGCTGGGCGGTACCTGGAGACCTACAAGGCCTATGAGCAGAAACCAGCGGACCTCCTGATGGAGAAGCTAGAGC
AGGACTTCGTCTCCCGGGTGACTGAATGTCTGACCACCGTGAAGTCAGTCAACAAAACGGACAGTCAGACCCTCCTGACCACATTTGGAT
CTCTGGAACAGCTCATCGCCGCATCAAGAGAAGATCTGGCCTTATGCCCAGGCCTGGGCCCTCAGAAAGCCCGGAGGCTGTTTGATGTCC
TGCACGAGCCCTTCTTGAAAGTACCCTGATGACCCCAGCTGCCAAGGAAACCCCCAGTGTAATAATAAATCGTCCTCCCAGGCCAGGCTC
CTGCTGGCTGCGCTGGTGCAGTCTCTGGGGAGGGATTCTGGGGGTGTCACCTTCTGGTGGCCCAGGTGGGCACCTTCAGCTTTCTTTAGT
TCCTCAGTTTCCCGGGGGCAGACTACACAGGCTGCTGCTGCTGCTGCTTCCGCTTCTTGTCCCGGCCTGTGGGAGCCTCCTCCCCAGACT
CTGAATTCAGTGGCGGCCCTGGCATCTCCTCTTGGGGCACTGTCTCTGGCATCCGGCTTTCCTGACTCTGCTTCTTCCTCTTCTTGGTGG
ATCCCGGAGTTGCCCTGGCTTCAGGCTGTCCCTCCCCTGGCAGTTCAGGCTCTAGTGGCTGAATTGGCTCAGTCACTGTGTGACCTCTCT
CTTTCTTCTTCTTCTTCTTCTTGGTGGATGTGGGAGCTGCCTGAGGCTCAAGGTCATCCGGCAGCTCAGGCCCCACCACCTCTGTCTCTG
GCTCCACTGTGGCATCTTGCTGTTTTTCTTTCTTCGTCTTCTTTTTGGGAGCTGCCAGAGCTGCCTGGGCCTGAGGCTTCGCTCCTTCTG
GCTGTTGAGGCGCCATGGTCCCCCCTGGGGACTCCAGAGGCTTCATCTCCGGCTCCACTGGCTCCATCGCCTCCGTCCCTGGCTCCATCA
TTGCCATCTGTCCCTTTTCTTTTTTCCTCTTCTTCGTAGGGGGCAGAGGGATGGCTTCCTCCAGTGGCTCCACCTTCACCTGTGGCTGAG
ACTCAACTGTCACCCCCTCCTCTGGCTCCATCCCTTCCGTCCCCTTTTGCCTCTTTCTCTTTTTGGTCGGGGACAGGACTGTGTCTTCTA
GAGGCTCAGTGTTAATCTGTTCCTGCTTCACTGTCTTGTCTTCTGGCTCGAAGGTTTCTTTCCCTTTGGGCTTCTTCCTCTTCTTGGTGG
TGGACGGGAACAGCACTCCCAGAGGCTCCAGTGTCTCCACTGTGGGCTCTGTCCCCACAGGCCCTGCTGCCTCTGGTTCTTTCAGCTGCT
GATTTTTTTTCTTCTTCTTCTTCCGCACATCCATTTCTGGCGACCCCAAAGCCATGTCCACCTCCAGGGCCCCGTGCCCATTCACTGCCT
CCTGAGTGACTGGGGCCTCTGTCACCTGCATCTCCTTTTTCTTCTTCCCTGAGGTGAGCAGGTTGGGGGCCAAGGCTGACCTAGGCCCTG
TGACTGGTGGGTTGCCCCCAAAGGCACAGAACCGAGGCCTCAGGCCAGGAGGGATCTGTGGTGGGGGACTTGCTGGGATGGGCTGCAGAG
GGCTCCCTGACAGGGATTGCTGGGGACCCTCAAGGATCCTTAGGGTGCCCTGGGGGGCTGAGGCACAGGTGAGTCCACCTCCTGCCTCCG
TTGAGGGGGCCAGCAGGGTCGCTTCTCCAGCTTGGGGACAGCTGCTGAGGACTCGATAGCGGTGCCGCTTGCCTGCCAATTTGCCCTTGA
CGATCTGGGAGCCAGAGAGAGGCACATGCCGCCCATTGAAGCTACAGAGAGAAACAGGGAGGGCAGAGGCTTAAGTGGAACAGGAGAGGG
AAGGTTTTTTGATTTTTTTTTTGTTTTTTTTTGAGAGAGTCTTGCTCTGTTGCCTAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTG
CAATGTCCACCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCTCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCCCAGCCAAT
TTTTGTATTTTTAGTAGAGACAATTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCTGCTCGCCTCGGCCTCCC
AAAGGATGGGATTACAGGCACCAGCCACTGCGCCTGGCTGGCCTCTGGTTTTTAATAAAACATGACTAGAGTGACTCCATCTTAAAGTGA
GTAGCTAGGCACTTACAAGGTTCATGCTTATGGCCTGAAAATAACCACATCCCAGGCTGACCACCAATTATAATTACAGAATATTTATGG
CCATACAGAACATGTTCCACCAAGCCTGCAGAATGTCCAAATGTCCTAAGAATGCAGCCCCCATTACTTAAATATAACATAAATGAGCAA
GCTTAGGTTGCAGGATTAATGGTCGTGGATAACACCAATAGCCCCTACCTTTAGTGAGCTTATCTGCACACTCCAAGTTTAACTATAGTT
CCTTATAGTTTCTTATAAGTAGAAATACTAACAAAGGGCTGTGGGTTTCTCCCCCTGCTTTCTGAGGACACTCTACTCTGTAAAGGAGTA

>39897_39897_2_INSR-ERCC1_INSR_chr19_7293803_ENST00000341500_ERCC1_chr19_45924651_ENST00000300853_length(amino acids)=438AA_BP=
MAGKRHRYRVLSSCPQAGEATLLAPSTEAGGGLTCASAPQGTLRILEGPQQSLSGSPLQPIPASPPPQIPPGLRPRFCAFGGNPPVTGPR
SALAPNLLTSGKKKKEMQVTEAPVTQEAVNGHGALEVDMALGSPEMDVRKKKKKKNQQLKEPEAAGPVGTEPTVETLEPLGVLFPSTTKK
RKKPKGKETFEPEDKTVKQEQINTEPLEDTVLSPTKKRKRQKGTEGMEPEEGVTVESQPQVKVEPLEEAIPLPPTKKRKKEKGQMAMMEP
GTEAMEPVEPEMKPLESPGGTMAPQQPEGAKPQAQAALAAPKKKTKKEKQQDATVEPETEVVGPELPDDLEPQAAPTSTKKKKKKKERGH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for INSR-ERCC1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for INSR-ERCC1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for INSR-ERCC1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source