Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:INTS8-ESRP1 (FusionGDB2 ID:39987)

Fusion Gene Summary for INTS8-ESRP1

Fusion gene summary

Fusion gene information	Fusion gene name: INTS8-ESRP1
	Fusion gene ID: 39987
		Hgene	Tgene
	Gene symbol	INTS8	ESRP1
	Gene ID	55656	54845
	Gene name	integrator complex subunit 8	epithelial splicing regulatory protein 1
	Synonyms	C8orf52\|INT8\|NEDCHS	DFNB109\|RBM35A\|RMB35A
	Cytomap	8q22.1	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	integrator complex subunit 8protein kaonashi-1	epithelial splicing regulatory protein 1RNA-binding motif protein 35ARNA-binding protein 35A
	Modification date	20200313	20200313
	UniProtAcc	Q75QN2	Q6NXG1
	Ensembl transtripts involved in fusion gene	ENST00000447247, ENST00000523731, ENST00000520845,	ENST00000358397, ENST00000433389, ENST00000454170, ENST00000523347, ENST00000423620,
Fusion gene scores	* DoF score	8 X 7 X 3=168	14 X 16 X 7=1568
	# samples	8	15
	** MAII score	log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1568*10)=-3.38589115361933 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: INTS8 [Title/Abstract] AND ESRP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ESRP1(95718262)-INTS8(95862169), # samples:2 INTS8(95841254)-ESRP1(95718153), # samples:2
Anticipated loss of major functional domain due to fusion event.	INTS8-ESRP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. INTS8-ESRP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. INTS8-ESRP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	INTS8	GO:0016180	snRNA processing	16239144
Tgene	ESRP1	GO:0043484	regulation of RNA splicing	19285943

Fusion gene breakpoints across INTS8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ESRP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A181-06A	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
ChimerDB4	SKCM	TCGA-EE-A181-06A	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
ChimerDB4	SKCM	TCGA-EE-A181-06A	INTS8	chr8	95841254	-	ESRP1	chr8	95718153	+
ChimerDB4	SKCM	TCGA-EE-A181-06A	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+

Top

Fusion Gene ORF analysis for INTS8-ESRP1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000447247	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000447247	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000447247	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000447247	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000523731	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000523731	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000523731	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-3UTR	ENST00000523731	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
5CDS-intron	ENST00000447247	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000447247	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000447247	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000447247	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
5CDS-intron	ENST00000447247	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000447247	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
5CDS-intron	ENST00000447247	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000523731	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000523731	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000523731	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000523731	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
5CDS-intron	ENST00000523731	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
5CDS-intron	ENST00000523731	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
5CDS-intron	ENST00000523731	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
Frame-shift	ENST00000447247	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
Frame-shift	ENST00000447247	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
Frame-shift	ENST00000447247	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
Frame-shift	ENST00000523731	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
Frame-shift	ENST00000523731	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
Frame-shift	ENST00000523731	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
In-frame	ENST00000447247	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
In-frame	ENST00000523731	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-3CDS	ENST00000520845	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
intron-3CDS	ENST00000520845	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
intron-3CDS	ENST00000520845	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-3CDS	ENST00000520845	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
intron-3UTR	ENST00000520845	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-3UTR	ENST00000520845	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-3UTR	ENST00000520845	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-3UTR	ENST00000520845	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+
intron-intron	ENST00000520845	ENST00000358397	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
intron-intron	ENST00000520845	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
intron-intron	ENST00000520845	ENST00000433389	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
intron-intron	ENST00000520845	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
intron-intron	ENST00000520845	ENST00000454170	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+
intron-intron	ENST00000520845	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95704905	+
intron-intron	ENST00000520845	ENST00000523347	INTS8	chr8	95841254	+	ESRP1	chr8	95709080	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000523731

INTS8

chr8

95841254

ENST00000423620

ESRP1

chr8

95718153

2245

703

723

211

ENST00000447247

INTS8

chr8

95841254

ENST00000423620

ESRP1

chr8

95718153

2238

696

716

211

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000523731	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+	0.001446667	0.99855334
ENST00000447247	ENST00000423620	INTS8	chr8	95841254	+	ESRP1	chr8	95718153	+	0.001902027	0.99809796

Top

Fusion Genomic Features for INTS8-ESRP1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
INTS8	chr8	95841254	+	ESRP1	chr8	95709079	+	1.27E-07	0.9999999
INTS8	chr8	95841254	+	ESRP1	chr8	95718152	+	7.06E-09	1
INTS8	chr8	95841254	+	ESRP1	chr8	95704904	+	3.76E-09	1
INTS8	chr8	95841254	+	ESRP1	chr8	95709079	+	1.27E-07	0.9999999
INTS8	chr8	95841254	+	ESRP1	chr8	95718152	+	7.06E-09	1
INTS8	chr8	95841254	+	ESRP1	chr8	95704904	+	3.76E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for INTS8-ESRP1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:95718262/chr8:95862169)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INTS8 Q75QN2	ESRP1 Q6NXG1
FUNCTION: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. {ECO:0000269\|PubMed:28542170}.	FUNCTION: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity). {ECO:0000250\|UniProtKB:Q3US41, ECO:0000269\|PubMed:19285943}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000447247

250_288

190

979.0

Repeat

Note=TPR 1

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000447247

320_356

190

979.0

Repeat

Note=TPR 2

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000447247

570_603

190

979.0

Repeat

Note=TPR 3

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000447247

833_866

190

979.0

Repeat

Note=TPR 4

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000523731

250_288

190

996.0

Repeat

Note=TPR 1

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000523731

320_356

190

996.0

Repeat

Note=TPR 2

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000523731

570_603

190

996.0

Repeat

Note=TPR 3

Hgene

INTS8

chr8:95841254

chr8:95718153

ENST00000523731

833_866

190

996.0

Repeat

Note=TPR 4

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000358397

225_302

689

1099.6666666666667

Domain

RRM 1

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000358397

326_406

689

1099.6666666666667

Domain

RRM 2

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000358397

445_525

689

1099.6666666666667

Domain

RRM 3

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000423620

225_302

653

660.0

Domain

RRM 1

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000423620

326_406

653

660.0

Domain

RRM 2

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000423620

445_525

653

660.0

Domain

RRM 3

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000433389

225_302

693

1074.3333333333333

Domain

RRM 1

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000433389

326_406

693

1074.3333333333333

Domain

RRM 2

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000433389

445_525

693

1074.3333333333333

Domain

RRM 3

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000454170

225_302

606

609.0

Domain

RRM 1

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000454170

326_406

606

609.0

Domain

RRM 2

Tgene

ESRP1

chr8:95841254

chr8:95718153

ENST00000454170

445_525

606

609.0

Domain

RRM 3

Top

Fusion Gene Sequence for INTS8-ESRP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>39987_39987_1_INTS8-ESRP1_INTS8_chr8_95841254_ENST00000447247_ESRP1_chr8_95718153_ENST00000423620_length(transcript)=2238nt_BP=696nt
GTTTCCGGGACGTTCGGAGGGTGGCCTCTCTCCCACCGGGTTCCGCATACCCCAGGCACCGGCCCGCATCCAAGTGTCAGGTTGGAGCCG
GGAAGCGGCCCTGGTGGTAGCGGCGGCGGGGGCAGGATGAGCGCGGAGGCGGCGGACCGGGAGGCGGCCACCTCCAGCCGGCCCTGCACC
CCGCCGCAGACCTGCTGGTTTGAGTTTCTGCTGGAGGAGTCACTGTTGGAGAAACATCTGCGCAAGCCCTGCCCGGATCCTGCACCAGTT
CAACTTATAGTTCAGTTTTTGGAACAGGCTTCCAAACCTTCAGTTAATGAACAAAACCAAGTTCAACCTCCGCCTGATAACAAGAGAAAT
CGTATTTTAAAACTACTTGCTCTTAAAGTTGCTGCACATTTGAAGTGGGACTTAGACATATTAGAGAAAAGTTTGTCTGTTCCAGTATTG
AATATGCTACTAAATGAACTACTCTGCATCAGTAAAGTTCCTCCTGGGACAAAGCATGTAGACATGGATCTGGCCACTTTACCTCCGACC
ACTGCCATGGCTGTACTTCTCTATAATAGATGGGCAATTAGGACAATTGTTCAAAGTAGTTTTCCAGTCAAACAGGCAAAACCCGGACCC
CCTCAGTTAAGTGTTATGAATCAAATGCAACAGGAAAAAGAGCTAACAGAAAACATTTTGAAAGTGTGTTTGAAAGATGTATGGTGATCT
TGAAACCTCCAGACACAAGAAAACTTCTAGCAAATTCAGGGGAAGTTTGTCTACACTCAGGCTGCAGTATTTTCAGCAAACTTGATTGGA
CAAACGGGCCTGTGCCTTATCTTTTGGTGGAGTGAAAAAATTTGAGCTAGTGAAGCCAAATCGTAACTTACAGCAAGCAGCATGCAGCAT
ACCTGGCTCTTTGCTGATTGCAAATAGGCATTTAAAATGTGAATTTGGAATCAGATGTCTCCATTACTTCCAGTTAAAGTGGCATCATAG
GTGTTTCCTAAGTTTTAAGTCTTGGATAAAAACTCCACCAGTGTCTACCATCTCCACCATGAACTCTGTTAAGGAAGCTTCATTTTTGTA
TATTCCCGCTCTTTTCTCTTCATTTCCCTGTCTTCTGCATAATCATGCCTTCTTGCTAAGTAATTCAAGCATAAGATCTTGGAATAATAA
AATCACAATCTTAGGAGAAAGAATAAAATTGTTATTTTCCCAGTCTCTTGGCCATGATGATATCTTATGATTAAAAACAAATTAAATTTT
AAAACACCTGAAGATAAATTAGAAGAAATTGTGCACCCTCCACAAAACATACAAAGTTTAAAAGTTTGGATCTTTTTCTCAGCAGGTATC
AGTTGTAAATAATGAATTAGGGGCCAAAATGCAAAACGAAAAATGAAGCAGCTACATGTAGTTAGTAATTTCTAGTTTGAACTGTAATTG
AATATTGTGGCTTCATATGTATTATTTTATATTGTACTTTTTTCATTATTGATGGTTTGGACTTTAATAAGAGAAATTCCATAGTTTTTA
ATATCCCAGAAGTGAGACAATTTGAACAGTGTATTCTAGAAAACAATACACTAACTGAACAGAAGTGAATGCTTATATATATTATGATAG
CCTTAAACCTTTTTCCTCTAATGCCTTAACTGTCAAATAATTATAACCTTTTAAAGCATAGGACTATAGTCAGCATGCTAGACTGAGAGG
TAAACACTGATGCAATTAGAACAGGTACTGATGCTGTCAGTGTTTAACACTATGTTTAGCTGTGTTTATGCTATAAAAGTGCAATATTAG
ACACTAGCTAGTACTGCTGCCTCATGTAACTCCAAAGAAAACAGGATTTCATTAAGTGCATTGAATGTGGATATTTCTCTAAGTTACTCA
TATTGTCCTTTGCTTGAATGCAATGCCGTGCAGATTTATGAGGCTGCTATTTTTATTTTCTGTGCATTACTTTAACACCTTAAAGGGAGA
AGCAAACATTTCCTTCTTCAGCTGACTGGCAATGGCCCTTTAACTGCAATAGGAAGAAAAAAAAAAAGGTTTGTGTGAAAATTGGTGATA
ACTGGCACTTAAGATCGAAAAGAAATTTCTGTATACTTGATGCCTTAAGATGCCCAAAGCTGCCCAAAGCTCTGAAAGACTTTAAGATAG

>39987_39987_1_INTS8-ESRP1_INTS8_chr8_95841254_ENST00000447247_ESRP1_chr8_95718153_ENST00000423620_length(amino acids)=211AA_BP=
MEPGSGPGGSGGGGRMSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDN
KRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAK

--------------------------------------------------------------
>39987_39987_2_INTS8-ESRP1_INTS8_chr8_95841254_ENST00000523731_ESRP1_chr8_95718153_ENST00000423620_length(transcript)=2245nt_BP=703nt
TGTGTGAGTTTCCGGGACGTTCGGAGGGTGGCCTCTCTCCCACCGGGTTCCGCATACCCCAGGCACCGGCCCGCATCCAAGTGTCAGGTT
GGAGCCGGGAAGCGGCCCTGGTGGTAGCGGCGGCGGGGGCAGGATGAGCGCGGAGGCGGCGGACCGGGAGGCGGCCACCTCCAGCCGGCC
CTGCACCCCGCCGCAGACCTGCTGGTTTGAGTTTCTGCTGGAGGAGTCACTGTTGGAGAAACATCTGCGCAAGCCCTGCCCGGATCCTGC
ACCAGTTCAACTTATAGTTCAGTTTTTGGAACAGGCTTCCAAACCTTCAGTTAATGAACAAAACCAAGTTCAACCTCCGCCTGATAACAA
GAGAAATCGTATTTTAAAACTACTTGCTCTTAAAGTTGCTGCACATTTGAAGTGGGACTTAGACATATTAGAGAAAAGTTTGTCTGTTCC
AGTATTGAATATGCTACTAAATGAACTACTCTGCATCAGTAAAGTTCCTCCTGGGACAAAGCATGTAGACATGGATCTGGCCACTTTACC
TCCGACCACTGCCATGGCTGTACTTCTCTATAATAGATGGGCAATTAGGACAATTGTTCAAAGTAGTTTTCCAGTCAAACAGGCAAAACC
CGGACCCCCTCAGTTAAGTGTTATGAATCAAATGCAACAGGAAAAAGAGCTAACAGAAAACATTTTGAAAGTGTGTTTGAAAGATGTATG
GTGATCTTGAAACCTCCAGACACAAGAAAACTTCTAGCAAATTCAGGGGAAGTTTGTCTACACTCAGGCTGCAGTATTTTCAGCAAACTT
GATTGGACAAACGGGCCTGTGCCTTATCTTTTGGTGGAGTGAAAAAATTTGAGCTAGTGAAGCCAAATCGTAACTTACAGCAAGCAGCAT
GCAGCATACCTGGCTCTTTGCTGATTGCAAATAGGCATTTAAAATGTGAATTTGGAATCAGATGTCTCCATTACTTCCAGTTAAAGTGGC
ATCATAGGTGTTTCCTAAGTTTTAAGTCTTGGATAAAAACTCCACCAGTGTCTACCATCTCCACCATGAACTCTGTTAAGGAAGCTTCAT
TTTTGTATATTCCCGCTCTTTTCTCTTCATTTCCCTGTCTTCTGCATAATCATGCCTTCTTGCTAAGTAATTCAAGCATAAGATCTTGGA
ATAATAAAATCACAATCTTAGGAGAAAGAATAAAATTGTTATTTTCCCAGTCTCTTGGCCATGATGATATCTTATGATTAAAAACAAATT
AAATTTTAAAACACCTGAAGATAAATTAGAAGAAATTGTGCACCCTCCACAAAACATACAAAGTTTAAAAGTTTGGATCTTTTTCTCAGC
AGGTATCAGTTGTAAATAATGAATTAGGGGCCAAAATGCAAAACGAAAAATGAAGCAGCTACATGTAGTTAGTAATTTCTAGTTTGAACT
GTAATTGAATATTGTGGCTTCATATGTATTATTTTATATTGTACTTTTTTCATTATTGATGGTTTGGACTTTAATAAGAGAAATTCCATA
GTTTTTAATATCCCAGAAGTGAGACAATTTGAACAGTGTATTCTAGAAAACAATACACTAACTGAACAGAAGTGAATGCTTATATATATT
ATGATAGCCTTAAACCTTTTTCCTCTAATGCCTTAACTGTCAAATAATTATAACCTTTTAAAGCATAGGACTATAGTCAGCATGCTAGAC
TGAGAGGTAAACACTGATGCAATTAGAACAGGTACTGATGCTGTCAGTGTTTAACACTATGTTTAGCTGTGTTTATGCTATAAAAGTGCA
ATATTAGACACTAGCTAGTACTGCTGCCTCATGTAACTCCAAAGAAAACAGGATTTCATTAAGTGCATTGAATGTGGATATTTCTCTAAG
TTACTCATATTGTCCTTTGCTTGAATGCAATGCCGTGCAGATTTATGAGGCTGCTATTTTTATTTTCTGTGCATTACTTTAACACCTTAA
AGGGAGAAGCAAACATTTCCTTCTTCAGCTGACTGGCAATGGCCCTTTAACTGCAATAGGAAGAAAAAAAAAAAGGTTTGTGTGAAAATT
GGTGATAACTGGCACTTAAGATCGAAAAGAAATTTCTGTATACTTGATGCCTTAAGATGCCCAAAGCTGCCCAAAGCTCTGAAAGACTTT

>39987_39987_2_INTS8-ESRP1_INTS8_chr8_95841254_ENST00000523731_ESRP1_chr8_95718153_ENST00000423620_length(amino acids)=211AA_BP=
MEPGSGPGGSGGGGRMSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNEQNQVQPPPDN
KRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for INTS8-ESRP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for INTS8-ESRP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for INTS8-ESRP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source